INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Yakun Li,Pinhua Rao,Jincheng Wang,Shiqiang Song,Runkai Wang,Shihui Liu,Lei Che
All kinds of soil conditioners have been used to improve soil quality. The application of many traditional soil conditioners was limited by single performance. In this study, a novel multifunctional microspheric soil conditioner was prepared based on Arabic gum , gelatin, chitosan and β-cyclodextrin. Arabic gum and gelatin (AG-GL) microspheric carriers, which could load ferrous sulfate (FS), were synthesized via complex coagulation method. The AG-GL(FS) microspheres were covered by chitosan quaternary ammonium salt (CQAS) through single coagulation method. And β-cyclodextrin (β-CD) was used as the outermost shell to improve chemical stability of the soil conditioner by saturated solution method. Finally, the novel multifunctional microspheric soil conditioner AG-GL/CQAS/β-CD-FS was obtained and characterized by Fourier transform infrared spectroscopy , thermogravimetric analyzer, polarizing microscope, scanning electron microscope and particle size analyzer. The novel soil conditioner shows good nutrient slowly-releasing, water retention, heavy metal ions adsorption and antibacterial performances with the particle size of 14–17 μm and high thermal decomposition temperature, which has the potential application in improving soil quality.
研究领域:
农业科学
·
材料科学
·
环境科学
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DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2023
·
IF 1.4
Mingguang Zhang,Wenlong Wang,Cheng Guo,Chunhuan Jiang
Alkyl-substituted testosterone derivatives are promising platforms for new drug discovery in medicinal chemistry. This approach provides a simple and efficient method for introducing an alkyl substituent to steroids at the C-4 position. In this study, the novel compound 3α-hydroxy-3β-methyl-4,4-dimethyl-5α-21-bromo-19-nor-pregnan-20-one is synthesized from 19-nor-testosterone. The protocol involves methylation of the dienolate, reduction of the alkene, the Grignard reaction of the carbonyl group, a Wittig reaction, hydroboration with BH3, the oxidation and bromination with a 49% overall yield. For the methylation and reduction steps, the effects of the base, solvent, and reactant ratio on the conversion and yield are investigated. The structures of the synthesized compounds are determined by nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) (electrospray ionization (ESI)).
研究领域:
药物化学
·
有机化学
·
生物化学
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DOI
高影响因子
Biomedical Materials
·
2022
·Vol. 17
·期 2
·024105
·
IF 4.103
Yuheng Cao,Haobo He,Kaili Cao,Yongyang Liu,Dehua Huang,Tuanwei Li,Guangcun Chen
Controllable regulation of stem cell differentiation is a critical concern in stem cell-based regenerative medicine. In particular, there are still great challenges in controlling the directional differentiation of neural stem cells (NSCs) into neurons. Herein, we developed a novel linear-branched poly(β-amino esters) (S4-TMPTA-BDA-DT, STBD) through a two-step reaction. The synthesized linear-branched polymers possess multiple positively charged amine terminus and degradable intermolecular ester bonds, thus endowing them with excellent properties such as high gene load, efficient gene delivery, and effective gene release and transcription in cells. In the mCherry transfection test, a high transfection efficiency of approximately 70% was achieved in primary NSCs after a single transfection. Moreover, STBD also showed high biocompatibility to NSCs without disturbing their viability and neural differentiation. With the high gene delivery property, STBD is capable of delivering siRNA (shSOX9) expression plasmid into NSCs to significantly interfere with the expression of SOX9, thus enhancing the neuronal differentiation and maturation of NSCs. The STBD/DNA nano-polyplex represents a powerful non-viral approach of gene delivery for manipulating the differentiation of stem cells, showing broad application prospects in NSC-based regenerative therapy for treating neurodegenerative diseases.
研究领域:
再生医学
·
基因治疗
·
干细胞生物学
·
神经科学
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Ruirui Zhang,Shugui Hua,Yuan Dang,Bing Zhang,Xiaoqin Sun,Sha Yu,Yingying He,Shuangli Chen,Yuanzhen Zhou
In this paper, the electrocatalytic performance of Ti/β-PbO 2 anode was improved by doping Cs into SnO 2 intermediate layer (Ti/Cs-SnO 2 /β-PbO 2 ) for the efficient degradation of fluoroquinolone wastewater. Compared with the conventional Ti/Sb-SnO 2 /β-PbO 2 anode, Cs-SnO 2 with the rougher surface increased the deposition amount and the thickness of β-PbO 2 active layer, thus forming the denser PbO 2 coating with smaller particle size and exposing more active sites. The partial replacement of Sn by Cs with the smaller ion radius induced the deformation of crystal lattice of SnO 2 , which further led the outer β-PbO 2 active layer grew along the advantageous (200) crystal plane and formed more point defects in the crystal lattice of β-PbO 2 . Thereby, the electron transfer rate at the anode interface was accelerated and the electrocatalytic performance of Ti/β-PbO 2 was significantly improved. To verify the practical application of the improved Ti/Cs-SnO 2 /β-PbO 2 electrode, levofloxacin (LFX) and ciprofloxacin (CIP) were selected as the typical target fluoroquinolones to evaluate the degradation efficiency of Ti/Cs-SnO 2 /β-PbO 2 anode. The removal rate exceeded more than 90% for the single and mixed fluoroquinolones wastewater. Moreover, after 5 times’ recycle, the degradation efficiency of LFX on Ti/Cs-SnO 2 /β-PbO 2 anode still remained over 90%. The potential mechanism of the enhanced electrocatalytic performance of Ti/Cs-SnO 2 /β-PbO 2 and the degradation pathways of fluoroquinolones were also inferred. It’s the first time to enhance the electrocatalytic performance of the Ti/β-PbO 2 anode by introducing monovalent alkali metal (C S ) into the SnO 2 intermediate layer and the proposed Ti/Cs-SnO 2 /β-PbO 2 anode would be a promising candidate to realize the efficient removal of the practical fluoroquinolones antibiotic wastewater.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Xiya Zhang,Fenfen Zhao,Yawei Sun,Tiejun Mi,Liye Wang,Qian Li,Jiayin Li,Wentao Ma,Wanjing Liu,Jingnan Zuo,Xinyu Chu,Bing Chen,Wenxin Han,Yexuan Mao
This study aimed to improve the sensitivity of lateral flow immunoassay (LFIA) using two strategies, including using a high sensitivity label and an indirect-labeling format, which were simultaneously applied to develop a highly sensitive LFIA to detect 22 β-lactams. In the new format, β-lactam receptors were used without any labeling, and anti-receptor monoclonal antibodies (mAbs) were labeled with amorphous carbon nanoparticles (ACNs). The new LFIA is based on the following steps: 1) screening mAbs against the receptors for antigen-antibody binding sites away from the active site of the receptors; and 2) detecting immune complexes using receptor-mAb-ACNs. The cut-off values against ampicillin, amoxicillin, benzylpenicillin, dicloxacillin, cloxacillin, oxacillin, nafcillin, cefquinome, cefoperazone, cefapirin, ceftazidime, cephalothin, cefepime, cefoxitin, cefazolin, ceftriaxone, ceftiofur, cefotaxime, cefalexin, imipenem, meropenem, and ertapenem were 1, 2, 2, 10, 10, 10, 10, 3, 3, 3, 5, 10, 10, 20, 20, 20, 30, 30, 100, 10, 15, and 15 ng/mL, respectively, which is significantly lower than that of receptor-mAb-colloidal gold-LFIA using the same immune reagents.
研究领域:
食品科学
·
免疫学
·
纳米技术
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Shiqing Li,Wenhui Shi,Xiaoyan Wang,Xiaona Hu,Shujing Li,Yuxi Zhang
In this study, a multifunctional food packaging material (G-Eug-NPs-NF) based on gelatin nanofiber membranes (G-NF) containing eugenol nanoparticles (Eug-NPs) were prepared. The Eug-NPs were fabricated through the electrostatic self-assembly by using two ionic polysaccharides chitosan and sulfobutylether-β-cyclodextrin (SCD). Compared with G-NF, the G-Eug-NPs-NF exhibited better antioxidant capacity , which positively correlated with Eug-IC concentration, up to 84.17%. In addition, the latter had a good inhibitory effect on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) , and was more conducive to inhibit the growth of S. aureus . At the same time, the sustained release experiment showed that the incorporation of Eug-NPs in nanofiber membranes improved the sustained release ability of G-Eug-NPs-NF. G-Eug-NPs-NF exhibits the promising application of Eug in food, medicine and other fields.
研究领域:
食品科学
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纳米技术
·
生物医学工程
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Shan-Shan Yang,Qing-Yun Lv,Juan Fu,Tian-Yi Zhang,Yi-Si Du,Xin-Juan Yang,Le Zhou
As our further research, a series of new 7-chloro-9-methyl-2-phenyl-3,4-dihydro-β-carbolin-2-iums were designed and synthesized. Twelve compounds were found with excellent inhibition activity in vitro on three to five out of six phytopathogenic fungi, superior to standard drugs thiabendazole and/or azoxystrobin. Especially, 18 displayed the highest activity against three out of the fungi and the highest comprehensive activity for all of the fungi. The test in vivo revealed that 18 at 50 μg/mL was able to completely control Physalospora piricola infections in apples over 8 days. Scanning/transmission electron microscopic observations found that 18 could damage the hyphal integrity and cell membrane structure of P. piricola. The safety evaluation showed that 18 had no effect on the germination rate of cowpea seed at ≤200 μg/mL. The SAR revealed that the combination of 7-Cl and 2′- or 4′-alkyl is conducive to improvement of the activity. Thus, 7-chloro-9-methyl-2-phenyl-3,4-dihydro-β-carbolin-2-ium is a promising antifungal lead scaffold.
研究领域:
植物病理学
·
药物化学
·
农学
✓ 已验证
DOI
PubMed
高影响因子
Results in Engineering
·
2025
·
IF 7.9
Jiayan Zhang,Zhe Xu,Jincui Chen,Changyong Cai,Kam C. Tam,Zhijian Tan
With the rapid growth of artificial insect breeding, the management of insect shell waste has emerged as a pressing concern. In this study, insect shells were treated with environmentally friendly deep eutectic solvents (DESs) to yield chitin nanofibers (CNFs) for stabilizing Pickering emulsion. The purity of chitin extracted from Tenebrio molitor shells was 94.89 %, and CNFs with lengths between 100 and 300 nm were produced. This Pickering emulsion was stabilized using CNFs, and its stability was enhanced by optimizing environmental conditions, such as NaCl and pH, allowing for stable storage over a period of 180 days. At a β-carotene of 1.5 mg/g and an oil phase mass fraction of 45 %, the emulsion achieved an encapsulation efficiency of 98.47 ± 0.12 %, with no significant changes observed after 30 days of storage. These findings demonstrate that insect shells can be effectively utilized to stabilize Pickering emulsions and encapsulate bioactive compounds, offering a sustainable strategy for valorizing waste resources.
研究领域:
食品科学
·
纳米技术
·
高分子科学
·
可持续化学
·
胶体与界面科学
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Hui Zhou,Jihang Zhai,Huiyuan Gong,Ru Fang,Yongmei Zhao,Wen Luo
Background The formation of amyloid-β (Aβ) plaques is one of the key neuropathological hallmarks of Alzheimer's disease (AD). Near-infrared (NIR) probes show great potential for imaging of Aβ plaques in vivo and in vitro. Dicyanoisophorone (DCIP) based Aβ probes have attracted considerable attention due to their exceptional properties. However, DCIP probes still has some drawbacks, such as short emission wavelength (<650 nm) and low fluorescence intensity after binding to Aβ. It is clear that further modification is needed to improve their luminescence efficiency and sensitivity. Results We designed and synthesize four novel pyrrolidine-alkylamino-substituted DCIP derivatives ( 6a - d ) as imaging agents for β-amyloid (Aβ) aggregates. Compound 6c responds better to Aβ aggregates than the other three compounds ( 6a , 6b and 6d ) and its precursor DCIP. The calculated detection limit is to be as low as 0.23 μM. Compound 6c shows no cytotoxicity in the tested concentration for SH-SY5Y and HL-7702 cells. Additionally, compound 6c is successfully applied to monitor Aβ aggregates in live SH-SY5Y cells and APP/PS1 transgenic mice . The retention time in the transgenic mice brain is much longer than that of age-matched wild-type mice. Significance The results indicates that compound 6c had an excellent ability to penetrate the blood-brain barrier and it could effectively distinguish APP/PS1 transgenic mice and wide-type mice. This represents its promising applications for Aβ detection in basic and biomedical research .
研究领域:
神经生物学
·
医学影像学
·
药物化学
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DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2015
·
IF 2.729
Tingxuan Wu,Zhiguang Liu,Yujing Guo,Chuan Dong
In this work, a simple and highly sensitive electrochemical method was developed to detect luteolin based on thio-β-cyclodextrin functionalized graphene/gold nanoparticles modified glassy carbon electrode (SH-β-CD-GNs/AuNPs/GCE). The peak currents of luteolin on the SH-β-CD-GNs/AuNPs/GCE can be greatly enhanced compared to the SH-β-CD-GNs/GCE and the bare GCE. It suggests that the nanocomposite not only shows the excellent electrical properties of GNs and AuNPs but also exhibits higher enrichment ability of cyclodextrins via the host-guest interaction between cyclodextrin and luteolin . At the SH-β-CD-GNs/AuNPs/GCE, the peak currents increased linearly with the concentration of luteolin in the range of 10.0 pM to 10.0 μM. The detection limit was estimated to be 3.3 pM (S/N = 3), which was more sensitive or comparable with the previous electrochemical sensors for luteolin detection. The analytical performance of this sensor has been evaluated for the detection of luteolin in human serum with satisfactory results. Furthermore, the method might open up a new possibility by using the nanohybrids to monitor other flavonoids which can form host–guest complexes with cyclodextrins.
研究领域:
分析化学
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纳米生物技术
·
电分析化学
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药物代谢
·
生物传感器
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DOI
高影响因子
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2013
·Vol. 12
·期 9
·1628-1635
·
IF 2.923
Li Qiu-Ping,Yan Bing
A series of luminescent polymers are synthesized by incorporating rare earth complex units into polymer matrices. Firstly, we functionalize the selected polymer matrices with the imidazolium moieties, and then introduce the rare earth tetrakis(β-diketonate) complexes into polymer matrices through a mild anion exchange method. The resulting materials are characterized by FTIR, XRD, EDAX, SEM, thermogravimetric analysis, luminescence excitation spectra and emission spectra, luminescence lifetime measurements and diffuse reflectance UV-Vis spectra. The photoluminescence measurements indicate that all these rare earth complex functionalized polymers exhibit a characteristic luminescence emission originating from the corresponding rare earth ions. Among the hybrids, the europium tetrakis(TTA) complex functionalized polymers show remarkable luminescence quantum yields and relatively long 5 D 0 lifetimes at room temperature.
研究领域:
材料化学
·
高分子科学
·
光物理学
·
无机功能材料
·
发光材料
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DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 59
·51110-51119
·
IF 4.6
Puying Qi,Hongwu Liu,Yue Li,Daiyu Tang,Lei Shao,Junjie Wang,Qifei Zhu,Taibai Jiang,Lixia Li,Shilong Jiang,Fan Wu,Yanhong Guo,Yong Liu,Lihong Shi,Yin Wang,Jun Sun
Xanthomonas oryzae pv. Oryzae, result in rice bacterial blight, is the most severe bacterial disease affecting rice, and in certain regions, it is considered the most critical disease overall, with the potential to reduce yields by as much as 50%. It is difficult to control rice bacterial blight and lacking of pesticides. 1,2,3,4-Tetrahydro-β-carboline (THC) and their analogues show a diverse range of activities; however, research specifically focusing on THC remains limited, particularly concerning its antibacterial properties. Given its promising characteristics, THC holds potential for development as an environmentally friendly green pesticide. These outcomes reveal that THC signally inhibits both the cell growth and biofilm formation, thereby reducing its pathogenicity. Consequently, THC holds promise as a novel green pesticide aimed at targeting bacterial biofilms to effectively manage rice bacterial leaf blight.
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）