INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yiyu Wang,Chunqing Niu,Guiting Yu,Yuhong Lin,Binbin Li,Zheng Jin,Xiaona Wu,Jian Shi,Chibo Liu,Xinyu Wang,Kai Zhao
Angiogenesis plays a vital role in the treatment of full-thickness wounds. Deferoxamine (DFO) has been employed to promote neovascularization, however, smart drug delivery systems are needed to optimize its utilization. In this study, an injectable extracellular matrix (ECM)-mimicking hydrogel (HOG@P&D) was developed by leveraging the dynamic Schiff base and hydrogen bonds among a chitosan derivative (HACC), oxidized alginate (OSA), gelatin, and DFO-loaded polydopamine nanoparticles (P&D) for efficient wound healing. The incorporation of P&D enables HOG@P&D to respond to near-infrared (NIR) irradiation, converting laser energy into heat to trigger an on-demand, rapid release of DFO, thereby effectively enhancing angiogenesis. In vitro tube formation assays revealed that the number of meshes in the HOG@P&D group was fourfold higher than that of the control group. Additionally, HOG@P&D exhibited superior mechanical properties, tissue adhesion, and injectability, allowing it to cover wounds seamlessly. This hydrogel also demonstrated antibacterial and antioxidant properties, creating a conducive microenvironment for wound healing. In vivo studies further confirmed that HOG@P&D promoted angiogenesis and mitigated inflammation by upregulating angiogenic growth factor expression, thereby accelerating full-thickness wound healing. This nanocomposite hydrogel shows significant potential as a high-performance wound dressing.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhiqiang Fang,Yangkai Xiong,Lei Huang,Jipeng Li,Daxiong Hu,Qitong Mao,Hao Jiang,Xuewei Tang,Panpan Tang,Zheng Li,Guoqing Wang
Polymer coatings are inherently susceptible to deformation and irreversible damage when they are subjected to external forces during service. Self-healing coatings integrated with exceptional mechanical robustness and corrosion resistance are essential for industrial applications but have been deemed challenging. Here, we present a NIR-triggered self-healing coating by combining a toughness epoxy network with melanin-modified silica (MMS). Moreover, to investigate the impact of pore size and porosity of silica on the corrosion protection performance, three types of various silica particles are selected as building blocks. The melanin-modified fumed silica/epoxy coatings demonstrate superior elongation (275 %), outstanding tensile strength (5.31 MPa) and high toughness (7.37 MJ·m 3 ). Moreover, the introduction of the MMS can not only improve the anticorrosion performance (|Z| 0.01 Hz value of 1.24 × 10 10 Ω·cm 2 ) but also realize fast photo-thermal repair (60 s). Our strategy furnishes a universal layout prototype for the manufacture of robust self-healing coatings with a scalable and cost-effective preparation method.
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ACS Nano
·
2025
·
IF 16
Xue-Mei Dong,Chen Chen,Yin-Xiang Li,Hong-Chao Sun,Bin Liu,Zi-Fan Li,Kai-Li Wang,Zi-Xi He,Meng-Na Yu,Wei Huang,Ju-Qing Liu
Neuromorphic vision sensors capable of multispectral perception and efficient recognition are highly desirable for bioretina emulation, but their realization is challenging. Here, we present a cocrystal strategy for preparing an organic nanowire retinamorphic vision sensor with UV–vis–NIR perception and fast recognition. By leveraging molecular-scale donor–acceptor interpenetration and charge-transfer interfaces, the cocrystal nanowire device exhibits ultrawide photoperception ranging from 350 to 1050 nm, fast photoresponse of 150 ms, high specific detectivity of 8.2 × 1012 Jones, and responsivity of 15 A W–1, as well as retina-like photosynaptic plasticity behaviors. Utilizing the sensor nerve and convolutional neural network, the architecture achieves 90% accuracy in recognizing colorful images. The cocrystal design offers an effective method for constructing nanowire photosynases with high performance in artificial visual systems.
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POLYMER
·
2018
·
IF 3.483
Changhong Lin,Dekun Sheng,Xiangdong Liu,Shaobin Xu,Fance Ji,Li Dong,Yan Zhou,Yuming Yang
In this work, a crosslinker terminal maleimide groups (EDM) has been synthesized and was used in reactions with the pendant furan groups of polyurethane (PUE) to prepare the self-healing electrically conductive composites based on Diels-Alder reaction, and Ag nanowires (AgNWs) as the conductive network inlaid in the surface layer of the polymer matrix layer. Inspired by the graphene-based materials for its versatility in both material and chemical properties, and we present a new synthetic strategy for the preparation of functional graphene nanosheets with DA group that can be employed in the self-healing polyurethane system. To our best knowledge, it hasn't been reported yet the structure graphene oxide materials (rmGO) in any systems. The rmGO served as fillers to reinforce the composites and would participated in the DA reactions. The excellent NIR light-induced self-healing property of prepared composites was realized through the photo-thermal effect of rmGO. The composite is capable of both structural and electrical healing via NIR irradiation. The injured samples can be locally repaired with high precision and efficiency without an obvious influence on those uninjured parts. The underlying polymer matrix can reform via the dynamic dissociation/recombination of Diels-Alder bonds to bring the separated areas of the AgNWs layer into contact to restore the conductivity. The NIR light-induced self-healing electrically conductive composites have wide potential for many fields, e.g., soft robots, flexible devices, and health-monitoring.
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ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Chen Luo,Youjia Chen,Jinxuan Gu,Huihui Cai,Huijin Lin,Zhigang Jin,Chaobiao Huang
Epinephrine (EP) is an essential catecholamine in the human body. Currently, most EP detection methods are not suitable for in vivo detection due to material limitations. An organic small molecule fluorescent probe based on a chemical cascade reaction for the detection of EP was designed. Anionic heptamethine cyanine dye was selected as a fluorescent dye because of its NIR fluorescence emission with excellent biocompatibility. The secondary amine of EP nucleophilically attacks the carbonate of the probe with its stronger nucleophilicity and further undergoes intramolecular nucleophilic cyclization to release the fluorophore. Other substances containing only primary amines or no β-OH lack reaction competitiveness due to their weaker nucleophilicity or inability to undergo further cyclization. The fluorescence recovery of the probe was linearly related to the EP concentration of 2–75 μmol/L. The detection limit was 0.4 μmol/L. The recovery rate was 94.78–111.32%. Finally, we successfully achieved bioimaging of EP in living cells and EP analogue in nematodes.
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Materials Today Communications
·
2024
·
IF 3.7
Chensi Zeng,Yanfang Gong,Chenxi Qi,Xianghua Zeng,Ni Tan
Capecitabine (CAP) is a kind of prodrug that can be metabolized into 5-fluorouracil (5-FU) in vivo, so it is usually classified as the antimetabolite fluoropyrimidine deoxynucleoside analog. In this paper, CAP, upconversion nanoparticles (UCNPs), 3,5-dicarboxy-4-methacrylate-based azobenzene (MAPDIA)/acrylic acid-functionalized gelatin, N,N′-methylene bisacrylamide (MBA), and ammonium persulfate (APS) were used as template, light trigger, bifunctional monomers, cross-linking agent and initiator, respectively. By using the free-radical polymerization and the molecular imprinting technique, the potential drug delivery nanocontainer CAP-MIP with the dual-responsive performance to pH/near infrared light (NIR) was successfully prepared. Furthermore, the characterization of CAP-MIP was also carried out by the modern instrumental analysis such as FTIR, XRD, TGA, BET and so on. The stimulus-responsive release experiment in vitro indicated the maximum cumulative release rate of CAP changed from 1.71 % to 89.54 % when the pH value in medium varied from 1.2 to 8.3, and the equilibrium release time point also greatly prolonged to 420 min from 40 min, respectively. When irradiated by 980 nm monochromatic NIR light in the same solution of pH 6.8, the maximum release rate of the sample could reach 96.21 % at 180 min, which respectively corresponded to the data of 41.84 % at 420 min under the condition of the absence of additional NIR light. In addition, CAP-MIP also had the excellent specific adsorption for CAP with the selectivity factor of 2.904 and the maximum CAP-loaded capacity of 7 mg•g −1 . The above information denoted the target material should be of some potential in drug delivery system application.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Qi Zhong,Kangdong Wang,Gao Pan,Shuping Peng,Cijun Shuai
CeO2 nanozymes have demonstrated the potential to enhance biological scaffolds with chemodynamic therapy. However, their catalytic efficacy is limited by the slow conversion of Ce4+ to Ce3+ and the lack of substrates like H2O2 and H+. To address these challenges, we adopted a dual-pronged strategy that utilized the plasmonic resonance of Au nanoparticles and their glucose-oxidase mimicry to boost electron and hydrogen transfer. Specifically, we integrated Au/CeO2 nanozymes into poly-l-lactic acid scaffolds via selective laser sintering. This conversion of Ce3+ to Ce4+ in the scaffolds enhanced the reduction of H2O2 to a hydroxyl radical, inducing oxidative stress in tumor cells. The Au nanoparticles played a crucial role in boosting the Ce3+/Ce4+ catalytic cycle by providing both the energy and the catalytic substrates. They recycled Ce4+ back to Ce3+ by exploiting plasmonic-induced hot electrons and catalyzed glucose oxidation to supply H2O2 and H+. Our nanoscale and atomic-scale simulations confirmed that the Au/CeO2 hybrid structure utilized near-field coupling to amplify the plasmonic resonance and the Au–O–Ce bridge reduced the electron transfer barrier. Consequently, the Au/CeO2 scaffold decreased the activation energy from 22.57 to 9.92 kJ/mol. These findings highlight the significant promise of the Au/CeO2 nanozyme scaffold for NIR-enhanced chemodynamic therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yu Lan,Haixia Zhang,Ruichen Xie,Kecheng Li,Feiran Xie,Peihong Xiao,Li Jiang
Glaucoma is a leading cause of irreversible blindness worldwide and characterized by progressive loss of retinal ganglion cells (RGCs). As glaucoma progresses asymptomatically and the lack of specific biomarkers or noninvasive imaging tools during the early stage, it is often discovered at a relatively late stage without cure. Development of an effective tool for early diagnosis remains a necessity. As well known, endoplasmic reticulum (ER) stress and subsequent accumulation of reactive oxygen species (ROS) play a vital role in the development of glaucoma, with peroxynitrite (ONOO − ) as one of the most abundant cytotoxic ROS. In this work, we constructed a novel near-infrared (NIR) fluorescent nanoprobe named ER-ONOO-NPs. It specifically and sensitively targets ER-associated ONOO − with low biotoxicity in cultured RGCs. Systematically applied to the NMDA-induced mouse model of glaucoma, ER-ONOO-NPs performs well for real-time dynamic monitoring of ONOO − fluctuations at the Ganglion cell layer of mice prior to RGCs apoptosis. Thus, our results suggest that the ER-targeted NIR fluorescent nanoprobe could be a noninvasive imaging tool for early diagnosis of glaucoma in high-risk population.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xiaofeng Bi,Jinyue Feng,Xiyuan Feng,Dianpeng Li,Yumin Wang,Shulin Zhao,Liangliang Zhang
The development of intelligent nanotheranostic technology that integrates diagnostic and therapeutic functions holds great promise for personalized nanomedicine. However, most of the nanotheranostic agents exhibit “always-on” properties and do not involve an amplification step, which may largely limit imaging contrast and restrict therapeutic efficacy. Herein, we construct a novel nanotheranostic platform (Hemin/DHPs/PDA@CuS nanocomposite) by assembling DNA hairpin probes (DHPs) and hemin on the surface of PDA@CuS nanosheets that enables amplified fluorescence imaging and activatable chemodynamic therapy (CDT) of tumors. The cancer-relevant APE1 triggers nucleic acid amplification with DHPs to generate activatable and amplified fluorescence signals for discriminating cancer cells from normal cells. Meanwhile, excessive G-quadruplex/hemin-based DNAzyme are also activated, and they function as Fenton-like catalysts to catalyze the production of highly toxic hydroxyl radicals (•OH) for CDT. Moreover, owing to the excellent photothermal conversion efficiency in the near-infrared-II (NIR-II) window, the PDA@CuS not only improves the catalytic performance of CDT but also furnishes PTT. A remarkable antitumor therapeutic effect is demonstrated both in vitro and in vivo. Therefore, the Hemin/DHPs/PDA@CuS nanocomposite is expected to provide a promising avenue for precise imaging-guided antitumor therapy.
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BIOMATERIALS
·
2024
·
IF 12.8
Yanzhen Sun,Yao Li,Xiaokang Ding,Pan Xu,Xiaodong Jing,Hailin Cong,Hao Hu,Bing Yu,Fu-Jian Xu
Chronic diabetic wounds are difficult to treat due to imbalanced inflammatory responses, high blood glucose levels, and bacterial infections. Novel therapeutic approaches based on nucleic acid analogues have been proposed, with unique advantages in improving angiogenesis, increasing collagen synthesis, and exerting anti-inflammatory effects. However, the inherent electronegativity of nucleic acids makes them less susceptible to cellular uptake. In this paper, a kind of near infrared (NIR)-responsive nanocomposite hydrogel loaded with nucleic acid vectors was proposed for promoting wound healing. The redox system composed of molybdenum disulphide nanosheets (MoS 2 NSs) initiated the copolymerization of quaternized chitosan containing double bonds and N -isopropylacrylamide (NIPAAm) to form the matrix. In addition, MoS 2 NSs with photothermal conversion performance endow the nanocomposite hydrogel to have NIR-response property and act as physical crosslinking points in the matrix. Polydeoxyribonucleotides (PDRN), which have the effect of promoting wound healing, were made into nucleic acid vectors, and loaded into the NIR-responsive hydrogel. MoS 2 NSs can convert NIR irradiation into heat, causing phase transitions of temperature-sensitive segments that trigger volume contraction of the hydrogel to extrude the nucleic acid vector. Promoting angiogenesis, slowing inflammation, and guiding tissue regeneration were demonstrated in the diabetic wound model treated with the NIR-responsive nanocomposite hydrogel.
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高影响因子
SENSORS
·
2024
·Vol. 24
·期 12
·3744
·
IF 3.4
Chenqian Ye,Axue Wang,Yuxin Lu,Xinye Lin,Luqiang Huang,Daliang Li
To monitor the biological function of H2S in real time, this investigation demonstrated the design and synthesis of a novel fluorescent probe integrated with cyanine and 2,4-dinitrophenol for the qualitative and quantitative detection of H2S. An NIR sensitive sensor (FS-HS-1) was provided with a straightforward process. Spectroscopy experiments elucidated that FS-HS-1 could selectively detect H2S in a PBS solution (containing 40% acetonitrile) with a 111-fold fluorescence enhancement at 715 nm (ex. 605 nm). The response towards NaHS occurred in less than 2 min, and the detection limit was confirmed to be as low as 4.47 ± 0.11 nmol/L. Furthermore, the probe is capable of monitoring changes in exogenous H2S concentrations within living cells with confocal and 2P imaging.
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Journal of Materials Chemistry C
·
2024
·
IF 5.7
Min Jia,Xiangyu Zhang,Xue Yang,Zehao Lin,Dingjun Jia,Yuqiang Wang,Sining Yun,Dangli Gao
Multi-mode storage phosphors with photo/thermo/mechano-stimulated luminescence (PSL/TSL/ML) hold great potential applications in many fields such as biological imaging, human-machine interface, robotic manipulation, and stress/temperature visualization sensing. However, the physical mechanisms underlying this 'self-sustaining' luminescence are still debated, which in turn hinders the development of materials. Here, we demonstrated that the intrinsic defects such as the VO•• and Oi′′ in the matrix play an important role in the electronic structure and various physical properties of LiGa5O8 storage phosphor by combining first-principles calculations and experimental methods. Specifically, the intrinsic defects lead to the smaller bulk (B) and shear (G) modulus, Young’s moduli (E), Poisson’s ratio (v), B/G, and the bigger elastic anisotropy index (AU) and hardness (H) in three LiGa5O8 defect models, which is extremely advantageous for PSL/TSL/ML. We also demonstrate that the ML process, that is different from PSL/TSL processes, are intimately linked to the activation threshold of charge carriers in traps. This threshold can be lowered under axial stress by bandgap narrowing via weakening the binding force of polyhedral units to bind electrons in the converting process between mechanical energy and light energy under stress load. This study provides not only direct evidence for potential variation in ML process, but also guidance for designing the storage phosphors via defect engineering.
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