OPTICAL MATERIALS
·
2020
·
IF 2.779
Hua Li,Xiaobo Shi,Xia Li,Lingbo Zong
Size-tunable β-NaYF 4 : Yb/Er (50–400 nm) up-converting nanoparticles (UCNPs) with a strong green emission were successfully prepared by a facile thermal decomposition method in a short period of time. The effects of the reaction time, the oleic acid (OA) content, and the doped Gd 3+ concentration on the crystal structure, the size evolution mechanism and the luminescence mechanism of the β-NaYF 4 : Yb/Er nanoparticles were discussed in detail. Characterization was completed using X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution (HR-TEM), scanning electron microscopy (SEM), and photoluminescence (PL). The results reveal that the phase transition was completed at 15 min and the morphology of the NaYF 4 : Yb/Er UCNPs changed from spherical to large hexagonal disks (200–400 nm) in non-doped Gd 3+ . An appropriate decrease in the volume ratio of oleic acid (OA) to 1-octadecene (ODE) promoted NaF production, resulting in the formation of the hexagonal phase crystals and the subsequent increase of luminous intensity by 30–40 times. More importantly, the size of the β-NaYF 4 : Yb/Er decreased with Gd 3+ doping, and the UCNPs ultimately transformed into small hexagonal prisms (50 nm) with high monodispersity when the doping concentration of Gd 3+ was 60 mmoL. The PL spectra confirmed that the luminous intensity of the UCNPs with doped Gd 3+ was much higher than that of the undoped UCNPs. The results show that this route for UCNP fabrication with high luminous efficiency and a small size could be extended to other UCNP systems for multifunctional biomedical applications.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Huanhuan Li,Qiyi Bei,Md. Mehedi Hassan,Murugavelu Marimuthu,Selorm Yao-Say Solomon Adade,Quansheng Chen,Muhammad Zareef
Abuse of tetracycline (TC) leads to the development of drug-resistant bacterial strains that threaten public health. This paper proposed a novel Cu 2+ -modulated UCNPs@RBD sensor for detecting TC. The sensor utilizes rhodamine B derivatives (RBD) that bind to Cu 2+ , forming RBD-Cu through a spirolactam open-loop reaction. The fluorescence of upconversion nanoparticles (UCNPs) is quenched by RBD-Cu via the inner filter effect (IFE). Upon addition of TC, TC-Cu forms due to electron-donor groups in TC, which decreases the generation of RBD-Cu, thereby enhancing the fluorescence of UCNPs . Under optimized conditions, the sensor exhibits remarkable accuracy across a concentration range of 50–50000 µg L −1 , with a limit of detection (LOD) of 1.72 µg L −1 . Moreover, the sensor demonstrates high selectivity for TC, validated by its application in food samples. The relative standard deviation (RSD) in real sample analysis was below 4.17 %, and the results were consistent with the HPLC method ( P > 0.05). Hence, the sensor exhibited a high level of sensitivity and reliability, making it suitable for the detection of TC in food.
研究领域:
食品科学
·
分析化学
·
生物传感
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 88
·85293-85302
·
IF 3.289
Kai Yan,Min Chen,Shuxue Zhou,Limin Wu
Multifunctional triggered drug release systems have been one of the most intriguing and challenging topics. In this study, we synthesize amphiphilic copolymers composed of hydrophilic oligo ethylene glycol methyl ether methacrylate and hydrophobic azobenzene-containing methacrylate. These amphiphilic copolymers can easily self-assemble into micelles in aqueous media and show smart responses to temperatures, UV/vis lights and ions. Interestingly, the obtained copolymers can self-assemble onto hydrophobic upconversion nanoparticles in aqueous media via hydrophobic interaction to form hybrid colloidal clusters with the hydrophobic nanocrystal core and hydrophilic polymeric shell. The hybrid colloidal clusters exhibit a thermo-responsive and photosensitive performance. When served as a drug carrier, both the near-infrared light and temperature triggered drug release can be realized, which have potential applications in intelligent drug delivery.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2016
·
IF 4.035
Hongyu Chen,Aijin Fang,Li He,Youyu Zhang,Shouzhuo Yao
Diabetes mellitus is an epidemic disease that it has became a worldwide public health problem. Thus, blood glucose monitoring has attracted extensive attention. Here, we report a nanosensor based on inner filter effect (IFE) between upconversion nanoparticles (UCNPs) and squaric acid (SQA)-iron(III) for the highly sensitive and selective detection of glucose levels in human serum. In this assay, GOx-catalyzed oxidization of glucose produces gluconic acid and hydrogen peroxide (H 2 O 2 ). The latter can catalytically oxidize iron(II) to iron(III) which can rapidly (<1 min) coordinate with the SQA to produce (SQA)-iron(III). The absorption band of (SQA)-iron(III) largely covered the emission band of UCNPs, resulting the fluorescence emission of UCNPs was effectively quenched. Therefore, the glucose can be monitored based on the formation of SQA-iron(III). Under the optimal condition, the fluorescence quenching efficiency shows a good linear response to glucose concentration in the ranges of 7–340 μmol/L with a detection limit of 2.3 μmol/L. The developed method has been further applied to monitor glucose levels in human serum with satisfactory results. Compared with other fluorescence methods , current method displayed high sensitivity and signal-to-noise ratio. Meanwhile, this nanosystem is also generalizable and can be easily expanded to the detection of various H 2 O 2 -involved analytes.
研究领域:
生物化学
·
医学诊断
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Tong Wei,Fengming Yang,Qingshen Jing,Chuanzhen Zhao,Mingchao Wang,Mingrun Du,Yanyan Guo,Qingjun Zhou,Zepeng Li
Multi-functional up-conversion (UC) phosphors are highly desirable for many potentially technological applications. Here, Er3+- and Yb3+-doped SrBi4Ti4O15 (SBT:xEr3+/yYb3+) UC nanoparticles (NPs) have been successfully synthesized for the first time by a convenient EDTA-citrate approach. The structures and morphologies were characterized by powder X-ray diffraction, Fourier transform infrared reflectivity spectra, scanning electron microscopy, and transmission electron microscopy . Under 980 nm excitation, SBT:xEr3+/yYb3+ UCNPs exhibited bright green and weak red emissions. The UC emission properties were disclosed to be tightly dependent on the Yb3+ and Er3+ concentration and the involved UC mechanism was discussed. More importantly, the noncontact optical thermometric ability were assessed based on the thermo-responsive fluorescence intensity ratio (FIR) technique and the maximum sensitivity (Smax) of SBT:0.15Er3+/0.15Yb3+ UCNPs is about 0.0036 K–1. Excellent repeatability and stability were proven by the thermal-cycling measurements. Furthermore, prominent photo-thermal (PT) effect was obtained with the temperature coefficients (η) being 0.24 and 0.49 °C∙mm2/mW for SBT:0.15Er3+/0Yb3+ and SBT:0.15Er3+/0.15Yb3+ UCNPs, respectively, which showed that the incorporation of Yb3+ was a promising strategy to improve the PT capability. In addition, regularly dynamic response of the PT agent under periodic laser stimulation was also observed. These results imply that SBT:xEr3+/yYb3+ UCNPs could be potentially utilized in thermometers and PT agents.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 8
·5075-5083
·
IF 6.895
Yu Dai,Dongpeng Yang,Danping Yu,Songhai Xie,Biwei Wang,Juan Bu,Bin Shen,Wei Feng,Fuyou Li
Fabricating lanthanide doped up-conversion luminescence based nanocomposites has drawn increasing attention in nanoscience and nanotechnology. Although challenging in precise synthesis, structure manipulation and interfacial engineering, fabricating dendritic mesoporous silica coated up-conversion nanoparticles (UCNP@dMSNs) with a tunable pore size is of great importance for the functionalization and application of UCNPs. Herein, we report a strategy to prepare uniform monodisperse UCNP@dMSNs with a core–shell structure. The silica shell has tunable center-radial and dendritic mesoporous channels. The synthesis was carried out in the heterogeneous oil–water microemulsion phase of the Winsor III system reaction system, which allows silica to be deposited directly on hydrophobic UCNPs through the self-anchoring of micelle complexes on the oleic acid ligand. The average pore size of UCNP@dMSNs could be tailored from ∼10 to ∼35 nm according to the varied amounts of co-solvent in the mixture. The microemulsion approach could also be used to prepare hierarchical UCNP@dMSNs with a multi-generational mesostructure. The resultant UCNP@dMSNs exhibit the unique advantage of loading “guest” nanoparticles in a self-absorption manner. We proved that Cu1.8S NPs (∼10 nm), Au NPs (∼10 nm) and Fe3O4 NPs (∼25 nm) could be incorporated in UCNP@dMSNs, which in turn validates the high adsorption capacity of UCNP@dMSNs.
研究领域:
纳米科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTIK
·
2020
·
IF 2.187
Xuelong Liu,Long Yan,Songbin Liu,Qiqing Li,Bo Zhou
Lanthanide-doped upconversion nanomaterials in particular the ultrasmall (<10 nm) nanoparticles have recently gained substantial attention owing to their bright potential in diverse frontier applications such as multicolor displays and biomedical applications. However, it is still lack of mechanistic researches on crystal growth and a fine-tuning of luminescent properties for the ultrasmall nanoparticles. Herein, we report the controllable synthesis of ultrasmall hexagonal core-shell nanoparticles through controlling the crystal growth kinetics processes. By precise manipulation of the reaction temperature and lanthanide ions doping, the size of utrasmall nanoparticles can be reduced to 2.51 nm still with the hexagonal phase, which is critically important for upconversion. Besides, an epitaxial growth of a NaGdF 4 inert-shell layer outside the core nanoparticles leads to a 23.5 times enhancement of the upconversion emission still with the ultrasmall size (6.21 nm). Moreover, the RGB primary color emissions are achieved through properly lanthanide ions doping in these ultrasmall nanoparticles and a set of multicolor output covering the visible spectral range are further obtained by precisely adjusting the mix ratio of the RGB ultrasmall nanoparticles, which shows a great potential in full-color displays and anti-counterfeiting applications.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Optical Materials Express
·
2017
·Vol. 7
·期 3
·913-923
·
IF 2.591
Qian Yang,Chuang Zhao,Jun Zhao,Yong Ye
Interaction between upconversion nanoparticles (UCNPs) and natural photosensitizers (Ps) has not been investigated so far. In order to make new near infrared photosensitizers, the conjugates (Ps-UCNPs) were synthesized by NaYF4 as a substrate and hydrothermal reaction of lanthanide ions Yb3+ with Er3+ or Tm3+, and then interaction with pheophorbide A (Pha) and resveratrol (Res) respectively. Based on the intensity of the fluorescence emission by Ps-UCNPs, the optimal reaction conditions are 16 mM Yb3+/0.4 mM Er3+ at 120°C for 20 h for Pha-UCNPs, and 80 mM Yb3+/0.1 mM Tm3+ at 180°C for 20 h for Res-UCNPs. The nanoparticles have a hexagonal phase or cubic phase with an average diameter size of 220 nm, and selectively emit the stronger red (670 nm) or violet (380 nm) fluorescence. Pha-UCNPs show the strong effects, and the maximum yield of singlet oxygen was seven times more than UCNPs and pheophorbide A alone under 980 nm illumination. It is attributed to the efficient resonance energy transfer from UCNPs to pheophorbide A. Pha-UCNPs is an effective NIR photosensitizer with potential for deep tissue disease photodynamic therapy.
研究领域:
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2016
·Vol. 45
·期 27
·11129-11136
·
IF 4.177
Yue Su,Xiuling Liu,Pengpeng Lei,Xia Xu,Lile Dong,Xianmin Guo,Xingxu Yan,Peng Wang,Shuyan Song,Jing Feng,Hongjie Zhang
Core–shell–shell heterostructures of α-NaLuF4:Yb/Er@NaLuF4:Yb@MF2 (M = Ca, Sr, Ba) have been successfully fabricated via the thermal decomposition method. Upconversion nanoparticles (UCNPs) were characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), upconversion luminescence (UCL) spectroscopy, etc. Under 980 nm excitation, the emission intensities of the UCNPs are remarkably enhanced after coating the MF2 (M = Ca, Sr, and Ba) shell. Among these samples, CaF2 coated UCNPs show the strongest overall emission, while BaF2 coated UCNPs exhibit the longest lifetime. These results demonstrate that alkaline earth metal fluorides are ideal materials to improve the UCL properties. Meanwhile, although the lattice mismatch between the ternary NaREF4 core and the binary MF2 (M = Sr and Ba) shell is relatively large, the successfully synthesized NaLuF4:Yb/Er@NaLuF4:Yb@MF2 indicates a new outlook on the fabrication of heterostructural core–shell UCNPs.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2013
·Vol. 43
·期 10
·3861-3870
·
IF 3.806
Wenyan Yin,Gan Tian,Wenlu Ren,Liang Yan,Shan Jin,Zhanjun Gu,Liangjun Zhou,Juan Li,Yuliang Zhao
Herein, alkali ion doped CaF2 upconversion nanoparticles (UCNPs) were first reported as a multifunctional theranostic platform for dual-modal imaging and chemotherapy. Interestingly, we found that the alkali ions doping approach could efficiently enhance the upconversion luminescence (UCL) intensity, whereas slightly affect the phase and morphology of the resulting products. In order to further improve the UCL efficacy for bioimaging, a pristine CaF2 shell was grown on the CaF2:Yb, Er core surface to enhance the UCL intensity. After being transferred into hydrophilic UCNPs, these water-soluble UCNPs could be served as contrast agents for in vitro/in vivo UCL imaging and X-ray computed tomography (CT) imaging. Furthermore, the as-prepared UCNPs could also be employed as nano-carriers for drug delivery. Doxorubicin (DOX) can be easily loaded onto the UCNPs and the DOX-loaded UCNPs exhibit a good cell killing ability. Therefore, the multifunctional core–shell CaF2 UCNPs with UCL/CT imaging and drug carrier properties may find extensive applications in simultaneous imaging diagnosis and therapy.
研究领域:
生物医学工程
·
纳米医学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2016
·Vol. 27
·期 12
·125601
·
IF 3.573
Meili Yin,Zhenhua Li,Li Zhou,Kai Dong,Jinsong Ren,Xiaogang Qu
Recently, antibiotic drug-resistant therapies have become very important due to the emergence of antibiotic-resistant bacterial strains. The development of novel antibacterial materials has received significant attention. Here, quaternized chitosan hydrogels incorporated with NaYF4:Er/Yb/Mn@photosensitizer-doped silica (UCNPs/MB) were synthesized for effective killing of both gram-positive oxacillin-resistant S. aureus (DR-S. aureus) and gram-negative kanamyclin-resistant E. coli (DR-E. coli) bacteria upon near-infrared (NIR) laser irradiation. In this system, the cationic macroporous nature of the hydrogel acts as a molecular 'anion sponge', which sucks the outer part of the anionic microbe membrane into the gel interior voids and causes microbe membrane disruption. By incorporating UCNPs/MB-doped silica into the hydrogel, we have combined photodynamic therapy (PDT) with quaternized chitosan to obtain a high therapeutic index via a synergistic effect. In vitro experiments have demonstrated that our system had excellent antibacterial efficiency to both DR-S. aureus and DR-E. coli bacteria. More importantly, our new synergistic treatment modality provided an excellent therapy platform for drug-resistant bacteria, which could improve antimicrobial efficiency.
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Mingzhou Meng,Tianmei Zhang,Jiaoyu Wang,Zhenlong Cheng,Yuanli Liu,Xin Qiao,Jian Wen,Ute Resch-Genger,Wen Long,Jun Ou
The core–shell NaYF4:Yb3+/Tm3+@NaYF4:Yb3+ upconversion nanoparticles were successfully prepared by a solvothermal method, and a layer of mesoporous silica (mSiO2) was successfully coated on the periphery of the core–shell nanoparticles to transform their surface from lipophilic to hydrophilic, further expanding their applications in biological tissues. The physical phase, morphology, structure, and fluorescence properties were characterized by X-ray diffraction (XRD), field emission transmission electron microscopy (TEM), Fourier infrared spectroscopy (FT-IR), ζ potential analysis, and fluorescence spectroscopy. It was found that the material has a hexagonal structure with good hydrophilicity and emits intense fluorescence under 980 nm pump laser excitation. The non-contact temperature sensing performance of nanoparticles was evaluated by analyzing the upconversion fluorescence of Tm3+ (1G4 → 3F4 and 3F3 → 3H6) in the temperature range of 284–344 K. The absolute and relative sensitivities were found to be 0.0067 K–1 and 1.08 % K–1, respectively, with high-temperature measurement reliability and good temperature cycling performance. More importantly, its temperature measurement in phosphate-buffered saline (PBS) solution is accurate. In addition, the temperature of the cells can be increased by adjusting the laser power density and laser irradiation time. Therefore, an optical temperature sensing platform was built to realize the application of real-time monitoring of cancer cell temperature and the dual function of photothermal therapy.
研究领域:
生物医学工程
·
纳米医学
·
光学成像
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）