SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Peiyao Wang,Xiaoluan Yang,Shuoze Geng,Lei Guo,Guiying Li
The development of integrated platform for the simultaneous detection and removal of heavy metal ions remains critical challenge in environmental monitoring. Herein, tetraphenylethylene-modified mesoporous silica nanoparticles (MSN-TPE) were fabricated via Schiff base reaction, and then incorporated into sodium alginate (SA) hydrogel for simultaneous detection and adsorption of Fe 3+ . The as-prepared hydrogel and MSN-TPE probe exhibited strong aggregation-induced emission (AIE) fluorescence, excellent stability against long-term storage, varied pH and temperatures. The hydrogel achieved sensitive and selective fluorescence quenching response to Fe 3+ , with a detection limit as low as 0.460 μM. Thanks to its porous network structure and abundant active sites, the hydrogel also demonstrated significant adsorption capacity for Fe 3+ , with the maximum theoretical adsorption capacity of 383.06 mg/g. Mechanism analysis indicated that Fe 3+ quenched the fluorescence of probe through static quenching, and the adsorption process was mainly driven by the coordination and electrostatic interactions between Fe 3+ and the nitrogen/oxygen functional groups in hydrogel. Combined with simple preparation and excellent anti-interference ability, this dual-functional hydrogel shows broad application prospects in water quality monitoring and heavy metal purification.
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高影响因子
CELLULOSE
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2025
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IF 4.8
Wu Yuewei,Che Wenrong,He Ziyang,Chi Yuhang,Li Baohui,Zheng Jianwei,Zeng Xianhai,Zuo Miao
Cellulose nanocrystals (CNCs) are one of the most important biomass-derived materials for reinforcing hydrogels. Nevertheless, there is a lack of comparative studies examining the impact of CNCs synthesized via disparate methodologies on the toughening of hydrogels. This study synthesized two different CNCs through the sulfuric acid hydrolysis and deep eutectic solvent (DES) synthesis methods from Gleditsia sinensis peel, a forest residue, and compared their effects on the enhancement of the mechanical properties of SA/PAAM (sodium alginate/polyacrylamide) hydrogels. The comprehensive characterizations demonstrated that the mechanical properties of hydrogels derived from DES-CNCs are superior to those derived from S-CNCs (sulfuric acid-CNCs). The DES-CNC/SA/PAAM hydrogels revealed a homogeneous structure with excellent strain (2534%), high transparency (90%), and self-adhesiveness (15 kPa). The flexible sensor assembled using hydrogels exhibited accurate real-time monitoring capabilities for minor and larger strains during movement. To investigate the enhancement mechanism of CNCs on hydrogels, this work evaluated weak interaction forces between DES-CNC/SA/PAAM components through the quantum chemical theoretical calculations, with the combination of wave function analysis method and Molecular dynamics (MD) simulation. This work provides comparative tests of forestry biomass sources in hydrogel synthesis and sensing applications and suggests a new idea for high-value utilization of biomass feedstocks.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Shuai Qiang Jiang,Su Ping Dai,Yin Wang,Dong Ju Zhou,Ya Wei Chen,Hui Yun Zhou,Hyun Jin Park
In this study, using chitosan (CS) and β-cyclodextrin (β-CD) as raw materials, a cyclodextrin grafted chitosan (CD-g-CS) derivative was successfully synthesized. A novel CD-g-CD-SA-based thermosensitive hydrogel was developed by physical crosslinking in the existence of sodium glycerophosphate (GP) using CD-g-CS and sodium alginate (SA) as materials. The gel time of hydrogel was short, which was <5.00 min. The results of SEM showed that the hydrogel had porous reticular structures. In vitro swelling test and lysozyme degradation experiment demonstrated the good swelling and biodegradability of hydrogel. Using berberine hydrochloride (BBH) as the model drug, the hydrogel showed a slow and controlled release over 36 h and the cumulative release of 36 h was 59.87 %, which demonstrated the hydrogel had good drug release effects. The antioxidant experiments showed that hydrogel had a good antioxidant capacity. The results of the hemocompatibility test and the cytotoxicity test confirmed that the hydrogel had good biocompatibility and biosafety. In vitro antibacterial tests proved that the hydrogel had significant antibacterial effects on both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). In summary, the CD-g-CD-SA/GP hydrogel has great potential for development in the field of biomaterials such as drug sustained release and bacteriostatic materials.
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PubMed
高影响因子
Food Bioscience
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2025
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IF 5.9
Jindan Zhang,Deyang Yu,Jun Zhao,Yiping Chen,Mingqian Tan
Utilizing natural colorant-based colorimetric sensors for food freshness monitoring is an effective approach to reduce food waste and foodborne illness. However, it is hard to modulate the colorimetric endpoint of the pH-responsive natural colorants to determine the food quality accurately. Herein, Kojic acid (KA)-modulated anthocyanin (ACN)/ hydroxypropyl methylcellulose (HPMC)-sodium alginate (SA) film-based colorimetric sensor was prepared using drop casting method. HPMC and SA provided a homogeneous framework to incorporate ACN. KA, a natural product derived from fermented foods, was introduced to manipulate the colorimetric endpoint of ACN to realize an accurate prediction for the freshness of salmon. Molecular dynamics (MD) simulations and density functional theory (DFT) revealed not only the molecular interactions among KA, ACN, HPMC, and SA, but also the strong interactions between the KA-ANC/HPMC-SA colorimetric sensor and trimethylamine (TMA). Results of UV-vis spectra and TMA response experiments illustrated that the KA can inhibit the deprotonation process and promote the hydration equilibrium of ACN, which makes the KA-ACN/HPMC-SA colorimetric sensors exhibit different color responses comparing to the pristine ACN/HPMC-SA. Among all colorimetric sensors, the 1KA-ACN/HPMC-SA exhibited the most sensitive response to TMA with a limit of detection (LOD) of 15.79 μM. When applied in the real-time monitoring of the freshness of salmon at 4°C, the 1KA-ACN/HPMC-SA showed the most significant total color difference (ΔE) of 31.28±0.76 and synchronous color change with the spoilage of salmon after 10 days. The degradation and seed germination experiments of the colorimetric sensors indicated that the colorimetric sensors were environmentally degradable and had good biosafety. This work proposes a novel and effective strategy to modulate the colorimetric endpoint of ACN, and the prepared colorimetric sensors show applicable potential in the quality monitoring of salmon.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yurou Feng,Amatjan Sawut,Rena Simayi,Xieraili Maimaitiyiming,Xueying Jiao
With the advancement of science and technology, the issue of wastewater pollution has escalated, necessitating urgent attention to wastewater treatment . In this study, a highly efficient adsorbent for Cu 2+ was successfully synthesized through in situ self-assembly using Ca 2+ as the cross-linking agent in ZIF-8@ALG composite hydrogel. The results demonstrated that the incorporation of Ca 2+ as the cross-linker enhanced both adsorption capacity and swelling properties of ZIF-8@ALG composite hydrogel. Adsorption performance evaluation revealed that the hydrogel followed pseudo-second-order kinetic model for Cu 2+ adsorption and Freundlich isotherm model with a theoretical maximum adsorption capacity of 309.57 m g −1 . Thermodynamic analysis indicated that Cu 2+ adsorption onto the hydrogel occurred spontaneously with heat absorption. Furthermore, excellent reusability was observed after five cycles of usage without significant loss in adsorption efficiency. Overall, these findings highlight the potential application of ZIF-8@ALG composite hydrogel as an effective solution for wastewater remediation and recovery of heavy metal ions.
研究领域:
环境科学
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材料科学
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化学工程
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环境污染治理
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重金属去除
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DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Pengrui Wu,Xindi Wei,Zhihong Song,Chunling Nie,Zhonghui Shen,Yijun Liu,YanBo Wang,JianGuo Wang,Hong Zeng
Developing environmentally friendly delivery systems capable of encapsulating, protecting, and promoting the absorption of bioactive components in the human body is crucial for those with low oral bioavailability and poor stability. This study developed W/O/W emulsion-filled sodium alginate (SA) hydrogel for the co-delivery of hydrophilic riboflavin and hydrophobic curcumin. Firstly, W/O/W emulsion was prepared using peanut protein isolate (PPI)-bacterial cellulose nanofibers (BCNFs) as the hydrophilic emulsifier and lecithin as the lipophilic emulsifier, and the effect of stabilizer concentrations on emulsion stability was investigated. Results showed that PPI and BCNFs self-assembled into stable complexes through electrostatic interaction and hydrogen bonding, thereby improving the emulsification properties of PPI. Subsequently, SA was added to the outer aqueous phase of emulsions, and its influence on emulsion properties and stabilization mechanism was investigated. SA significantly improved the stability and rheological properties of PPI-BCNFs-stabilized W/O/W emulsions. Finally, the loading capacity of this system for riboflavin and curcumin and its gastrointestinal fate were evaluated. We found this delivery system efficiently co-delivered both hydrophilic and hydrophobic bioactive components and improved their photostability and thermal stability. Moreover, the bioaccessibilities of riboflavin and curcumin were significantly increased to 61.97% and 45.66%, respectively. This was attributed to SA forming a composite interfacial layer on droplets and a dense gel network in the continuous phase, thereby acting as a physical barrier to better protect the encapsulated components. This delivery system holds promise for the development of functional foods incorporating multiple nutraceuticals.
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PubMed
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Applied Materials Today
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2026
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IF 6.9
Ruiwen Zhou,Yuchen Li,Yi Jiang,Miqi Hu,Zhaohui Li,Yu-E Lian,Hui Gao,Lanmei Chen,Dongdong Sun
The rapid emergence of antibiotic resistance and resilient bacterial biofilms poses a critical threat to global public health. To address this challenge, we developed SA-GDL-Ru—a novel sodium alginate hydrogel integrated with a synthesized ruthenium(II) complex ( Ru , RuCl(η⁶-C₆H₆)(TolBig)). This hydrogel overcomes the poor aqueous solubility and toxicity limitations of traditional metal complexes while enhancing antibacterial efficacy. In vitro studies demonstrated potent activity against Staphylococcus aureus (MIC = 13.90 μM) and Escherichia coli (MIC = 20.85 μM), with the SA-GDL-Ru hydrogel (SGR-2) exhibiting 6–8-fold greater reactive oxygen species (ROS) induction than Ru alone. Transcriptomic analysis revealed that SA-GDL-Ru downregulates fabH (fatty acid synthase) and sigB (biofilm synthesis) genes while upregulating quorum-sensing regulators (agrA/agrC), disrupting biofilm integrity. Molecular docking confirmed Ru ’s binding affinity with biofilm-associated proteins, inhibiting key enzymatic functions. Crucially, SA-GDL-Ru accelerated wound closure in S. aureus -infected mice by 4 days through EGFR/Akt pathway activation, increasing VEGF-A/HIF-1α and reducing Caspase-3 expression. In acute pneumonia models, it achieved near-complete bacterial eradication with suppressed inflammation. Safety assessments confirmed minimal cytotoxicity (< 25 μM in zebrafish) and no hemolysis or organ damage. This work establishes SA-GDL-Ru as a translatable therapeutic platform combating biofilm-mediated infections while promoting tissue regeneration.
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POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Hong Qian,Huiwen Chen,Si Ouyang,Yanlin Tian,Kai Chen,Kao Wu,Qian Zhang,Fatang Jiang
The skin-friendliness of aerogels has been gradually extended into the biomedical and personal care fields. The purpose of this study is to define the skin-friendly properties as three aspects, namely comfort and fit, slippage, and irritation, and to systematically evaluate the skin-friendliness of the deacetylated konjac glucomannan (KGM)/sodium alginate (D-KS) aerogel facial mask substrate. The results indicated that deacetylated KGM interacted with sodium alginate through hydrogen bonds, showing good compatibility and forming a continuous three-dimensional network structure. The deacetylation and sodium alginate optimized the microstructure of the aerogels, resulting in a low density of 72.5 mg/cm 3 and a high porosity of 98%, as well as a high shrinkage rate of 43%, which met the requirements of a facial mask. Compared with non-woven fabric, the aerogels exhibited comfortable and fitting characteristics and had the same wettability and moisture permeability. The elongation at break of the aerogel increased by 1.5 times, the compressive strain reached 60%, the slip height decreased by 68%, and the maximum peel force increased by 53.8%. Human skin tests demonstrated that the moisture content of the stratum corneum increased by 35% to 48%. In the biosafe assays, the D-KS aerogels did not cause any negative irritation on mouse cells and skin. The D-KS aerogel retained a compressive strength retention rate of 85.3%. For the loaded allantoin, the aerogels achieved sustained release, with a cumulative release rate of 88%. Summary The skin-friendly properties of biomass aerogel were defined. It showed good compatibility between D-KGM and SA based on hydrogen bonds. The D-KS aerogels exhibited comfortable and fitting characteristics. The D-KS aerogels showed good wettability and moisture permeability. The D-KS aerogels did not cause any negative irritation to the skin.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Fangtong Xiong,Xin Jiang,Xinyu Liu,Xueshun Ji,Weizhao Hu,Yanbei Hou,Yuan Hu
Developing spray-applied fire-retardant materials for wildfire suppression requires rapid deployment, effective surface retention, and sustained protection after water loss and during prolonged heating. This poses a significant challenge to traditional water-based fire-retardant materials, whose protective effectiveness often decreases as water evaporates. Herein, a sprayable ceramifiable sodium alginate-based hydrogel is developed, enabled by the gradual release of Ca 2+ from the CaCO 3 /GDL system under ambient conditions. The hydrogel retained water for up to 17 h at 60 °C. Among all formulations, the incorporation of montmorillonite provided the best overall fire-protection performance, prolonging the ignition time to 215 s and reducing the peak heat release rate, total heat release, and total smoke release by 67.3%, 21.5%, and 62.7%, respectively. During combustion, the sodium alginate/Ca 2+ gel network progressively transformed into a compact carbonaceous–inorganic residue, forming a ceramic-like barrier through the integration of carbonaceous and aluminosilicate-containing components. This work establishes a practical strategy for designing low-cost, spray-applied, bio-based-polymer fire-protection materials for sustainable wildfire prevention.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Saeed Ahmed Memon,Wenting Li,Yun Wei
The rising demand for rare earth elements (REEs) in agriculture and industry highlights the risk of environmental contamination due to their inherent toxicity and potential for ecological accumulation. In this work, a simple and cost-effective alendronate modified sodium alginate composite hydrogel (SA@ANDS) was designed and successfully fabricated. Using the adsorption of REEs La (III) as a scenario, several parameters including pH, adsorbent dosage, time, initial concentration and temperature were systematically examined. Furthermore, isothermal adsorption was adopted to analyze the adsorption mechanism. The results revealed that the adsorption capacity of the adsorbent was 163.93 mg g −1 . Moreover, the density functional theory calculations revealed an adsorption energy of −9.54 eV, indicating SA@ANDS has a good affinity for La (III). Additionally, the SA@ANDS composite hydrogel showed good adsorption capacities of 169.49, 175.43 and 178. 57 mg g −1 for Ce (III), Pr (III) and Sm (III), respectively. The comparative adsorption performance results demonstrated the SA@ANDS composite hydrogel exhibited a stronger binding affinity for La (III) compared to Al (III), Mg (II), Co (II), and Cd (II). The SA@ANDS composite hydrogel showed good recyclability for La (III) of 82.73 % after 5 cycles and was successfully applied for the extraction of La (III) from industrial wastewater.
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DOI
PubMed
高影响因子
Nanomedicine-Nanotechnology Biology and Medicine
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2026
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IF 4.3
Weijie Dong,Tingshu Su,Xinyun Zhang
Hydrogels have the structure and composition of extracellular matrix, but single component hydrogels are often difficult to meet the needs of multi-function. Therefore, in view of the common requirements of anti-infection and promoting bone regeneration in bone tissue, this paper, based on GelMA modified by gelatin, added sodium alginate to blend, and constructed a double network hydrogel of photocrosslinking/ion crosslinking. At the same time, nano hydroxyapatite modified by polydopamine is added to enhance the mechanical properties of the hydrogel on the one hand, and improve the function of the hydrogel material on the other hand. Regarding the preparation of PHA@SA/GEL hydrogel, the physical and chemical properties of system were tested and the possibility of using it as a scaffold for bone tissue engineering was discussed. Therefore, the nanocomposite double network hydrogel prepared in this study has the potential to be used as a scaffold material for bone tissue regeneration.
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高影响因子
CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Xiumei Zhang,Kejun Liu,Miao Qin,Weiwei Lan,Longfei Wang,Ziwei Liang,Xiaochun Li,Yan Wei,Yinchun Hu,Liqin Zhao,Xiaojie Lian,Di Huang
The acidity of high tannic acid (TA) content solution can destroy the structure of protein, such as gelatin (G). This causes a big challenge to introduce abundant TA into the G-based hydrogels. Here, the G-based hydrogel system with abundant TA as hydrogen bonds provider was constructed by a “protective film” strategy. The protective film around the composite hydrogel was first formed by the chelation of sodium alginate (SA) and Ca 2+ . Subsequently, abundant TA and Ca 2+ were successively introduced into the hydrogel system by immersing method. This strategy effectively protected the structure of the designed hydrogel. After treatment with 0.3 w/v TA and 0.06 w/v Ca 2+ solutions, the tensile modulus, elongation at break and toughness of G/SA hydrogel increased about 4-, 2-, and 6-fold, respectively. Besides, G/SA-TA/Ca 2+ hydrogels exhibited good water retention, anti-freezing, antioxidant , antibacterial properties and low hemolysis ratio. Cell experiments showed that G/SA-TA/Ca 2+ hydrogels possessed good biocompatibility and could promote cell migration. Therefore, G/SA-TA/Ca 2+ hydrogels are expected to be used in the field of biomedical engineering. The strategy proposed in this work also provides a new idea for improving the properties of other protein-based hydrogels.
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PubMed
高影响因子
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