Biosensors-Basel
·
2024
·Vol. 15
·期 1
·5
·
IF 4.9
Jianxiao Fang,Yunting Jia,Zelong Liao,Bairui Qi,Tao Huang
The early monitoring of cardiovascular biomarkers is essential for the prevention and management of some cardiovascular diseases. Here, we present a novel, compact, and highly integrated skin electrode as a mechanical–electrochemical dual-model E-skin, designed for the real-time monitoring of heart rate and sweat ion concentration, two critical parameters for assessing cardiovascular health. As a pressure sensor, this E-skin is suitable for accurate heart rate monitoring, as it exhibits high sensitivity (25.2 pF·kPa−1), a low detection limit of 6 Pa, and a rapid response time of ~20 ms, which is attributed to the iontronic sensing interface between the skin and the electrode. Additionally, the electrode functions as a potassium ion-selective electrode based on chemical doping, achieving an enhanced response of 11 mV·mM−1. A test based on the real-time monitoring of a subject riding an indoor bike demonstrated the device’s capability to monitor heart rate and sweat potassium ion levels reliably and accurately. This advancement in wearable technology offers significant potential for enhancing patient care based on the early detection and proactive management of cardiovascular conditions.
研究领域:
生物医学工程
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可穿戴设备
·
传感器技术
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DOI
PubMed
高影响因子
AICHE JOURNAL
·
2016
·Vol. 63
·期 6
·2212-2220
·
IF 2.98
Lei Qin,Jiangsheng Li,Hongye Cheng,Lifang Chen,Zhiwen Qi,Weikang Yuan
An innovative intensified vitamin E (VE) recovery process from the methylated oil deodorizer distillates (MODDs) was proposed, where VE was in situ transferred into a deep eutectic solvent (DES) with an organic salt. To design the process, the chlorine based quaternary ammonium salts were primarily investigated, and [N 4,4,4,4 ]Cl was selected as an association solvent which can efficiently form DES with α-tocopherol of the representative compound of VE. Based on the determined phase diagram of the DES freezing points, four phase regions were classified, and the effect of the [N 4,4,4,4 ]Cl/tocopherol ratio and temperature on the extraction performance and phase transformation was figured out. Moreover, an intensified association extraction process via in situ forming DES of α-tocopherol with [N 4,4,4,4 ]Cl was designed and validated by experiments. VE products were finally obtained from both model MODD (purity of 99.63%) and practical MODDs (purity of >79.18%), which verifies the excellent extraction efficiency for the proposed recovery method. © 2016 American Institute of Chemical Engineers AIChE J , 63: 2212–2220, 2017
研究领域:
化学工程
·
生物技术
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Yunkai Sun,Xiaoxia Wu,Meng Cao,Xiaoqiang Xue,Dongfang Jiang,Zhao Liu
In the classical route of synthesizing of avanafil, the last step of the reaction uses EDCI and HOBT as an acid and amine binding agent. HOBT may contain residues of hydrazine, and potential mutagenic impurities containing acylhydrazide structures may be formed. The intermediate product (M6) of avanafil was synthesized by 6 steps using diethyl ethoxylmethylmalonate and S-methyl isothiourea semisulfide as starting materials. The potentially genotoxic impurity E (Imp-E) of avanafil was given by the reaction of M6 and hydrazine sulfate acid amine, yield of 20%. The single crystal of Imp-E was cultivated by solvent volatilization method, and its structure was analyzed by high resolution mass spectrometry (HRMS) and nuclear magnetic resonance spectroscopy (NMR). The Flack parameter of Imp-E was -0.03(3) by X-ray single crystal diffraction analysis, and the absolute configuration of Imp-E was determined as S configuration. The intramolecular / intermolecular hydrogen bonds of Imp-E make the molecules maintain a stable arrangement in space.
研究领域:
药物化学
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晶体学
·
毒理学
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DOI
高影响因子
MACROMOLECULES
·
2021
·
IF 5.985
Jing Wang,Qian Jiang,Shuang Cao,Chenchen Sun,Yuping Zhang,Yuan Qiu,Hong Wang,Guochuan Yin,Yonggui Liao,Xiaolin Xie
The structure–property relationship of luminescent liquid crystalline polymers (LLCPs) with AIEgens has attracted much attention. However, the effect of the AIEgen configuration on the properties is still unclear because of the difficulty in designing LLCPs with a single configuration. In addition, it is expected that this effect can be amplified through constructing the AIEgen on the backbone of LLCPs. Herein, for the first time, we have synthesized two kinds of main-chain polyesters with a single configuration of an AIEgen, E-PM7 and Z-PM7, via melt polycondensation. Interestingly, E-PM7 shows two coexisting phases of rectangular columnar and smectic liquid crystalline phases, whereas Z-PM7 exhibits no liquid crystalline properties. Moreover, E-PM7 with AIE behavior and liquid crystalline properties can be used to prepare fluorescent patterns printed on flexible films and glass substrates through the photocyclization of AIE units, which endows this kind of material with promising applications ranging from anti-counterfeiting to information storage.
研究领域:
材料科学
·
化学
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DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Binchen Wang,Shaohua Dou,Shang Wang,Yi Wang,Sufang Zhang,Xinping Lin,Yingxi Chen,Chaofan Ji,Yiwei Dai,Liang Dong
Unsaturated aliphatic aldehyde oxidation plays a significant role in the deep oxidation of fatty acids to produce volatile chemicals. Exposing the oxidation process of unsaturated aliphatic aldehydes is crucial to completely comprehend how food flavor forms. In this study, thermal desorption cryo-trapping in conjunction with gas chromatography-mass spectrometry was used to examine the volatile profile of (E)-4-decenal during heating, and 32 volatile compounds in all were detected and identified. Meanwhile, density functional theory (DFT) calculations were used, and 43 reactions were obtained in the 24 pathways, which were summarized into the peroxide reaction mechanism (ROOH), the peroxyl radical reaction mechanism (ROO·) and the alkoxy radical reaction mechanism (RO·). Moreover, the priority of these three oxidative mechanisms was the RO· mechanism > ROOH mechanism > ROO· mechanism. Furthermore, the DFT results and experimental results agreed well, and the oxidative mechanism of (E)-4-decenal was finally illuminated.
研究领域:
食品科学
·
化学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2014
·
IF 3.107
Dong-Mei Wang,Cheng-Chen Zhang,Qiang Zhang,Nusrat Shafiq,Gennaro Pescitelli,Deng-Wu Li,Jin-Ming Gao
Five new sesquiterpene polyol esters with a dihydro-β-agarofuran skeleton, designated as wightianines A–E (1–5), besides two known compounds, were isolated from the methanolic extract of the whole plant of the traditional herbal medicine Parnassia wightiana Wall. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses, including two-dimensional nuclear magnetic resonance techniques (correlation spectroscopy, heteronuclear multiple-quantum coherence, nuclear Overhauser effect spectrometry, and heteronuclear multiple-bond correlation) and electronic circular dichroism studies. The antifungal and insecticidal activities of five compounds were evaluated against several plant pathogenic fungi and armyworm larvae (Mythimna separata Walker). Among the test metabolites, compounds 2 and 7 both exhibited potent antifungal activity against the phytopathogenic fungus Cytospora sp. with minimum inhibitory concentration values of 0.78 μg/mL, which are equal to the two positive controls, hymexazol and carbendazim. However, no insecticidal activity of the test compounds was observed in the present study. Compounds 2 and 7 could be promising leads for developing new fungicides against agriculturally important fungus Cytospora sp.
研究领域:
植物化学
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药理学
·
农业科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Xiang Luo,Yuanyuan Chen,Zhe Jiang,Hongze Wu,David Julian McClements,Chang Zhang,Yanyan Zhou,Hongliang Fu,Xuguang Yin,Wenna Huang,Zhixin Wang,Lemao Yu,Xin Tang,Kangli Li,Kewu Zhu
A new multifunctional emulsifier was synthesized by coupling maltodextrin with a dextrose equivalent of 19 to vitamin E succinate. Two emulsifiers with varying degrees of vitamin E succinate substitution were prepared based on different mass ratios of vitamin E succinate to maltodextrin. The molecular structure and purity of these emulsifiers were analyzed. Nanoemulsions were prepared using octenyl succinic anhydride modified starch as a control to investigate the physical stability, antioxidant capacity, oxidative stability, and in vitro simulated digestive properties of the nanoemulsions. The emulsifying and antioxidant activity of the maltodextrin-vitamin E succinate conjugate was significantly superior to that of octenyl succinic anhydride modified starch, demonstrating good physical and oxidative stability. Additionally, they were rapidly digested under simulated small intestinal conditions. This new emulsifier shows broad application potential for the encapsulation, protection, and delivery of hydrophobic bioactive substances in the fields of medicine, food, and healthcare products.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
Biology-Basel
·
2025
·Vol. 14
·期 8
·992
·
IF 3.5
Kaicheng Gu,Lindong Yang,Yi Jiang,Zhiqiang Wang,Jiannan Chen
Simple SummaryBisphenol E (BPE), a typical endocrine disruptor, is widely present in various environmental media. Using zebrafish as a model, this study systematically evaluated the toxic effects of BPE on embryonic development and the nervous system. By integrating a network toxicology analysis and molecular docking techniques, the neurotoxic mechanism was revealed: BPE inhibits the activity of NOS3/PKG, blocks the transmission of the cGMP/PKG signaling pathway, and ultimately induces neurotoxic damage. This research advances the understanding of endocrine disruptor toxicity by providing novel experimental evidence and delivers key theoretical pillars for building a health risk assessment system targeting environmental pollutants.As typical environmental hormones, endocrine-disrupting chemicals (EDCs) have become a global environmental health issue of high concern due to their property of interfering with the endocrine systems of organisms. As a commonly used substitute for bisphenol A (BPA), bisphenol E (BPE) has been frequently detected in environmental matrices such as soil and water in recent years. Existing research has unveiled the developmental and reproductive toxicity of BPE; however, only one in vitro cellular experiment has preliminarily indicated potential neurotoxic risks, with its underlying mechanisms remaining largely unelucidated in the current literature. Potential toxic mechanisms and action targets of BPE were predicted using the zebrafish model via network toxicology and molecular docking, with RT-qPCRs being simultaneously applied to uncover neurotoxic effects and associated mechanisms of BPE. A significant decrease (p< 0.05) in the frequency of embryonic spontaneous movements was observed in zebrafish at exposure concentrations ≥ 0.01 mg/L. At 72 hpf and 144 hpf, the larval body length began to shorten significantly from 0.1 mg/L to 1 mg/L, respectively (p< 0.01), accompanied by a reduced neuronal fluorescence intensity and a shortened neural axon length (p< 0.01). By 144 hpf, the motor behavior in zebrafish larvae was inhibited. Through network toxicology and molecular docking, HSP90AB1 was identified as the core target, with the cGMP/PKG signaling pathway determined to be the primary route through which BPE induces neurotoxicity in zebrafish larvae. BPE induces neuronal apoptosis and disrupts neurodevelopment by inhibiting the cGMP/PKG signaling pathway, ultimately suppressing the larval motor behavior. To further validate the experimental outcomes, we measured the expression levels of genes associated with neurodevelopment (elavl3,mbp,gap43,syn2a), serotonergic synaptic signaling (5-ht1ar,5-ht2ar), the cGMP/PKG pathway (nos3), and apoptosis (caspase-3,caspase-9). These results offer crucial theoretical underpinnings for evaluating the ecological risks of BPE and developing environmental management plans, as well as crucial evidence for a thorough comprehension of the toxic effects and mechanisms of BPE on neurodevelopment in zebrafish larvae.
研究领域:
环境毒理学
·
神经毒理学
·
发育生物学
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分子生物学
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生态毒理学
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DOI
PubMed
高影响因子
Materials Today Chemistry
·
2023
·
IF 7.3
Shiwei Feng,Chengping Zhang,Hengdao Quan
A facile, safe, and environmentally friendly preparation method is described for the synthesis of AlF x (OH) 3-x by the activation of γ-Al 2 O 3 using HCFO-1233zd( E ) under various temperatures. Comprehensive characterization techniques including XRD , XPS, N 2 sorption, SEM, TEM , 27 Al MAS NMR, FTIR, and py-IR were employed, revealing that at lower temperatures such as 275 °C and 300 °C, the synthesis yielded AlF(OH) 2 , while at higher temperatures like 350 °C and 375 °C, pyrochlore AlF 1.5 (OH) 1.5 and metastable hexagonal tungsten bronze-type (HTB) β-AlF 3 were formed, with α-AlF 3 detected at 325 °C. Notably, a significant quantity of AlF(OH) 2 can be obtained at 325 °C within a specific time frame. This amorphous phase exhibits weak Lewis acid sites and a lower acid density, rendering it significantly more effective in the isomerization of HCFO-1233zd( E ) compared to strong Lewis acid catalysts such as AlF 1.5 (OH) 1.5 and β-AlF 3 , which could promote coke formation, leading to catalyst deactivation . Moreover, due to its limited further fluorination at 290 °C, the optimal catalyst exhibits prolonged lifespan and high efficiency in HCFO-1233zd( E ) isomerization.
研究领域:
材料科学
·
化学工程
·
催化化学
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DOI
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Qiqi Zhang,Leping Chu,Qin Yang,Wenqing Wo,Anlin Xu,Yide He,Yongjun Zhang
E-peroxone process is an emerging electrochemical oxidation process , based on ozone and the in-situ cathodic generation of H 2 O 2 , but the stability of cathode is one of the key restraining factors. In this study, we designed a multilayer gas diffusion electrode (GDE) decorated with a commercial hydrophobic membrane for the degradation of pyridine. It was found that a proper control of membrane pore sizes and hot-pressing temperature can significantly promote the GDE stability. Subsequently, key operational parameters of the constructed E-peroxone system were investigated, including the ozone concentration, current density, pH value, electrolyte type and initial concentration of pyridine. The degradation pathways were proposed according to six identified transformation products. The toxicity variation along the degradation progress was evaluated with microbial respiration tests and Toxicity Estimation Software Tool (T.E.S.T.) calculation and an efficient detoxification capacity of E-peroxone was observed. This research provides a theoretical basis and technical support for the development of highly efficient and stable E-peroxone system for the elimination of toxic organic contaminants.
研究领域:
环境科学
·
电化学工程
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DOI
PubMed
高影响因子
VACCINE
·
2016
·
IF 3.413
Tengfei Ma,Yongxia Liu,Jia Cheng,Yanhan Liu,Wentao Fan,Ziqiang Cheng,Xudong Niu,Jianzhu Liu
To obtain an effective vaccine candidate against duck Tembusu viral (DTMUV) disease which causes egg-drop and great economical loss in the Chinese duck industry, liposome vaccines containing recombinant E protein were prepared and assessed in this study. The recombinant plasmid (PET28a-E) was constructed and transformed into BL21 (DE3) cells to produce E proteins. The recombinant E proteins were purified and entrapped by liposomes through reverse-phase evaporation. Eighty-four cherry valley ducks were randomly divided into seven groups and inoculated intramuscularly at one- or seven-day-old with liposomes-E protein or Freund's adjuvant-E protein vaccine. Blood samples were collected from the first week to the tenth week for serum antibody , plasma for viremia , as well as oropharyngeal and cloacal swabs for virus shedding analyses after being challenged with a 10 2.4 50% tissue culture infective dose (TCID 50 ) of duck Tembusu virus. Results showed that serum antibody level of the liposomes vaccine was higher than the Freund's adjuvant vaccine, and inoculating twice was superior to once; furthermore, the viremia and virus shedding tests also proved that the liposomes vaccine can provide complete protection against DTMUV challenge. These results demonstrated that the liposomes-E protein vaccine could be used as a potential candidate vaccine to prevent DTMUV infection in ducks.
研究领域:
兽医学
·
病毒学
·
分子生物学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Yingchong Chen,Wenhui Hu,Lizhen Huang,Yuling Liu,Fang Li,Haibin Zou,Pengfei Yue
In glioma treatment, the poor penetration of therapeutic drugs through the blood–brain barrier (BBB) to the tumor region, along with the intrinsic resistance of glioma cells via multiple survival mechanisms, remain major challenges. Liposomes are a popular choice for glioma therapy due to their ability to help drugs penetrate the BBB. However, unmodified liposomes have drawbacks, such as poor stability, low drug entrapment efficacy, and rapid removal from circulation, leading to reduced drug absorption at the lesion sites. To address these issues, a novel F127-grafted vitamin E succinate (F127–VES) was designed to prepare multifunctional modified liposomes for delivery of harmine (HAR). Compared to conventional liposomes (Ordinary-Lip), F127–VES-Lip shows greater potential in enhancing the anti-glioma effect of HAR. This is attributed to several key features: Firstly, Pluronic can enhance the transport across the blood–brain barrier. Secondly, the presence of F127 in the formulation extends the circulation time of the drug in the bloodstream. Finally, the combination of F127 and VES in F127–VES-Lip can induce tumor cell apoptosis. In vitro and in vivo results confirmed that the F127–VES-Lip could significantly elevate cellular uptake, promote apoptosis and increase the antitumor effect for C6 glioma cells. The F127–VES-Lip is a promising nanoformulation to enhance the effect of HAR for glioma treatment.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
·
神经科学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）