CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yuanchu Qin,Mude Zhu,Yi Tang,Xueqin Chen,Fu Wang,Xiaoyun Fan
How to efficiently treat a type of new emerging organic pollutant, carbamazepine (CBZ), with the features of environmental persistence, toxicity, and bioaccumulation, is now posing a challenge to scientists. Piezocatalysis, through the harvesting of mechanical energy, has a high capacity to degrade organic pollutants and is gaining increasing attention. Herein, a novel piezo material Cd 4 BiO(BO 3 ) 3 (CBB) with a 3-chromophore asymmetric structure showing an excellent CBZ degradation activity has been synthesized. The removal efficiency can reach 96.2% in 60 min, which is 4.13 times that of tetragonal phase BaTiO 3 (BTO) under the same conditions. The superior catalytic performance can be attributed to the easily polarized 3-chromophore asymmetric structure units of CBB, d 10 Cd 2+ ion, stereochemically active lone pair of Bi 3+ , and π-delocalization of BO 3 , which can generate a very strong internal alternating piezoelectric field under the action of ultrasonic vibration. Driven by this internal electric field force, the excited free charges can be easily separated and transferred to the surface of the material to take part in the redox reactions. Besides, CBB also exhibits high stability and excellent removal efficiency for rhodamine B (Rh B) and tetracycline (TC). Hydroxylation and aldehyde oxidation are the main processes of CBZ degradation. The eco-toxicity of CBZ and its intermediates was evaluated using T.E.S.T. software. This study shows that the easily strongly polarized borate material has a potential application in the piezocatalytic degradation of organic pollutants.
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Current Pharmaceutical Analysis
·
2023
·Vol. 19
·期 6
·511-520
·
IF 0.6
Zhang Mengmeng,Zou Qiaogen
Background: Atopic dermatitis (AD) is an allergic skin disease that can be inherited. Crisaborole is a specific drug developed to deal with this disease. The compounds of 4-(4- Bromo-3-formyl-phenoxy)-benzonitrile and 4-(4-(4-bromo-3-formylphenoxy)-3- formylphenoxy) benzonitrile
are the representative impurities in the synthesis of Crisaborole active pharmaceutical in gradient (API). Owing to the genotoxic impurities that could lead to cancer and gene mutations, it is necessary to develop a simple, efficient, sensitive, and accurate method to detect these impurities.
In this study, the 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile and 4-(4-(4- bromo-3-formylphenoxy)-3-formylphenoxy)benzo- nitrile present in Crisaborole API were detected using UPLC-MS/MS. Methods: The separation was made on a ZORBAX Eclipse XDB-Pheny column (4.6 mm ×75mm, 3.5
μm) with the mobile phase of acetonitrile solution containing 0.1% trifluoroacetic acid (A) and water containing 0.1% formic acid (B) in gradient elution mode. Quantification was performed using positive ion electrospray ionization (ESI), and the contents of two compounds were determined
using the multiple reaction monitoring (MRM) modes. Results: The quantitative analytical method was fully validated with respect to linearity (r > 0.9998), sensitivity, precision, accuracy (the average recovery of two impurities was 84.1% to 90.7%), and robustness. Conclusion:
Three batches of samples were detected by UPLC-MS/MS, indicating that the proposed approach was applicable for the quality evaluation of Crisaborole.
研究领域:
药物分析
·
皮肤病学
·
毒理学
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Danyang Ji,Yahui Du,Hongmin Meng,Lin Zhang,Zhongming Huang,Yalei Hu,Jianjun Li,Fei Yu,Zhaohui Li
In this work, cobalt oxyhydroxide nanoflakes (CoOOH nanoflakes) were reported to possess a high oxidizability toward TMB for the first time and based on which we have developed a new strategy for qualitative and quantitative detection of ascorbic acid (AA). In our design, CoOOH nanoflakes can directly oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) to oxTMB with an obvious blue color emerging, and AA can selectively inhibit the oxidation of TMB to oxTMB by resolving CoOOH nanoflakes to Co 2+ , resulting in a decrease in the absorbance of oxTMB and bleaching of blue color. As such, the concentration of AA could be identified very easily by UV–vis spectroscopy and bare eyes. Under optimal conditions, this sensing platform showed a highly sensitive response to AA with a detection limit of 142 nM and a short assay time of 5 min. This assay was also successfully used to quantify AA in human serum samples and practical food samples. Importantly, using this fabricated sensing strategy, we have further developed a paper-based strip sensor for AA detection with satisfactory results, showing its great potential for point of care applications.
研究领域:
分析化学
·
医学诊断
·
食品科学
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INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 31
·18475-18483
·
IF 4.6
Zhang Quan-Wei,Tian Zi-Han,Wu Ming-Xing,Ma Chen-Yuan,Bi Xing-Yu,Fang Zhi,Duan Mei-Hong
Exploring high-performance birefringent crystals holds
paramount
significance in modern optics, yet traditional candidates generally
struggle to reconcile substantial birefringence with broad spectral
transparency. To circumvent this long-standing bottleneck, a synergistic
multifunctional-group assembly strategy has been devised to guide
the rational design of birefringent crystals. Correspondingly, driven
by lanthanide coordination and hydrogen bonding, two kinds of π-conjugated
units were successfully incorporated into a new birefringent crystal,
Ce(2,2 ′ -bipyridyl) 3 (SCN) 3 . Synthesized
via a facile solution evaporation method, Ce(2,2 ′ -bipyridyl) 3 (SCN) 3 was characterized by a large birefringence
of 0.18@546 nm, broad transmission windows (nearly spanning 0.445–25
μm), and moderate thermal stability (up to 270 ° C), making
it favorable for practical applications.
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INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Mingyang Liu,Zhongwen Ouyang,Xiaochen Liu,Jiaojiao Cao,Tongtong Xiao,Zhengcai Xia,Zhenxing Wang
Isolated large-spin Heisenberg antiferromagnetic uniform chain is quite rare. Here, we have successfully synthesized an ideal one-dimensional (1D) S = 5/2 linear-chain antiferromagnet [C2NH8]3[Fe(SO4)3], which crystallizes in a trigonal lattice with the space group R3c. A broad maximum at Tmax = 18 K is observed in the magnetic susceptibility curve. Notably, no long-range magnetic ordering is observed down to 2 K even if the material has a large Curie–Weiss temperature of θCW = −25.5 K. High-field magnetization at 2 K shows a linear increase until saturation at 30 T, and a high-field electron spin resonance (ESR) reveals the absence of a zero-field spin gap. The intrachain interaction J and interchain interaction J′ are determined. Quite a small ratio of J′/J < 2.5 × 10–3 suggests that [C2NH8]3[Fe(SO4)3] behaves as an ideal 1D uniform linear-chain antiferromagnet, in which the magnetic ordering is prevented by the extremely small interchain interaction and quantum fluctuation even for a classical spin of S = 5/2.
研究领域:
物理学
·
材料科学
·
磁学
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Yuhang Xue,Chengjun Wu,Haiwen Li,Cunde Wang
Acetic acid-catalyzed (3 + 2) cyclization reaction of substituted 2-aroyl-3-aryl-1,1-dicyanocyclopropanes with arylhydrazines was investigated for the efficient synthesis of 4-dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles in good yields, in which 4,5-double substituents are predominantly trans selective. This approach included the consecutive condensation, ring opening, and double nucleophilic cyclization reaction.
研究领域:
有机化学
·
合成方法学
·
杂环化学
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Shuyang Shi,Baozhong Ma,Shuang Shao,Yongqiang Chen,Chengyan Wang
An original technology named HNO3 pressure leaching has been proposed by our team to leach Al from coal gangue and fly ash. Although the preliminary separation of Al and Fe had been achieved during leaching, a small amount of Fe impurity was still unavoidably dissolved into the leach liquor. To obtain pure Al2O3 during subsequent pyrolysis, it is imperative to synchronously remove Fe3+ during the crystallization of Al(NO3)3·9H2O. Herein, the phase equilibria of the Al(NO3)3–Fe(NO3)3–H2O(−HNO3) system at 25–40 °C and 0–8.12 mol kg–1 of HNO3 molality were investigated. The results indicated that the ternary system was a simple cosaturated type consisting of an immutable point, two univariate curves, and two crystallization regions. Notably, the solubility and crystallization region of Al(NO3)3·9H2O were barely impacted by acidity, while the opposite was true for Fe(NO3)3·9H2O. This finding was instructive for the crystallization of Fe(NO3)3·9H2O from the liquor with high Fe and low Al. Moreover, a high crystallization yield could be obtained at low temperatures. Finally, an appropriate crystallization procedure was provided. This study is expected to provide basic data and theoretical support for the crystallization and separation of mixed nitrates containing Al and Fe.
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JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Chenli Wei,Zeyu Guo,Yongjie Li,Jie Huang
A new nitrogen-rich energetic complex Cd(DMF) 2 BTZAF (1) (DMF= N,N-Dimethylformamide, H 2 BTZAF= 3, 3′-bis(1H-tetrazol-5-yl)-4, 4′-azofurazan) was first synthesized by the reaction of Cd(NO 3 ) 2 ·4H 2 O with 4-amino-3-(5-tetrazolate)-furazan. The compound 1 was characterized by elemental analysis and FT-IR spectrum analysis, respectively. The crystal structure of complex 1 was determined by single-crystal X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P2 1 /c. A Cd 2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, four nitrogen atoms are from the four BTZAF 2− ions and the other two oxygen atoms are from two DMF molecules. Moreover, the thermal decomposition behavior of compound 1 was studied with DSC and TG-DTG methods. The non-isothermal kinetic parameters of compound 1 was calculated by Kissinger's method and Ozawa-Doyle's method. In addition, the thermal safety performance and the impact sensitivity of complex 1 were measured and calculated, and the results showed that the synthetic compound has good insensitivity and stability.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 47
·7862-7870
·
IF 4.776
Jian Chen,Dongya Zhang,Yan Zou,Zhongjie Wang,Mingcong Hao,Meng Zheng,Xue Xue,Xiaoxi Pan,Yiqing Lu,Jiefei Wang,Bingyang Shi
Nanohybrids fabricated with upconversion nanoparticles (UCNPs) and gold nanoparticles (NPs) hold great promise for near-infrared photothermal therapy (NIR-PTT) and upconversion fluorescence imaging. However, the obstacles of poor solubility in water and finite hydrophilic modification method for UCNPs limit their application in biological fields. Herein, we report a novel UCNP@Al(OH)3/Au nanohybrid mediated by a highly hydrophilic and biocompatible Al(OH)3 layer to realize a synergistic targeted PTT and fluorescence imaging capability to U87MG tumor-bearing mice under NIR light irradiation. The modification with Al(OH)3 layers can improve the water solubility of UCNPs. And cytotoxicity assays and hemolysis assay showed that the modification with Al(OH)3 layers makes UCNPs have low cytotoxicity and good biocompatibility. In addition, the Al(OH)3 layers are thin enough to allow fluorescence resonance energy transfer (FRET) between UCNPs and gold NPs to occur, giving the NPs a good PTT effect for tumor-bearing mice. Meanwhile, as the pH-sensitive Al(OH)3 layers decompose in acidic tumor microenvironments with Au NPs detached from their surface, the FRET effect no longer occurred, subsequently leading to the fluorescence intensity of naked UCNPs being recovered for good imaging effects. The study suggests that Al(OH)3 mediation layer as a promising hydrophilic nanoplatform can potentially be used for the preparation of superior hydrophilic NPs and pH-stimulated drug release carriers for theranostic application in vivo.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2018
·
IF 2.441
Qiong Lou,Jun Wen,Yuanying Jiang,Jinghua Huang,Guorong Fan,Fenyun Song
A reliable liquid chromatography/tandem mass (LC-MS/MS) method was developed for quantitation of 3′, 4′-dimethoxy flavonol-3-β- d -glucopyranoside (DF3G) in rat plasma using pantoprazole as the internal standard. An Agilent C18 column (100 mm × 3 mm, 3.5 μm) was performed for chromatographic separation with the mobile phase composed of methanol-water (containing formic acid) at a flow rate of 0.4 mL/min. A triple-quadrupole mass spectrometry equipped with an electrospray ionization (ESI) source in positive ion mode was applied to quantitative analysis by multiple reacting monitoring (MRM). The MRM precursor-product ion transition of DF3G and Pantoprazole (IS) were m / z 461.1 → 299.2 and 383.9 → 200.2, respectively. Calibration curves were recovered in a concentration range of 1–500 ng/mL for plasma with a limit of lower quantification (LLOQ) of 1 ng/mL. The intra-day and inter-day precision were not >10%. The accuracy of DF3G ranged from −10% to 0.53% in quality control (QC) samples at three concentrations. DF3G was not degraded during the analysis and the storage period. All the data were validated in accordance with the FDA bioanalytical method validation guideline. The LC-MS/MS method was successfully employed in the pharmacokinetic study of the DF3G after oral administration and intravenous injection in rats.
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IONICS
·
2015
·Vol. 21
·期 9
·2567-2574
·
IF 1.754
Liu Guishen,Ma Yanhui,Hou Xiaodong,huang Yina,Chen Jianpeng,Zhan Guoqing,Li Chunya
1-[3-(N-Pyrrole)propyl]-3-[1-tert-butoxy-carbonylamino-propyl]imidazolium tetrafluoroborate ionic liquid was successfully synthesized and characterized. The ionic liquid was electrochemically polymerized onto a glassy carbon electrode surface using a multi-potential step technique. Morphology and electrochemical properties of the polymerized ionic liquid film electrode were studied with scanning electronic microscopy and electrochemical impedance spectroscopy. Using the polymerized ionic liquid film as a sensing platform, electrochemical behaviors of magnolol were investigated by voltammetry. Under optimal experimental conditions, the oxidation peak currents were linearly related to magnolol concentrations in the range from 5.0 × 10 −8 to 1.0 × 10 −5 mol L −1 . The detection limit calculated from the standard deviation of the intercept was 2.3 × 10 −7 mol L −1 . Practical application of the polymerized ionic liquid film electrode was demonstrated by determining magnolol in the traditional Chinese medicine. The result is consistent with that obtained using high performance liquid chromatography.
Polymerized ionic liquid film electrode fabricated with potential step technique and application in voltammetric sensing of magnolol
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MATERIALS LETTERS
·
2016
·
IF 2.437
Peng Zou,Hairong Liu,Yongsheng Li,Jiying Huang,Yao Dai
The proliferation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro is a key challenge for cartilage tissue engineering and their clinical applications. In this study, novel dextran grafting PHBV (PHBV-DEX) fibrous scaffolds were fabricated via surface modification. Compared with the electrospun PHBV fibrous scaffolds, dextran modified ones exhibited significantly enhanced surface hydrophilicity and bioactivity. The water contact angle (WCA) of those scaffolds was reduced from 117.3±4.30° to 56.03±1.13° after dextran modification. PHBV-DEX scaffold significantly promoted the growth of BMSCs compared with unmodified one, suggesting that it can be potentially applied in tissue engineering.
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