ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Boquan Qin,Shizhou Wu,Hongxian Dong,Shu Deng,Yunjie Liu,Wanli Zhang,Guoying Feng,Lei Lei,Huiqi Xie
Diabetic wounds, a prevalent chronic disease, are associated with older age. The hyperglycemic microenvironment in diabetic wounds significantly reduces the immune system, inducing bacterial invasion. The coupling of tissue repair and antibacterial treatment is critical for infected diabetic ulcer regeneration. In this study, a dual-layered sodium alginate/carboxymethyl chitosan (SA/CMCS) adhesive film cored with an SA-bFGF microsphere-loaded small intestine submucosa (SIS) hydrogel composite dressing with a graphene oxide (GO)-based antisense transformation system was developed to promote infected diabetic wound healing and bacterial eradication. Initially, our injectable SIS-based hydrogel composite stimulated angiogenesis, collagen deposition, and immunoregulation in diabetic wound repair. The GO-based transformation system subsequently inhibited bacterial viability in infected wounds by post-transformation regulation. Meanwhile, the SA/CMCS film provided stable adhesion covering the wound area to maintain a moist microenvironment, which promoted in situ tissue repair. Our findings provide a promising clinical translation strategy for promoting the healing of infected diabetic wounds.
研究领域:
材料科学
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生物医学工程
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伤口愈合
·
组织工程
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PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2016
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IF 2.857
Gaoshuang Hu,Wei Sheng,Yan Zhang,Junping Wang,Xuening Wu,Shuo Wang
A novel fluorescence immunoassay for detecting sulfaquinoxaline (SQX) in animal-derived foods was developed using NaYF4:Yb/Tm upconversion nanoparticles (UCNPs) conjugated with antibodies as fluorescence signal probes, and monodisperse magnetic polystyrene microspheres (MMPMs) modified with coating antigen as immune-sensing capture probes for trapping and separating the signal probes. Based on a competitive immunoassay format, the detection limit of the proposed method for detecting SQX was 0.1 μg L–1 in buffer and 0.5 μg kg–1 in food samples. The recoveries of SQX in spiked samples ranged from 69.80 to 133.00%, with coefficients of variation of 0.24–25.06%. The extraction procedure was fast, simple, and environmentally friendly, requiring no organic solvents. In particular, milk samples can be analyzed directly after simple dilution. This method has appealing properties, such as sensitive fluorescence response, a simple and fast extraction procedure, and environmental friendliness, and could be applied to detecting SQX in animal-derived foods.
研究领域:
分析化学
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食品科学
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纳米技术
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生物技术
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PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Yanhua Zhang,Jing Liu,Yumei Xiao,Ziyi Guo,Liuli Zou,Tao Li,Xing Xiang,Jiadong Deng
P2-Na 0.67 Ni 0.33 Mn 0.67 O 2 is considered a promising cathode material for sodium-ion batteries. However, its practical application is still hindered by sluggish Na + diffusion kinetics and structural degradation caused by repeated Na + intercalation/deintercalation during cycling. Herein, by transforming the precursor structure from olive-like hierarchical structure to the peanut-like hierarchical structure, and finally to a microsphere-like hierarchical structure, a P2-Na 0.67 Ni 0.33 Mn 0.67 O 2 cathode material with a hollow hierarchical microsphere structure was obtained. This unique structure shortens Na + diffusion pathways, facilitates electrolyte infiltration, and effectively buffers volume variation during cycling. ICP-MS results indicate that the optimized sample has a relatively higher Na content, which may contribute to a higher charge capacity. SEM and XRD analyses after cycling reveal that the hollow hierarchical microsphere cathode suppresses particle fragmentation and structural degradation, while ex-situ XRD confirms its improved structural reversibility during charge/discharge. Intermittent current titration and multi-sweep cyclic voltammetry further demonstrate higher Na + diffusion coefficients. As a result, the optimized cathode delivers 79.3 mA h g −1 at 10C, corresponding to 76% of the capacity at 0.1C, and 75% higher than that of the olive-like cathode. It also achieves stable cycling for 2000 cycles at 5C, with capacity retentions of 87.51%, 76.83%, and 63.67% after 500, 1000, and 2000 cycles.
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JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Xiaomeng Wang,Siyu Wang,Xinrui Xu,Qiwei Pan,Zhiyong Chen
Fluorous chromatography traditionally relies on large volumes of toxic organic solvents as mobile phase, conflicting with sustainable development principles. Here, we introduce a superhydrophobic fluorinated microporous microsphere stationary phase (SFMMS) for separating highly polar pyrimidine compounds under aqueous mobile phases. The SFMMS exhibited a high specific surface area of 497.7 m²/g and ultrahigh water repellency (contact angle > 150 ° across diverse aqueous conditions), enabling drastically reduced back pressure compared to commercial columns. Baseline separation of cytosine, uracil, and 5-fluorouracil was achieved under highly aqueous systems containing minimal acetic acid or a ChCl-EG deep eutectic solvent (DES) as green mobile phases. Thermodynamic analyses revealed negative Gibbs free energy changes (ΔG < 0) and exothermic enthalpy changes (ΔH < 0), indicating spontaneous and enthalpically driven adsorption. Density functional theory (DFT) calculations confirmed binding energies of up to -3.05 kcal/mol for 5-fluorouracil, supporting a multi-interaction mechanism involving fluorine-fluorine (F-F) and fluorine-π (F-π) interactions. The high surface area provided abundant binding sites, contributing to prolonged retention of polar analytes on the fluorinated column. Column reproducibility was demonstrated by relative standard deviations (RSDs) of retention times ranging from 0.44% to 0.56% for intra-day tests and from 0.61% to 1.18% for inter-day tests. Spike-and-recovery results verified mean recoveries for 5-fluorouracil in urine samples ranging from 80.9% to 98.5%, with RSDs between 0.54% and 1.80%. This work offers a novel strategy for the separation of polar pyrimidines under water mobile phases on a fluorinated column, aligning with the principles of green liquid chromatography.
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高影响因子
ADVANCED POWDER TECHNOLOGY
·
2026
·Vol. 37
·期 5
·105239
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IF 4.5
Yuli Wang,Qichao Xin,Chengling Zou,Yu Wang,Yuanyuan Li,Hai Nan,Fengqi Zhao,Haixia Ma
3,4-Bis(4′-nitrofurazano-3′-yl)furoxan (DNTF), a high-energy–density material, is severely restricted in practical applications due to its high mechanical sensitivity. This study develops an advanced desensitization strategy for DNTF composite via electrostatic spraying technology. The DNTF/FOX-7@NC (FOX-7, 1,1-diamino-2,2-dinitroethene; NC, nitrocellulose) hollow microsphere structure was formed through controlling the propulsion rate and the FOX-7 content. The composites retain the crystalline features of DNTF and FOX-7, while NC forms a continuous protective surface layer. Subsequently, the influence of FOX-7 content on the safety performance and combustion efficiency of the composites is systematically investigated. Results indicated that DNTF/FOX-7@NC hollow microsphere composites achieved a favorable balance between energy output and safety performance. Specifically, composites (with 38 % FOX-7 content) demonstrate superior thermal stability compared to raw DNTF. Its impact sensitivity increased by 14.7 J compared to raw DNTF (4.9 J), the critical load for friction sensitivity exceeds 360 N, demonstrating superior mechanical safety. Simultaneously, the combustion efficiency of the DNTF/FOX-7@NC hollow microsphere composite is significantly optimized, benefiting from the architecture of the hollow microspheres facilitating heat and mass transfer. This resulted in a 43 % reduction in ignition delay time of composite (from 109.24 s to 61.71 s). This work resolves the energy-safety trade-off in energetic materials via hollow microsphere structural design by electrostatic spray strategy, offering a scalable strategy for next-generation munitions.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Shiwen Gong,Wentao Ma,Die Hu,Haixing Xu,Binbin Li,Xinyu Wang
Inflammatory bowel disease ( IBD) is an idiopathic, lifelong, and devastating chronic inflammatory disease of the gastrointestinal tract. Berberine, an alkaloid extracted from the Chinese herb Huanglian, is a pharmaceutical ingredient with antibacterial, anti-inflammatory, and antiviral pharmacological effects in Chinese medicine. However, direct administration of berberine requires high doses due to its low bioavailability and high waste in the stomach. In this study, we prepared berberine-loaded pH-responsive Eudragit® FS 30D-attapulgite (FS-ATT) microspheres for the targeted treatment of colitis. The microspheres had pH-responsive release behavior, with minimal berberine release (about 5.97%) in simulated gastric fluid and high berberine release in simulated colonic fluid (about 69.27%). In addition, it was revealed by in vivo biological evaluations that, compared with drugs in an equivalent solution form taken orally, a significant improvement in IBD symptoms was observed after oral administration of drug-loaded FS-ATT microspheres, leading to an increase in the diversity of intestinal microbiota, inhibition of inflammatory cytokines, and enhanced therapeutic effects of berberine. The pH-responsive FS-ATT microspheres could offer a promising drug delivery platform for managing and treating many gastrointestinal diseases.
研究领域:
药剂学
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生物医学
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胃肠病学
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高影响因子
Nanoscale Research Letters
·
2017
·Vol. 12
·期 1
·1-10
·
IF 2.833
Hu Min,Zhang Zhenwei,Luo Chenkun,Qiao Xiuqing
In this paper, hierarchical Ag-decorated SnO 2 microspheres were synthesized by a facile one-pot hydrothermal method. The resulting composites were characterized by XRD, SEM, TEM, XPS, BET, and FTIR analysis. The catalytic performances of the samples were evaluated with the reduction of 4-nitrophenol to 4-aminophenol by potassium borohydride (KBH 4 ) as a model reaction. Time-dependent experiments indicated that the hierarchical microspheres assembled from SnO 2 and Ag nanoparticles can be formed when the react time is less than 10 h. With the increase of hydrothermal time, SnO 2 nanoparticles will self-assemble into SnO 2 nanosheets and Ag nanoparticles decorated SnO 2 nanosheets were obtained. When evaluated as catalyst, the obtained Ag-decorated SnO 2 microsphere prepared for 36 h exhibited excellent catalytic performance with normalized rate constant ( κ
nor ) of 6.20 min −1 g −1 L, which is much better than that of some previous reported catalysts. Moreover, this Ag-decorated SnO 2 microsphere demonstrates good reusability after the first five cycles. In addition, we speculate the formation mechanism of the hierarchical Ag-decorated SnO 2 microsphere and discussed the possible origin of the excellent catalytic activity.
研究领域:
材料科学
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环境科学
·
化学工程
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2018
·
IF 3.716
Jing Li,Li Xu,Zhi-guo Shi
In this study, the ethyl-bridged hybrid silica microsphere with hierarchically meso-macroporous structure was initially synthesized through a method combining dispersion polymerization with sol-gel transition and phase separation. The flow-through macropores rendered the microsphere a rough surface like a waxberry, and thus the material was named as waxberry-like ethyl-bridged hybrid silica sphere (WEHS). WEHS was characteristic of appropriate alkali-stability, which was highly difficult for the pure silica. Additionally, WEHS possessed hierarchical meso- and macropores, which added additional value for faster mass transfer than the conventional fully porous silica materials. Taking the advantages of WEHS, it was successfully applied as the substrate to immobilize lipase; the prepared immobilized lipase exhibited high catalytic activity and favorable reusability under alkaline conditions, which was significant in pitch control of neutral-alkaline papermaking industry. Moreover, as the high-performance liquid chromatographic stationary phase matrix, WEHS made the separation under alkaline mobile phase into a reality for the silica-based materials. Besides, an ultra-fast and efficient separation in minutes was achieved with lower consumption of solvents and saving analytical time, which is highly desired in modern analysis. In general, WEHS was a novel and promising candidate in the myriads of silica-based materials.
研究领域:
材料科学
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生物化学
·
分析化学
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jiaqing Zhang,Yong Long,Xuetong Duan,Jiyan Li,An Li
The intermittent nature of solar energy supply causes photothermal materials in interfacial evaporation systems to be unable to achieve continuous and stable photothermal conversion and water supply functions. To this end, this paper constructs a Janus composite membrane (MSHS@TDA@PAN) with both photothermal conversion and thermal energy storage capabilities through electrospinning. In MSHS@TDA@PAN, MgO/Pt multi-shell hollow microspheres impregnated with tetradecylamine (TDA) form a hydrophobic photothermal layer, while hydrophilic polyacrylonitrile (PAN) nanofibers act as a water-transporting layer, together driving efficient photothermal interfacial evaporation. It achieves an intrinsic light absorption of 80.7 %, a photothermal conversion efficiency of 79.83 %, and a phase change enthalpy of 90.7 J·g −1 . Experimental results show that the average evaporation rate of the photothermal membrane over one phase change cycle (One hour each for solar irradiation and dark field) is increased from 2.402 kg·m −2 of the membrane without phase change materials to 2.67 kg·m −2 . It can increase the production of fresh water by 3.24 kg·m −2 ·d −1 . Especially under no-light conditions, the evaporation rate of MSHS@TDA@PAN is 2.1 times that of the control group, which significantly alleviates the performance attenuation caused by intermittent illumination. In conclusion, MSHS@TDA@PAN effectively solves the intermittency problem of solar energy utilization through the synergistic mechanism of photothermal conversion, thermal energy storage and continuous heat release. It has application prospects in the fields of continuous seawater desalination and photothermal utilization.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Haibo Ouyang,Wenlu Li,Cuiyan Li,Tianzhan Shen,Leer Bao,Sirui Wu
ZrO 2 @C spherical powder was synthesized via a solvothermal method and utilized in the fabrication of ZrC ceramics through direct ink writing (DIW) to enhance rheological properties and reduce sintering temperature. The effects of solid content on the rheological behavior and printability of the ZrO 2 @C paste were systematically investigated. The ZrO 2 @C paste exhibited typical pseudoplastic fluid characteristics and viscoelastic properties, demonstrating excellent shape retention and shear-thinning behavior. Optimal solid content and printing speed were determined to be 54 wt% and 100 mm/s, respectively, leading to superior printability. Using these optimized parameters, green bodies with planar and lattice structures were rapidly and precisely fabricated. After reactive sintering at 1600 °C, the resulting ZrC ceramic achieved a promising bending strength of 30.9 MPa. This study provides a robust strategy for the rapid fabrication of ultrahigh-temperature ceramics with complex geometries.
研究领域:
材料科学
·
陶瓷工程
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Lei Qiao,Zhihong Zhou,Mingkun Wang,Zhiwei He
Frequent oil spills and the discharge of oily wastewaters have caused a serious threat to the environment, ecological systems, and the health of human beings. Herein, a durable photothermal and superhydrophobic melamine sponge has been prepared by decorating lignin microspheres (LMs) and TiO2 nanoparticles via the self-polymerization of dopamine. The superhydrophobic sponge shows excellent chemical stability, thermal stability, mechanical durability, and recyclability. The adsorption capacities of the superhydrophobic sponge for oils and organic solvents range from 22.4 to 84.2 g/g, showing high separation efficiencies larger than 98.6% after 15 cyclic tests. Due to the photothermal effect, the maximum surface temperature of the superhydrophobic sponge reaches 65.2 °C under solar irradiation (1 sun), and the superhydrophobic sponge successfully achieves the ice-free property at a low temperature of −17.8 °C under solar irradiation (0.5 sun). Besides, the LMs@TiO2 composite coating can be employed on several substrates (i.e., filter paper, carbon cloth, steel mesh, Al sheet, Cu sheet, and NdFeB) to realize surface superhydrophobicity, and exhibits excellent anticorrosion for the coated NdFeB. Therefore, this study proposes a low-cost and multifunctional superhydrophobic MS, opening a new avenue to the rational design of superhydrophobic MS for applications in oil/water separation, anti-icing, and anticorrosion.
研究领域:
材料科学
·
环境科学
·
化学工程
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DOI
PubMed
高影响因子
SusMat
·
2024
·
IF 18.7
Anxiong Liu,Lu Chen,Luhe Qi,Jing Huang,Yongkang Zou,Zhiwen Hu,Le Yu,Zibiao Zhong,Qifa Ye,Chaoji Chen
Sepsis is responsible for approximately 5.3 million deaths globally each year. Here, we constructed hierarchical chitin microspheres loaded with MOF-919 (Ch/metal–organic frameworks [MOFs]) for the rapid and efficient removal of lipopolysaccharide (LPS) in complex blood environments. Furthermore, abundant active sites on MOF-919(Sc) also enable a record-high adsorption capacity of 9.56 mg/g in biomass-based adsorbents due to the coordination interactions between endotoxin and MOF-919(Sc). The LPS level of sepsis rabbits was less than 2 EU/mL (clearance rate >95%) after 90-min hemoperfusion, showing no adverse effect on the rabbit organs. Additionally, compared to the commonly used LPS scrubber Toraymyxin (polymethyl methacrylate), the chitin adsorbent is significantly more cost-effective and environmentally friendly. The preparation strategy for hierarchical porous microspheres offers notable advantages in designability, recyclability, and renewability, providing a new approach to sepsis treatment and promising prospects for the biomedical application of sustainable biomass materials.
研究领域:
生物医学工程
·
材料科学
·
败血症治疗
·
生物材料
·
环境科学
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DOI
高影响因子
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