JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 52
·期 1
·547-558
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IF 2.047
Zhou Jian,Ren Sili
The phosphor-converted white light-emitting diode (WLED) has received tremendous attention as a promising alternative to traditional light sources in lighting and displays. Herein, a novel broadband red emitter Ca 2 Sr(PO 4 ) 2 :Mn 2+ was successfully designed and synthesized based on the Sr-alloying and Mn-doping of Ca 3 (PO 4 ) 2 . The phase purity of the materials was verified by x-ray diffraction (XRD) analyses, while a scanning electron microscope (SEM) coupled with an energy-dispersive spectrometer (EDS) was employed to confirm the uniform dopant distribution. XRD Rietveld refinements were further performed to clarify the site occupation of alloying Sr and the Mn dopants. Effective site engineering confined the Mn dopants in a highly symmetric Ca5 site and excluded the immersion of Sr, leading to an extraordinarily long fluorescence lifetime. Density functional theory (DFT) simulations also revealed the good potential of the materials as host matrices for activators such as Mn 2+ . Finally, Ca 2 Sr(PO 4 ) 2 :Mn 2+ was used to fabricate a WLED prototype based on a near-ultraviolet (n-UV) commercial LED chip, which realized a warm white-light emission and high color rendering index (Ra) of 82.9. This WLED was able to survive the long-term stability test while maintaining high luminous efficacy of ~ 60 lm/W within 20 h, showing its great potential in practical applications.
研究领域:
材料科学
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光电技术
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照明技术
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固体物理
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DOI
高影响因子
XENOBIOTICA
·
2022
·
IF 1.997
Kunna Li,Ying Zou,Yang Wang,Mengyue Zhou,Jing Li,Rong Tan,Shiyu Zhang,Weiwei Li,Jiang Zheng
2-Methylnaphthalene (2-MN) is an environmental pollutant. Studies have shown that 2-MN is teratogenic, carcinogenic, and cytotoxic. However, the mechanisms of 2-MN induced toxicities remain unclear.This study aimed to characterise reactive metabolites of 2-MN, to define the metabolic pathway, and to determine the enzymes participating in the metabolic activation.A hydroxylation metabolite of 2-MN, 2-naphthalenemethanol (2-NM), was observed in 2-MN-containing mouse liver microsomes.A glutathione (GSH) conjugate was detected in mouse S9 incubations fortified with 2-MN and GSH. A GSH conjugate and an NAC conjugate were found in mouse liver and urine, respectively, in animals given 2-MN. Hepatic protein covalent binding derived from 2-NM was observed in animals administered 2-MN.Cytochrome P450 enzymes and sulfotransferases participated in the metabolic activation of 2-MN.
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产品关联
DOI
PubMed
高影响因子
Research
·
2023
·
IF 11
Guangchun Song,Jia Xu,Hong Zhong,Qi Zhang,Xin Wang,Yitong Lin,Scott P. Beckman,Yunbo Luo,Xiaoyun He,Jin-Cheng Li,Kunlun Huang,Nan Cheng
The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment. However, research on alleviating metabolic diseases, such as hyperglycemia, has not been reported. Herein, we found that the single-atom Ce-N4-C-(OH)2 (SACe-N4-C-(OH)2) nanozyme promoted glucose absorption in lysosomes, resulting in increased reactive oxygen species production in HepG2 cells. Furthermore, the SACe-N4-C-(OH)2 nanozyme initiated a cascade reaction involving superoxide dismutase-, oxidase-, catalase-, and peroxidase-like activity to overcome the limitations associated with the substrate and produce •OH, thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β, and the expression of glycogen synthase, promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice. Altogether, these results demonstrated that the novel nanozyme SACe-N4-C-(OH)2 alleviated the effects of hyperglycemia without evident toxicity, demonstrating its excellent clinical application potential.
研究领域:
纳米技术
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生物化学
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代谢疾病
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药理学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Xiang Ye,Wen Chen,Fu-Jie Yan,Xiao-Dong Zheng,Peng-Cheng Tu,Peng-Fei Shan
Berries and their functional components have been put forward as an alternative to pharmacological treatments of type 2 diabetes mellitus (T2DM), and more attention has been paid to the gut microbiome in the pathophysiology of T2DM. Thus, we tried to examine the metabolic impact of red bayberry-derived cyanidin-3-O-glucoside (C3G) and investigate whether the antidiabetic effects of C3G were associated with the gut microbiome. As a result, C3G administration was found to reduce blood glucose levels of diabetic db/db mice, accompanied by increased levels of glucagon-like peptide (GLP-1) and insulin. Moreover, 16S rRNA analysis showed that the dominant microbiota modulated by C3G were pivotal in the glucose metabolism. Furthermore, the modulation of C3G on metabolic activities of gut bacteria leads to an increase in intestinal levels of key metabolites, particularly short-chain fatty acids. This contribution helps in promoting the secretion of GLP-1, which in turn increases insulin release with the purpose of reducing blood glucose levels. Overall, these findings may offer new thoughts concerning C3G against metabolic disorders in T2DM.
研究领域:
药理学
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糖尿病研究
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微生物学
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营养保健品
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代谢紊乱
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Lemeng Wang,Chi Fang,Xiaoqian Du,Kun Fu,Xiangfeng Tian,Pan Zhang,Dong Fu
The surface tensions ( γ ) and viscosities ( η ) of 1-dimethylamino-2-propanol (DMA2P) − 1-(2-aminoethyl)piperazine (AEP) and DMA2P − 1,5-diamino-2-methylpentane (DAMP) were measured and correlated. According to the CO 2 capture temperature from the thermal power plant flue gas (around 313 K), the experimental temperatures were selected to be 303.2 K, 313.2 K and 323.2 K. The mass fractions of DMA2P ranged from 0.300 to 0.500, and those for activators (AEP and DAMP) ranged from 0.050 to 0.150. Temperature and composition dependences of γ and η were demonstrated on the basis of experiments and calculations. The activation energy ( E a) was estimated from the temperature dependence of viscosity. Analytical formulations of surface entropy ( S S ) and surface enthalpy ( H S ) were deduced from the analytical equation of γ . S S and H S were calculated and their variations with respect to mass fraction were analyzed.
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2013
·
IF 2.004
Chao Guo,Shaoyun Chen,Yongchun Zhang
Solubility measurements of carbon dioxide (CO2) in aqueous 2-(2-aminoethylamino)ethanol (AEEA, 15 wt %), AEEA + N-methyldiethanolamine (MDEA, 5, 10 wt %), and AEEA + 2-amino-2-methyl-1-propanol (AMP, 5, 10 wt %) solutions as CO2 absorbents were performed at CO2 partial pressure from (0.8 to 800) kPa and temperatures of (303, 313, and 323) K. With increasing the MDEA/AMP amount to AEEA, CO2 loading of the absorbents decreased, while the absorption rate increased. At low CO2 partial pressure (< 30 kPa), the loading of AEEA + AMP was higher than that of AEEA + MDEA, while at high CO2 partial pressure (> 100 kPa), the loading of AEEA + AMP was lower than that of AEEA + MDEA at the same concentration. Furthermore, the absorption rate was in the order AEEA + AMP > AEEA + MDEA > AEEA.
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产品关联
DOI
高影响因子
Journal of Advanced Ceramics
·
2022
·Vol. 11
·期 3
·392-402
·
IF 11.534
Feng Chao,Zhou Xu,Tao Bingjing,Wu Haitao,Huang Shifeng
Dense microwave dielectric ceramics of Ce 2 [Zr 1 − x (Al 1/2 Ta 1/2 ) x ] 3 (MoO 4 ) 9 (CZMAT) ( x = 0.02–0.10) were prepared by the conventional solid-state route. The effects of (Al 1/2 Ta 1/2 ) 4+ on their microstructures, sintering behaviors, and microwave dielectric properties were systematically investigated. On the basis of the X-ray diffraction (XRD) results, all the samples were matched well with Pr 2 Zr 3 (MoO 4 ) 9 structures, which belonged to the space group \(R\bar 3c\) . The lattice parameters were obtained using the Rietveld refinement method. The correlations between the chemical bond parameters and microwave dielectric properties were calculated and analyzed by using the Phillips—Van Vechten—Levine (P—V—L) theory. Excellent dielectric properties of Ce 2 [Zr 0.94 (Al 1/2 Ta 1/2 ) 0.06 ] 3 (MoO 4 ) 9 with a relative permittivity ( ε r ) of 10.46, quality factor ( Q × f ) of 83,796 GHz, and temperature coefficient of resonant frequency ( τ f ) of −11.50 ppm/°C were achieved at 850 °C.
研究领域:
材料科学
·
陶瓷
·
微波介电材料
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DOI
高影响因子
Polymer Chemistry
·
2014
·Vol. 5
·期 20
·5967-5977
·
IF 5.368
Bo Zhang,Hui Tang,Peiyi Wu
Dynamic thermal phase transition behavior of a well-defined poly(N-isopropylacrylamide)–poly(2-hydroxyethyl methacrylate) (PNIPAM–PHEMA) interpenetrating polymer network (IPN) microgel in D2O synthesized by two-step precipitation polymerization was studied by means of IR spectroscopy in combination with the perturbation correlation moving window (PCMW) technique and two-dimensional correlation spectroscopy (2Dcos) analysis. Due to the hydrophobic and non-thermo-responsive properties of PHEMA and the special IPN structure, the IPN microgel exhibited an unusual thermally induced collapse process. The introduction of PHEMA would lower the volume phase transition temperature (VPTT) and the volume phase transition degree. 2Dcos was finally employed to discern the sequence order of all the group motion during heating and cooling processes. PHEMA plays different roles in different stages during the volume phase transition. Additionally, as PHEMA exhibits only a slight response to temperature, it would provide the PNIPAM–PHEMA IPN microgel with good reversibility.
研究领域:
高分子科学
·
生物材料
·
药物递送
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智能响应材料
·
热敏性水凝胶
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Xiaoqin Shi,Chenxu Li,Hui Guo,Shufeng Shen
Blends of amines with alkoxyethanols have been potentially used as alternative absorbents to conventional aqueous amines for energy-efficient CO2 capture, due to the lower specific heat capacity and enthalpy of vaporization of organic solvents than water. In this work, densities and viscosities were measured at atmospheric pressure for binary liquid mixtures of 2-(methylamino)ethanol (MAE) + 2-methoxyethanol (EGME), MAE + 2-ethoxyethanol (EGEE), and MAE + 2-butoxyethanol (EGBE) over the entire composition range and at temperatures of 293.15–353.15 K. The excess molar volume and viscosity deviations were also calculated and fitted by the Redlich–Kister equation. The calculated values of density and viscosity from the proposed correlations are in good agreement with the experimental values, with average absolute relative deviations within 0.06 and 1.23% for density and viscosity, respectively. The variations of excess or deviation properties with temperature and components were also discussed in terms of intermolecular interactions and structural effects.
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产品关联
DOI
高影响因子
Journal of Evidence-Based Integrative Medicine
·
2024
·
IF 3.3
Shu Dong,MD,Panling Xu,MD,Peiwen Yang,MD,Juying Jiao,MD,Chien-shan Cheng,MD,PhD,Lianyu Chen,MD,PhD
BackgroundHuanglianjiedu decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) prescription with thousand years of clinical use against various malignancies, including pancreatic adenocarcinoma (PAAD). However, its potential bioactive component and molecular mechanism remains unclear.AimsThis study is to inspect the HLJDD mechanisms of action against PAAD via integrated computational and pharmacochemistry strategy, in vivo and in vitro experiments to validate associated targets and pathways.MethodsA PAAD xenograft model was established by subcutaneous injecting Panc02 cells into C57BL/6 mice. Ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was engaged to determine constituents of HLJDD and assessed for pharmacokinetic scheme using the TCM Systems Pharmacology Platform (TCM-SP). Differentially expressed genes (DEGs) of PAAD was retrieved from the transcriptome dataset GSE43795, followed by recognizing overlapping targets the oncogenes and target genes of PAAD and HLJDD, respectively. Putative signaling pathways of HLJDD in treating PAAD were enriched using KEGG and GO analyses. The anti-PAAD effects of HLJDD was assessed in vivo and in vitro, besides, the potential mechanism was validated using immunoblotting and immunohistochemical assays.ResultsHLJDD significantly suppressed the growth of transplanted PAAD tumors, constrained PAAD progression, and induced apoptosis and S-phase arrest. Seventy-five active components meeting the drug-likeness criteria and 278 target genes of HLJDD were identified. KEGG analysis indicated that the top three enriched pathways were cancer, AGE-RAGE signaling, and IL-17 signaling pathways. Disease enrichment analysis highlighted immune, pharmacological, and cancer-related diseases as the top three categories. A total of 47 potential target genes were identified. Immunoblotting revealed that HLJDD inhibited PI3K and MAPK-related signaling pathways, while immunohistochemical staining confirmed that HLJDD suppressed the expression of phosphorylated MAPK and ERK1/2.ConclusionHLJDD inhibited PAAD in vitro and in vivo via the modulation of multiple mechanisms, including regulation of PI3K/AKT/mTOR and MAPK/ERK1/2 signaling pathways.
研究领域:
肿瘤学
·
中医药学
·
药理学
·
分子生物学
·
系统生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Yan Runhan,Cui Hongmin,Shi Jinsong,Yan Nanfu,Weng Yaqing,Cheng Ting,Wang Wei
There are still challenges in the recovery of rare earth elements (REEs) from leaching liquor of ion-adsorption type rare earth ore. In this paper, unsaponified N, N-di(2-ethylhexyl)-diglycolamic acid (HDEHDGA) was used to develop a green extraction process for efficient separation and enrichment of REEs. The cation exchange mechanism of RE(III) extraction was proposed by slope analysis and FT-IR spectra. HDEHDGA exhibited excellent extraction performances, such as short equilibrium time, high selectivity towards RE(III) and easy stripping by 0.5 mol/L HCl solution. REEs was enriched from 287.5 mg/L to 63.30 g/L by five-stage counter-current extraction and three-stage counter-current stripping using unsaponified HDEHDGA. The enrichment factor reached 220, and the proportion of REEs was increased from 80.76 wt% to 98.82 %. The loss of REEs was controlled below 2.14 wt%. This extraction strategy helps to improve the REEs recovery and avoid ammonia–nitrogen wastewater, which demonstrates its application potential in the ion-adsorption type rare earth ore.
研究领域:
化学工程
·
冶金工程
·
环境科学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Hang Liu,Hua Yin,Xiaolong Yu,Minghan Zhu,Zhi Dang
In this work, the amino-functionalized metal-organic frameworks (MIL-88B-NH 2 ) was synthesized, characterized and used as heterogeneous photo-Fenton catalyst for tris-(2-chloroisopropyl) phosphate (TCPP) degradation. The photo-Fenton activity of MIL-88B-NH 2 was investigated on the basis of influence factors, such as initial pH and TCPP concentration, and coexisting impurities. The results revealed that MIL-88B-NH 2 +H 2 O 2 +Vis system exhibited a satisfactory degradation efficiency of TCPP (almost 100%) within 60 min accompanied by a good reusability. Noticeably, the degradation kinetics constant of TCPP by MIL-88B-NH 2 +H 2 O 2 +Vis system was 0.086 min −1 , which was visibly higher than that of MIL-88B+H 2 O 2 +Vis system (0.021 min −1 ) since the addition of amino-functionalized organic linker inhibiting the recombination rate of the photo-generated electron-hole pairs and improving the visible light response. Combined with the characterization, the conversion of Fe III to Fe II could be accelerated by the photo-generated electron from the excitation of Fe-O clusters and NH 2 functionalities, which strengthened the decomposition of H 2 O 2 and formed plenty •OH. Simultaneously, six steady products were validated and potential degradation pathways of TCPP were proposed. It was anticipated that MIL-88B-NH 2 could be considered as a desirable and alternative candidate in the application of heterogeneous photo-Fenton reaction to control the environmental risks caused by organophosphate flame retardants (OPFRs).
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）