JOURNAL OF MOLECULAR STRUCTURE
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2025
·
IF 4.7
Hanfei Xiang,Yonghe Zhang,Zhefeng Wang,Jie Sun,Zhengcheng Zhang,Zengrui Xing,Peng Zhang,Zhenghua Ju
A donor-acceptor1-acceptor2 (D-A1-A2) pyridine derivative (P263) was designed and synthesized. The theoretical calculations showed that the mixed character of the locally excited (LE) and intramolecular charge transfer (ICT) in the T n states could be beneficial to achieve high spin-orbit coupling (SOC) values, thereby promoting efficient intersystem crossing (ISC). The fluorescence emission spectra of P263 exhibited an obvious solvent-dependent emission behavior, which was attributed to the effective ICT through the introduction of dual acceptor units. In addition, the protonation/deprotonation processes of the nitrogen atoms in the pyridine units induced the alterations in the emission spectra, rendering P263 a fluorescent sensor for proton ( H + ) detection. Moreover, the pyridine units could form the hydrogen-bonding interactions with the poly(vinyl alcohol) (PVA) matrix, which was favorable for the suppression of the nonradiative decays and the stabilization of the triplet excitons. The obtained P263@PVA film through doping P263 into PVA showed room-temperature phosphorescence (RTP) properties with a long lifetime of 535 ms and the quantum yields of 3.62 %.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
·
IF 7.7
Jian Li,Tingting Wang,Xun Zhang,Xinhui Su,Nian Liu
High-resolution optoacoustic visualization of amyloid-β (Aβ) plaques facilitates assessment of Alzheimer's disease (AD)’s states and related pathological mechanisms. However, it still lacks effective Aβ-probes due to suboptimal optoacoustic properties. In this study, we proposed the use of N, N-dimethylaniline as the Aβ recognition unit and chalcogenapyrylium as the acceptor to construct a novel D-π-A typed probe (DMA-Te). This design not only enhances the near-infrared optoacoustic signal but also maintains this enhancement upon Aβ fibrils binding through the preservation of twisted intramolecular charge transfer state. Furthermore, the stringent structure of DMA-Te exhibits high blood-brain barrier permeability and Aβ-binding capacity. Leveraging these advantages, dual-wavelength optoacoustic microscopy can effectively visualize Aβ plaques and diminished blood vessels in the AD brain. Therefore, this study presents a promising optoacoustic probe for the detailed depiction of AD progression.
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Cell Reports Physical Science
·
2025
·
IF 7.3
Yanan Wang,Teng Wang,Boran Li,Yitong Lin,Qi Zhang,Fei Chang,Yutong Han,Wenxuan Li,Hao Zhang,Xiaoyun He,Huilian Che,Kunlun Huang,Nan Cheng
Pd@Pt nanozymes are recognized for their extensive specific surface area and enzyme-like catalytic capabilities. However, the role of Pd@Pt nanoparticles in managing metabolic disorders such as diabetes and its related disorders remains poorly understood. This study endeavors to explore the regulatory function of Pd@Pt nanoparticles in metabolic balance, elucidating the associated mechanisms. We demonstrate that Pd@Pt inhibits the production of reactive oxygen species and modulates oxidative stress through its superoxide-dismutase-like enzyme activity in palmitic-acid-induced insulin resistance cell model. Furthermore, Pd@Pt was found to enhance glucose uptake, reduce hyperglycemia, and improve glucose tolerance and insulin sensitivity, attributable to its anti-inflammatory effects. Additionally, the effectiveness of the multifunctional Pd@Pt-based microneedle in expediting the healing of diabetic wounds was confirmed by suppressing key inflammatory signaling pathways. Collectively, our findings highlight the potential of Pd@Pt nanoparticles as powerful anti-inflammatory agents, offering promising therapeutic options for type 2 diabetes and its associated complications.
研究领域:
纳米医学
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糖尿病研究
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炎症生物学
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代谢紊乱
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生物材料
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CRYSTENGCOMM
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2017
·Vol. 19
·期 17
·2349-2358
·
IF 3.474
Yu-Peng Zhou,Zhang-Wen Wei,Zhuo-Jia Lin,Hui-Tao Ling,Zhengang Guo,Mei Zhang,Chi-Keung Lam,Bao-Hui Ye,Hsiu-Yi Chao
With the idea of supramolecular hosts encircling monoanions, a series of urea-containing trinuclear cationic copper complexes were designed, prepared and structurally analyzed. Copper(I) acetylides [Cu3(μ-dppm)3(μ3-η1-CCC6H4-4-NHC(O)NHC6H4-4-R)2]+ (dppm = bis(diphenylphosphino)methane; R = NO2 (1), CF3 (2), Cl (3), H (4), tBu (5), and OCH3 (6)) were prepared with F−, BF4−, or NO3− present as the anion. Eight 1-D anion coordination polymers (ACPs), 1·F, 2·F, 3·BF4, 4·F, 5·F, 5·BF4, 5·NO3 and 6·0.5F·0.5BF4, were clearly determined by X-ray diffraction. Diversity in the polymeric architecture is generated by both the choice of R-group used and anion present. 2·F, 3·BF4, 4·F, and 5·F show linear 1-D structures; 5·BF4 and 5·NO3 feature single-stranded helical structures; 1·F and 6·0.5F·0.5BF4 exhibit meso-helical structures. Solid state UV-vis absorption and luminescence properties are also discussed.
研究领域:
化学
·
材料科学
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Journal of Biomedical Nanotechnology
·
2021
·Vol. 17
·期 4
·627-639
·
IF 4.099
Yu Xiao,Pan Jielu,Shen Nan,Zhang Haiyan,Zou Lu,Miao Hongyu,Xing Lianjun
The mortality rate of ethanol induced liver disease has substantially raised to alert level with an increasing use of alcohol, but development of definite hepatoprotective drug is still challenging. The efficacy of Saikosaponin D, one of the natural herbal medicine has been studied
in different diseases. Nonetheless, its clinical application is restricted by poor bioavailability, stability and solubility. This study sought to develop a Saikosaponin D loaded liposome via thin film hydration method. The surface morphology, encapsulation efficiency and drug loading capacity
were detected with transmission electron microscopy and HPLC, in vitro dissolution was via dialysis method, but efficacy and safety evaluation was through pharmacokinetics, while the assessment of hepatoprotective activity on alcohol induced acute hepatitis mice models was conducted.
The optimized liposomes showed significant greater therapeutic effect on liver, through decreased serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), total cholesterol (TC) and triglyceride (TG)
in liver homogenate. In contrast, levels of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were increased significantly. Pathological study exhibited remarkable alteration of hepatitis liver architecture to almost normal state after administration of Saikosaponin D
liposome. The increased hepatoprotective effect of Saikosaponin D liposome was observed during the attenuation of alcoholic hepatitis in mice, which might be ascribable to the anti-oxidative and anti-inflammatory properties of the drug. This study provides a theoretical basis for developing
advanced system of Saikosaponin D delivery for the promotion of the therapeutic effects of the liposome against various kinds of diseases.
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EXPERIMENTAL GERONTOLOGY
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2022
·
IF 4.253
Yan-Ling Su,Dong Liu,Yao-Jie Liu,Yang-Lin Ji,Gui-Shan Liu,Ji-Li-Te Wang,Biao Wang,Hao Wang
We explored the effect of phlorizin against cholinergic memory impairment and dysbacteriosis in D-galactose induced ICR mice . The control (CON) group, D-galactose model (DGM) group, and three groups (DG-PL, DG-PM, DG-PH) treated with phlorizin at 0.01%, 0.02%, and 0.04% (w/w) in diets were raised for 12 weeks. Supplementing with phlorizin reversed the loss of organ coefficient and body weight caused by D-galactose. The functional abilities of phlorizin on hippocampal-dependent spatial learning and memory, anti-oxidation, anti-inflammation were also observed. Meanwhile, phlorizin intervention upregulated the gene expression of Nrf2, GSH-PX, SOD1, decreased the gene expression of NF-κB, TLR-4, TNF-α, and IL-1β in the hippocampus , while enhanced the gene expression of JAM-A, Mucin2, Occludin in the caecum. Furthermore, a neurotransmitter of acetylcholine (ACh) was enhanced, while acetylcholinesterase (AChE) activity was inhibited by phlorizin administration. Moreover, phlorizin administration increased short-chain fatty acids (SCFAs) content, and reduced lipopolysaccharides (LPS) levels, which may relate to the rebuilding of gut microbiota homeostasis . Treatment with phlorizin may be an effective intervention for alleviating cognitive decline and gut microbiota dysbiosis.
研究领域:
神经科学
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药理学
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微生物学
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分子生物学
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MICROCHEMICAL JOURNAL
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2023
·
IF 4.8
Ying-ying Hu,Xiao-qin Wu,He-ping Shi,Xue-hong Wei
The nature of amino acids as the building blocks of proteins leading to detection and identification is a current hot topic. Therefore, {[Zn 3 (L − ) 2 (HBTC 2− ) 2 ]·2H 2 O·CH 3 CN} n ( Zn-1 , H 3 BTC = 1,3,5-benzenetricarboxylic acid, HL = 6-aminonicotinic acid, CH 3 CN = acetonitrile), a 2D Zn-MOF which can sensitively detect and selectively recognize D -tyrosine was synthesized by solvothermal method . Identification of D -tyrosine was determined by increasing fluorescence intensity and red-shifting of the emission wavelength . Zn-1 is highly stable in methanol (MeOH) and aqueous solution (H 2 O), so it was dissolved in them as fluorescence probes, namely Zn-1/MeOH probe and Zn-1/H 2 O probe , respectively. The two probes worked for lower limits of detection, 8.93 × 10 −2 μM for Zn-1/MeOH probe and 79.70 × 10 −2 μM for Zn-1/H 2 O probe . The Stern-Volmer quenching constant of Zn-1/MeOH probe is 1.28 × 10 4 M −1 and of Zn-1/H 2 O probe is 4.55 × 10 2 M −1 . In addition, the two probes still show excellent immunity to interference under the interference of 18 amino acids. Zn-1/H 2 O probe was also applied to the determination of D -tyrosine in real milk samples with good results. This study provides a fast, simple, convenient and relatively accurate method for detecting D -tyrosine.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2023
·
IF 4.5
Haibo Chen,Chengqi Zhao,Yu Li,Junyao Li,Wenrong Cai,Yong Kong,Zheng-Zhi Yin
Au nanoparticles (AuNPs) is first combined with d -methionine ( d -Met) through Au–S bond, and the obtained Au- d -Met was self-assembled with chitosan (CS) via electrostatic driving. Both d -Met and CS are important chiral sources, and therefore the resultant Au- d -Met/CS displays distinct chirality. Interestingly, the chirality of the Au- d -Met/CS can be reversed depending on the ratio of d -Met to CS, as revealed by circular dichroism spectra. Due to the high electrical conductivity of AuNPs as well as the intrinsic chirality of d -Met and CS, the resultant Au- d -Met/CS is used as the electrochemical chiral sensing platform for the discrimination of tryptophan (Trp) enantiomers. Although the Trp enantiomers can be successfully discriminated by the developed chiral sensing platform, the electrochemical signals of l -Trp and d -Trp can be reversed on the differential pulse voltammograms (DPVs) when different ratios of d -Met to CS are used, which can be ascribed to the reversible chirality of the Au- d -Met/CS complexes prepared by different ratios of d -Met to CS.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Jiaxin Liu,Keke Ning,Yao Fu,Yujie Sun,Jiangong Liang
N-acetyl-beta-D-glucosaminidase (NAG) is an important biomarker for early clinical diagnosis of renal disease, suggesting the necessity to develop a fast and sensitive method for its detection. In this paper, we developed a fluorescent sensor based on polyethylene glycol (4 0 0) (PEG-400)-modified and H 2 O 2 -assisted etched sulfur quantum dots (SQDs). According to the fluorescence inner filter effect (IFE), the fluorescence of SQDs can be quenched by the p-nitrophenol (PNP) generated by NAG-catalyzed hydrolysis of p-Nitrophenyl-N-acetyl-β-D-glucosaminide (PNP-NAG). We successfully used the SQDs as a nano-fluorescent probe to detect the NAG activity from 0.4 to 7.5 U·L −1 , with a detection limit of 0.1 U·L −1 . Furthermore, the method is highly selective and was successfully used in the detection of NAG activity in bovine serum samples, suggesting its great application prospect in clinical detection.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Fen Ma,Chenguang Jiang,Wenyuan Xie,Defeng Wu
Using polysaccharide nanocrystals such as chitin nanocrystals (ChNCs) as nanofiller for biodegradable aliphatic polymers is an attractive way of developing all-degradable nanocomposites. Crystallization study is vital for well regulating final performance of these type polymeric nanocomposites. In this work, ChNCs were incorporated with the poly( l -lactide)/poly( d -lactide) blends and as-obtained nanocomposites were used as target samples for the study. The results showed that ChNCs acted as nucleating agent, promoting the formation of stereocomplex (SC) crystallites and accelerating overall crystallization kinetics as a result. Therefore, the nanocomposites possessed higher SC crystallization temperatures and lower apparent activation energy as compared to the blend. However, the formation of homocrystallites (HC) was dominated by nucleation effect of SC crystallites and accordingly, the fraction of SC crystallites reduced more or less in the presence of ChNCs, despite the nanocomposites possessed higher rate of HC crystallization. This study also provided valuable information on accessing more applications of ChNCs to be used as SC nucleator for polylactide.
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PHARMACEUTICAL BIOLOGY
·
2018
·
IF 1.918
Wenlong Yang,Guanlin Zhou,Shubing Zou,Wentao Yang,Aihong Liu,Shuilin Sun,Baogang Xie
Context: d-Glucaro-1,4-lactone (1,4-GL) exists in many vegetables and fruits. Metabonomics has not been used to investigate the role of 1,4-GL in preventing liver cancer.Objective: The pharmacological effects and metabolite alterations of 1,4-GL on the prevention of diethylnitrosamine (DEN)-induced liver cancer were investigated.Materials and methods: Ten healthy Sprague–Dawley rats served as control and 46 were used to establish rat liver cancer model. 1HNMR-based metabonomics was used to compare the effects of oral 1,4-GL (50 mg/kg) in liver cancer rats (n = 26) after 10 consecutive weeks of intervention. The amino acids in rat serum were quantified by HPLC-UV, and the changes in Fischer’s ratio were calculated.Results: The 20-week survival rate of DEN-induced liver cancer rats administered with oral 1,4-GL was increased from 45.0 to 70.0% with reduced carcinogenesis of the liver and significantly lowered serum α-fetoprotein level (14.28 ± 2.89 ng/mL vs. 18.56 ± 4.65 ng/mL, p = 0.012). The serum levels of leucine, valine, 3-hydroxybutyrate, lactate, acetate and glutamine in the DEN + 1,4-GL group returned to normal levels compared with those of the DEN group on week 20. Fischer’s ratio in the rat serum of DEN group was 1.62 ± 0.21, which was significantly lower than that in healthy rats (2.3 ± 0.12). However, Fischer’s ratio increased to 1.89 ± 0.22 in the DEN + 1,4-GL group.Discussion and conclusions: 1,4-GL exerted positive effects on liver carcinogenesis in rats by pathological examination and metabonomic analysis. Its mechanism may be related to the restoration of amino acid and energy metabolism.
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JOURNAL OF MOLECULAR LIQUIDS
·
2018
·
IF 4.513
Kemeng Shi,Christian Marcus Pedersen,Zhaohui Guo,Yanqiu Li,Hongyan Zheng,Yan Qiao,Tuoping Hu,Yingxiong Wang
The tautomer distributions of d ‑fructose, a popular model compound for biorefinery , in various lower alcohols and DMSO‑ d 6 (ROHs/DMSO‑ d 6 ) mixtures at 298 K were investigated by quantitative 13 C NMR. The tautomer distributions of d ‑fructose in ethanol/DMSO‑ d 6 and methanol/DMSO‑ d 6 with different volume ratios of alcohols to DMSO‑ d 6 were also examined. For these normal alcohols (methanol, ethanol, n ‑propanol and n ‑butanol)/DMSO‑ d 6 , the tautomer distribution of d ‑fructose in methanol/DMSO‑ d 6 exhibited the shortest equilibration time (46 h) and the lowest concentration of β‑furanose (39.0%) at equilibrium. The fraction of fructofuranose (α‑furanose and β‑furanose) at equilibrium and time needed to reach equilibrium in branched chain alcohols/DMSO‑ d 6 obey the following order: 2‑propanol/DMSO‑ d 6 (62.2%, 320 h) > tert ‑butanol/DMSO‑ d 6 (61.6%, 307 h) > 2‑butanol/DMSO‑ d 6 (60.6%, 216 h) > isobutanol/DMSO‑ d 6 (57.8%, 134 h). For the diols/DMSO‑ d 6 , the time for the tautomer distribution of d ‑fructose to reach the equilibrium was found to be: 1,4‑butanediol/DMSO‑ d 6 (113 h) > 1,2‑propanediol/DMSO‑ d 6 (38 h) > ethylene glycol/DMSO‑ d 6 (36 h). For ethanol/DMSO‑ d 6 and methanol/DMSO‑ d 6 with respectively different volume ratios, the experimental results showed that the high concentration of ethanol or methanol increases the conversion rate of tautomers.
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