Catalysts
·
2025
·Vol. 15
·期 7
·610
·
IF 4
Wei Wang,Jiaqi Liu,Guang Shi,Shiqi Wu,Nan Zhang,Ruixia Yuan
Spherical Cu2O nanoparticles were obtained by reducing copper acetate in N,N-dimethylformamide (DMF) system using glucose as the reducing agent and polyvinylpyrrolidone (PVP) as the surfactant, with which spherical PdCu nanocatalysts were thus synthesized by disproportionation. The catalyst was used for the activation of peroxymonosulfate (PMS) and showed an excellent degradation effect on rhodamine B and methylene blue-contained printing and dyeing wastewater with good stability. Additionally, the surface morphology analysis of the catalyst was carried out by SEM and TEM. The structure was characterized by XRD and FT-IR. The valence state and composition of the catalyst were characterized by XPS. The catalytic performance of the prepared catalysts was investigated with methylene blue and rhodamine B used as target pollutants. The results showed that the catalytic reduction efficiency of PdCu nanocatalyst for the two pollutants could reach 99% at 20 °C, when catalyst concentration was 60 mg/L and PMS concentration was 1.0 g/L and 0.6 g/L, respectively. The degradation efficiency of the catalyst was significantly reduced when Cl−,HCO3−and HA were present in the water. The degradation efficiency was above 90% when the pH was in the range of 5–11. The excellent performance of the PdCu/PMS system in the treatment of RhB-contained wastewater was further confirmed by taking into account of the data of free radical quenching experiment and the results of electron paramagnetic resonance (EPR) experiment. After three cycles, the removal rate of MB and RhB could still be maintained at more than 90%, which proved its excellent recyclability due to its remarkable stability and efficiency.
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MOLECULES
·
2025
·Vol. 30
·期 13
·2701
·
IF 4.6
Jie Zhou,Xinrui Wang,Yangyuxin Liu,Xiaochen Li,Mingze Huang,Helong Bai,Jingang Mo
Obesity is a chronic epidemic caused by abnormal fat metabolism. As a key digestive enzyme, pancreatic lipase (PL) is an important target for regulating fat metabolism. The inhibitory potential of 5,10,15,20-Tetrakis (4-aminophenyl) porphyrin (TAPP), 5,10,15,20-Tetrakis (4-hydroxyphenyl) porphyrin (THPP), meso-Tetra (4-carboxyphenyl) porphine (TCPP), Cu (II) meso-Tetra (4-carboxyphenyl) porphine (Cu-TCPP) on PL was studied by enzymatic kinetics, multi-spectral, and molecular simulation technology. THPP, TCPP, TAPP, and Cu-TCPP all had good PL inhibitory activity (IC50range: 97.49–248.70 μM) and were uncompetitive inhibitors. The order of inhibitory ability was: THPP > TCPP > TAPP > Cu-TCPP. The fluorescence quenching mechanism of THPP to PL was a mixed quenching dominated by static quenching, while TCPP, TAPP, and Cu-TCPP were static quenching. The binding of THPP, TCPP and TAPP to PL was mainly driven by hydrogen bonds and van der Waals forces, while Cu-TCPP was mainly driven by a hydrophobic interaction. Four porphyrin compounds changed the conformation of PL, affected the microenvironment of Tyr and Trp residues, and induced changes in the secondary structure of PL, thereby reducing the stability and catalytic activity of PL. Hydrogen bonds played an important role in the binding stability of THPP, TCPP, TAPP, and PL.
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Catalysis Science & Technology
·
2025
·
IF 4.2
Bin Guan,Junyan Chen,Lei Zhu,Zhongqi Zhuang,Xuehan Hu,Chenyu Zhu,Sikai Zhao,Kaiyou Shu,Hongtao Dang,Junjie Gao,Luyang Zhang,Tiankui Zhu,Wenbo Zeng,Minfan Qian,Zhangtong Li,Yang Lu,Shuai Chen,Zhen Huang
Herein, Co–Zn bimetallic center-modulated ZIF-67@ZIF-8 composites were prepared by ultrasonic synthesis, and the effects of the metal ratio on the photothermal coupling catalytic CO2 reduction performance and product selectivity were systematically investigated. The experiments showed that catalysts with higher Zn content (e.g., Co0.1Zn0.9) exhibited higher CH4 selectivity (29.32%), while the high Co ratio (e.g., Co0.9Zn0.1) significantly enhanced the CO generation rate (3.13 μmol g−1 h−1). Characterization by N2 adsorption, XRD, XPS, UV-vis DRS, and in situ DRIFTS revealed that the metal ratio affected the CO2 adsorption and electron transport efficiency by modulating the catalyst specific surface area (1213 → 555 m2 g−1), the band gap width (3.53 → 3.39 eV), and the distribution of the surface-active sites. The DFT calculations further revealed the synergistic effect of Co/Zn: high Zn content lowers the *CHO generation barrier (3.45 eV) and promotes the CH4 pathway, while the Co center enhances CO2 activation. This study provides a theoretical and experimental basis for the optimization of CO2 reduction product selectivity through precise regulation of metal centers.
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Small Methods
·
2025
·
IF 9.1
Lin Cao,Jing Peng,Dengyi Duan,Haoran Cai,Qi Cao,Wenyi Zhang,Jinfeng Han,Kangkang Liu,Jianmin Li,Yuanjie Niu,Xuening Zhang,Yang Zhao,Gang Han
Inflammatory bowel disease is commonly treated with conventional therapies that suffer from poor drug bioavailability and significant side effects. This work develops a nanoparticle system using inulin, a naturally occurring polysaccharide, to address these challenges. This colon-targeted oral drug delivery system enables precise and efficient treatment of IBD by leveraging the colon-specific degradation of inulin by the enzyme inulinase. The nanoparticles demonstrate high stability in the upper gastrointestinal tract and ensure the release of the drug payload in the colon, triggered by inulinase activity. In mouse models, oral administration of these nanoparticles, both with and without drug loading, significantly reduce body weight loss, preserve colon length, and exhibit synergistic anti-inflammatory effects. Notably, even the nanoparticles without drug loading are effective in reducing inflammation and oxidative stress, likely due to the antioxidant properties of inulin. Additionally, the use of inulin promotes a beneficial shift in gut microbiota by decreasing pathogenic bacteria and increasing beneficial bacterial populations, further enhancing its therapeutic potential. These findings suggest that these prebiotic nanoparticles offer a targeted and effective strategy for IBD treatment by both anti-inflammatory benefits and microbiota modulation. This study highlights the potential of prebiotic-based nanomedicine for the treatment of IBD and possibly other colon-related diseases.
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Food Chemistry-X
·
2025
·
IF 8.2
Yuxin Wang,Jin Liu,Suzhen Li,Jizhen Fu,Xiaowen Wang,Li Li,Xu Jing
The widespread use of triazole fungicides has raised concerns over residual. This study presents an automated, environmentally friendly, simple, and efficient method for detecting triazole fungicides in food samples, utilizing high-throughput liquid processing, dispersive liquid-liquid microextraction, and ultra-high-performance liquid chromatography-tandem mass spectrometry. The automated liquid handling workstation was employed to automate the whole sample pre-treatment process. Fatty acid, bio-based solvent, and saturated sodium chloride solution were used as the extractant, dispersant, and demulsifier, respectively. The whole operation process obviated the use of toxic reagents and eliminated the need for time-consuming centrifugation. The linear ranged from 0.01 to 1 μg L −1 with limits of detection and quantification of 0.003 μg L −1 and 0.01 μg L −1 , respectively. Ten triazole fungicides were successfully detected in food samples with recoveries of 70.1 %–105.7 %. The automation of dispersive liquid-liquid microextraction demonstrates huge potential for broad applicability within the field of food safety testing.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xin-Yuan Gao,Xin-Ye Wu,Wei-Jia Wang,Jin-Zhe Xu,Wei-Zhi Liu,Shuai-Hao Xu,Zhi-Yun Peng,Dong-Ying Zhou,Liang-Sheng Liao
Metal halide perovskites exhibit great promise for applications in solid-state lighting and flat-panel display technologies. Despite significant progress, the current strategies for achieving high-performance perovskite light-emitting diodes (PeLEDs) are largely confined to additive engineering and upper interface modifications, with little attention paid to the buried interface, which plays a crucial role in perovskite crystal growth and charge transport. Here, we demonstrate a novel buried interface modification strategy by substituting polyethylenimine ethoxylated (PEIE) with phosphorylethanolamine (PEA). PEA functions as a bridging molecule between ZnO and perovskite, with its phosphate group anchoring on ZnO and its amino group serving as the nucleation site for perovskite as well as passivating perovskite defects. Furthermore, PEA also passivates the surface defects of ZnO and modulates its energy levels, thereby enhancing electron injection. The resultant PeLEDs exhibit a peak EQE of up to 22.3% with reduced efficiency roll-off and prolonged half-lifetime, which is superior to that of conventional PeLEDs at a peak wavelength of 798 nm.
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Small
·
2025
·
IF 12.1
Haoquan Wang,Weiqi Liu,Shiyong Xu,Haishen Jiang,Hong Wang,Lang Xu
Earth-abundant transition-metal-based single-atom catalysts and nanoparticulate catalysts exhibit relatively high performance for the electrocatalytic CO 2 reduction reaction (eCO 2 RR). However, the localized orbital structures of active sites of single-atom catalysts make it difficult to effectively couple key intermediates, thereby limiting their catalytic performance. Nanoparticulate catalysts are prone to aggregation during the eCO 2 RR, leading to an unwanted hydrogen evolution reaction. In response to these problems, a porous carbon catalyst with Ni─N─P ternary co-doping through a two-step pyrolysis process is prepared. Ni nanoparticles (NPs) are encapsulated in the carbon support and atomically dispersed Ni single atoms (SAs) are anchored to the carbon support surface. The internal Ni─NPs provide electrons for the surface Ni─SAs, thereby helping enhance the electron-transfer efficiency. The doping element P not only tailors the sizes of Ni─NPs, suppressing their hydrogen evolution activity but also forms the asymmetric NiN 3 P─SA active sites, enhancing the coupling strength between the catalyst and adsorbed intermediates. Given the unique structural features, this porous Ni─N─P ternary co-doped coal-based catalyst achieves increased CO selectivity (95%), current density (227.4 mA cm −2 ) and stability (120 h).
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Wenyi Wang,Yuanyuan Wang,Wencong Sun,Chao Liu,Long Tang,Peng Qiao,Xueqin Wang
The top-level design of oxygen reduction and evolution reaction (ORR/OER) bifunctional electrocatalyst materials with intrinsic activity and high site exposure is considered to be the most promising strategy to solve the problems of sluggish kinetics and unsatisfactory cycling durability faced by clean and renewable energy conversion systems. Herein, a directional strategy of bonding-strengthening to obtain a flexurally stable Fe–S–Ni bridge bond with high intrinsic activity by axial bonding of sulfur atoms introducing into hexa-coordinating FeNi dual sites (Fe–S–Ni-NC) at the atom design level to further enhance the asymmetry of the site and boost reversible ORR/OER bifunctional activity in pH-universal electrolytes with a lower potential gap of 0.66 V and higher turnover frequency, which is superior to the benchmark catalyst (Pt/C for ORR and RuO2 for OER). The Fe–S–Ni-NC catalyst endows the high-power density and prominent cycling stability in zinc-air batteries, proton exchange membrane fuel cells, and microbial fuel cells, which approaches or exceeds the performance of Pt/C and RuO2. This study provides a feasible strategy for reasonably and directionally constructing multifunctional electrocatalysts for the application of multilevel asymmetric sites to energy-related processes.
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Mingjin Tang,Huanhuan Lu,Xianjuan Pang,Yixuan Wang,Xiaoxuan Yang,Jianxin Xue,Lulu Wang,Shuai Wang,Chenfei Song,Yongzhen Zhang,Jie Li
Carbon fiber (CF)-reinforced polyether ether ketone (PEEK) composites exhibit excellent comprehensive properties. However, the inert surface and poor wettability of CF reduce the interfacial performance in CF/PEEK composites, thereby limiting their applicability in harsh environments. To address this limitation, CF was chemically grafted using two modifiers: a polyethyleneimine (PEI) sizing agent containing carboxylated multi-walled carbon nanotubes (MWCNTs), and a polyamidoamine (PAMAM) coupling agent also containing carboxylated MWCNTs. The amino groups in PEI and PAMAM can form amide bonds with carboxylated CF. Additionally, the long-chain structure of PEI physically entangles the CF, and its π–π conjugation with the PEEK matrix enhances interfacial bonding. As a result, CF-PEI-MWCNTs/PEEK composites (0.3 wt.% MWCNTs) demonstrated superior interfacial properties compared to CF-PAMAM-MWCNTs/PEEK composites (0.5 wt.% MWCNTs). The wear resistance of the composite is improved, and the wear mechanism changes from plastic deformation to mild adhesive wear.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Mengqing Yang,Jianhai Yang,Rong Liu,Liping Chen,Danyang Chen,Yu He,Yang Li,Huaying Wang,Keqi Tang,Zhengyan Hu,Zhenbin Zhang
Capillary coating plays a crucial role in the separation efficiency and reproducibility of capillary zone electrophoresis (CZE). In this study, a linear poly(N-(2-hydroxypropyl)methacrylamide) (LP(HPMA))-coated capillary was prepared by using the surface-confined aqueous reversible addition–fragmentation chain transfer polymerization method. The LP(HPMA)-coated capillary exhibits better biocompatibility and stability compared with the linear poly(acrylamide) (LPA)-coated capillary. Through systematic evaluation, the optimal conditions for fabricating LP(HPMA)-coated capillaries were determined as follows: 1 M HPMA, 2.7 × 10–3 M 4,4′-azobis(4-cyanovaleric acid), and a reaction time of 4 h. LP(HPMA)-coated capillaries prepared under these conditions exhibited the lowest electro-osmotic flow values of 3.7 × 10–6 and demonstrated exceptional performance when applied to the analysis of a HeLa cell digest. Following a 20-day treatment with 2 M NH4OAc (pH 7), the number of peptides identified using the LP(HPMA)-coated capillary decreased by 18.1% compared to the untreated LP(HPMA)-coated capillary; in contrast, the peptide numbers for the LPA-coated capillary decreased by 26.7% relative to its untreated counterpart. These results indicate that the LP(HPMA)-coated capillary exhibits superior pH stability compared to the LPA-coated capillary within the physiological pH range. The LP(HPMA)-coated capillary was employed in the clinical proteomics analysis of non-small cell lung cancer tissues and their corresponding paracancerous tissues via CZE-ESI-MS/MS. The differentially expressed proteins in each sample pair demonstrated minimal overlap, highlighting the heterogeneity of tumor tissues among different patients. Principal component analysis of the data could segregate the samples into a tumor tissue cluster and a paracancerous tissue cluster. Moreover, within each cluster, samples from different patients further separated into subclusters. This discovery validates that CZE-MS can not only distinguish between lung cancer tumor tissue and paracancerous tissue but also detect the heterogeneity among diverse patients, even with as little as 100 ng of sample. The obtained results were subsequently compared with those from nanoRPLC-MS using 1 μg of sample. Notably, the enrichment results within the three gene ontology categories for both methods showed a high level of consistency, corroborating the effectiveness of the CZE-MS method using an LP(HPMA)-coated capillary in identifying differentially expressed proteins from mass-limited clinical samples.
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ACS Nano
·
2025
·
IF 16
Shuang Wang,Chao Han,Xing Chen,Yifei Xiang,Qinzhen Li,Jinsong Chai,Sha Yang,Yuanxin Du,Qiquan Luo,Manzhou Zhu
In this study, we realized the removal of a single gold atom on the surface of the Au21(AdmS)13S(F3Ph3P) (Au21 for short) cluster by surface engineering and prepared Au20(AdmS)14(PhPy2P) (Au20 for short) with an atomic-level defect. The structural analysis and comparison showed that the 21st gold atom is directly related to the exposure of the ninth gold atom in the core, which can be a catalytically active site. In catalytic comparison, Au20 demonstrates more excellent catalytic activity than Au21 in eCO2RR, with the current density of Au20 being 3 times that of Au21 at −1.3 V. The maximum FECO of Au20 is 92.47%, while that of Au21 is 53.66% at −0.9 V. Finally, theoretical calculations point out that the charge transfer on the ninth gold atom is the most active for the increase in CO2 adsorption and promotes the CO2 reduction reaction.
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ChemistrySelect
·
2025
·Vol. 10
·期 23
·e02743
·
IF 2
Xiaoling Xie,Jingyuan Tian,Junying Wu,Ruijie Guo,Jie Zhang,Dongsheng Fu,Huifang Wang,Baolong Niu,Hong Yan
Graphical The novel antibacterial agent CuO@γ-CD-MOFs was synthesized and then incorporated into the PLA/PBAT composite films for food packing materials. The films exhibited superior antibacterial activity and strong UV-blocking ability and water vapor barrier property. Besides, the complementary PLA and PBAT endowed the composite films with enhanced elongation at break compared with that of brittle PLA, and higher tensile strength than PBAT. The biosafe and reusable γ-CD-MOFs were employed as the copper oxide (CuO) carriers to counter the agglomeration of CuO nanoparticles (NPs); and such a novel antibacterial agent CuO@γ-CD-MOFs was synthesized by a facile and eco-friendly direct calcination approach, and then incorporated into the polylactic acid (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) composite films for food packing materials. The effect of the CuO@γ-CD-MOFs nanoparticles on the antibacterial and physical properties was investigated, and the films with 5% CuO@γ-CD-MOFs NPs content displayed the optimal comprehensive performance. Specifically, the composite films PPM-5 exhibited superior antibacterial activity with the inhibition rates against Staphylococcus aureus and Escherichia coli exceeding 95%, which attributed to the uniformly dispersed CuO nanoparticles by metal organic frameworks (MOFs) carrier. Besides, the films provided strong UV-blocking ability and water vapor barrier property. Furthermore, the complementary PLA and PBAT endowed the composite films with enhanced elongation at break compared with that of brittle PLA, and higher tensile strength than PBAT. MTT assay confirmed the satisfactory biocompatibility. The composite films are expected to find great applications in the field of biodegradable food packing.
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