ENVIRONMENTAL POLLUTION
·
2017
·
IF 5.099
Jingjing Deng,Dingkun Lu,Xiaolei Zhang,Guoyue Shi,Tianshu Zhou
In this study, we demonstrated an assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase (AChE) fluctuation as a biomarker for organophosphorus pesticides (OPs) poisoning and management based on single layer MnO 2 nanosheets with graphene quantum dots (GQDs) as signal readout. Initially, the fluorescence of GQDs was quenched by MnO 2 nanosheets mainly due to the inner filter effect (IFE). However, with the presence of reductive thiocholine (TCh), the enzymatic product, hydrolyzed from acetylthiocholine (ATCh) by AChE, the redox reaction between MnO 2 and TCh occurred, leading to the destruction of the MnO 2 nanosheets, and thereby IFE was diminished gradually. As a consequence, the turn-on fluorescence of GQDs with the changes in the spectrum of the dispersion constituted a new mechanism for sensing of cerebrospinal AChE. With the method developed here, we could monitor cerebrospinal AChE fluctuation of rats exposed to OPs before and after therapy, and could thereby open up the pathway to a new sensing platform for better understanding the mechanism of brain dysfunctions associate with OPs poisoning.
研究领域:
生物化学
·
毒理学
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Zhuowen Wang,Haijun Chen,Shiyi Zhao,Dapeng Liang,Deming Dong,Zhiyong Guo,Jiao Qu,Haiyang Liu,Xiuyi Hua
The extensive use of antibiotics poses a significant risk to human health, and electrocatalysis has demonstrated effectiveness in treating antibiotic contamination. This study details the synthesis of MnO 2 /Pd(OAC) 2 @CA particle electrodes using a straightforward one-step sol–gel method and the development of a three-dimensional electrocatalytic reactor (3DER) to remove antibiotics from water. Under optimal conditions (1.5 g/L MnO 2 /0.3%Pd(OAC) 2 , pH 3 and 2.0 V), a degradation of 97.8% of tetracycline hydrochloride (TCH) at a concentration of 15 mg/L is achieved within 80 min. The rate constant in the 3DER ( k = 0.0389) is 9.26 times greater than that in a two-dimensional electrocatalytic reactor (2DER) ( k = 0.0043). After ten cycles of treatment, the degradation rate of TCH remains at 86.4%. Furthermore, under optimal conditions, the energy consumption of the 3DER is significantly lower than that reported in other studies, with an EEO value of only 0.033 kWh/m 3 . Radical scavenger experiments and electron paramagnetic resonance (EPR) studies identify the free radicals involved, including •OH, SO 4 • – , H*, and •O 2 – . Theoretical calculations and toxicity assessment reveal a general reduction in the toxicity of the intermediate products formed during the electrocatalytic degradation of TCH. In summary, the MnO 2 /Pd(OAC) 2 @CA particle electrodes exhibit high electrocatalytic degradation efficiency, excellent recyclability and reusability. The 3DER constructed using particle electrodes demonstrates broad applicability and environmental friendliness, providing a novel solution for remediating antibiotic-contaminated water.
研究领域:
环境科学
·
电化学工程
·
抗生素污染治理
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yaohua Wu,Yulian Li,Junyong He,Xun Fang,Peidong Hong,Mingxing Nie,Wu Yang,Chao Xie,Zijian Wu,Kaisheng Zhang,Lingtao Kong,Jinhuai Liu
In this work, 1D MnO 2 nano-needles were prepared and grown on the graphene oxide (GO) nano-sheets successfully. The morphology and structure of materials were explored. The MnO 2 nano-needles with a length of 200–400 nm were distributed uniformly on the GO nano-sheets. As a result of GO substrate, the MnO 2 /GO nano-hybrids (MnO 2 /GO) have the much larger surface area and more surface oxygen-containing functional groups than MnO 2 nano-needles, which are beneficial for enrichment and degradation of the norfloxacin (NOR). Results showed that more than 80% NOR was degraded within 20 min at the dose of 10 mM PMS and 0.8 g/L catalysts. Moreover, the optimal pH in MnO 2 /PMS and MnO 2 /GO/PMS system were both acidic condition. Furthermore, the mechanism of PMS activation by MnO 2 /GO was investigated through radical identification using quenching experiments and EPR techniques. According to this, the HSO 5 − of PMS reacted with Mn (IV)/Mn(III) to form a redox loop, and GO played an important role in the degradation process. Finally, the transformation intermediates of NOR were identified and four probable degradation pathways were speculated. This work would provide a potential contribution towards NOR removal in the environmental remediation.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2016
·Vol. 27
·期 4
·1604258
·
IF 11.382
Zhifang Ma,Xiaodan Jia,Jing Bai,Yudi Ruan,Chao Wang,Jianming Li,Mengchao Zhang,Xiue Jiang
Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal tissues, which inevitably leads to a limited efficacy for photodynamic therapy (PDT) and the enhanced systematic phototoxicity. Moreover, local hypoxia of the tumor tissue also seriously hinders the PDT. To overcome these limitations, an acidic H 2 O 2 -responsive and O 2 -evolving core–shell PDT nanoplatform is developed by using MnO 2 shell as a switchable shield to prevent the premature release of loaded PS in core and elevate the O 2 concentration within tumor tissue. The inner core SiO 2 -methylene blue obtained by co-condensation has a high PS payload and the outer MnO 2 shell shields PS from leaking into blood after intravenous injection until reaching tumor tissue. Moreover, the shell MnO 2 simultaneously endows the theranostic nanocomposite with redox activity toward H 2 O 2 in the acidic microenvironment of tumor tissue to generate O 2 and thus overcomes the hypoxia of cancer cells. More importantly, the Mn(ΙΙ) ion reduced from Mn(ΙV) is capable of in vivo magnetic resonance imaging selectively in response to overexpressed acidic H 2 O 2 . The facile incorporation of the switchable MnO 2 shell into one multifunctional diagnostic and therapeutic nanoplatform has great potential for future clinical application.
研究领域:
生物医学工程
·
肿瘤治疗学
·
纳米医学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Jinhua Lai,Feng Cheng,Shuolin Zhou,Sha Wen,Dongwen Guo,Wenguang Zhao,Xianxiang Liu,Dulin Yin
Nitrogen-containing polymer-supported Cu-doped MnO 2 (Cu-MnO 2 @PDVTA) nanowires were prepared and their catalytic performances were evaluated via oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The Cu-MnO 2 @PDVTA catalysts were characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, N 2 physical adsorption, transmission electron microscopy, and X-ray photoelectron spectroscopy. Both the Cu 2+ and MnO 2 nanoparticles were found to synergistically promote HMF oxidation to FDCA via 2,5-furandicarbaldehyde and 5-formyl-2-furancarboxylic acid intermediates. The Cu-MnO 2 @PDVTA-3 catalyst demonstrated the highest catalytic activity, providing FDCA with an excellent yield of 96.8% after 12 h at 80 °C. The time course of HMF oxidation revealed that oxidation of the hydroxyl group in HMF was easier than that of the aldehyde group. Cu-MnO 2 @PDVTA-3 could act as a reusable heterogeneous catalyst for HMF oxidation.
研究领域:
化学工程
·
材料科学
·
催化反应
✓ 已验证
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Lin Chai,Haoyu Chen,Xing Yang,Jing Liu,Qiquan Yang,Shu Huang,Min Tang,Xiaohua Zhu,Haitao Li,Youyu Zhang,Meiling Liu
Ratiometric fluorescent nanoplatforms with self-calibrating capabilities offer enhanced detection accuracy by minimizing environmental interference. However, challenges such as signal cross-interference and nanomaterial instability persist in complex biological systems. To address these issues, we developed a glutathione (GSH)-responsive ratiometric fluorescent nanoprobe by integrating a porphyrin-based metal-organic framework (PCN-224) with MnO 2 nanosheets (NSs). The PCN-224 serves as both a nanocarrier and luminescent moiety, while MnO 2 acts as oxidase (OXD) mimetic nanozyme and the reactive site for GSH. The ratiometric detection mechanism relies on the intrinsic fluorescence of PCN-224 (emission at 655 nm) and the OXD-like activity of PCN-224@MnO 2 , which catalyzes the oxidation of o -phenylenediamine (OPD) to generate fluorescent 2,3-diaminophenazine (DAP, emission at 570 nm). Upon GSH exposure, the redox reaction between GSH and MnO 2 produces Mn 2+ , quenching the OXD-like activity and diminishing the DAP fluorescence, while the PCN-224 fluorescence recovers due to MnO 2 decomposition. The nanoplatform exhibits a wide detection range spanning from 0.1 to 60 μM with a low detection limit of 15 nM and high selectivity. Furthermore, it enables accurate GSH quantification in complex biological matrices, including human serum and cell lysates, and facilitates real-time monitoring of endogenous and exogenous GSH in living cells via fluorescence imaging. This study not only presents sensitive and reliable platform for GSH detection, but also overcomes key limitations in ratiometric sensing, such as signal interference and nanomaterial instability, by utilizing a stimuli-responsive fluorescent nanoprobe design.
研究领域:
分析化学
·
纳米技术
·
生物化学
·
生物传感器
·
荧光成像
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Hanrui Zhao,Minfeng Chen,Xinxin Mi,Wei Li,Weiwei Qian,Qinghua Tian,Jizhang Chen
Aqueous zinc-ion batteries (AZIBs) have emerged as a promising technology in the realm of large-scale energy storage, with cathode material performance being a critical determinant of their practical viability. Among various cathode material candidates, MnO 2 has garnered substantial attention, whereas it suffers from poor cyclability and sluggish reaction kinetics. Herein, an efficient approach is presented to address these challenges through the development of a phytic acid-modified δ-MnO 2 , fabricated through a one-step oil-bath strategy. In the composite, the phytic acid coating can mitigate MnO 2 dissolution, and the insertion of phytic acid with excellent zincophilicity can promote Zn 2+ ion intercalation and diffusion, hence significantly improving electrochemical kinetics and reversibility. Owing to these advantages, the modified MnO 2 offers a large specific capacity of 233.4 mAh g –1 at 0.2 A g –1 , and maintains 83.6 % and 48.2 % of that capacity as the current density rises to 1 and 5 A g –1 , respectively. Under a large mass loading of 10 mg cm –2 , this material exhibits outstanding cycling stability, retaining 90.4 % of its initial capacity after 1000 cycles. This work provides valuable insights into material engineering for advanced battery technologies.
研究领域:
储能技术
·
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Can Cui,Xiaohuan Sun,Chuanqiang Zhou,Yingwei Liu,Huixin Xiong,Yanan Li,Jie Han
Pomegranate-like MnO 2 @polyaniline (PANI) sub-microspheres have been designed and successfully synthesized as a novel and highly effective sorbent material to remove heavy metal ions from water. Herein, pomegranate-like SiO 2 @PANI spheres were firstly fabricated by performing the oxidation polymerization of aniline in silica colloidal solution, followed by the removal of SiO 2 and in situ redox reaction between KMnO 4 and PANI . Compared with the mono-component PANI and MnO 2 materials, the obtained pomegranate-like MnO 2 @PANI sub-microspheres exhibited superior adsorption ability towards Pb(II) ions due to the synergistic effect. Influencing factors, including pH, Pb(II) ions concentration, adsorbents content and other ions on the Pb(II) ion sorption onto the MnO 2 @PANI hybrid were systematically studied. The sorption isotherm, kinetics and thermodynamic properties of the hybrids for Pb(II) ions adsorption were reflected by different models. Moreover, the adsorption ability of pomegranate-like MnO 2 @PANI sub-microspheres towards other heavy metal ions was also explored. This work would provide new insight on the design of hierarchical inorganic/organic nanosorbent.
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
DOI
高影响因子
DESALINATION
·
2023
·
IF 9.9
Xueying Gao,Zhenzhen Fu,Yanfei Sun,Dewei Wang,Xiaoxuan Wang,Zishan Hou,Jinrui Wang,Xia Liu,Shiyu Wang,Shuyun Yao,Huiying Zhang,Shuyuan Li,Zheng Tang,Weijie Fu,Kaiqi Nie,Jiangzhou Xie,Zhiyu Yang,Yi-Ming Yan
While MnO 2 has been identified as a potent agent in the desalination process , its efficacy is significantly impeded by its inherent poor electrical conductivity and substantial ion diffusion barriers . By orchestrating an interfacial electron bridge within the MnO 2 /g-C 3 N 4 heterostructure , reinforced through N p z -Mn d z 2 orbital hybridization, we have managed to significantly boost both SAC and SAR in the HCDI process. The reinforced N p z -Mn d z 2 orbital hybridization triggers a substantial electron transition from g-C 3 N 4 to MnO 2 , culminating in a high Mn d z 2 electron occupancy. Further analysis reveals the formation of a Mn N chemical bond at the MnO 2 /g-C 3 N 4 interface, operating as an essential electron transfer bridge from g-C 3 N 4 to MnO 2 . This process concurrently initiates a rise in the Mn d z 2 orbital energy level, equipping the Mn d z 2 electron with superior redox activity. With these enhancements, the manufactured MnO 2 /g-C 3 N 4 exhibits exemplary performance, boasting an improved SAC of 68 mg g −1 and SAR of 3.6 mg g −1 min −1 with a decreased energy consumption of 0.7224 kWh kg −1 at 1.2 V. This innovative work offers an unconventional roadmap for activating electron redox activity and thereby accelerating charge transfer in transition metal oxides .
研究领域:
材料科学
·
环境科学
·
电化学
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Diyu Wang,Subin Lin,Tuanwei Li,Xiaohu Yang,Xiang Zhong,Qian Chen,Guoqin Jiang,Chunyan Li
ABSTRACT Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO 2 nanosensitizer (R&F@Au/MnO 2 -CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO 2 is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO 2 -CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO 2 upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.
研究领域:
纳米技术
·
癌症研究
·
诊疗学
·
放射生物学
·
免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yueyue Ma,Yadong He,Chenlong Hao,Xiang Li,Ling Li,Youwei Zhao,Yucang Zhang,Wenming Zhang
With the continuous development of self-powered sensing systems, achieving efficient energy self-supply and high-performance signal acquisition simultaneously has emerged as a main trend for next-generation sensors. However, developing functional materials for such sensing systems is still facing crucial challenges. Herein, a multifunctional MnO 2 @PANI (MP) composite material was designed to realize a synchronized “integration” strategy. Specifically, the MP serves as a cathode in photo-assisted zinc-ion batteries (PA-ZIBs), enabling solar energy conversion and storage. The p-n heterojunction formed between MnO 2 and PANI promotes effective separation of photogenerated electron-hole pairs and enhances Zn 2+ kinetics. Therefore, the PA-ZIBs deliver a high self-charging voltage of 1.08 V and 33 % enhancement in specific capacity (reaching 249.5 mAh g −1 at 0.1 A g −1 ) under illumination. Meanwhile, it also functions as the active layer of a flexible strain sensor, achieving efficient mechanical signal detection. The core–shell structure and composite component improve both structural stability and conductivity. As a result, the sensor exhibits high sensitivity, a fast response time of 0.4 s, and excellent durability over 2000 cycles. Furthermore, proof-of-concept demonstrations validate the device’s capability to simultaneously harvest solar energy and detect physiological signals. This work offers a new solution for designing self-powered sensing systems and intelligent healthcare applications by merging energy-autonomous operation with multifunctional sensing capabilities.
研究领域:
材料科学
·
能源技术
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2020
·
IF 5.715
Wei Qian,Hui Huang,Zenghui Diao,Huankai Li,Hui Liu,Maoyou Ye,Yili Deng,Zhimin Xu
The deposal of residual hydrogen peroxide (H 2 O 2 ) in Fenton-like system and the requirement of oxygen in bioreactor are essential parts for the treatment of integrative Fenton-like/bioreactor. A novel low-cost integrative Fenton-like and MnO 2 -filled upward flow biological filter bed (Fenton-like/MBFB) equipped with the modified ceramsite was constructed to evaluate the main properties and catalytic activity of modified ceramsite, and the optimal conditions of integrative system and compare integrative and traditional systems. In this study, the Fenton-like reactor with modified ceramsite had higher catalytic ability whose Acid Orange 7 (AO7) degradation efficiency reached to 79.3% due to large surface area and high porosity, compared with that with raw ceramsite (44.3%). Furthermore, total utilization efficiency of H 2 O 2 in integrative system (from 32.41% to 53.51%) and removal efficiencies of COD and AO7 were remarkably improved, which would effectively decrease the waste of H 2 O 2 and the setting of regulation pool and aeration tank. Thus, the integrative system can save 0.51 CNY/m 3 in construction cost and 0.21 CNY/m 3 in operating cost. The average COD removal efficiency, AO7 degradation efficiency and effluent DO concentration were achieved to 64.8%, 79.5% and 9.3 mg/L respectively in integrative system were achieved in integrative system during sixty successive runs. Also, the potential degradation pathway of contaminants was also proposed according to the OH-enhanced at Fenton-like reactor due to catalyst and adsorption of modified ceramsite and the removal of microorganisms and modified ceramsite for contaminants at MBFB. This study demonstrated the feasibility of integrative Fenton-like/MBFB filled with modified ceramsite for simultaneously decreasing operational cost and complexity and enhancing removal efficiency, thus provided a one-step alternative for refractory dye wastewater.
研究领域:
环境科学
·
污水处理
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）