DRUG DELIVERY
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2020
·
IF 4.902
Rongqiang Liao,Ying Liu,Pin Lv,Di Wu,Meiling Xu,Xiaoyuan Zheng
A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, 1H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:ε-PL-CD was significantly improved compared with SCU:β-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:ε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 12
·A2419
·
IF 3.12
Xianhua Hou,Zishuai Zhang,Kaixiang Shen,Shikun Cheng,Qinyu He,Yumeng Shi,Denis Y. W. Yu,Ching-yuan Su,Lain-Jong Li,Fuming Chen
An anion flow battery has recently emerged as an option to store electricity with high volumetric energy densities. In particular, fluoride ions are attractive for these batteries because they have the smallest size among anions, which is beneficial for charge transport. To date, reported fluoride ion batteries either operate with an ionic liquid, organic electrolyte or solid-state electrolyte at high temperatures. Herein, an aqueous fluoride ion flow battery is proposed that consists of bismuth fluoride as the anode, 4-hydroxy-TEMPO (TEMPO) as the cathode, and NaF salt solution as the aqueous electrolyte. During the charging process, bismuth fluoride electrochemically releases fluoride ions with the formation of bismuth metal, while TEMPO captures the fluoride ions. A reversible and stable discharge capacity of 89.5 mAh g−1 was achieved at 1000 mA g−1 after 85 cycles. The fluoride ion battery possesses excellent rate performance. To the best of our knowledge, this is the earliest demonstration that fluoride ion batteries can work in aqueous solutions, which can be used for future clean energy applications.
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BIOCONJUGATE CHEMISTRY
·
2018
·
IF 4.485
Yali Hu,Yingqin Hou,Hao Wang,Hua Lu
The performance of many therapeutic proteins, including human interferon-α2b (IFN), is often impeded by their intrinsic instability to protease, poor pharmacokinetics, and strong immunity. Although PEGylation has been an effective approach to improve the pharmacokinetics of many proteins, a few noticeable limitations have aroused vast research efforts in seeking alternatives to PEG for bioconjugation. Herein, we report our investigation on the use of polysarcosine (PSar), a nonionic and hydrophilic polypeptoid, for IFN modification. The site-specific conjugate PSar-IFN, generated by native chemical ligation in high yield, is systematically compared with a similarly produced PEG–interferon conjugate (PEG-IFN) to evaluate the in vitro and in vivo behaviors. PSar is found to show comparable ability in stabilizing IFN from protease digestion in vitro and prolonging the circulation half-life in vivo. Interestingly, PSar-IFN retains more activity in vitro and accumulates more in the tumor sites upon systemic administration than PEG-IFN. Most importantly, PSar-IFN is significantly more potent in inhibiting tumor growth and elicits considerably less anti-IFN antibodies in mouse than PEG-IFN. Together, our results demonstrate for the first time that PSar is an outstanding candidate for therapeutic protein conjugation. Considering the low toxicity, biodegradability, and excellent stealth effect of PSar, this study suggests that such polypeptoids hold enormous potential for many biomedical applications including protein delivery, colloidal stabilization, and nanomedicine.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Zhongxiang Zhao,Yongjian Lou,Zenghui Dai,Feiya Fu,Xiangdong Liu
To improve processability of benzoxazine monomer in preparation of composites, a water-slurry strategy was examined using several laboratory-scale instances. The water slurries were fabricated by mixing solid resin powder of 3-furfury-8-methoxy-3,4-dihydro-2H-1,3- benzoxazine with water and one type of filler particle, i.e., calcium carbonate, montmorillonite, or hollow glass beads. Experimental data show that approving liquidity can be achieved when more than 180 phr of water was mixed in the solid mixtures containing the resin powder and 100 phr of solid filler. The biobased composite prepared using the optimized condition exhibits outstanding mechanical properties and antifatigue performance as the composites prepared via solvent method. This water-slurry approach provides an environmentally friendly strategy to manuscript benzoxazine composites, offering benzoxazine with more promising applications in many industries such as building, wind energy, aircraft, and automobile.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Wei Cao,Yong Wang,Qianfen Zhuang,Luyao Wang,Yongnian Ni
In the work, a ratiometric electrochemical sensor for tert-butylhydroquinone (TBHQ) detection is constructed based on the modified electrode consisting of manganese dioxide (MnO 2 ) and electrochemically reduced graphene oxide (ERGO) nanocomposite film. MnO 2 was electrodeposited onto the electrochemically reduced graphene oxide (ERGO) placed on a glassy carbon electrode (GCE) to form the MnO 2 /ERGO/GCE. The construction process of the MnO 2 /ERGO/GCE electrode was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. The electrochemical signal responses of the TBHQ sensor were recorded by differential pulse voltammetric measurements. The experimental results demonstrate that MnO 2 can be used as the inner reference electrochemical probe, and ERGO can improve the sensitivity for TBHQ detection. It can be found that as the TBHQ concentration increases, the anodic peak current of TBHQ at the MnO 2 /ERGO/GCE increases, but the anodic peak current of MnO 2 at such the modified electrode almost remains unchangeable. The net peak current ratio between TBHQ and MnO 2 is chosen for quantitative detection of TBHQ. The developed ratiometric sensor exhibits two linear ranges of 1.0–50.0 μM and 100.0–300.0 μM for detecting TBHQ. The detection limit for TBHQ detection is estimated to be 0.8 μM on the basis of signal-to-noise ( S / N ) of 3. Moreover, the ratiometric electrochemical sensor is successfully applied for TBHQ detection in real edible oil samples.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 21
·17756-17761
·
IF 3.201
Shen Zhang,Feng Wei,Xiaojun Han
Capsaicin, an active ingredient in red pepper, shows great antibacterial activity. Herein, a series of sodium alginate/pullulan composite films incorporated with different concentrations of capsaicin were fabricated. Their physico-chemical properties were systematically investigated. With the increased content of capsaicin, the transmittance, elongation at break, and moisture content of the films decreased, whereas the tensile strength, water vapor permeability, and surface contact angle increased. Furthermore, the liquid culture tests revealed that the composite films exhibited good antibacterial performance against E. coli and S. aureus. The practical application of these antibacterial films for apple protection also exhibited a positive result, which makes it possible to use them in food packaging.
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ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Rui Zheng,Sheng Wang,Ye Tian,Xinguo Jiang,Deliang Fu,Shun Shen,Wuli Yang
Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe3O4 particles. Compared with magnetic Fe3O4 particles and PDA nanospheres, the core–shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T2-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe3O4 particles and PDA nanospheres alone.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2015
·
IF 0.986
Naifeng Xu,Liguang Xu,Wei Ma,Hua Kuang,Chuanlai Xu
In this study, a highly sensitive monoclonal antibody (McAb) against chloramphenicol (CAP) was successfully raised and characterised by indirect competitive enzyme-linked immunosorbent assay (ic-ELISA). Three antigens coupled with different proteins were synthesised and determined by the UV-vis method. After five rounds of immunisation, antisera were collected from six Balb/C mice and screened by ic-ELISA. The standard inhibition curve of one CAP McAb (labelled 6F11) showed the best sensitivity to CAP after optimisation of the principal working conditions. The half-maximal inhibition concentration (IC50) was calculated to be 0.01 ng/mL and the linear working range was from 0.0028 ng/mL to 0.040 ng/mL with a correlation coefficient of 0.996. This McAb showed high specificity, with negligible cross-reactivities detected towards CAP analogues (florfinicol, florfinicol amine, thiamphenicol). The recovery rate was 98.9–106.8% while the coefficient of variation was 4.45–6.05%. The IC50 value and other parameters obtained for this CAP McAb suggest that it is likely to have a promising future in further applications in combination with different analytical techniques.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2013
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IF 3.172
Ren-Liang Wang,Yan-Mei Zhu,Xi-Man Zhang,Hai-Wei Ji,Li Li,Hai-Yan Ge
We report an economic method for synthesis of highly ordered silica with a mixing surfactant system containing short-chain cationic surfactant (decyltrimethyl ammonium bromide, denoted C 10 TMAB) and short-chain anionic surfactant (sodium octyl sulfate, denoted SOS) as the templating agents. Highly ordered supermicroporous silica was synthesized by judiciously chosen mixing ratio of surfactants. The samples were characterized by small-angle X-ray diffraction, transmission electron microscopy, and N 2 adsorption–desorption. The results showed that the pore structure of the resulting silica belongs to the two-dimensional hexagonal structure (space group 2D- p 6 mm ) with a pore size of ca. 2.2nm. Moreover, the method proposed herein is expected to facilitate the synthesis of not only porous silicas but also materials with other framework compositions.
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BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Jianping Li,Xionghui Ma,Mengxi Li,Yun Zhang
A novel glycoprotein imprinting strategy was proposed and was applied to the detection of the carbohydrate antigen 19-9. The glycosylated complex of glycoprotein was used as template to construct a glycosyl imprinted sensor. The eluted imprinted cavities showed good affinity for template glycosyls and glycoproteins carrying template glycosyl. The effect of template saccharide structure on glycosyl imprinted sensors is further discussed. More complex template structures can lead to better sensor performance including selectivity and sensitivity. As a result, the polysaccharide imprinted sensor showed preeminent linear response to CA19-9 in the range of 0.1–5 U/mL, with a detection limit of 0.028 U/mL (3δ/K), while the linear of the monosaccharide imprinted sensor was 1–60 U/mL and the detection limit was 0.17 U/mL. The complex structure on the template surface provides more possibilities for the recognition of the template molecules, consequently, led to the significant anti-interference capability of the polysaccharide imprinted sensor. Furthermore, recoveries ranging from 93.0% to 103.5% were achieved when human serum samples were assayed using the polysaccharide imprinted sensor.
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POLYMER
·
2016
·
IF 3.586
Hongqiang Yan,Chuang Sun,Zhengping Fang,Xiaoqing Liu,Jin Zhu,Hao Wang
An intrinsically flame retardant bio-based benzoxazine (diphenolic acid pentaerythritol caged phosphate benzoxazine, DPA-PEPA-Boz) monomer was synthesized from bio-based diphenolic acid (DPA) using a four-step process. The monomer of DPA-PEPA-Boz was characterized by FT-IR, 1 H NMR and 13 C NMR. The curing behavior of DPA-PEPA-boz was studied and compared with those of DPA based benzoxazine (DPA-Boz) and DPA ester derivative (MDP) based benzoxazine (MDP-Boz) without PEPA by means of non-isothermal differential scanning calorimetry . The results indicated that DPA-PEPA-Boz system showed a two-stage curing, assigned to the exothermic opening reactions of oxazine rings and P–O–C ring in PEPA respectively, while the DPA-Boz and MDP-Boz showed a one-stage curing. In addition, the effect of the introduction of PEPA on thermal and inflammable properties of the resin was evaluated. The residual char of the cured DPA-PEPA-Boz (P-DPA-PEPA-Boz) after 400 °C was much higher than those of cured DPA-Boz (P-DPA-Boz) and cured MDP-Boz (P-MDP-Boz) under nitrogen and air atmospheres. Meanwhile, total heat release (THR), peak heat release rate (PHRR) and heat release capacity (HRC) of P-DPA-PEPA-Boz were about half of those of P-DPA-Boz and P-MDP-Boz. P-DPA-PEPA-Boz had a limiting oxygen index (LOI) of 33.5% and achieved V0 rating in UL94 test. P-DPA-PEPA-Boz behaved as a very good intrinsic thermal and flame retardant bio-based benoxazine resin.
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NEW JOURNAL OF CHEMISTRY
·
2016
·Vol. 40
·期 7
·6332-6339
·
IF 3.277
Ren Liu,Huiwen Ge,Xue Wang,Jing Luo,Zhiquan Li,Xiaoya Liu
In this paper, a facile, economical and environmentally friendly synthetic method was developed to fabricate a Ag nanoparticle (NP) decorated graphene (GR/TA/Ag) composite with tannic acid (TA) as a reducing agent and stabilizing agent. The GR/TA/Ag composite was fully characterized using Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible absorption spectroscopy (UV-vis), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) demonstrated that Ag NPs with diameters of up to 6 nm were homogeneously and uniformly deposited on graphene sheets. With an increasing concentration of AgNO3 used for immersion, the amount of Ag NPs loaded kept increasing without aggregation or deformation. The antibacterial properties of the GR/TA/Ag composite were studied using Gram-negative E. coli ATCC 25922 and Gram-positive S. aureus ATCC 6538 via both the disk diffusion method and the shaking flask method. The disk diffusion method results showed that the synthesized GR/TA/Ag composite had great release antibacterial properties owing to the loading of Ag NPs. In addition, the presence of TA gave the composite good non-release antibacterial properties, based on the results of the shaking flask method. The ingenious combination of the release-killing capabilities of Ag NPs and the contact-killing capabilities of TA bestow two-level antibacterial activity on the GR/TA/Ag composite, promoting the GR/TA/Ag composite as part of a new generation of powerful antibacterial agents with promising applications.
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