INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Xing Liu,Ting Zhang,Lei Zhou,Ming Li,Rongxing He
A highly luminescent (C13H28N2)2Cu4I8 single crystal containing isolated γ-[Cu4I8]4– anionic cluster was synthesized without the use of unsaturated cations. To the best of our knowledge, compounds bearing such like anions are not dual-emitting under UV excitation. However, dual emission does occur in (C13H28N2)2Cu4I8. Moreover, the emission bands were found to be temperature-sensitive, allowing tuning of the emission colors from blue (0.19, 0.20) to green (0.33, 0.47) in the Commission International de L’ Eclairage (CIE) chromaticity coordinates. Remarkably, the color could be restored on returning to the initial temperature, confirming an efficient and reversible luminescent thermochromic effect in (C13H28N2)2Cu4I8. The origin of this excellent optical performance is discussed, and the difference in the mechanism with the dual-emissive Cu(I) halide complexes is also elucidated. Overall, our work provides a promising way to achieve efficient luminescent thermochromism. The developed (C13H28N2)2Cu4I8 represents one of the viable alternatives for eco-friendly luminescent thermochromic materials.
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Chemosensors
·
2024
·Vol. 12
·期 10
·214
·
IF 3.7
Yun Hui,Weijun Kong,Weiliang Shu,Zhiting Peng,Fengshan Shen,Mingyang Jiang,Zhen Xu,Tianzhun Wu,Wenhua Zhou,Xue-Feng Yu
The measurement of cardiac troponin I (cTnI) is of vital importance for the early diagnosis of acute myocardial infarction. In this study, an enhanced electrochemiluminescent immunoassay for the highly sensitive and precise determination of cTnI was reported. A biomimetic chip with nepenthes peristome surface microstructures to achieve single-layer microbead arrays and integrated microelectrode arrays (MEAs) for ECL detection was microfabricated. Ru@SiO2nanoparticles were prepared as signal amplificators labeling immunomagnetic beads. Dendrimer-encapsulated platinum nanoparticles (Pt DENs) were electrochemically modified on ITO MEAs. The resulting Pt DEN-modified ITO MEAs preserved good optical transparency and exhibited an approximately 20-fold ECL signal amplification compared to that obtained from bare ITO. The method made full use of the biomimetic chip with Pt DENs to develop single-layer immunomagnetic bead arrays with increasingly catalyzed electrochemical oxidation of the [Ru(bpy)3]2+–TPA system. Consequently, a limit of detection calculated as 0.38 pg/mL (S/N = 3) was obtained with excellent selectivity, demonstrating significant potential for the detection of cTnI in clinical diagnostics.
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Science China-Chemistry
·
2025
·
IF 9.7
Fan Huahua,Wang Runjia,Zhang Li,Liu Minghua
The G-quartet, a hydrogen-bonded macrocycle formed by cation-templated assembly of guanosine derivative, plays a vital role in areas ranging from structural biology to supramolecular chemistry and nanotechnology. Herein, we show a zinc-terpyridine derivative (Ftpy) that could form complex with various guanosine phosphates, exhibiting relatively weak circularly polarized luminescence CPL (dissymmetry factor, g lum ≈ 1 × 10 −3 ). Interestingly, when Ag + ions are involved, significantly boosted circularly polarized luminescence (CPL) is obtained in the assemblies of Ftpy with GTP, which the g lum can reach to 0.15. In contrast, no significant difference is observed in the presence of other cations (Na + , K + , Rb + , NH 4 + , Cu 2+ , and Sr 2+ ). It reveals that CPL signal is amplified due to the formation of G-quartet in the presence of Ag + ions, which further hierarchically self-associate into helically stacked supramolecular aggregates with the cooperation and π - π of Ftpy, contributing to the expression of chirality information. Furthermore, the co-assemblies of Ftpy/GTP/Ag + exhibit an enantioselective recognition of enantiomeric penicillamine by CPL spectra. This work provides a straightforward avenue to fabricate supramolecular assemblies with strong CPL based on G-quartet formation.
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Acta Biomaterialia
·
2024
·
IF 9.4
Xianjiao Tang,Liping Chen,Yuhan Wang,Pengwei Chen,Lin-Song Li,Xiaojing Yang,Mei-Xia Zhao
The construction and optimization of a single phototherapeutic agent with photoluminescence, type I photodynamic therapy (PDT), and photothermal therapy (PTT) functions remain challenging. In this study, we aimed to design and synthesize four donor–acceptor (D-A) type aggregation-induced emission molecules: PSI, TPSI, PSSI, and TPSSI. We employed phenothiazine as an electron donor and 1,3-bis(dicyanomethylidene)indan as a strong electron acceptor in the synthesis process. Among them, TPSSI exhibited efficient type I reactive oxygen species generation, high photothermal conversion efficiency (45.44 %), and near-infrared emission. These observations can be attributed to the introduction of a triphenylamine electron donor group and a thiophene unit, which resulted in increased D–A strengths, a reduced singlet-triplet energy gap, and increased free intramolecular motion. TPSSI was loaded into bovine serum albumin to prepare biocompatible TPSSI nanoparticles (NPs). Our results have indicated that TPSSI NPs can target lipid droplets with negligible dark toxicity and can efficiently generate O 2 •− in hypoxic tumor environments. Moreover, TPSSI NPs selectively targeted 4T1 tumor tissues and exhibited a good PDT-PTT synergistic effect in vitro and in vivo. We believe that the successful preparation of multifunctional phototherapeutic agents will promote the development of efficient tumor diagnosis and treatment technologies. Statement of Significance The construction of a single phototherapeutic agent with photoluminescence, type I photodynamic therapy, and photothermal therapy functions, and its optimization remain challenging. In this study, we construct four donor–acceptor aggregation-induced emission molecules using phenothiazine as an electron donor and 1,3-Bis(dicyanomethylidene)indan as a strong electron acceptor. By optimizing the molecular structure, an integrated phototherapy agent with fluorescence imaging ability and high photodynamic / photothermal therapy performance was prepared. We believe that the successful preparation of multifunctional phototherapeutic agents will promote the development of efficient tumor diagnosis and treatment technology.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Li Jun,Liu Hao,Yang Zhenzhong,Yu Qingqing,Zhao Lu,Wang Yi
Thrombosis is a key pathological event in cardiovascular diseases, and is also the most important targeting process for their clinical management. New drug development in thrombosis treatment is still in great demand. According to the traditional Chinese medicine (TCM) theory, thrombosis belongs to the syndrome of blood stasis. Salvia miltiorrhiza Bunge and Ligusticum striatum DC. are two common TCM herbs with long-term documented function in promoting blood circulation and inhibiting thrombosis, especially when used together. Guanxinning Tablet, a modern Chinese drug which contains extracts of the two herbs, also showed strong therapeutic effects in coronary heart disease. However, the pharmacological mechanism is still lacking for the compatibility of the two herbs. Here, through zebrafish-based in vivo fluorescence screening, we demonstrated the synergistic effects between S. miltiorrhiza Bunge and L. striatum DC. in regulating endogenous thrombosis. Moreover, combined with high-resolution mass spectrometry, the main compounds of the botanical drugs were analyzed and screened in our model system. Interestingly, cryptotanshinone and senkyunolide I, two representative compounds, respectively derived from the two herbs, also showed synergistic antithrombotic effects. Further analysis suggested that they may regulate thrombi formation at different levels via multiple signaling pathways, including oxidative stress, platelet activation and coagulation cascade. Taken together, our findings provided solid biological supports toward the drug compatibility theory of TCM, and suggested cryptotanshinone and senkyunolide I as promising drug candidates in thrombosis management.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xin Wang,Yubing Xu,Yuzhu Pan,Shunjie Chai,Jie Wu,Jingda Zhao,Yuwei Li,Zhiwei Zhao,Qing Li,Jun Wu,Jing Chen,Byung Seong Bae,Jianming Zhou,Ying Zhu,Wei Lei,Xiaobao Xu
Solution-processed lead halide perovskite single crystals (LHPSCs) are believed to have great potential in gamma-ray spectroscopy. However, obtaining low-defect LHPSCs from a solution at low temperatures is difficult compared to obtaining Bridgman single crystals such as CdTe and Si. Herein, noise from the intrinsic defects of LHPSCs is considered as the main problem hindering their gamma-ray detection performance. By isolating the defect-induced holes in LHPSCs via energy barriers, we show that NIN photodiodes based on three types of LHPSCs, i.e., MAPbBr3 (MA = CH3NH3), MAPbBr2.5Cl0.5, and cascade LHPSCs, have demonstrated good energy resolution in the range of 6.7–10.3% for 662 keV 137Cs gamma-ray photons. The noise for >10 mm3 devices is low, in the order of 340–860 electrons, and the electron collection efficiency reaches 23–43%. These results pave the way for obtaining low-cost, large, high energy-resolution gamma-ray detectors at room temperature (300 K).
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-10
·
IF 5.3
Wang Linhai,Hu Xiao,Yao Guoqing,Chen Qinhua,Wang Sicen
A visual aptasensor based on the combination of graphitic carbon nitride loaded with platinum nanoparticles (PtNPs/g-C 3 N 4 ) and deoxyribonuclease I (DNase I) was developed for detecting acetamiprid. The prepared PtNPs/g-C 3 N 4 exhibited excellent peroxidase (POD)-like activity, demonstrating the capacity to oxidize the colourless o-phenylenediamine (OPD) to produce the coloured product diaminophenazine (DAP) in the presence of hydrogen peroxide (H 2 O 2 ). The DNA aptamer of acetamiprid can adsorb onto the surface of PtNPs/g-C 3 N 4 , thereby inhibiting its POD activity. The binding of acetamiprid to its aptamer results in the aptamer desorbing from the surface of PtNPs/g-C 3 N 4 and subsequent digestion by DNase I. Ascribed to the synergistic effect of these factors, the aptasensor can achieve the rapid on-site detection of acetamiprid based on the acetamiprid-induced the colour change of the solution just with the smartphone. Furthermore, due to the remarkable fluorescence signal of DAP at 570 nm, the aptasensor under fluorescence mode enables highly sensitive and quantitative detection of acetamiprid with a linear range of 1 ng/mL to 4 µg/mL and a detection limit as low as 0.31 ng/mL. The aptasensor has successfully realized the detection of acetamiprid in river water and cucumber samples, offering a novel perspective for the rapid assessment of environmental pollution and food safety risks associated with acetamiprid residues. Graphical abstract
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Nanoscale
·
2024
·Vol. 16
·期 38
·17817-17824
·
IF 5.8
Zheng Liu,Jun-Jie Fang,Zhi-Yi Wang,Yun-Peng Xie,Xing Lu
The utilization of bifunctional ligands, specifically pyridine carboxylic acids, endowed with dual coordination sites, has been instrumental in the assembly of polymer materials. The ambidentate characteristics of these ligands play a crucial role in shaping the structure and framework of cluster-based polymers. In this study, we have synthesized a diverse array of multidimensional copper(I) alkynyl cluster-based polymers (CACPs) by employing four distinct pyridine carboxylic acids – namely, isonicotinic acid (INA), 6-isoquinolinecarboxylic acid (IQL), 4-pyridin-4-yl-benzoic acid (4-PyBA), and 3-pyridin-4-yl-benzoic acid (3-PyBA) – as linking ligands. These pyridine carboxylic acids not only serve as protective ligands but also act as pivotal linkers in constructing the cluster-based framework materials, exerting significant influence on the overall framework structures. Furthermore, the incorporation of auxiliary ligands has been shown to markedly impact the structural integrity and framework architecture of the CACPs. This study elucidates the indispensable role of pyridine carboxylic acids in the construction and stabilization of cluster-based framework materials, thereby advancing the frontier of research in metal cluster-based framework material synthesis.
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LANGMUIR
·
2025
·
IF 3.9
Linghui Meng,Jie Jiang,Xuesong Peng,Lin Zhu,Ruopeng Li,Yaqiang Li,Maozhong An
Developing a cyanide-free gold electrodeposition system is significant for replacing the cyanide electroplating gold plating system, which is highly harmful to the environment and toxic to human health. In our study, a cyanide-free system for electrodepositing gold (Au) coatings was proposed with AuCl as the main salt and 5,5-dimethyl hydantoin (DMH) as the Au (I) complexing agent. Through theoretical calculations and electrochemical test screening, 4,6-dimethyl-2-mercaptopyrimidine (DMP) is suitable for DMH-based gold electrodeposition and was selected as an electroplating additive. The role of DMP in gold electrodeposition was further studied. In particular, the adsorption–coordination mechanism was proposed to elucidate the role of DMP, based on calculations of the Bader charge density difference for DMP adsorbed on the gold surface and the interaction between DMP and Au+. Electrochemical tests such as cyclic voltammetry and chronoamperometry were utilized to study the impact of varying DMP concentrations on gold electrodeposition behavior. Chronoamperometric analysis indicates that Au electrodeposition obeys a 3D diffusion-controlled progressive nucleation process, independent of DMP concentration and applied potential, while the presence of DMP markedly suppresses grain growth. The addition of DMP significantly improved the surface morphology and brightness of the gold coating, resulting in a smooth and dense layer with a golden-yellow appearance. XRD results showed that the addition of DMP reduced the grain size of the Au coating from 22.1 to 15.7 nm, with the gold coating primarily growing along the Au (111) plane. The XPS test results show that the purity of the gold plating layer is high, and there is no inclusion of additives in the coating.
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BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Ruoxin Tu,Yining Wang,Ru Xu,Shusheng Wang,Jiabin Cai,Lin Sun,Pengfei Gao
Despite therapeutic advances, hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide. While dihydrotanshinone I (DHT) shows promising anticancer potential, its molecular mechanisms in HCC remain unexplored. Here, we unveil a novel chemokine (C-C Motif) receptor 5(CCR5)-mediated regulatory network targeted by DHT in HCC treatment. This study identifies CCR5 as a crucial survival factor in HCC, uncovers a novel CCR5-Nuclear factor erythroid 2-related factor 2(NRF2) regulatory axis, and reveals a dual-targeting mechanism of DHT through direct CCR5 inhibition and Reactive oxygen species(ROS)-dependent cell death induction, validating its therapeutic efficacy by disrupting redox homeostasis. This study uncovers a novel CCR5-ROS-NRF2 signaling axis in HCC and establishes DHT as a promising therapeutic agent through its unique targeting mechanism. These findings provide new insights into HCC pathogenesis and present an innovative therapeutic strategy for HCC treatment.
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TALANTA
·
2025
·
IF 6.1
Luke Wei,Yuxin Hu,Jiamin Wu,Jing Mao,Tianqin Yin,Jieqiong Qiu
Doxorubicin (DOX), a widely utilized chemotherapeutic antibiotic, increasingly threatens environmental and public health due to its persistence in marine ecosystems, bioaccumulation in organisms, and contamination of agricultural systems. In response to the urgent demand for effective DOX detection, we have developed a label-free fluorescent aptamer biosensor (FAB) that employs SYBR Green I (SG I)-mediated signal amplification. A key innovation in this design is the strategic fragmentation of the 41-mer complementary strand (CP) of the DOX aptamer into three 11-mer fragments. It significantly mitigates nonspecific SG I binding interference caused by the longer ssDNA CP, enhancing the fluorescence signal ratio (F dsDNA /F ssDNA ) from 4.6-fold to 12.6-fold. Upon DOX introduction, competitive binding between DOX, SG I, and DNA further suppresses background noise, yielding an exceptional fluorescence quenching ratio (F 0 /F) of 52.8. The optimized FAB demonstrates ultra-sensitive DOX detection, with a detection limit of 1.41 nM and a linear response between 1.41 nM and 300 nM. The recoveries of DOX spiked into pond water and drinking water samples ranged from 95.1% to 101.8%, with relative standard deviations (RSDs) below 3.46%, demonstrating negligible matrix effects and confirming the FAB method’s robustness for environmental monitoring applications. This strategy synergistically enhances signal transduction efficiency, and strengthens detection reliability, all while maintaining operational simplicity. As a result, this FAB for DOX detection holds transformative potential, poised to revolutionize biosensor technology in the fields of food safety, environmental monitoring, and biosecurity.
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Cell Metabolism
·
2024
·
IF 27.7
Li Zhang,Hao-li Wang,Ya-fang Zhang,Xin-tao Mao,Ting-ting Wu,Zhi-hui Huang,Wan-jun Jiang,Ke-qi Fan,Dan-dan Liu,Bing Yang,Mei-hui Zhuang,Guang-ming Huang,Yinming Liang,Shu Jeffrey Zhu,Jiang-yan Zhong,Guang-yin Xu,Xiao-ming Li,Qian Cao,Yi-yuan Li,Jin Jin
Irritable bowel syndrome with diarrhea (IBS-D) is a common and chronic gastrointestinal disorder that is characterized by abdominal discomfort and occasional diarrhea. The pathogenesis of IBS-D is thought to be related to a combination of factors, including psychological stress, abnormal muscle contractions, and inflammation and disorder of the gut microbiome. However, there is still a lack of comprehensive analysis of the logical regulatory correlation among these factors. In this study, we found that stress induced hyperproduction of xanthine and altered the abundance and metabolic characteristics of Lactobacillus murinus in the gut. Lactobacillus murinus -derived spermidine suppressed the basal expression of type I interferon (IFN)-α in plasmacytoid dendritic cells by inhibiting the K63-linked polyubiquitination of TRAF3. The reduction in IFN-α unrestricted the contractile function of colonic smooth muscle cells, resulting in an increase in bowel movement. Our findings provided a theoretical basis for the pathological mechanism of, and new drug targets for, stress-exposed IBS-D.
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