CHEMOSPHERE
·
2023
·
IF 8.8
Wenshan He,Run Jiang,Siqi Li,Minglu Zhang,Tingting Zhang,Xiaobiao Zhu,Xiaohui Wang
Chlortetracycline (CTC), a widely used typical tetracycline antibiotic, has raised increasing concerns due to its potential health and environmental risks. Biodegradation is considered an effective method to reduce CTC in environment. In this study, a strain Aspergillus sp. LS-1, which can efficiently degrade CTC, was isolated from CTC-rich activated sludge . Under optimal conditions, the maximum removal efficiency of CTC could reach 95.41%. Temperature was the most significant factor affecting the degradation efficiency of LS-1. The 19 products were identified in the CTC degradation by strain LS-1, and three degradation pathways were proposed. All the degradation pathways for CTC exhibited ring-cleaving, which may accelerate the mineralization of CTC. To gain more comprehensive insights into this strain, we obtained the genome of LS-1, which had high GC content (50.1%) and completeness (99.3%). The gene annotation revealed that LS-1 contains some vital enzymes and resistance genes that may carry functional genes involved in the CTC degradation. In addition, other antibiotic resistance genes were found in the genome of LS-1, indicating that LS-1 has the potential to degrade other antibiotics. This study provides a more theoretical basis for the investigation of CTC degradation by fungi and new insights into the biodegradation of CTC.
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JOURNAL OF ELECTRONIC MATERIALS
·
2025
·Vol. 54
·期 10
·8561-8569
·
IF 2.5
Dong Tianhao,Cui Yongpeng,Wei Lianghuan,Zhu Shengjie,Si Jianxiao
CaM(M = Cu, Ag)Sb Zintl-phase compounds have ignited tremendous research activities due to their promising thermoelectric properties. In this work, a series of CaCu 1− x Ag x Sb (x = 0, 0.2, 0.4, 0.6, 0.7, 0.8, 0.9, 1) samples have been synthesized and investigated. The continuous structure transition from the hexagonal CaCuSb to the orthorhombic CaAgSb is characterized as the composition regulation on Cu/Ag ratios. Lattice bonding hardens and the electrical band structure changes as a result of this transition. The lattice thermal conductivity of CaCu 0.2 Ag 0.8 Sb, which benefitted from the structure transition, showed a minimum value of 1.05 W m −1 K −1 at 323 K. At the same time, the Seebeck coefficient was improved as a result of the rise in effective mass. The findings show that the CaMSb compounds have flexible structural tunability for thermoelectric applications if the hole concentration can be further optimized. Graphical
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Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
·
2024
·
IF 1.4
Yao Xinyu,Shu Yang,Xu Lei,Wei Lijuan,Cui Minhe,Li Li,Zhang Peng,Fang Tianqi
Colistin is recognized as the “last line of defense” for the treatment of carbapenemase-producing “super-resistant” bacteria. However, the treatment of clinical bacterial infections has become more challenging due to the widespread prevalence of the novel resistance gene mcr-1 in multidrug-resistant pathogens. Currently, the use of natural compounds as novel adjuvants to colistin treatment is a safe, feasible, and promising approach compared to the high cost and unpredictability of developing novel antimicrobial drugs. Here, we identified a potential MCR-1 inhibitor, ursodeoxycholic acid, that may be used to treat infections caused by MCR-1-positive drug-resistant bacteria. In this study, checkerboard minimum inhibitory concentration assays demonstrated that ursodeoxycholic acid could reduce the MICs of colistin-resistant strains 4–64 times. Furthermore, a time-kill curve analysis, combined with disk diffusion testing and live/dead bacterial staining, demonstrated that ursodeoxycholic acid could effectively enhance the antibacterial activity of colistin, and when the concentration of ursodeoxycholic acid was lower than 512 μg/ml, it did not affect the normal growth of bacteria; thus, ursodeoxycholic acid imparts less selective pressure on bacteria and did not easily induce the emergence of drug resistance. In addition, through potential target prediction, molecular docking, RT-PCR analysis, membrane permeability detection, and scanning electron microscopy analysis, we demonstrated that ursodeoxycholic acid can form a complex with MCR-1, suggesting that UDCA may affect the activity of MCR-1. In addition, ursodeoxycholic acid combined with colistin was able to alter the electronegativity and permeability of the bacterial membrane, thereby disrupting the structural integrity of the bacterial membranes and significantly enhancing membrane damage–associated colistin activity. In summary, our findings indicate that the colistin/ursodeoxycholic acid combination may be a promising alternative approach for treating MCR-1-positive bacterial infections. Graphical Abstract
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Chemistry-An Asian Journal
·
2020
·Vol. 15
·期 8
·1272-1276
·
IF 4.056
Yueming Cao,Peipei Li,Tengteng Wu,Meiling Liu,Youyu Zhang
Graphical HKUST-1 (Cu−BTC, BTC=benzene-1,3,5 tricarboxylate) was selected as an electrocatalyst for the reaction of conversion N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent performance with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and Faraday efficiency (2.45%). Electrolytic ammonia synthesis from nitrogen at ambient conditions is appearing as a promising alternative to the Haber-Bosch process which is consuming high energy and emitting CO 2 . Here, a typical MOF material, HKUST-1 (Cu−BTC, BTC=benzene-1,3,5-tricarboxylate), was selected as an electrocatalyst for the reaction of converting N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent catalytic performance in the electrochemical synthesis of ammonia with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and good Faraday efficiency (2.45%). It is indicated that the good performance of the HKUST-1 catalyst may originate from the formation of Cu(I). In addition, the catalyst also has good selectivity for N 2 to NH 3 .
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Yi Yang Xu,Lei Meng,Miao Miao Zhao,Chu Xin Peng,Fei Yen
While all of the polymorphs of pure NH 4 I and KI are non-polar, we identify that (NH 4 ) 0.95 K 0.05 I is ferroelectric and (NH 4 ) 0.87 K 0.13 I and (NH 4 ) 0.83 K 0.17 I are pyroelectric through measurements of their pyroelectric current and complex dielectric constant. The order to disorder phase transitions occur near 245 K. Magnetic susceptibility measurements indicate that the proton orbitals of the NH 4 + continue to become ordered in the ground state in the (NH 4 ) 1–x K x I system up to x ≤ 0.17. The polar phases are proposed to stem from K + ions disrupting the symmetry of proton-orbital-lattice interactions between the NH 4 + and I – ions. Our work introduces a new pathway for the ordered phases of ammonium-based compounds to potentially become ferroelectric.
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Jinpeng Ma,Ke Zhu,Da Huo,Bingzhong Shen,Yang Liu,Xudong Qi,Enwei Sun,Rui Zhang
The performances of 1–3 piezocomposite materials under various poling conditions were compared and analysed. The dielectric , piezoelectric , and electromechanical properties of 1–3 piezocomposite materials were studied with variations in the electric field amplitude ( E p ), poling frequency ( f ), and number of cycles ( C ). It was found that the piezoelectric coefficient ( d 33 ), free dielectric constant ( ε 33 T / ε 0 ), and electromechanical coupling factor ( k t ) of 1–3 piezocomposite materials exhibit an increase of 21.4%, 13%, and 10.7%, respectively, under the optimum alternating current poling (ACP) condition ( f = 1.25 Hz, E p = 2 kV/mm, C = 16), compared with that of the samples poled using the direct current polarisation (DCP) method. The studies of the domain pattern indicate that the performance enhancement originates from the remarkable regularly striped domain structure and high domain wall density in ACP-poled samples. Our results suggest that the ACP method is effective in enhancing the performance of composite piezoelectric materials , which possess great benefits and potential for application in acoustic/medical transducers.
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JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Mengshi Jiang,Wei Li,Chunqi Zhu,Xiang Li,Junlei Zhang,Zhenyu Luo,Bing Qin,Yongzhong Du,Lihua Luo,Jian You
The application of nanocarriers as drug delivery system for chemotherapeutic drugs has become a research hotspot in cancer treatment. Chemotherapy with high tumor-targeting accuracy and drug release specificity is the key to improve the efficacy of tumor chemotherapy and reduce the side effects caused by repeated doses drugs. Here, we synthesized a redox-sensitive nano-micelle formed by hyaluronic acid (HA) conjugated with d -α-tocopherol succinate (TOS) using a disulfide bond as the linker (HA-SS-TOS, HSST), which could actively accumulate to the tumor sites and metastasis cancer cells with high expression of CD44. The micelles could dissociate under the high GSH level in cancer cells, triggering a release of paclitaxel (PTX). Surprisingly, the precise chemotherapy instead induced a suppressive tendency of immune system, manifested by a significant increase in TGF-β, which weakened the therapeutic effect of micelles. Moreover, the high levels of TGF-β might be related to the increased drug-resistance of cancer cells. Research has shown that PD-1 pathway blockade can result in reduction in TGF-β expression, thus, a PLGA microsphere encapsulating PD-1 antagonist peptides A12 ( [email protected] ) was further prepared to activate the host immune response. Our data indicated that PTX-loaded HSST could accurately “find” the tumors as well as metastasis cancer cells, and efficiently kill most of them. The joining of a durable PD-1 blockage significantly boosted the efficacy of [email protected] on multiple tumor models, including lung metastatic tumors and even multidrug-resistant tumors. Thus, our work presented an optimal chemo-immunotherapy combined system, which shows profound significance for future cancer therapy in clinic.
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CELLULAR SIGNALLING
·
2026
·
IF 4.7
Qiu-shuang Ma,Xiao-man Zhao,Wan-ying Zhang,Li-jun Shao,Yi-fan Liu,Li-ya Feng,Xiao-xia Yang,Xiu-li Guo
Enolase 1 (ENO1) is overexpressed in hepatocellular carcinoma (HCC) and correlates with poor patient prognosis, as evidenced by TCGA and Kaplan-Meier (KM) analysis. This study demonstrates that targeting ENO1 with its specific inhibitor, ENOblock, markedly enhances the antitumor efficacy of sorafenib in HCC cells. The combination of sorafenib and ENOblock significantly suppresses cell proliferation, migration, invasion, and angiogenesis in vitro and in vivo . Mechanistically, sorafenib and ENOblock synergistically promote ferroptosis by concurrently regulating the Keap1/Nrf2/NQO1 and TFR1/C-MYC/NCOA4/FTH1/LC3 pathways, independent of xCT/GPX4 pathway. These effects are characterized by elevated levels of reactive oxygen species (ROS), iron ions, and malondialdehyde (MDA). In vivo tumorigenic models further confirm that the enhanced therapeutic effect of sorafenib by ENOblock. Our findings not only elucidate a novel ferroptosis-based mechanism underlying sorafenib response in HCC, but also position ENOblock-sorafenib combination as a promising preclinical proof- of-concept strategy targeting ENO1 for HCC intervention.
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Reaction Kinetics Mechanisms and Catalysis
·
2012
·Vol. 108
·期 2
·531-544
·
IF 0.829
He Min-Qiang,Pan Ai-Xia,Xie Ji-Min,Jiang De-Li,Yuan Xin-Hua,Chen Min
Phosphotungstic heteropoly acid (PW) supported on various oxides (SiO 2 , TiO 2 , K-10 montmorillonite and γ-Al 2 O 3 ) were synthesized and used as catalysts for Friedel–Crafts acylation of pyrene with acetic anhydride to 1-acetylpyrene for the first time. The as-prepared catalysts were characterized by specific surface area measurement, X-ray diffraction, infrared spectroscopy, and temperature programmed desorption of ammonia. SiO 2 -supported phosphotungstic heteropoly acid (PW/SiO 2 , 40 wt%) was found to be the most active catalyst in the acylation giving 91.8 % yield and 100 % selectivity for 1-acetylpyrene at reaction temperature of 60 °C under ambient pressure. The effect of PW Loading, PW/SiO 2 amount, molar ratio of reactants, reaction temperature and reaction time on the catalytic acylation reaction were studied in detail to optimize the process parameters. The reusability of the PW/SiO 2 catalyst was appraised, and the possible pathway for the production of the Friedel–Crafts acylation of pyrene with acetic anhydride catalyzed by phosphotungstic heteropoly acid was also discussed briefly.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Jiani Guo,Xin Song,Yan Su,Yiran Zou,Renke Kang,Shang Gao
Polarity-dependent CMP behavior of 4H-SiC Si-face and C-face is systematically investigated. • The C-face exhibits higher material removal rate and stronger oxidation tendency. • A thicker oxygen-rich reacted layer forms on the C-face during CMP. • Enhanced interfacial charge transfer promotes oxidant–surface interactions on the C-face. • First-principles calculations reveal the origin of polarity-dependent CMP behavior. Chemical mechanical polishing (CMP) of SiC is fundamentally limited by its high hardness and chemical inertness, as well as the pronounced polarity-dependent anisotropy between the Si-face (0 0 0 1) and C-face (0 0 0 −1). In this work, the intrinsic mechanism governing polarity-dependent oxidation and material removal of 4H-SiC is systematically investigated by combining CMP experiments, surface characterization, electrochemical analysis, and first-principles calculations.Under identical polishing conditions, the C-face exhibits a significantly higher material removal rate (1900 nm·h −1 ) and lower surface roughness (0.13 nm) compared to the Si-face (1000 nm·h −1 , 0.65 nm). Electrochemical results reveal faster oxidation kinetics on the C-face, which is further confirmed by the formation of a thicker oxide layer and enhanced oxygen-containing species. DFT calculations demonstrate that the C-face possesses higher surface energy, lower work function, and stronger charge transfer capability, leading to more favorable oxidant adsorption and interfacial reactions. These results reveal that the superior CMP performance of the C-face originates from its intrinsically enhanced electronic activity and oxidation-assisted removal capability. This work establishes a clear structure–property–performance relationship for polarity-dependent CMP of SiC and provides new insights for improving polishing efficiency and achieving wafer-level uniformity. Download: Download high-res image (234KB) Download: Download full-size image
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yazhen Wu,Xiaoxiao Li,Zhengyu Jin,Birte Svensson,Yuxiang Bai
How to improve the solubility of linear dextrins (LD) and retain their characteristic helix amphiphilic cavities with flexible embedding capability, is a question worth exploring without adding new chemical groups. The strategy presented in this study is to attach a highly flexible (α-1 → 6) glucochain at the reducing end of LD by preparing a new type of dextrin, referred to as single-arm linear dextrin (SLD). In the actual synthesis, an (α-1 → 6) linked oligosaccharide of DP ¯ 10.7 (PDI = 1.28) was formed by extension of glucose units onto sucrose (2 M) by using L940W mutant of the glucansucrase GTF180-ΔN firstly. Next using γ-CD as glucosylation donor γ-CGTase extended this (α-1 → 6) glucochain with (α-1 → 4) bonds. SLD is a chimeric glucosaccharide comprising an (α-1 → 4) linked part ( DP ¯ 10.5) attached to the nonreducing end of an (α-1 → 6) glucochain as verified by enzyme fingerprinting and 1 H NMR. Furthermore, SLD was validated to show greatly improved solubility and dispersibility of resveratrol in water, as indicated by a 3.12-fold enhancement over the solubility in the presence of 0.014 M SLD. This study provided a new strategy for solving the solubility problem of LD and opens possibilities for new design of the fine structure of starch-like materials.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Xiao Qing,Liu Qi-Meng,Jiang Ru-Chao,Chen Kai-Feng,Zhu Xiang,Ma Lei,Li Wei-Xi,He Fei,Huang Jun-Jun
Previous studies have indicated that α1D/1A antagonist naftopidil (NAF) suppresses prostate growth by decreasing cell proliferation without affecting apoptosis and prostate volume in benign prostatic hyperplasia (BPH). A NAF-derived α1D/1A antagonist 1- benzyl-N-(3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl)-1H-indole-2- carboxamide (HJZ-12) has been reported from our laboratory, which exhibits high subtype-selectivity to both α1D- and α1A- AR (47.9- and 19.1- fold, respectively) with respect to a1B-AR in vitro. However, no further study was conducted. In the present study, a pharmacological evaluation of HJZ-12 in BPH was performed on an estrogen/androgen-induced rat BPH model and human BPH-1 cell line. In vivo, HJZ-12 exhibited better performance than NAF in preventing the progression of rat prostatic hyperplasia by not only decreasing prostate weight and proliferation (similar to NAF) but also, shrinking prostate volume and inducing prostate apoptosis (different from NAF). In vitro, HJZ-12 exhibited significant cell viability inhibition and apoptotic induction in BPH-1 cell line, without presenting cell anti-proliferation properties. Intriguingly, the role of HJZ-12 on cell viability and apoptosis was an α1-independent action. Furthermore, RNA-Seq analysis was applied to screen out six anti-apoptotic genes (Bcl-3, B-lymphoma Mo-MLV insertion region 1 [Bmi-1], ITGA2, FGFR3, RRS1, and SGK1). Amongst them, Bmi-1 was involved in the apoptotic induction of HJZ-12 in BPH-1. Overall, HJZ-12 played a remarkable role in preventing the progression of prostatic hyperplasia through α1-independent apoptotic induction, indicating that it will be a multi-target effective candidate for BPH treatment.
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