Regenerative Biomaterials
·
2026
·
IF 8.7
Shi Yaqiang,Liu Yaqin,Bai Xiaoyu,Gao Wentao,Ma Yawei,Wang Jieneng,Hu Yuan,Jiang Yongjie,Li Wei,Zhou Shifeng,Qi Quan
Myocardial Infarction (MI) is a leading cause of high global cardiovascular mortality and disability. Platelet-rich plasma (PRP), as a widely available autologous biological product rich in various growth factors, holds significant potential for promoting tissue healing and regeneration. However, its clinical application is limited by short in vivo retention time and transient therapeutic effects, necessitating the development of novel drug delivery systems to enhance its clinical value. In this study, a novel injectable PRP-gel composite was developed. Based on the Schiff base reaction, the composite gel exhibits excellent biocompatibility, biodegradability, appropriate mechanical properties, and enables controlled release of multiple growth factors from PRP. Results at 28 days post-intramyocardial injection demonstrated that, compared with the control group, the PRP-gel composite effectively promoted angiogenesis, inhibited cardiac cell apoptosis and injury, significantly reduced infarct size, decreased myocardial fibrosis, and preserved ventricular wall thickness, ultimately leading to a marked improvement in cardiac function. In summary, the composite gel developed in this study provides an optimized strategy for the clinical application of PRP and represents a promising therapeutic approach for myocardial regeneration following MI.
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yu Wang,Yuhe Dong,Bingmin Wu,Yao Liu,Zhenzi Yun,Xi Yu,Quancai Sun,Ying Xiao,Tian Zhong
To increase the survival and controlled-release properties of probiotics during storage and gastrointestinal digestion, this study develops a novel probiotic intestinal-targeted controlled-release tablet using a gelatin/sodium carboxymethyl cellulose (CMC)-based complex coacervation and double emulsification method integrated with spray drying and direct compression technology. The effects of three different CMCs on the complex coacervation process, as well as the microstructure, physicochemical characteristics, gastrointestinal controlled-release behavior, and storage stability of the resulting microcapsule tablets, were systematically evaluated. The results demonstrated that the complex coacervates formed from medium-viscosity CMC and gelatin exhibited the highest probiotic encapsulation efficiency (EE) (87.27%) in the double emulsion system. Following spray drying, the microcapsule powders exhibited favorable physicochemical properties. Second, the microcapsule tablets formulated with medium-viscosity CMCs provided the most effective protection for probiotics, with a survival rate of 48.74%, which was significantly higher than that of the unencapsulated tablet group (21.09%, p < 0.05). These advantages can be attributed to the moderate molecular chain length and steric hindrance exhibited by medium-viscosity CMC, which enable the coacervate to achieve sufficient emulsification performance and protective capability. In simulated gastrointestinal digestion experiments, the survival rate of probiotics in the microcapsule tablets at the end of intestinal digestion ranged from 75.41% to 85.68%, which was also markedly higher than that of the unencapsulated group (11.46%, p < 0.05). Furthermore, after storage at 37°C for six months, the viable bacterial count in the microcapsule tablets decreased by only 0.9×10 9 to 1.57×10 9 CFU/tablet. This study systematically investigated the impact of CMC viscosity on the encapsulation and controlled-release performance of a gelatin/CMC (G/CMC) complex coacervation system, leading to the successful development of a probiotic controlled-release tablet with high survival rates, enhanced stability, and targeted delivery.
研究领域:
食品科学与技术
·
制药工艺学
·
微胶囊技术
·
药物控释
·
益生菌制剂
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Shuqi Dong,Yan Gao,Jungang Yang,Guoyuan Zou,Wentian He,Liang Yuan,Bing Cao
Controlled-release fertilizers (CRFs) offer significant potential for reducing environmental pollution and enhancing fertilizer utilization efficiency. However, achieving improved controlled-release and degradability in high bio-content polyurethane (HB-PU) coated fertilizers remains challenging, limiting their further agricultural application. In this work, HB-PU coatings were synthesized via a one-pot process primarily using castor oil (CO), lysine diisocyanate (LDI), and polymethylene polyphenyl polyisocyanate (PAPI). Results demonstrate that the enhanced controlled-release performance of the HB-PU coating is associated with the type and concentration of metal ions within the complexation layer formed on the surface of the urea. After constructing the Cu coordination layer, the nutrient-controlled release period of castor oil-based polyurethane with bio-content over 70 % (PCU1-Cu) coated urea with 2.5 % coating percentage was extended by 20 days compared to the control. The chemical structure, thermodynamic stability, and microscopic morphology of the HB-PU with Cu coordination layer were analyzed. XPS confirms that the metal ion coordination was mainly enriched in the inner layer of the coating material. The Fenton-like reaction confirmed the presence of Cu ions in the PCU1-Cu coating and with catalytic reactivity. Degradation studies in NaOH solution demonstrated that introducing Cu ions accelerates the HB-PU degradation. The application of PCU1-Cu coated urea on Pakchoi ( Brassica rapa ssp. chinensis ) exhibited increased yield. This study prepared HB-PU controlled-release fertilizers with excellent controlled-release properties by constructing a metal coordination layer, while also providing a novel design method for supplementing essential trace metal elements for plant growth.
研究领域:
农业材料
·
高分子科学
·
可持续农业
·
环境化学
·
植物营养
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xian He,Wenxin Dai,Shaoxian Liang,Yunyun Qin,Haoyue Liu,Kang Cheng,Mingyu He,Wanshui Yang,Xinsheng Qin
The benefits of synbiotics in ulcerative colitis are now supported by a growing amount of evidence. However, achieving its targeted delivery in vivo and reaching effective doses for therapeutic effects remains to be explored. To further explore the potential role of synbiotics in alleviating ulcerative colitis, this study designed a dual-response “egg–box” shaped microgel microsphere for targeted delivery and precise release of synbiotics. The internal “egg” structure was constructed using an apple pectin–zein hybrid particles (AZHPs) stabilized W 1 /O/W 2 double emulsions system, while a dense network formed by poly–L–lysine (PLL) and calcium alginate constituted the protective “box” shell. We investigated the physicochemical characteristics of W 1 /O/W 2 double emulsions prepared with different concentrations of AZHPs. The synbiotics–loaded W 1 /O/W 2 double emulsions were coated with PLL and calcium alginate to prepare microgel beads. In vitro digestion results demonstrated that the survival rate of probiotics within the microgel beads was significantly higher than that in a free state. Oral microgel beads alleviate colitis by modulating tight junction proteins (ZO–1, Claudin 1 and Occludin), reducing inflammatory factors (IL–1β, IL–6 and TNF–α), promoting the production of short–chain fatty acids. After treatment with EPMB, the number of Firmicutes in the intestinal flora increased while the number of Bacteroidetes decreased, and synbiotics intervention successfully restored the abundance of gut microbiota. This indicated that the loaded synbiotics “egg–box” shaped microgel beads offer a new option for the current treatment of colitis.
研究领域:
食品科学与技术
·
药物递送
·
纳米医学
·
胃肠病学
·
生物材料
·
微胶囊技术
·
营养免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Packaging and Shelf Life
·
2020
·
IF 4.244
Shenyu Yang,Qiuju Miao,Yiping Huang,Peishan Jian,Xiaoping Wang,Mei Tu
Cinnamaldehyde (Ci) is a highly effective natural broad-spectrum antibacterial agent and preservative, but its strong volatility and short duration have a negative impact on its application in the field of agriculture and food. In order to improve these properties, porous PHA/CS microspheres were prepared by using polyhydroxyalkanoate (PHA) and chitosan (CS) as basic materials based on Poiseuille flow principle, and PHA/CS scaffolds were obtained by sintering the microspheres at low temperature. The effect of the ratio of PHA and CS on the particle size and charge of microspheres was studied. It was found that the particle size increased with the increase of the ratio of PHA and CS, while the surface charge changed from negative to positive. The SEM results showed that the microspheres exhibit a porous structure, and the CS adsorb on the surface of microspheres resulted in the reduction of surface pores. FTIR spectrum confirmed that there was only physical interaction between PHA and CS. PHA-based microspheres exhibited high encapsulation efficiency and loading capacity for Ci. Ci-loaded PHA-based microspheres and scaffolds had different release rates, and the release time can be adjusted in the range of 7–60 days. Antimicrobial activity and fruit preservation ability of the loaded Ci microspheres showed that it can effectively inhibit the growth of bacteria and extend the shelf life of the strawberry. This novel Ci carrier with good biocompatibility, biodegradability and adjustable release rate would have a broad application in the field of food preservation and antibacterial.
研究领域:
食品科学
·
材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2012
·Vol. 15
·期 1
·206-212
·
IF 3.842
Xin-Yu Zhao,Ying-Jie Zhu,Feng Chen,Bing-Qiang Lu,Jin Wu
In this paper, a surfactant-free rapid microwave-assisted hydrothermal synthesis of hydroxyapatite nanosheet-assembled flower-like hierarchical nanostructures (NFHNs) is reported. The effects of the experimental conditions on the morphology and crystal phase of the product are investigated. A possible formation mechanism of hydroxyapatite NFHNs is proposed. The morphology of the product can vary from flower-like to polyhedra by adjusting the microwave heating temperature. The protein and DNA adsorption properties of the as-prepared hydroxyapatite NFHNs are studied. The loading capacities of the as-prepared hydroxyapatite NFHNs for bovine serum albumin (BSA), hemoglobin (Hb) and fish sperm DNA are determined to be 165, 164 and 112 mg g−1, respectively. The protein release process is conducted at different pH values (pH 7.2, 5.5 and 4.8) in phosphate buffer saline (PBS), and the pH-controlled protein release behavior has been found. Thus, the as-prepared hydroxyapatite NFHNs are promising for protein drug delivery applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 13
·2685-2697
·
IF 4.726
Xinyu Hu,Wei Wei,Xiaoliang Qi,Hao Yu,Liandong Feng,Junjian Li,Shiming Wang,Jianfa Zhang,Wei Dong
Salecan is a novel water-soluble extracellular β-glucan produced by a salt-tolerant strain Agrobacterium sp. ZX09. Salecan is suitable for the fabrication of hydrogels for biomedical applications due to its excellent physicochemical and biological properties. In this paper, a series of pH-sensitive hydrogels were prepared in aqueous solution by the graft copolymerization of Salecan and acrylic acid (AA) using N,N′-methylene diacrylamide as a crosslinker for controlled drug delivery. The structure and thermal stability of the resulting hydrogels were characterized by FT-IR, XRD and TGA. By SEM analysis, freeze-dried hydrogels displayed an interconnected porous structure with tunable pore size in the range of 23.2–90.3 μm. The swelling behavior of the hydrogels was shown to be highly dependent on the environmental pH, salt type and concentration, as well as the contents of Salecan and BAAm. They are almost unswellable at pH 1.2 and swollen extensively at pH 6.86. Meanwhile, the increase in the content of hydrophilic Salecan could enhance the swelling ratio, whereas the presence of more BAAm reduced the swelling capacity but promoted the water retention to some extent. Rheological tests revealed that storage modulus G′ was strongly influenced by the crosslink density of the obtained hydrogel network. Especially, doxorubicin (DOX) as a model anti-cancer drug was very efficiently loaded into the negatively charged hydrogels (up to 69.4 wt%) through electrostatic interactions. More importantly, the release of DOX from this intelligent system exhibited pH-responsive behavior and a sustained release pattern. For SPA2, the cumulative release profile showed a low level of drug release (about 12.3 wt% in 24 h) at pH 7.4, and was significantly accelerated at pH 4.0 (over 40 wt% in 6 h). Cytotoxicity experiments confirmed that all blank hydrogels were non-toxic to A549 cells, while DOX released from the drug-loaded hydrogels remained biologically active and had the capability to kill cancer cells. The preliminary results clearly suggested that the Salecan-g-PAA hydrogels may be promising carriers for controlled drug delivery.
研究领域:
生物医学工程
·
药学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 4
·1911
·
IF 4.6
Xiaocui Wu,Guishan Lin,Wengui Duan,Baoyu Li,Yucheng Cui,Bo Cen,Fuhou Lei
Twenty-two novel longifolene-derived diphenyl ether-carboxylic acid compounds7a–7vwere synthesized from renewable biomass resources longifolene, and their structures were confirmed by FT-IR,1H NMR,13C NMR, and HRMS. The preliminary evaluation of in vitro antifungal activity displayed that compound7bpresented inhibition rates of 85.9%, 82.7%, 82.7%, and 81.4% againstAlternaria solani, Cercospora arachidicola,Rhizoctonia solani,andPhysalospora piricola, respectively, and compound7lpossessed inhibition rates of 80.7%, 80.4%, and 80.3% againstR. solani,C. arachidicola,P. piricola, respectively, exhibiting excellent and broad-spectrum antifungal activities. Besides, compounds7fand7ashowed significant antifungal activities with inhibition rates of 81.2% and 80.7% againstA.solani, respectively. Meanwhile, a reasonable and effective 3D-QSAR mode (r2= 0.996,q2= 0.572) has been established by the CoMFA method. Furthermore, the drug-loading complexes7b/MgAl-LDHwere prepared and characterized. Their pH-responsive controlled-release behavior was investigated as well. As a result, complex7b/MgAl-LDH-2exhibited excellent controlled-releasing performance in the water/ethanol (10:1, v:v) and under a pH of 5.7.Keywords:longifolene;hydrotalcite;antifungal activity;3D-QSAR;controlled-releasing
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 44
·e54614
·
IF 3
Yingxue Xu,Na Liang,Jia Fu,Zhe Zong,Xueling Long,Shaoping Sun
In this study, a polymer with tumor targeting function and dual redox/pH sensitivity is designed and synthesized by integrating chitosan (CS), Poloxamer 407 (P407), cholesterol (CHO), folic acid (FA), and disulfide bonds into one molecule (P407-CS(FA)-SS-CHO). The polymer can self-assemble in water to form micelles and solubilize paclitaxel (PTX). The mean particle size of PTX-loaded P407-CS(FA)-SS-CHO micelles is 133 nm. In vitro drug release study demonstrates the acid and glutathione (GSH) triggered PTX release behavior of the micelles. In vitro and in vivo experiments demonstrate the excellent tumor growth inhibition efficacy and low systemic toxicity of the PTX-loaded micelles. The P407-CS(FA)-SS-CHO micelles will be potential intelligent drug carriers for PTX delivery.
✓ 已验证
产品关联
DOI
高影响因子
Coatings
·
2022
·Vol. 12
·期 11
·1749
·
IF 3.236
Zheng Liu,Biao Zhang,Hao Yu,Zhicai Zhang,Wenjuan Jiang,Zengsheng Ma
When mesoporous nanomaterials and graphene oxide have been used in anti-corrosion coatings, new nanocoatings have attracted greater attention. Adding nano-fillers with special structures and corrosion inhibitors to epoxy coatings has been proven to effectively enhance the corrosion resistance of coatings. However, studies have pointed out that the added corrosion inhibitors are easily degraded by UV light and react with the metal substrate or materials in the coating, resulting in a significant reduction in the service life of the coating. To this end, in this study, the corrosion inhibitor was encapsulated in mesoporous silica with pH response, and the functional silica was composited with graphene oxide to prepare novel graphene oxide/functional mesoporous silica nanoparticles. Coatings with this special filler added have strong anti-corrosion potential and can be applied in marine anti-corrosion contexts, such as containers, in the future. The filler not only has a physical barrier ability but also can effectively prevent the degradation of the inhibitor due to ultraviolet rays. At the same time, in the early stage of corrosion, the release of inhibitors can be effectively controlled by the change in PH to achieve the purpose of preventing corrosion. UV spectrophotometry confirmed the stable encapsulation and controlled release of the inhibitor. Electrochemical-impedance spectroscopy showed that the |Z|0.01 Hzvalue of the smart anti-corrosion epoxy coating was about 10,000 times higher than that of the pure epoxy coating. Through the FT-IR mapping test, it was found that in the area of mechanical damage, the alkaline environment created by the initial corrosion can induce the release of tannic acid and react with common corrosion products to form iron tannins, which effectively inhibits the further occurrence of corrosion. This method provides an effective method for the design of heavy-duty anti-corrosion coatings.Keywords:stimuli-responsive;micro/nano container;in situ polymerization;smart anticorrosion coating
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Tongtong Ding,Luyao Xu,Xiangting Liu,Liang Ma,Yingxin Cui,Dalong Li,Xiuhua Sun,Changlu Gao
To achieve prolonged and sustainable release of copper ion in Cu 2 O-containing marine coatings, poly(lauryl methacrylate)-b-poly(2-( N , N -dimethylamino)ethyl methacrylate) (PLMA-b-PDMAEMA) diblock copolymers with different block ratios and molecular weights were synthesized by atom-transfer radical polymerization (ATRP) method. It was proved that the copolymers are able to coordinate with copper ion. And the surface wettability tests showed that the amphiphilic copolymers may undergo structure change in seawater. Taking advantage of the structure transformation and copper coordination abilities, the copolymer was employed to encapsulate Cu 2 O for the preparation of antifouling coatings. A controllable and continuous release of copper ion from Cu 2 O/copolymer coatings was then obtained. More importantly, it showed that higher PLMA/PDMAEMA block ratio exhibited better bactericidal rate. Actually, the bactericidal ability of the coating depends on the time duration of copper ion on the surface instead of the hydrolysis speed of the coating, in other words, the hydrophobic interaction of PLMA with the resin may play a major role in the antifouling performance of the marine coating. Self-polishing coatings Cu 2 O/copolymer/polycaprolactone (PCL) were then prepared and applied for marine field test, the antifouling performances were proved to be comparable to that of the commercially available self-polishing coatings.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jinming Dai,Wei Hu,Hongying Yang,Changzhu Li,Haiying Cui,Xiangzhou Li,Lin Lin
There are still many limitations in the application of natural active compounds in meat preservation. Herein, thymol was first inserted into the cavity of β -cyclodextrin ( β -CD) to form a stable inclusion complex (THY/ β -CD-IC). The computational investigation showed that the optimized complexation energy for THY/ β -CD-IC was −12.95 kcal mol −1 . It contributed to the improvement of the thermal stability of thymol in the inclusion compound. Furthermore, the functionalized nanofibers (THY/ β -CD-IC-NFs) loaded with THY/ β -CD-IC were successfully fabricated by electrospinning of the mixture of casein and polyethylene oxide. When dealing with protease-producing bacteria, controllable release of thymol from THY/ β -CD-IC-NFs was achieved through the response of casein to the hydrolysis of bacterial protease. The application results indicated that the prepared THY/ β -CD-IC-NFs had a long-term antimicrobial activity for chilled beef preservation during 7-days storage. The information from this study presents a feasible strategy for the development of natural extracts for use in meat preservation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）