COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
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IF 4.389
Bin Zou,Yan Yan,Jiaojiao Xia,Liming Zhang,Idowu Onyinye Adesanya
A novel integrated lipase nanogel based on functional ionic liquid modification and polymerization immobilization with improved stability was designed. Characterization before and after modification and polymerization was conducted using infrared spectroscopy, Circular dichroism spectroscopy, fluorescence spectroscopy, and scanning electron microscopy. It was shown that the modification of the ionic liquid influenced the catalytic behavior of lipase significantly due to the changed structure and surface properties of lipase. The enzymatic properties, including acid-base stability, thermal stability, organic solvents stability, and storage stability of CRL nanogel, were investigated in the p-nitrophenyl palmitate hydrolysis reaction (CRL, Lipase from Candida Rugosa ). The results indicated that CRL nanogel has a better pH, heat, and organic solvent tolerance after immobilization. After seven weeks of storage, the natural CRL gradually lost its enzymatic activity, and only 17.5±1.7 % of the catalytic activity remained, the residual activity of CRL nanogel was 97.3±1.8 %. It was indicated that the novel CRL nanogel was an excellent biocatalyst.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Jing Zhang,Chengcheng Lv,Zhenyang Yu,Yangyuan Zhou
Reproductive toxicities of imidazolium- ([EMIM]X) and pyridinium-based ([APYR]X) ionic liquids (ILs) are essential to fully assess their hazards. Presently, effects of five ILs on the intricate processes of reproduction, including sperm-oocyte interactions, were explored in Caenorhabditis elegans . Results showed that 1-ethylpyridinium bromide ([EPYR]Br) stimulated oocytes, zygotes and total reproduction. 1-Octylpyyridinium bromide ([OPYR]Br) inhibited oocytes and stimulated zygotes, it inhibited the initial and total reproduction. 1-Dodecylpyridinium bromide ([DPYR]Br) inhibited oocytes and zygotes, but stimulated the initial and total reproduction. 1-Ethyl-3-methylimidazolium bromide ([EMIM]Br) inhibited oocytes, but stimulated zygotes and reproduction. 1-Ethyl-3-methylimidazolium iodide ([EMIM]I) inhibited germcells and oocytes but stimulated zygotes and reproduction. Regarding hormones and lipid metabolism, the ILs commonly reduced main sperm protein, sperm transmembrane protein 9 and spermatocyte protein 8. The qRT-PCR results showed that the ILs commonly down-regulated the expressions of mpk-1 , while up-regulated those of inx-14 , with influences on the expressions of vab-1 , unc-43 and rme-2 . These biochemicals and genes were directly connected with the sperm-oocyte interactions. Transcriptomic analysis results supported the involvement of cAMP and cGMP-PKG signaling pathways underlying the effects on the sperm-oocyte interactions. The results also implied ILs’ impacts on neural and immune diseases and even cancers that should be considered in the future.
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高影响因子
CHINESE SCIENCE BULLETIN
·
2013
·Vol. 58
·期 11
·1262-1266
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IF 1.319
Wang Jing,Liu ZhengPing
Poly(aryl ether ketone)s (PAEKs) were successfully synthesized via nucleophilic aromatic substitution (S N AR) mechanism, using ionic liquids as green reaction media. The influence of various reaction parameters including monomer concentration, dehydration time, polymerization temperature and duration, IL’s cations and anions nature, upon PAEKs molecular weight was investigated. In addition, the peculiarities of hydrogen-bonding ability of ILs were investigated. The interaction of 2,2-bis(4-hydroxyphenyl) propane (bisphenol A) with ILs has a strong influence on PAEKs synthesis. Various moderate molecular weight PAEKs have been obtained in high yields with molecular weights ranging from 10000 to 18000 g mol −1 .
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Soft Matter
·
2021
·Vol. 17
·期 12
·3494-3502
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IF 3.679
Wenchang Zhuang,Chunhua Zhao,Yue Pan,Qintang Li
As tailorable solvents, the physiochemical properties of ionic liquids can be tuned by the structure of ions. Herein, we investigate the structural effects of ILs on the self-assembly of surfactants. It has been confirmed that the cationic surfactant 1-hexadecyl-3-methylimidazolium bromide (C16mimBr) can self-assemble into micellar and lamellar lyotropic liquid crystal phases in the aprotic ionic liquid (AIL) 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF4). In this work, we explore the aggregation behaviours in AILs with different alkyl chains on the imidazolium group, i.e., 1-propyl-3-methylimidazolium tetrafluoroborate ([Pmim]BF4), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4), 1-hexyl-3-methylimidazolium tetrafluoroborate ([Hmim]BF4) and 1-octyl-3-methylimidazolium tetrafluoroborate ([Omim]BF4). With the increase of the cation chain length, AILs have better solubility of the solvophobic part of the surfactants and hence a weaker driving force for self-assembly. Therefore, the critical micellization concentration of C16mimBr in AILs increases as confirmed by the surface tension and small angle X-ray scattering characterizations. More interesting things happen to the phase behaviours. Besides the micellar and lamellar lyotropic liquid crystal phases, a hexagonal lyotropic liquid crystal phase is formed in [Pmim]BF4 while hexagonal and bicontinuous cubic lyotropic liquid crystal phases are formed in [Bmim]BF4, [Hmim]BF4 and [Omim]BF4. It is surprising to observe richer phase behaviours in solvents of lower cohesive energy. The detailed structural information of various aggregates has been obtained by small-angle X-ray scattering. It is demonstrated that AILs work as not only solvents but also co-surfactants.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Kaibo Hu,Hongshuai Gao,Yi Nie,Haifeng Dong,Junjun Yan,Xiangping Zhang,Fujian Li
The efficient extraction separation of yttrium (Y) from holmium (Ho) and erbium (Er) is always difficult because of their similar physical and chemical properties. In this work, three pyridine carboxylic acid ionic liquids were synthesized and used to extraction of Y. The effects of aqueous phase acidity, extraction time, extractant concentration, temperature and alkyl chain length of ionic liquids on extraction of Y were investigated systematically. The extraction efficiency of [(CH 2 ) 7 COOHpyr][NTf 2 ] for Y increased with an increase in pH, and could reach 99.3% at a pH of 2.5. Meanwhile, the extraction process could achieve equilibrium completely within 5 min. In addition, both the separation coefficients of Ho/Y and Er/Y were greater than 2, which were higher than other ionic liquid extractants. At last, 98.5% of Y could be stripped from the loaded ionic liquid phase with a single step using 0.04 mol/L HCl, and the extraction efficiency of the [(CH 2 ) 7 COOHpyr][NTf 2 ] for Y still maintained about 98% after 8 cycles. A possible cation exchange extraction mechanism was proposed by slope analysis and FTIR spectroscopy.
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AICHE JOURNAL
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2026
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IF 4.4
Bin Jiang,Ruisong Zhu,Qinghua Liu,Yongqiang Cheng,Minghao Song,Fei Zhao,Zhigang Lei
Traditional phosphonic acid extractants such as P507 often exhibit limited extraction efficiency. Herein, a synergistic extraction strategy is developed to enhance the recovery and separation of valuable metals from acidic leachates of spent lithium-ion batteries (LIBs) by modulating P507 with lidocaine (Lid), thereby eliminating the need for saponification pretreatment and acidification. Metal extraction proceeds via combined cation-exchange and coordination mechanisms. Quantum chemical calculations and molecular dynamics simulations reveal the metal-binding sites in the ionic liquid [LidH][P507], providing theoretical guidance for synergistic extractant design. The system achieves high recoveries of Co 2+ (98.85%), Ni 2+ (95.13%), and Mn 2+ (99.97%), with separation factors of up to 250.56 (
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Advanced Healthcare Materials
·
2026
·
IF 11
Lianyi Yang,Yazhen Wang,Lei Lei,Bin He,Yuanwei Chen,Jun Cao
The pathological process of androgenic alopecia (AGA) is closely associated with oxidative stress in the perifollicular microenvironment. Existing antioxidant small-molecule drugs are often constrained by low permeability, necessitating the urgent development of active therapeutic agents that can effectively penetrate the skin barrier and precisely deliver antioxidants to hair follicles. This study reported a taurine-based active pharmaceutical ingredient ionic liquid (CTIL) synthesized via a one-step method, which not only acted as a delivery carrier but also served as a therapeutic material capable of modulating the perifollicular microenvironment by scavenging reactive oxygen species (ROS). An in vitro study demonstrated that the hydrogen-bond network structure of CTIL facilitated its penetration through the stratum corneum barrier, thus improving the targeted accumulation of taurine within deep hair follicle structures. More importantly, in the AGA animal model, CTIL effectively eliminated excessive ROS in the perifollicular microenvironment, alleviated tissue oxidative damage and inflammatory infiltration, thereby inhibiting the miniaturization process of hair follicles and promoting hair regrowth. This study provided an innovative strategy integrating delivery and treatment for AGA therapy and revealed the potential of bioactive ionic liquids in regulating the microenvironment of skin diseases.
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MONATSHEFTE FUR CHEMIE
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2026
·
IF 2.2
Wang Yun,Zhang Qiang-qiang,Liu Zi-yin,Xie Zhuang-dong
The synthesis of 2-aryl-2,3-dihydroquinolin-4(1 H )-ones from aromatic aldehydes and and 1-(2-aminophenyl)ethanone catalyzed by l -proline in ionic liquids was achieved for the first time. High yields up to 88.7% were achieved. Mild reaction conditions, enhanced rates, improved yields, and reagents’ reactivity, which is different from that in standard organic solvents, are the remarkable features observed in ionic liquids. In addition, the reaction mechanism was studied using computational methods, and the results were consistent with experimental findings. Graphical abstract
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POLYMER DEGRADATION AND STABILITY
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2026
·
IF 8.1
Sarah Elfadil Ali,Jianhui Li,Yuanqing Shen,Xiaochun Chen
With global plastic production soaring, developing efficient chemical recycling methods for polyethylene terephthalate (PET) is critical. While synergistic systems of ionic liquids and metal salts have shown promise for PET glycolysis, they often face significant challenges in catalyst separation and recyclability, hindering practical application. To address these limitations, this study introduces a heterogeneous catalyst [P 66614 ]Cl-ZnO, synthesized through an ultrasonication-assisted method. Comprehensive characterization reveals that the ionic liquid forms a stable composite through electrostatic interactions, creating a bifunctional acid catalyst with both Lewis and Brønsted acid sites, as confirmed by pyridine-FTIR. Critically, the mesoporous architecture of [P 66614 ]Cl-ZnO (surface area = 57.5 m 2 /g, mean pore diameter = 35.48 nm) is more than double that of pure ZnO and specifically designed to facilitate rapid diffusion of bulky PET polymer chains through catalyst pores, overcoming typical mass-transport limitations in polymer depolymerization. Under optimized conditions (195°C, 80 min), the catalyst achieves complete PET conversion and an 89.89% yield of bis(2-hydroxyethyl) terephthalate (BHET), while reducing the activation energy to 102.3 kJ·mol −1 . The heterogeneous nature of the catalyst allows for easy recovery, demonstrating consistent performance in ten consecutive cycles. The high purity of the BHET product was verified by NMR, MS, and elemental analysis. This work provides a robust, efficient, and reusable catalytic system for PET glycolysis, highlighting the importance of tailored textural and acidic properties in catalyst design.
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Siqi Jiang,Zhiyong Su,Jiahui Zhang,Yu Li,Ye Yang,Chao Pan,Yufeng Hu
1,3,5-Trioxane (TOX) is an important organic synthetic intermediate, but the separation of water (H2O)/TOX, which can form an azeotrope, is the main challenge of the synthesis of TOX. Consequently, developing an innovative approach to efficiently recover TOX has become critically important. This study presents vapor–liquid equilibrium (VLE) measurements of TOX/H2O incorporating the ionic liquid 1-ethyl-3-methylimidazolium bromide ([EMIM][Br]) conducted at atmospheric pressure. The results show that the addition of [EMIM][Br] can effectively break the azeotropic effect of the original components. Correlation of the acquired ternary VLE data sets was performed employing four distinct thermodynamic models: the Wilson, d-Wilson, NRTL, and e-NRTL equations. Comparative assessment demonstrated that the NRTL model achieved optimal consistency with the empirical observations. Furthermore, the mechanism of [EMIM][Br] separation of TOX/H2O was explored through electrostatic potential (ESP) analysis, calculation of binding energy, and COSMO-RS. Subsequently, the extractive distillation process (EDP) was designed by the Aspen Plus V11 software, and the NSGA-II algorithm was written to optimize the parameters of EDP. Finally, process intensification design was carried out using heat integration to reduce the total annual cost (TAC). This method provided a new idea for the design of extractive distillation for TOX/H2O and promoted the practical application of the ionic liquid in advancing TOX separation technology.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Weiguo Wu,Ran Gao,Mingyue Wu,Ting Sun,Xijun Hao,Chongyang Hu,Yikang Shu,Danhua Li,Shuai Ji
Immobilized kinases are capable of catalyzing the in vitro phosphorylation of substrates, offering the advantages of recoverability and reusability. Nevertheless, existing immobilization strategies are often limited by intricate procedures and suboptimal biocompatibility. In this work, we selected Akt (protein kinase B) as a model enzyme and developed an efficient immobilization strategy based on a magnetic aldehyde-functionalized ionic liquid support. Key advantages of this approach include a short immobilization time, avoidance of toxic crosslinkers, and applicability to protein-level phosphorylation. A dual-aldehyde-functionalized ionic liquid was synthesized using 4-(imidazol-1-yl)benzaldehyde as the cation and 3-bromo-4-aldehyde-benzoic acid as the anion. This ionic liquid was anchored onto Fe 3 O 4 to yield the novel magnetic nanocomposite Fe 3 O 4 @SiO 2 @[ImBa][BABa], which was characterized by SEM, TEM, IR, EDS, TGA and VSM analyses. Akt was immobilized onto this carrier via Schiff base covalent linkage between aldehyde and amino groups. The optimal immobilization parameters were identified, and the immobilized Akt exhibited enhanced catalytic activity relative to conventional immobilization approaches. Furthermore, the immobilized enzyme demonstrated superior substrate affinity and storage stability compared with its free counterpart, as well as proof-of-concept reusability over four cycles (>80% residual activity). Importantly, the immobilized Akt retained its ability to catalyze the phosphorylation of both peptide and protein (GSK3β) substrates, underscoring its practical potential. To the best of our knowledge, this study represents the first application of magnetic ionic liquids for kinase immobilization and the first establishment of an immobilization protocol for Akt.
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COMBUSTION AND FLAME
·
2026
·
IF 5.9
Bingxi Song,Yue Li,Yijie Cai,Xingyu Wang,Yingying Cao,Long Liu,Yanqiang Zhang
The tunability of ionic liquids allows the cations and anions to play different roles, with the cations acting as fuel and the anions serving as catalysts. • Ionic liquid propellants are free of metals and can enhance the performance of the fuel. • The thermodynamic mechanism and ignition mechanism of ionic liquid iodine promoters were studied, providing a theoretical foundation for subsequent research. The H₂O₂-ILs spontaneous combustion propellant can solve the problems associated with traditional propellants, such as the toxicity, volatility and corrosive nature of oxidants. However, a long ignition delay time (IDT) has resulted in by the weak acidity and high latent heat of H₂O₂. This paper presents the synthesis of two non-metallic polyiodide promoters: 1,3-dimethyl-4,5-diiodoimidazolium iodide (P-1) and 1,3-dimethyl-4,5-diiodoimidazolium triiodide (P-2). The physical and chemical properties, as well as the combustion behaviour, of the two promoters when compounded with ionic liquid fuels (1-allyl-3-ethylcyanoammonium bromide ([AEIM][BH₃CN]) were studied. The IDT of the fuel system was reduced from 2870 ms to 90 ms (P-1, 15%) and 55 ms (P-2, 20%), respectively, after compounding the promoters. This improvement in ignition performance is primarily due to the promoter reducing the fuel's decomposition activation energy and the Gibbs free energy of the dehydrogenation reaction between hydrogen peroxide and H₃BCN anions in the fuel-H₂O₂ reaction. This study will inform the improvement of the performance of H₂O₂-ILs as spontaneous combustion propellants. Download: Download high-res image (141KB) Download: Download full-size image
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