JOURNAL OF NANOBIOTECHNOLOGY
·
2015
·Vol. 13
·期 1
·1-10
·
IF 4.115
Chen Jun,Yang Xiao-Quan,Qin Meng-Yao,Zhang Xiao-Shuai,Xuan Yang,Zhao Yuan-Di
Background X-ray computed tomography (CT) imaging can be used to reveal the three-dimensional structure of deep tissue with high spatial resolution. However, it cannot reveal molecular or cellular changes, and has great limitations in terms of specificity and sensitivity. Fluorescence imaging technology is one of the main methods used for the study of molecular events in vivo and has important applications in life science research. Therefore, the combination of CT and fluorescence imaging is an ideal dual-modal molecular imaging method, which can provide data on both molecular function and tissue structure, and has important research value. In a previous study, Bi2S3 nanoparticles were wrapped with quantum dots in SiO2 to generate CT and fluorescence imaging. However, this type of probe led to low survival and caused innegligible in vivo toxicity in mice. Therefore, it is necessary to develop new multifunctional probes that demonstrate biocompatibility and safety in vivo.Methods A polyethylene glycol-phospholipid bilayer structure was used to synthesize hybrid clusters containing hydrophobic Bi2S3 nanoparticles and quantum dots for combined CT/fluorescence imaging. Mean particle size, polydispersity index, and zeta potential were used to study the stability over an 8-week test period. In vivo CT and fluorescence imaging experiments were performed, and the in vivo safety of the probe was evaluated, using histopathological, biochemical, and blood analyses.Results The probe distinctly enhanced the CT contrast and had fluorescence imaging capability. In addition, the nanocomposite hybrid clusters showed a longer circulation time (>4 h) than iobitridol. The results also showed that the Bi2S3-QD@DSPE probe had good biocompatibility and safety, and did not affect normal organ functioning.Conclusion sBi2S3-QD@DSPE hybrid clusters exhibited remarkable performance in CT angiography and fluorescence imaging in vivo.
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产品关联
DOI
PubMed
高影响因子
Nanoscale Research Letters
·
2016
·Vol. 11
·期 1
·1-8
·
IF 2.584
Yan Xinyu,Wang Kan,Lu Wenting,Qin Weijian,Cui Daxiang,He Jinghua
Carbohydrate antigen 72-4 (CA72-4) is an important biomarker associated closely with diagnosis and prognosis of early gastric cancer. How to realize quick, sensitive, specific, and quantitative detection of CA72-4 in clinical specimens has become a great requirement. Herein, we reported a CdSe/ZnS quantum dot-labeled lateral flow test strip combined with a charge-coupled device (CCD)-based reader was developed for rapid, sensitive, and quantitative detection of CA72-4. Two mouse monoclonal antibodies (mAbs) against CA72-4 were employed. One of them was coated as a test line, while another mAb was labeled with quantum dots and coated onto conjugate pad. The goat anti-mouse IgG was immobilized as a control line. After sample was added, a sandwich structure was formed with CA72-4 and these two mAbs. The fluorescent signal from quantum dots (QD)-labeled mAb in sandwich structure was related to the amount of detected CA72-4. A CCD-based reader was used to realize quantitative detection of CA72-4. Results showed that developed QD-labeled lateral flow strips to detect CA72-4 biomarker with the sensitivity of 2 IU/mL and 10 min detection time. One hundred sera samples from clinical patients with gastric cancer and healthy people were used to confirm specificity of this strip method; results showed that established strip method own 100 % reproducibility and 100 % specificity compared with Roche electrochemiluminescence assay results. In conclusion, CdSe/ZnS quantum dot-labeled lateral flow strips for detection of CA72-4 could realize rapid, sensitive, and specific detection of clinical samples and could own great potential in clinical translation in near future.
研究领域:
医学诊断
·
生物化学
·
纳米技术
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Xiaoping Chen,Jianwei Lin,Yafeng Zhuang,Siqi Huang,Jinghua Chen,Zhizhong Han
A new ratiometric fluorescence sensor is prepared for selective detection of chlorotetracycline (CTC) through dual-mode fluorescence method. The sensor is composed of carbon dots (CDs) with blue emission and carboxyl-modified CuInS 2 /ZnS quantum dots (QDs) with dark-red emission. Usually QDs are used as fluorescent probes or signal sources, but it is interesting in this strategy that CuInS 2 /ZnS QDs innovatively work as quenching agent to reduce the fluorescence of CDs, mainly due to the fluorescence resonance energy transfer (FRET). After the addition of CTC, the interaction between CDs and CuInS 2 /ZnS QDs is restrained, resulting in the fluorescence recovery of CDs, whilst the QDs’ fluorescence remains unaffected. In this work, CTC is detected in the range of 0–50 μM by conventional fluorescence and synchronous fluorescence methods under an excitation wavelength of 360 nm or Δλ = 90 nm, and the detection limits of the two methods are 0.46 μM and 0.36 μM, respectively. The designed sensor displays good selectivity compared with other tetracycline drugs with similar structure to CTC, different ions and various natural - amino acids. And the sensor can also be applied to determine CTC in tap water and milk.
研究领域:
分析化学
·
纳米技术
·
环境科学
·
食品科学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Li Xiaoguang,Chen Jia,Li Aoqi,Li Jing,Wang Mingyu,Li Liangsheng,Shangguan Enbo
A novel in situ self-sulfidation approach was devised to fabricate ZnO/ZnS/C ternary nanocomposites as highly stable anodes for alkaline Zn–Ni batteries. Zinc sulfate acted as a dual-purpose precursor, providing both zinc and sulfur, whereas acrylamide served as the carbon source and in situ reductant. In a single-step carbothermal pyrolysis at 800 °C, the carbon matrix converted sulfate ions to sulfide, facilitating the simultaneous generation of electrochemically active ZnO, a protective ZnS layer, and a conductive carbon network during a single thermal treatment. The optimized ZnO/ZnS/C-2 electrode exhibited a discharge capacity of 576.8 mAh g −1 after 600 cycles at 1 C and maintained 513.2 mAh g −1 at 15 C. Under identical conditions at 10C, the ZnO/ZnS/C-2 electrode delivered a capacity of 545.3 mAh g −1 , which is 41.5% higher than that of commercial ZnO (385.4 mAh g −1 ). Upon the current density reverting to 0.2 C, it regained 96.6% of its original capacity, indicating remarkable reversibility. Post-cycling scanning electron microscopy images validated the successful inhibition of zinc dendrite proliferation. The performance improvements arise from the synergistic combination of the protective ZnS layer, the interconnected conductive carbon framework, and the advantageous ZnO/ZnS heterointerface, which collectively boost structural stability and charge transfer kinetics.
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DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Tianyu Hu,Kangwei Zhu,Huangyu Cheng,Yuanjie Teng,Zaifa Pan
The development of cadmium-free cyan-emitting quantum dots (QDs) is of paramount importance for application in anti-counterfeiting, display and bioimaging. II-VI alloyed ZnGa2S4 (abbreviated as ZGS) QDs have large Stokes shifts and wide bandgaps, and thus developing rapidly as an attractive candidate for cadmium-free cyan luminescent QDs. However, the synthesis method of monodisperse ZGS QDs and constructing core-shell energy band structure are not well established. In this paper, ternary ZGS core QDs were synthesized by a thermal decomposition method with a systematic reaction optimization. Furthermore, type-I core-shell structured ZnGa2S4@ZnS (abbreviated as ZGS@ZS) was constructed according to the core-shell energy band engineering principle. The obtained core-shell QDs had an average particle size of approximately 4 nm. A broad emission band was exhibited ranging from 400 to 600 nm and peaking at 480 nm with obvious cyan emission. Fluorescence quantum yield was enhanced from 24.6% to 37.3%, showing a superior fluorescent performance in ZGS@ZS core-shell QDs. Color-controlled ZGS@ZS showed a good application in anti-counterfeiting technology. Furthermore, after surface modification of polyethylenimine (PEI), water-soluble ZGS@ZS-PEI QDs showed good biocompatibility, and thus exhibiting excellent fluorescent labelling application in bioimaging.
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2013
·
IF 5.695
He-Fang Wang,Ye-Yu Wu,Xiu-Ping Yan
A room-temperature phosphorescence (RTP) strategy was developed for direct, additive-free discrimination of catechol from resorcinol and hydroquinone based on sodium tripolyphosphate capped Mn-doped ZnS quantum dots (STPP-Mn-ZnS QDs). The RTP response of STPP-Mn-ZnS QDs to the three isomers was pH-dependent, and the greatest difference in the RTP response to the isomers was observed at pH 8.0: catechol enhanced the RTP intensity of the QDs, while resorcinol and hydroquinone had little effect on the RTP intensity of the QDs. The enhanced RTP intensity of 1 μM catechol was not affected by the coexistence of 30 μM resorcinol and 50 μM hydroquinone at pH 8.0. The detection limit of this RTP method was 53 nM catechol, and the precision was 3.2% (relative standard deviation) for five replicate detections of 1 μM catechol. The discrimination mechanism was ascribed to the weak bonded ligand of STPP-Mn-ZnS QDs and the different interaction between the three isomers and STPP-Mn-ZnS QDs. The strong binding of catechol to Zn resulted in the extraction of Zn from the surface of STPP-Mn-ZnS QDs and the generation of holes that were trapped by Mn2+ to form Mn3+. Catechol also promoted the reduction of Mn3+ into Mn2+ excited state, thus ultimately inducing the enhanced RTP response of STPP-Mn-ZnS QDs.
研究领域:
分析化学
·
纳米材料
·
发光传感器
·
环境监测
·
化学传感
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DOI
高影响因子
LUMINESCENCE
·
2014
·Vol. 29
·期 8
·1177-1182
·
IF 1.675
Lili Pang,Jian Xu,Chang Shu,Jin Guo,Xiaona Ma,Yu Liu,Wenying Zhong
High luminescence quantum yield water-soluble CdTe/ZnS core/shell quantum dots (QDs) stabilized with thioglycolic acid were synthesized. QDs were chemically coupled to fully humanized antivascular endothelial growth factor 165 monoclonal antibodies to produce fluorescent probes. These probes can be used to assay the biological affinity of the antibody. The properties of QDs conjugated to an antibody were characterized by ultraviolet and visible spectrophotometry, fluorescent spectrophotometry, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, transmission electron microscopy and fluorescence microscopy. Cell-targeted imaging was performed in human breast cancer cell lines. The cytotoxicity of bare QDs and fluorescent probes was evaluated in the MCF-7 cells with an MTT viability assay. The results proved that CdTe/ZnS QD–monoclonal antibody nanoprobes had been successfully prepared with excellent spectral properties in target detections. Surface modification by ZnS shell could mitigate the cytotoxicity of cadmium-based QDs. The therapeutic effects of antivascular endothelial growth factor antibodies towards cultured human cancer cells were confirmed by MTT assay. Copyright © 2014 John Wiley & Sons, Ltd.
研究领域:
纳米技术
·
癌症研究
·
分子成像
·
生物偶联
·
生物医学工程
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DOI
高影响因子
Small
·
2019
·Vol. 15
·期 9
·1804861
·
IF 10.856
Liang Cao,Bao Zhang,Xing Ou,Chunhui Wang,Chunli Peng,Jiafeng Zhang
Metal sulfides possess tremendous potentials owing to their high specific capacity for sodium storage. However, the huge volume expansion, accompanied with structural collapse and unsatisfied electric conductivity upon continuous cycling, always lead to inferior rate capability and severe cycling fading. In this work, binary metal sulfide (ZnS/SnS 2 ) nanoboxes confined in N/S dual-doped carbon shell (ZSS@NSC) are fabricated through a facile co-precipitation method involving the wrapping of polypyrrole, and subsequent in situ sulfidation process. Such a well-designed heterogeneity between ZnS and SnS 2 provides rapid Na + insertion and enhanced charge transport by creating an electric field at the heterointerface. More significantly, the formation of polypyrrole-derived N/S dual-doped carbon is synergistically coupled with the ZnS/SnS 2 to create a unique and robust architecture, further strengthening the interconnect function at the heterointerface, which improves electric/ion transfer and mitigates the volume variation during the long-term cycling process. Herein, this as-prepared ZSS@NSC exhibits satisfied specific capacity, excellent rate property, and superior cyclic stability (a reversible capacity of 456.2 mAh g −1 with excellent capacity retention of 97.2% after 700 stable cycles at ultrahigh rate of 5 A g −1 ). The boosted Na-storage properties demonstrate that the optimized strategy of structure-engineering has a broad prospect to promote energy storage applications.
研究领域:
材料科学
·
储能
·
电化学
·
纳米材料
·
电池技术
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Jie Zhao,Zhefeng Fan
Melamine (MA)-passivated Mn-doped ZnS quantum dots (QDs) were synthesized by a hydrothermal method . The MA-passivated QDs can form a charge-transfer complex with picric acid (PA) at 80 °C, thereby quenching the phosphorescence of the QDs. A sensitive method for detecting PA was established based on this principle of phosphorescence quenching . When the PA concentration ranged from 2.0 to 180 ng mL −1 , the concentration was linearly related to the quenching intensity of the QDs, with a detection limit of 1.4 ng mL −1 . When applied to detect PA in environmental water samples, the proposed method showed superior analytical performance compared with other PA analysis methods. Furthermore, we verified the static quenching mechanism by density functional theory . MA on the surface of QDs and PA formed a stable structure with a binding energy of 12.43 eV.
研究领域:
分析化学
·
纳米材料
·
环境监测
·
荧光传感
·
量子点
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 12
·9598-9605
·
IF 3.201
Yajiao Song,Haichao Duan,Siyao Zhu,Jianhua Lü,Changli Lü
Novel temperature-responsive block copolymer-functionalized graphene oxide (GO) nanosheets were successfully prepared via non-covalent π–π stacking interactions between GO and pyrene-terminated PNIPAM-b-P(OEGMA-co-MQ). The pyrene-terminated block copolymer was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization using a pyrene functional RAFT agent and the monomers N-isopropylacrylamide (NIPAM), oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA) and 5-(2-methacryloyl-ethyloxymethyl)-8-quinolinol (MQ). ZnS nanoparticles were also integrated into the block copolymer-decorated GO via the coordination of MQ units of the block copolymers to fabricate a fluorescent nanocomposite with good temperature-responsive behavior based on a conformation change in the PNIPAM blocks on the GO sheets. The as-prepared block copolymer anchored graphene oxide@ZnS NPs nanocomposite can be used as a fluorescent sensing platform for sensitive and selective detection of nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) with a detection limit of 4.4 nM via a fluorescence resonance energy transfer (FRET) process.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
环境科学
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DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2014
·
IF 2.291
Li-Na Wen,Meng-Xia Xie
s G-quadruplex DNA is an effective target for anticancer drug, and investigation of the G-quadruplex DNA with natural compounds plays a key role in the development of anticancer drugs. In this article, room temperature phosphorescence sensing system based on l -cysteine-capped Mn-doped ZnS QDs has been established. Sanguinarine can adsorb on the surface of Mn-doped QDs and quenched the phosphorescence emission of the sensor. When the G-quadruplex sequences combined with the sanguinarine of the QDs-sanguinarine system, the phosphorescence intensities of the QDs sensors would be restored, and the binding abilities of the G-quadruplex DNA with the sanguinarine can be evaluated by the phosphorescence recoveries of the sensor system. Based on the developed approach, the interaction of sanguinarine and six G-quadruplex DNA with various sequences (tel24-1, tel24-2, tel22, k-ras, HIF-1α and c-kit1) has been investigated. The results showed that the binding abilities of the G-quadruplex DNA with sanguinarine were related to their number of bases and conformations. The conformational changes of the six G-quadruplex DNA, after binding with sanguinarine, have also been probed by circular dichroism. Combining the changes of the phosphorescence lifetime, the binding mechanism of the G-quadruplex DNA and sanguinarine has been discussed. The developed method was simple, rapid and specific, and can avoid fluorescence interferences of the system, and it would be prospective to evaluate the interaction of the drug with different G-quadruplexes.
研究领域:
生物化学
·
分析化学
·
分子生物学
·
癌症研究
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 6
·4161-4171
·
IF 3.553
Wang Pan,Wu Zhihai,Wu Manyu,Wei Jiao,Sun Yanni,Zhao Zhenfu
The low-cost, solution-processed and stable perovskite quantum dots (QDs) light-emitting diodes (QLEDs) have great potential applications for the new-generation displays technology and white-LEDs. The stability of perovskite QDs has been improved via polymers or inorganic encapsulation strategies, but at the cost of their semiconducting properties, so it is not suitable for active light-emitting devices. In this paper, the Zn-doped CsPbBr 3 /ZnS QDs heterojunction were fabricated via a simple solution-phase method, which demonstrated simultaneously enhanced the optical properties and stability of perovskite QDs films without damaging their semiconducting properties. The photoluminescence quantum yields and stability of the Zn-doped CsPbBr 3 /ZnS heterojunction QDs films have been significantly improved because of good surface passivation on the surface defects of perovskite QDs with ZnS nanoclusters and Zn 2+ doping. Finally, solution-processed n-ZnO nanoparticles (NPs) and p-NiO NPs as carrier transport layers are used to fabricate all-inorganic Zn-doped CsPbBr 3 /ZnS QLEDs. The QLEDs show high-efficiency green light emission with a maximum luminance of 8600 cd/m 2 and external quantum efficiency of 4.8%. Moreover, the researched green perovskite QLEDs also show good working stability after a long test time in the outside environment. This study may provide an effective way for the preparation high-performance perovskite QLEDs with good environmental stability, making practical applications possible.
研究领域:
材料科学
·
光电技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）