MICROPOROUS AND MESOPOROUS MATERIALS
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2018
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IF 3.649
Xiubin Xu,Shaoyu Lü,Can Wu,Zhiyong Wang,Chen Feng,Na Wen,Mingzhu Liu,Xinyu Zhang,Zhen Liu,Yongqi Liu,Chunzhen Ren
We reported the facile preparation of self-fluorescent mesoporous silica nanoparticles based on a triple-role curcumin polymer shell as stimuli-responsive multifunctional nanocarriers for drug delivery. This curcumin polymer shell integrates multiple function of acting as fluorescent agents, increasing the drug loading ratio of curcumin, and controlling the open and close of the pores in a “smart” way. This novel drug nanocarrier will inspire the development of smart and self-fluorescent drug nanocarrier to achieve imaging and therapeutic goals for cancer therapy.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2018
·Vol. 219
·期 14
·1800062
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IF 2.492
Hailiang Feng,Changrong Wang,Junhui Zhou,Jinjian Liu,Jianhua Zhang,Ruiwei Guo,Jianfeng Liu,Anjie Dong,Liandong Deng
To achieve low leakage at pH 7.4, pH-controlled drug release remains a major challenge of cancer nanomedicine. Here, pH-responsive mPEG 113 - b -polycaprolactone (PCL) x - b -PAEMA y (PELA x ) nanoparticles (NPs)-pH7.4 with different poly(2-azepane ethyl methacrylate) (PAEMA) lengths and PELA4 nanoparticles (NPs)-pH x with different pH conditions of preparing NPs based on mPEG 113 - b -PCL x - b -PAEMA y are prepared to investigate influences of PAEMA lengths and pH condition of preparing NPs on properties of NPs. PELA x NPs-pH7.4 and PELA4 NPs-pH x both undergo differently sharp property changes of size, charge, pH-responsive drug release, cellular uptake, and cytotoxicity, because of the protonation of PAEMA block (p K a ≈ 6.5–6.7). Among PELA x NPs-pH7.4 and PELA4 NPs-pH x , it can be found that the NPs prepared at p K a value of PAEMA exhibited exciting pH-responsive drug release, improving cellular uptake ability and obvious high cytotoxicity toward HepG-2 cells. This system not only holds great potential for drug delivery but also provides a new strategy to prepare pH-responsive NPs.
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FOOD CHEMISTRY
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2023
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IF 8.8
Lixin Kang,Qiufang Liang,Qayum Abdul,Arif Rashid,Xiaofeng Ren,Haile Ma
To prevent food spoilage caused by microbial infection, the development of an environmentally friendly antimicrobial preservation material is crucial. Here, the microporous γ-CD-MOFs was utilized to encapsulate the hydrophobic active substance curcumin, resulting in the preparation of a non-toxic antimicrobial material (Cur-CD-MOFs). The results revealed that curcumin encapsulation in Cur-CD-MOFs occurred primarily in the carbonyl group, benzene ring, and enolic side ring of curcumin. The Cur-CD-MOFs had a 100% bactericidal effect on Escherichia coli and Staphylococcus aureus at 4 h and 8 h, and a strong inhibitory effect on aerial mycelium of Penicillium expansum and Botrytis cinerea . Furthermore, the incorporation of Cur-CD-MOFs improved the Pul/Tre film barrier and mechanical properties. The effectiveness of Cur-CD-MOFs-Pul/Tre in retaining fruit freshness was validated using Centennial Seedless grapes. This study confirmed that Cur-CD-MOFs is a promising antibacterial material, and Cur-CD-MOFs-Pul/Tre will be a potent candidate for food preservation.
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Acupuncture and Herbal Medicine
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2023
·Vol. 3
·期 4
·343
·
IF 0
Liu Rui,Liu Zhongyan,Guo Xueli,Kebebe Dereje,Pi Jiaxin,Guo Pan
Objective: Inhibition of tumor angiogenesis has become a new targeted tumor therapy. In this study, we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR. Methods: The targeted polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) modified with Asn–Gly–Arg (NGR) peptide was prepared and characterized by 1 H nuclear magnetic resonance and Fourier-transform infrared spectrometry. NGR-PEG-PLGA was used to construct curcumin (Cur)-loaded micelles by the solvent evaporation method. The physicochemical properties of the micelles were also investigated. Additionally, we evaluated the antitumor efficacy of the polymer micelles (PM) using in vitro cytology experiments and in vivo animal studies. Results: The particle size of Cur-NGR-PM was 139.70 ± 2.51 nm, and the drug-loading capacity was 14.37 ± 0.06%. In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles, leading to the apoptosis of tumor cells. Then, in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe. Conclusions: NGR-modified micelles significantly optimized the therapeutic efficacy of Cur. This strategy offers a viable avenue for cancer treatment. Export
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Shuhui Zheng,Xiuzhi Fu,Jing Lu,Yiting Wang,Qingdong Ji,Liping Yang,Yixing Tu,Feng Gao
The treatment of inflammatory bowel disease (IBD) remains difficult because of the insufficient drug accumulation at lesion sites and the difficulty in regulating the complex reactive oxygen species (ROS) and hydrogen sulfide (H 2 S) microenvironment. Metal nanozymes, which have catalytic abilities similar to those of natural enzymes, provide a promising method for targeted drug delivery and therapeutic regulation. Therefore, in this research, a new oral nanoparticle drug delivery system was constructed. This system achieved targeted delivery and modulated ROS and H 2 S levels. In this system, curcumin (Cur) and magnesium (Mg) coordination driven nanozymes (C-M) were constructed, followed by encapsulation with chitosan, chondroitin sulfate, and alginate to create a C-M-encapsulated nanoparticle (C-M@aNP). C-M@aNP exhibited uniform particle size, strong stability in acidic environments, and pH-responsive characteristics, enabling effective scavenging of ROS and H 2 S. This nanosystem demonstrated excellent biocompatibility and facilitated CD44 receptor targeting, thereby promoting cellular uptake and endocytosis, which enhanced its anti-inflammatory functions. In a colitis mouse model, the C-M@aNP not only effectively regulated excessive levels of ROS and H 2 S in the inflamed colon but also reduced the expression of proinflammatory cytokines (TNF-α, IL-6, and IL-1β) and increased the expression of anti-inflammatory cytokines (TGF-β) while inhibiting the activity of proinflammatory enzymes (COX-2 and iNOS). In conclusion, C-M@aNP exhibits biological safety and significant therapeutic potential for IBD, suggesting its potential as a promising clinical treatment strategy. Download: Download high-res image (247KB) Download: Download full-size image
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JOURNAL OF FOOD SCIENCE
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2026
·Vol. 91
·期 2
·e70821
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IF 4.1
Zeynep Karahaliloğlu,Baki Hazer
Unlike conventional preservation methods that passively store food, active packaging materials proactively prevent microbial contamination and, when combined with polyphenols, can also serve as intelligent systems for freshness monitoring. In this study, polypropylene (PP)-based membranes incorporating curcumin (Cur) and quercetin (Quer) were developed and characterized to evaluate their potential use in food packaging applications. The membranes exhibited low water vapor permeability, indicating strong barrier properties. Among the formulations, the PP-Cur-A2 (Cur-loaded PP-A2, where A2 refers to chlorinated polypropylene (PP-Cl) obtained from Sigma-Aldrich) membrane showed superior mechanical performance (tensile strength: 24.10 ± 1.06 MPa; elongation at break: 378%) and achieved complete curcumin release within 20 days. Importantly, the membranes displayed distinct color transitions under different pH conditions, confirming their functionality as pH-responsive indicators. In addition, when tested both with fresh shrimp in Petri dishes and in aqueous ammonia environments, the membranes exhibited visible and progressive color changes in response to spoilage-related volatile compounds. Overall, the developed membranes demonstrated efficient bioactive release, excellent barrier characteristics, and reliable colorimetric indicator functionality, underscoring their promise for sustainable and intelligent food packaging applications.
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产品关联
DOI
PubMed
高影响因子
Food and Bioprocess Technology
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2026
·Vol. 19
·期 3
·155
·
IF 5.6
Fan Zhihao,Shen Yu,Usman Muhammad,Su Kerui,Shahid Ayesha,Zhao Anqi,Li Xinyu,Zhang Beixiao,Xu Jingliang
Spirulina platensis is a nutrient-rich cyanobacterium with immune-enhancing, anti-aging, and cholesterol-lowering properties. However, fresh Spirulina is highly susceptible to spoilage during storage. This study developed a preservation strategy based on curcumin encapsulated in hydroxypropyl- β -cyclodextrin (HBC-Cur) to improve the storage stability of fresh Spirulina . During storage, treatment of fresh Spirulina with 2 mg/mL HBC-Cur exhibited protective effects by synergistically inhibiting microbial growth and mitigating oxidative reactions. Chlorophyll content was retained at 74.39% of the initial level. In terms of lipid and protein oxidation, malondialdehyde (MDA) content decreased by 45.73%, and protein carbonyl formation was reduced by 19.69%, indicating effective alleviation of oxidative deterioration. In addition, biogenic amines remained at consistently low levels, with putrescine content reduced by 76.53% relative to the control after 8 days. During the late storage phase, oxidative rancidity and spoilage-related VOCs, including hexanal, heptanal, nonenal, propionic acid, and nitrogen- and sulfur-containing volatiles, significantly increased in the control, whereas the VOCs of HBC-Cur-treated Spirulina remained relatively stable. This approach may offer a potential strategy for preserving bioactive components and suppressing the formation of spoilage-related compounds in Spirulina with implications for the development of sustainable food storage technologies. Graphical
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Polymers
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2026
·Vol. 18
·期 3
·
IF 5.8
Hui Liu,Teresa Olszewska,Hao Liu
Bio-based bismaleimide (BMI) resins can reduce environmental impact and impart intrinsic flame retardancy, but achieving a high glass transition temperature (Tg) remains challenging. Here, we replace the conventional petrochemical co-monomer O,O′-diallyl bisphenol A (DABPA) with a synthesized tri-allyl derivative of curcumin (AEC) in 4,4′-bismaleimidodiphenylmethane (BDM)-based resins. The AEC monomer, synthesized via exhaustive O- and C-alkylation of curcumin, acts as a trifunctional crosslinker. By systematically varying the imide:allyl molar ratio, we optimized the network properties. We optimize the network’s thermal and fire-safety properties. The optimized formulation (BDM: AEC = 1:0.87, denoted BA-0.87) yields 43.06% char at 800 °C and reduces the peak heat release rate (PHRR) by 13.2% compared to the conventional BDM/DABPA control (BD-0.87). Meanwhile, BA-0.87 passes UL-94 V-0 with no dripping and attains aTg above 400 °C—nearly 100 °C higher than BD-0.87. These enhancements arise from curcumin’s rigid conjugated structure, which increases crosslink density and promotes char formation during decomposition. Our work demonstrates a viable, bio-derived pathway to engineer BMI resins that simultaneously improve thermal stability and intrinsic flame retardancy. Such resins are promising for demanding aerospace and high-temperature electronic applications that require both fire safety and stability.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
·
IF 5.6
Ya-Ru Yang,Ji-Tao Tang,Bing-Qiang He,Lin-Xia Zhao,Huan-Jun Lu,Ling-Jie Ma,Yong-Jing Gao
Uterine pain associated with labor, dysmenorrhea, or endometriosis is often driven by inflammation, which enhances nociceptive signaling and contributes to hyperalgesia. Although nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids are commonly prescribed, their clinical application is limited by side effects, and a subset of patients exhibit inadequate or no response to NSAID therapy. Curcumin, a natural polyphenol extracted from Curcuma longa , exhibits well-documented anti-inflammatory and analgesic properties. In this study, we investigated the analgesic efficacy and underlying mechanisms of curcumin in a mouse model of uterine pain. Both intraperitoneal and intrathecal administration of curcumin significantly reduced writhing responses and improved locomotor performance in open-field tests. Molecular analyses revealed that estrogen and oxytocin treatment induced activation of glial cells in the dorsal root ganglia (DRG) and spinal cord. Intrathecal curcumin attenuated the activation of satellite glial cells and macrophages in the DRG, suppressed MAPK signaling (ERK, JNK, and p38), and decreased the expression of proinflammatory mediators, including IL-6, TNF-α, IL-1β, CCL2, and CXCL1. Similarly, in the spinal cord, curcumin reduced astrocyte and microglia activation, MAPK phosphorylation, and inflammatory cytokine and chemokine levels. Moreover, curcumin diminished p-ERK expression in DRG neurons and reduced c-Fos expression in the spinal dorsal horn. Collectively, these findings demonstrate that curcumin alleviates uterine pain by suppressing glial activation, MAPK signaling, and inflammatory mediators' production, ultimately reduces markers of neuronal activation and plasticity in the DRG and spinal cord. This provides mechanistic support for curcumin's potential in managing uterine pain.
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RENAL FAILURE
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2026
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IF 3.8
Yongli Yang,Zhiying Xiao,Liangjin Liu,Tingting Hu,Yi Liu,Duan Wang
Acute kidney injury (AKI) is a frequent complication of sepsis. It has been reported that curcumin can alleviate sepsis-associated AKI (SA-AKI). This study aims to elucidate the regulatory effects and mechanisms of curcumin on ferroptosis in the context of SA-AKI. In this study, septic mice and lipopolysaccharide-stimulated HK-2 cells were employed to simulate the pathological conditions of SA-AKI. The status of renal injury and ferroptosis-related indicators was determined to assess the regulatory effect of curcumin on ferroptosis in SA-AKI. Furthermore, the expression of α7 nicotinic acetylcholine receptor (α7nAChR) was intervened to investigate the specific protective mechanism of curcumin in SA-AKI. Finally, the nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor ML385 was incorporated to further elucidate the potential pathway through which α7nAChR regulates ferroptosis. The results demonstrated that curcumin exerted a significant protective effect on SA-AKI cells and animal models, markedly reducing cellular damage and renal injury in mice, attenuating the inflammatory response, and effectively inhibiting ferroptosis in renal cells and tissues. Furthermore, curcumin treatment upregulated the expression of α7nAChR in both SA-AKI cells and animal models. Nevertheless, the inhibition of α7nAChR expression partially counteracted the ameliorative effects of curcumin on injury and ferroptosis in SA-AKI cells and animal models. The overexpression of α7nAChR attenuated LPS-induced ferroptosis in HK-2 cells, whereas ML385 reversed the inhibitory impact of α7nAChR upregulation on cellular ferroptosis. In conclusion, these findings indicate that curcumin suppresses ferroptosis by upregulating α7nAChR to activate the antioxidant capacity of NRF2, thereby providing a protective effect against SA-AKI.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Yuanyuan Li,Yu Wang,Haowen Li,Jianping Xing,Haozhan Huang,Changzhe Shi,Jinle Duan,Liqiang Yue,Kai Li
Curcumin is extensively existed in plants and is commonly used as food additives. However, excessive intake of curcumin may lead to side effects like nausea and vomiting. Traditional techniques such as high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS) are constrained by cumbersome operations and low efficiency. Herein, a triple-emission surface molecularly imprinted fluorescence sensor (TPP&RhB-SMIPs) was fabricated via precipitation polymerization on halloysite nanotubes (HNTs), using aggregation-induced emission luminogen (AIEgen) TPP-M and allyl rhodamine B as fluorophores. This sensor exhibits distinct fluorescence color transitions (purple-fuchsia-carnation-yellow-chartreuse) with increasing curcumin concentrations, coupled with a linear range of 0.1–4.0 μmol L −1 and a low detection limit of 44 nmol L −1 . It demonstrates excellent selectivity and achieves satisfactory recoveries in ginger and beverage samples. A smartphone-integrated portable device was further developed for on-site visual detection of curcumin. This work provides a reliable, rapid, and cost-effective strategy for curcumin analysis, holding great promise for food safety monitoring.
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Food Chemistry-X
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2026
·
IF 9.2
Zhihua Liu,Lingying Chen,Xiaozhi Zheng,Junlin Li,Jiankun Ding,Chen Cai,Xiaofang Chen,Haiming Yu,Qunlong Pan
Conventional plastic packaging faces significant challenges due to its non-biodegradable nature and lack of active preservation functionality, leading to environmental pollution and food waste. To address these issues, this study developed a curcumin-zein composite film as a multifunctional active packaging material based on natural polymers. Systematic characterization confirmed that curcumin was incorporated into the zein matrix through intermolecular interactions. Functional evaluations demonstrated that the composite film exhibits excellent UV-shielding performance, remarkable antioxidant and antibacterial activities, as well as favorable biodegradability and biosafety. In preservation tests on cherry tomatoes and black grapes, the 5% Cur-Zein composite film effectively delayed fruit quality deterioration, reducing weight loss, color changes, and nutrient consumption. This study demonstrates that the Cur-Zein composite film represents a green and high-performance active packaging material with good potential for reducing food loss and extending the shelf life of fruits.
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