JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2017
·
IF 4.233
Huifang Xu,Na Du,Yawen Song,Shue Song,Wanguo Hou
Single-tailed short-chain alkyl keto-acids/salts, a class of fatty acid/salt derivatives, such as sodium 2-ketooctanate (KOCOONa), are a kind of weakly acid/salt type amphiphiles and plausible prebiotic molecules, and the current understanding of their aggregation behavior in aqueous solutions is still limited. Herein, the aggregation behavior of KOCOONa in aqueous solution was studied by changing its concentration ( C ), using equilibrium surface tension, conductivity, and fluorescence measurements. The aggregates formed were characterized using freeze-fracture and cryogenic transmission electron microscopy, dynamic light scattering, atomic force microscopy, and confocal laser scanning microscopy. A concentration-driven stepwise aggregation was identified in the KOCOONa solution. Vesicles can spontaneously form from the single-component aqueous solution, with a critical vesicle concentration (CVC) of ∼15 mM, which is obviously lower than that of octanoic acid/salt (120–200 mM). With increasing C , a vesicle-to-micelle transition can occur, showing a critical micelle concentration (CMC) of ∼80 mM. In addition, the membrane permeability of the KOCOONa vesicles was examined using small-size Calcein and large-size FITC-BSA as fluorescence probes, showing a size-selective permeability, similar to short-chain (C8-C11) fatty acid vesicles. For the first time, the aggregation behavior of single-tailed keto-acid salt surfactant is reported.
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Eco-Environment & Health
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2025
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IF 17.6
Lianzhou Shen,Yue Cai,Juan Gao
Nanoscale zero-valent iron loaded on biochar (nZVI@BC) has been proven to be effective in activating persulfate to remediate soil organic pollutants. However, studies on subsequent plant growth and microbial community changes in remediated soil remain limited. In this study, nZVI@BC, nZVI, and nanoscale biochar (nBC) were ball-mill produced and applied as amendments in pot experiments with PAH-contaminated soil to investigate their impacts on soil-crop (radish, Raphanus sativus L.) systems, and the widely distributed phenanthrene (Phe) was selected as model pollutant. The results indicate that nZVI@BC could induce more (75%) Phe accumulation in radish compared to the control treatment, but did not result in significant differences in plant biomass or enzyme activity. In Phe contaminated treatments, the Fe content of radish shoots increased from 86.87 ± 5.61 mg/kg DW without material application to 125.20 ± 11.93 mg/kg DW with nZVI@BC, while no significant differences were observed in roots. nZVI@BC and nBC increased the non-desorbed fraction of PAHs with low bio-availability by 13.6% and 10.2%, respectively, after 45 days compared to the control treatment. Illumina MiSeq sequencing revealed that nZVI@BC did not adversely affect the richness and diversity of soil microbial communities. Instead, it promoted the enrichment of bacteria related to the degradation of organic pollutants, such as Lysobacter and Spingomonas . The findings suggest that nZVI@BC after chemical oxidation remediation might be harmful to subsequent plants and ecosystems but much better than nZVI alone. The amount of nZVI@BC should be accurately calculated before chemical oxidation remediation.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
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IF 3.973
Qin-Qin Gao,Chuan-Min Zhang,En-Xia Zhang,Hui-Ying Chen,Yu-Hong Zhen,Shu-Biao Zhang,Shu-Fen Zhang
As zwitterionic polymers show great promise in drug delivery, hyaluronic acid (HA) was deacetylated and grafted with dodecylamine to prepare a pH-sensitive zwitterionic polymer dHAD used as a carrier for antitumor drugs. The polymer was negatively charged at pH 7.4 and became positive at pH 6.2. In vitro delivery of DOX against MCF-7 cells showed that the blank micelle dHAD had low cytotoxicity and the dHAD-DOX micelles could greatly prohibit the growth of the MCF-7 cells. In addition, the dHAD-DOX micelles had higher cellular uptake, indicating that the micelles were rapidly internalized into the cells via CD44 receptor-mediated endocytosis. The in vivo delivery of DOX to tumor-bearing mice confirmed that the dHAD-DOX micelles greatly inhibited the tumor growth and significantly reduced systemic toxicity of DOX. These results demonstrated that biocompatible pH-responsive zwitterionic dHAD micelles are promising carriers for the delivery of DOX.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 411
·期 18
·4073-4084
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IF 3.286
Xia Ling,He Yuanyuan,Xiao Xiaohua,Li Gongke
Herein, a total online device based on field-assisted extraction (FAE), micro-solid-phase extraction (μ-SPE), and high-performance liquid chromatography (HPLC) was designed. Solid samples were pretreated with ultrasound-microwave synergic effects, and then the extract was cleaned up online with a monolithic column, followed by HPLC analysis. The cross-actions between ultrasound and microwave along with other extraction parameters were studied systematically. The efficiency of this online method was verified in the determination of polycyclic aromatic hydrocarbons (PAHs) in foods and tetracycline antibiotics (TCAs) in cosmetic samples. The detection limits of nine PAHs including fluorene, phenanthrene, anthracene, fluoranthene, benzo[k]fluoranthene, benz[a]anthracene, benzo[b]fluoranthene, pyrene, and benzo[a]pyrene were all within 0.075–0.30 μg/kg, as well as four TCAs including oxytetracycline, tetracycline, chlortetracycline, and doxycycline were within 0.02–0.06 μg/kg. Six PAHs were found in roast potatoes and baked fish and the recoveries were in the range of 71.5–119.7% with RSDs of 0.2–10.9% ( n = 3). The recoveries for TCAs in cosmetic samples were in the range of 75.3–118.0% with RSDs lower than 8.2% ( n = 3). Compared with those offline methods, this total online FAE-μ-SPE-HPLC method not only simplifies the operation process, but also increases the precision and accuracy. Beyond trace analytes analysis in solid and semi-solid matrixes, application of this total online analysis method can also be extended to investigate field-assisted extraction mechanisms.
Graphical abstract
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
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IF 4.192
Yingnan Liu,Yaqing Xiao,Min Yu,Yuanyuan Cao,Fan Li,Pei Jia,Du Guo,Xinyu Sun,Li Wang
In view of the potential harm caused by illegal feeding of clenbuterol (CLB) in the livestock industry, herein, a novel ratiometric fluorescent probe based on graphene quantum dots (GQDs)@[Ru(bpy)3]2+ was elaborately constructed for CLB detection. In this probe, GQDs acted as response signals, and their fluorescence was remarkably quenched by CLB through the diazotization-coupling reaction. As for [Ru(bpy)3]2+ as a reference signal, its fluorescence was hardly affected. The intensity ratio of two fluorophores showed good linearity with CLB concentration in the range of 0.05–40 μM, accompanied by visualization of fluorescence variation from yellow to red. The detection limit was as low as 0.029 μM. Particularly, the probe was successfully used to detect CLB in pork and beef samples with satisfactory recoveries. To our knowledge, this is the first report on a ratiometric fluorescent probe for the detection of CLB, which possesses broad application prospects in food safety risk monitoring.
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TALANTA
·
2025
·
IF 6.1
Hui Bai,Yinan Zhao,Lei Chen
The inherent presence of structurally similar stereoisomers in natural products poses great challenges for chiral quality control in pharmaceutical and botanical industries, particularly in differentiating the pharmacological activity of high-purity enantiomers. Multi-column methods are commonly used to separate multiple pairs of enantiomeric components, serious impact on the separation efficiency. To address this issue, a star hydroxypropyl cyclodextrin polymer (Star-HPCD) mixed-mode ligand with higher selectivity was designed to achieve both chiral recognition and structural selectivity. Sil-Star-HPCD chiral stationary phase (Sil-Star-HPCD CSP) enabled the simultaneous separation of three pairs of quinoline alkaloid stereoisomers during a single chromatographic run with a separation factor (α) greater than 1.5, significantly improving the analytical efficiency. Compared with the linear polymer structures, the supramolecular structure formed by star-shaped polymer significantly reduces the steric hindrance and improves the ligand density, which provides a prerequisite for adequate chiral recognition. Complementary evidence from molecular simulations and chiral NMR revealed multiple interactions at the molecular level for this single-column separation results. This work establishes a new strategy for the preparation of functionalized chiral ligands through structural design, which facilitates efficient stereoisomer analysis and chiral quality control in natural products.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Qiao Qiao,Jie Li,Chunying Tao,Meiyang Yang,Weijun Chen,Lipeng Qiu,Huiming Tu
Studies have shown that inflammation is closely linked to the cancer development, and the patients with inflammatory bowel disease (IBD) have a higher risk of colon cancer. Celecoxib (CXB) and camptothecin (CPT) showed potential treatment for IBD and colon cancers, respectively. However, their applications are limited by synchronous delivery, water insolubility, and off-target side effects. Herein, a glutathione (GSH) responsive chondroitin sulfate A (CSA)-SS-CXB micelle loaded with CPT (CSA-SS-CXB@CPT) was prepared as a targeted system to treat colon cancer by anti-inflammatory and antitumor synergistic effect. Specifically, CSA had tumor tumor-targeting effect due to colon cancer lesion-high expression of CD44 receptors. In vitro results verified that CSA-SS-CXB@CPT selectively internalized into colon cancer HT-29 cells and had strong reactive oxygen species (ROS) elimination ability. The CSA-SS-CXB@CPT could rapidly release CXB and CPT in the tumor microenvironment for playing an anti-tumor role. In vivo experiments illustrated that CSA-SS-CXB@CPT significantly targeted tumor tissues and suppressed tumor growth without producing serious side effects in tumor-bearing nude mice. Therefore, this work provides an opportunity for targeted co-delivery of anti-inflammatory and chemotherapy drugs to treat colon cancer.
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TALANTA
·
2025
·
IF 6.1
Ya Sun,Ziwen Zhao,Jie Zhao,Lide Hu,Yawei Shi,Mengqi Li
Aniline pollutants can cause great harm to human health and the ecosystem, while rapid and selective quantification of aniline compounds in environment samples at trace levels is a highly complex target. In this study, a novel, efficient nanochannel sensor based on dummy molecularly imprinted polymer (DMIP) was fabricated. The sensor works on the principle of the ion current rectification across the asymmetric charged nanoporous capillary. With the help of the electric-concentration multi-field coupling model and controlled experiments, the ion distribution and transport in the nanoporous capillary. and the key influencing factors were examined for optimization of the sensor. At the concentration of 1 nmol/L ∼ 0.1 mmol/L, the rectification ratio of the nanosensor and logarithm aniline concentration exhibited a good linear relationship with the limit of detection of 0.2 nmol/L. The concentration of anilines in the real seawater sample was tested with the DMIP nanochannel sensor, and the average recovery rate was 88.31%. The prepared DMIP nanochannel based sensor has established itself a promising method for trace aniline detection in real environmental samples, with the advantages of low cost, small size, simple operation, high accuracy and excellent reproducibility.
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Journal of the American Chemical Society
·
2025
·
IF 15.6
Jinyang Zhang,Jiao Gao,Hong Wang,Jiwen Guan,Guangxian Xu,Lili Xing,Donald G. Truhlar,Zhandong Wang
Understanding the growth of polycyclic aromatic hydrocarbons (PAHs) is essential for combustion, astrochemistry, and carbon-based nanomaterial synthesis. This study presents theory-guided experiments on radical–radical combination reactions of propargyl (•C3H3). The addition of •C3H3 to three cyclopenta-fused PAH radicals─1-indenyl (•1-C9H7), acenaphthenyl (•C12H9), and 4H-cyclopenta[def]phenanthrenyl (•C15H9)─revealed that the reaction between the dominant propyne-3-yl resonance configuration of •C3H3 and the three radicals consistently produces PAHs with all hexagonal rings, while the reaction between the less dominant allene-1-yl resonance configuration of •C3H3 and the three radicals selectively preserves the cyclopenta ring and forms a new hexagonal ring. Elusive intermediates and isomeric products were observed and identified by combining molecular beam-sampling synchrotron photoionization mass spectrometry with gas chromatography–mass spectrometry. The complementary results suggest a high selectivity of the allene-1-yl addition pathway, which is thermodynamically controlled. The findings presented here are based on a combination of experimental capabilities, and they provide new mechanisms and insights into the selective formation of bowl-shaped PAHs, serving as templates for fullerene and nanotube structures. The high selectivity of the allene-1-yl pathway provides a rational synthetic strategy for cyclopenta-fused PAHs, bearing barrierless and facile radical–radical reaction pathways in various environments, including high-temperature combustion, circumstellar envelopes, and cold molecular clouds.
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Materials Today Bio
·
2025
·
IF 10.2
Weitong Sun,Bingbing Fan,Xiaohan Qin,Xin Zhang,Pengxia Zhang,Yu Zhang
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, driven by complex interactions between inflammatory pathways, gut microbiota dysbiosis, and tumor microenvironment remodeling. Conventional therapies, particularly single-target oral chemotherapeutics, are hindered by poor bioavailability, systemic toxicity, and drug resistance. To address these limitations, we engineered KGM-PTX/CSM microspheres, a dual-responsive drug delivery system leveraging the elevated reactive oxygen species (ROS) in CRC and β-mannanase overexpression in the colorectum. The system comprises ROS-sensitive prodrug micelles (PSM) encapsulated within konjac glucomannan (KGM). PSM micelles were synthesized by conjugating hydrophilic chitosan oligosaccharides (COS) with the hydrophobic anti-inflammatory agent mesalazine (MSL) via ROS-labile thioether bonds, followed by paclitaxel (PTX) encapsulation. Upon oral administration, KGM undergoes β-mannanase-triggered degradation in the colon, releasing PSM micelles that subsequently disintegrate in the ROS-rich tumor microenvironment, enabling spatiotemporally controlled drug release. In vitro studies demonstrated ROS-responsive drug liberation (91.2% cumulative release within 48 h) and enhanced cytotoxicity against PTX-resistant SW480/PTX cells (IC 50 : 9.33 μg/mL vs. 45.68 μg/mL for free PTX). Mechanistic investigations revealed synergistic interactions among the system’s components: PTX stabilized microtubules to induce apoptosis, while MSL counteracted COX-2/P-gp-mediated drug resistance and alleviated PTX-associated intestinal inflammation. In the AOM/DSS-induced orthotopic CRC model, KGM-PTX/CSM significantly inhibited colorectal tumor growth, improved survival rates, and suppressed inflammatory cytokine expression (TNF-α, IL-1β, IL-6, and IL-10) in serum and colorectal tissues. Immunomodulatory effects included enhanced CD8 + T-cell activity, suppression of Treg-mediated immune evasion, and macrophage polarization toward the tumor-suppressive M1 phenotype. Gut microbiota analysis demonstrated restored operational taxonomic unit (OTU) counts, increased beneficial bacterial populations, elevated alpha and beta diversity, reduced pro-inflammatory bacteria, and increased short-chain fatty acid (acetate, propionate, and butyrate) concentrations, collectively improving intestinal microecology and inhibiting tumor progression. This study synergistically enhanced the anti-CRC effect through multiple mechanisms of action such as chemotherapy, reversal of chemotherapy resistance, regulation of intestinal flora, anti-inflammation, activation of immune cells, etc., which will provide a certain reference for the research of synergistic drug therapy for CRC.
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TALANTA
·
2025
·
IF 6.1
Hao Gong,Yang Li,Yaru Liu,Yuting Shan,Yijie Wang,Cuiping Ma,Chao Shi
Pathogenic bacteria represent a significant threat to public health and the global economy due to their high infectiousness and lethality. Consequently, the rapid and accurate identification of these bacteria remains a major challenge. Electrochemical amplification-free detection methods have shown several advantages, including rapidity, simplicity and high sensitivity. However, these methods also possess certain drawbacks, such as the inefficient solid-phase hybridization of long-chain nucleic acids on the electrode surface, it is challenging to directly detect long-chain nucleic acids. In response, we have established a novel sensor platform for efficient and rapid detection of long chain nucleic acids based on the principle of HRP signal amplification. This platform incorporates macromolecular crowding agents and electric field assistance to enhance pathogenic bacteria detection efficiency in clinical samples without amplification. The detection process begins by introducing the target into a strand displacement reaction system containing a crowding agent. The crowding effect of the crowding agent is such that the long chain target rapidly replaces the biotinylated probe. Subsequently, an electric field is applied to the surface of the screen-printed electrodes for rapid hybridization, which has been modified with a capture probe. This assay is straightforward and expeditious, reducing hybridization time from 150 min to 90 s. The sensor platform showed a detection linear range of 10 2 –10 7 CFU mL −1 with the limit of detection of 10 CFU mL −1 within 25min. This platform showcases the significant potential for on-site detection of pathogenic bacteria in clinical settings and is expected to be integrated into existing diagnostic equipment.
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CARBON
·
2025
·
IF 11.6
Yuting Liu,Heping Niu,Zhihong Wang,Jialin Liang,Liang Ren,Jisheng Zhou
Hard carbons (HCs) derived from pitch show promise as low-cost anodes for sodium-ion batteries (SIBs) due to their high carbon yield. However, pitch's complex polyaromatic structure makes its modification and HC microstructure control difficult. This study selects bicyclic naphthalene (Nap), tricyclic phenanthrene (Phe) and tetracyclic pyrene (Pyr) as model precursors to investigate how the aromatic ring number impacts HCs' cross-linking mechanisms, microstructure, and electrochemical performance. HCs based on Nap, Phe and Pyr are prepared via combined molecular and oxidative cross-linking. After molecular cross-linking, polycyclic aromatic resin's layer size and aromaticity grow with precursor ring number, R-Pyr having the largest aromatic layers and strongest π-π interactions. During oxidative cross-linking, these layers enhance –C(O)O group retention and 3D stacking, leading to closed pores with smaller size, larger volume, and thicker graphite microcrystals. Consequently, Pyr-based HCs (Pyr-HC) exhibit superior electrochemical performance, with a reversible capacity of 328.20 mAh g −1 at 0.1 A g −1 . In full-cell tests, the Pyr-HC || NVP reaches 184.8 mAh g −1 at 1 A g −1 and an energy density of 147.2 Wh kg −1 , retaining 74.78 % of its capacity after 200 cycles. This work highlights the importance of precursor structure for HC optimization and screening pitch precursors.
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危险品化学品经营许可证（带存储）