CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Anjun Gao,Weizhang Zhao,Xuefei Wang,Ping Wang,Shaowen Cao,Guoqiang Luo,Rong Tu,Qiang Shen,Lianmeng Zhang
Current wet-chemical approaches for synthesizing small-sized and monodisperse barium titanate (BT) nanoparticles can produce BT particles of less than 100 nm. However, because of poor recyclability, they often involve complex reaction systems, expensive precursors, and environmental concerns, thus driving the need for a simple, stable method to advance the miniaturization of multilayer ceramic capacitors. Herein, we present a simplified hydrothermal synthesis using only TiO 2 and Ba(OH) 2 ·8H 2 O as raw materials in the presence of NaOH, without additional additives, to obtain irregular BT with an average size of 80 nm. Further, we systematically investigated TiO 2 precursors of varying morphologies and sizes to elucidate the hydrothermal synthesis mechanism, disproving the in situ transformation mechanism and establishing an inverse correlation between BT particle size and the specific surface area of TiO 2 . Further validation using mixed TiO 2 precursors (1:1 ratio) led to the proposal of a dissolution–precipitation nucleation mechanism in which the precursor surface area governs dissolution kinetics, subsequently determining the nucleation rate and final particle size. This study not only provides a practical and scalable synthesis route but also offers valuable insights into hydrothermal crystallization processes.
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Journal of Energy Storage
·
2025
·
IF 9.8
Changhai Zhang,Zhiqi Zhou,Xue Zhang,Xu Tong,Chao Wang,Tiandong Zhang,Wenju Wu,Qingguo Chi
High-temperature applications demand polymer dielectrics with a high glass transition temperature ( T g ), wide bandgap, and high dielectric constant for superior energy storage performance. However, inherent trade-offs among these key parameters in existing polymers lead to soaring leakage currents and increased energy losses at elevated temperatures, severely limiting further performance enhancement. To address this issue, this paper uses polyisopren-imide (PNI) as the matrix material, attempting to decouple the T g , bandgap, and dielectric constant using fluorination modification and the creation of physical-chemical double-crosslinked networks. First, electron-withdrawing fluorine atoms were incorporated into PNI to form FPNI 50 , enhancing the polymer's bandgap and thereby inhibiting charge excitation and reducing leakage current. Subsequently, dicyclopentadiene (DCPD) was employed as a chemical crosslinking agent to construct a covalent-bonded crosslinked network (FPNI 50 D 5 ) which effectively restricted molecular chain mobility and reduced dielectric loss. Finally, 4,4-dihydroxy dicyclohexane (BCHD) was introduced to form physical crosslinking via hydrogen bonding between hydroxyl groups and fluorine atoms. BCHD, featuring high polarity and a wide bandgap (8.84 eV), enhances the dielectric constant of the polymer while simultaneously suppressing carrier transition. Consequently, the FPNI 50 D 4.5 B 0.5 achieves complete decoupling of T g (250.4 °C), bandgap (4.229 eV), and dielectric constant (4.01), while exhibiting outstanding high-temperature energy storage performance. At 150 °C and an electric field strength of 600 MV/m, it delivers an energy storage density of 6.5 J/cm 3 with an efficiency of 90 %. The performance not only surpasses that of the pure polymer PNI but also demonstrates strong competitiveness among reported polymer composites.
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BIOMATERIALS
·
2025
·
IF 12.9
Xindan Zhang,Ruinan Hao,Jianfeng Tong,Hongtao Hu,Jinzhi Du,Bowen Gong,Feng Tian,Yonglai Lu,Jiajia Xue
Severe skin injuries require scaffolds capable of dynamically regulating cell migration and proliferation to accelerate wound closure and tissue regeneration. However, most existing strategies rely on a single mode of guidance and fail to recapitulate the coordinated spatiotemporal cues present in native healing environments. Here, we report a graded nanofiber scaffold that integrates biophysical and biochemical cues to provide topographic, haptotactic, and chemotactic signals for promoting efficient skin repair. The scaffold is composed of radially aligned poly(ε-caprolactone) nanofibers surface-deposited with epidermal growth factor (EGF)-loaded collagen nanoparticles in a radial density gradient, fabricated via coaxial electrospraying. This design enables sustained release of bioactive EGF for up to 10 days while guiding cell migration toward the wound center. In vitro studies demonstrated enhanced directional migration and proliferation of keratinocytes and fibroblasts. Transcriptomic analysis revealed activation of cytoskeletal remodeling, membrane fluidity regulation, and integrin-mediated adhesion pathways, highlighting the scaffold’s role in orchestrating cell motility. In a full-thickness rat skin injury model, the scaffold accelerated wound closure, enhanced cell proliferation, and promoted collagen deposition, resulting in skin wound healing. This study presents a simple and versatile platform for delivering spatially graded cues, offering strong potential for clinical translation and extension to other tissue regeneration applications.
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JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 11
·e70312
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IF 2.8
Pangwei Liu,Shenao Zhang,Yuge Jiang,Huan Wu,Shijian Cao,Hongfei Wu,An Zhou
Copper (Cu) is an essential trace element for maintaining normal cellular functions; however, excessive Cu accumulation has been confirmed to induce hepatotoxicity, while the metabolic mechanisms underlying Cu-induced hepatotoxicity remain unclear. In this study, an innovative integrated separation strategy was established, combining hydrophilic interaction liquid chromatography (HILIC) and reversed-phase liquid chromatography (RPLC), coupled with quadrupole-time-of-flight mass spectrometry (Q-TOF/MS), to systematically resolve metabolomic perturbations in CuCl 2 -exposed rat BRL-3A hepatocytes. Based on their complementary separation mechanisms—HILIC enables efficient retention and separation of polar metabolites via hydrophilic interactions, while RPLC separates nonpolar/weakly polar lipid molecules based on hydrophobic interactions—this analytical strategy significantly expanded the coverage of detectable metabolites and improved the reliability of metabolite identification through cross-validation between the two chromatographic platforms. The results showed that a total of 25 metabolites with significant changes were identified when BRL-3A cells were exposed to 50 µM CuCl 2 (with a cell viability of 85%). These changes were mainly enriched in metabolic pathways such as glutathione metabolism (characterized by a significant decrease in the GSH/GSSG ratio, p < 0.01), arachidonic acid (AA) metabolism (a 42% reduction in AA, p < 0.05), and glycerophospholipid metabolism (a 1.8-fold increase in the levels of lysophospholipids [LysoPCs/LysoPEs], p < 0.05). These findings reveal that oxidative stress, membrane structure damage, and energy metabolism imbalance are the core mechanisms of Cu-induced hepatotoxicity. The integrated liquid chromatography-mass spectrometry (LC-MS) analytical framework established in this study not only provides a novel molecular perspective for elucidating the mechanisms of Cu-induced hepatotoxicity but also demonstrates the application potential of advanced complementary separation technologies in the risk assessment of environmental pollutants.
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
U.T. Uthappa,Jia Cheng Niu,Yan Zhou,Ben Wang
The presence of carcinogenic and persistent micropollutants in the aquatic systems exist at ng–μg·L −1 levels, yet their active, selective, and recoverable removal remains challenging. Micro/nanomotors (MNMs) offer propulsion-enhanced mass transfer mechanisms in pollutants removal. However, widely explored metal–organic framework (MOF-MNMs) suffers from chemical/structural instability, multistep or high-temperature fabrications, and difficult in post-use recovery. Owing to the covalent organic frameworks (COFs) superior intrinsic stability which can be considered as alternative emerging MNMs. However, some of the conventional COF-MNMs are hindered by hydrophobicity, limited adsorption, reliance on peroxide or light fuels, expensive building blocks and face recovery issues (due to powder nature). Here we report a mesoporous COF functionalized with magnetic particles (MP-COF) and ionically crosslinked with alginate biopolymer to obtain fuel-free, steerable, retrievable microbead motors. Under rotating field, they navigate in complex environment achieving ~58 % DOX removal in 15 min and up to 72 % DOX and 86 % CV with modest removal performances in river, sea, rain and tap waters and only a 10–20 % decline in natural organic matter. Further, synergistic π–π, hydrogen bonding, electrostatic and pore-filling interactions underpin adsorption mechanisms and validated with better reusable feature. This magnetically recoverable COF microbead motors platform overcomes several limitations providing a modular route toward an active remediation approach for dual carcinogenic pollutants in aqueous environments.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2025
·
IF 7.8
Lei Hu,Yuxuan Tian,Ning Ding,Hong Liu
In this study, iron-doped molybdenum disulfide (FeMoS 2 ) was hydrothermally synthesized and subsequently coupled with calcined graphitic carbon nitride (g-C 3 N 4 ) to construct a heterojunction . Comprehensive characterization confirmed the stable crystalline structure of the composites and the formation of robust interfacial coupling, which facilitated efficient photogenerated charge separation. Furthermore, UV-Vis diffuse reflectance spectroscopy revealed a significant extension of the visible-light absorption edge compared to pristine FeMoS 2 , with the bandgap narrowing to 1.99 eV. Under optimized conditions (0.6 g/L catalyst dosage, 1.0 mM peroxydisulfate (PDS), pH 6), the FeMoS 2 /g-C 3 N 4 /PDS system achieved 88 % Chlorella vulgaris inactivation in 60 min under visible light, retaining more than 60 % efficiency after five cycles. Mechanistic investigations revealed that superoxide radicals (·O 2 - ) and photogenerated holes (h + ) synergistically inactivated Chlorella via reactive oxygen species (ROS)-induced membrane peroxidation and antioxidant system disruption. Algal physiological assays and microscopic imaging further corroborated that photocatalytically generated ROS compromised cellular membrane integrity and induced chloroplast degradation.
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Journal of Macromolecular Science Part B-Physics
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2025
·
IF 1.4
Jianxun Yao,Jifan Zhan,Hanwu Liu,Tingting Yan
Auricular reconstruction remains a significant challenge in tissue engineering due to the auricle’s complex anatomy and functional requirements. To address the limitations of autologous cartilage grafts, we developed a composite scaffold consisting of porous ultra-high molecular weight polyethylene (UHMWPE) integrated with a polyvinyl alcohol/chitosan (PVA/CS) double-network hydrogel reinforced with 2 wt% nano-hydroxyapatite (HA). The scaffold was fabricated via powder sintering and physical crosslinking and exhibited high porosity (>41%), a tensile strength of 2.80 MPa, and enhanced water retention. The addition of HA improved both the mechanical strength and antibacterial properties of the composite. The hydrogel component demonstrated stable swelling behavior, hemolysis rates below 5%, and good cytocompatibility. These findings demonstrate that the UHMWPE/PVA-CS/HA composite scaffold, combining the rigidity of a sintered porous framework with the flexibility and bioactivity of a reinforced hydrogel, offers a novel and promising platform for patient-specific auricular reconstruction with balanced mechanical, biological, and antibacterial properties.
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ELECTROPHORESIS
·
2025
·Vol. 46
·期 21
·1576-1587
·
IF 2.5
Tao Huang,Chunsu Liang,Xiaomei Ling
High-performance capillary electrophoresis (CE) has been widely applied in the analysis of organic acids, especially monocarboxylic acids (MAs), but no studies on the CE analysis of dissociated states of MAs have been reported. Here, 15 MAs were analyzed by the newly developed universal interface-induced current detector (IICRD). Two current signal peaks were observed in current electrophoretograms (CR-EGs), whereas only one peak with low sensitivity can be obtained by diode array detector (DAD). The current signal peaks of MAs were accurately identified by adding a charge-neutral marker and calculating by p K a . The qualitative analysis indicated that the two current signal peaks of MAs were charge-neutral forms [MA ± ] and monovalent anions [MA − ] in order. Quantitative analysis showed that CE-IICRD can enhance the sensitivity of MA analytes to 40 µM in limit of detection (LOD), with a linear range from 10 −6 to 10 −2 M. Furthermore, interactions between different dissociated states of MAs and monocarboxylate transporter 1 (MCT1) were studied by combined application of nonimmobilized cell CE (NICCE) method for the first time. The binding kinetic parameters and mole number of MCT1 on cell membranes can also be obtained. Besides, competitive binding experiments proved that BAY-8002 (MCT1-specific inhibitor) and lactic acid shared the same binding site. CE-IICRD provides a new method to reveal the interaction between different dissociated forms of MAs or other biomolecules and essential receptors.
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Small
·
2025
·
IF 12.1
Siying Huang,Tingting Wang,Nuo Sheng,Qiwen Zhang,Xiaolong Xu,Xiaowei Ma
Salmonella Typhimurium—a gut-colonizing pathogen that invades mucosa and triggers colitis—remains clinically challenging due to host barriers limiting oral antibiotic efficacy. To address this issue, an innovative co-crystal nanoparticle platform is developed for targeted therapy. This platform consists of PC@Kana@TA nanoparticles (PC@Kana@TA NPs), synthesized through a simple, cost-effective, and scalable process involving two key steps: 1) self-assembly of tannic acid (TA) with kanamycin (Kana) to form the antimicrobial core Kana@TA nanoparticles (Kana@TA NPs), enhancing drug stability and bactericidal efficacy; and 2) subsequent coating of Kana@TA NPs with mixed pectin–chitosan (PC) to generate the final PC@Kana@TA NPs. This dual-layer coating strategy not only provides gastric acid resistance but also enables pectinase-responsive release in the intestinal tract, thereby significantly improving oral bioavailability compared to conventional formulations. In vitro, Kana@TA NPs exhibit above 70% intracellular Salmonella clearance rate in both the RAW264.7 and Caco-2 cells. Animal experiments revealed that PC@Kana@TA NPs achieved a 5-log reduction in luminal Salmonella, with inflammatory cytokine levels nearly returned to baseline. Notably, the relatively beneficial gut bacteria abundance is 30.53% higher than the Kana group. This strategy presents a versatile strategy for nano-enabled intracellular infection therapies, unlocking new opportunities for drug repurposing and optimization.
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Nature Communications
·
2025
·Vol. 16
·期 1
·9451
·
IF 15.7
Bai Ju,Xiao Luqi,Zhang Xiangping,Liu Hongyan,Wang Can,Gong Lili,Luo Shuangjiang,Zhu Yihan,Shan Linglong,Fan Hongwei,Zhang Suojiang
Oriented metal-organic framework (MOF) membranes hold significant promise for advanced helium (He) separation, but their synthesis remains a challenging task. We report the preparation of an oriented MOF membrane using metal-organic polyhedra (MOP) fragment as metallocene-anchor. The metallocene-anchor induces the growth of homoligand Zr-MOF along the c-axis, resulting in the {001}-oriented structure. This orientation increases the transition energy barrier of methane (CH 4 ), enabling precise He/CH 4 separation with a selectivity of 77.3 and a He permeance of 695.1 GPU. The membrane exhibits exceptional robustness, demonstrating resistance to high-pressure conditions (up to 40 bar), thermal shock (−25 °C to 85 °C), and long-term stability (1000 h). The separation performance surpasses that of existing MOF membranes and exceeds the Robeson upper bound. Additionally, a three-stage membrane process enables the concentration of low He concentrations of 0.3% up to 99.9%, highlighting the potential of membranes for helium extraction. The successful fabrication of various oriented MOF membranes indicates the universality of this strategy.
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Communications Materials
·
2025
·Vol. 6
·期 1
·233
·
IF 9.6
Wang Ruoming,Yang Guangping,Yang Tianxiang,Lu Yuzheng,Raza Rizwan,Zhu Bin,Lund Peter D.,Yun Sining
High ionic conductivity at reduced temperatures may allow electrochemical cell applications to be efficiently scaled up. Herein, we introduce an approach that exploits electrode-electrode synergy and in situ structural transformation to increase the ionic conductivity of an electrolyte within the electrochemical cell. This transformation is based on the formation of a Li 2 TiO 3 -Li 2 CO 3 heterostructure electrolyte via the combination of a TiO 2 semiconductor precursor, polystyrene spheres as the soft skeleton, and the lithium-based electrode LiNi 0.8 Co 0.15 Al 0.05 O 2 . The unique surface and interface of the heterostructure electrolyte enable the formation of long-range ion transport channels that lower electrode impedance, resulting in a superior ionic conductivity of 0.23 S cm −1 at 550 °C and a high-power density of 1239 mW cm −2 . Our general method to form superionic electrolytes shows potential in fuel cell technologies.
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Science Advances
·
2025
·Vol. 11
·期 51
·
IF 12.5
Linping Liu,Guanyun Zhang,Jiachen Ma,Dexin Wang,Juan Wang,Lixia Xuan,Junshuo Nie,Guo Wang,Yifeng Wang
Piezoelectric materials usually exist in solid-state forms with obscure structures, hindering atomic-level understanding of structure-property relationships. Here, we report the piezoelectric high-nuclearity titanium-oxide molecular cluster, Ti 26 Pb 10 , constructed via a dopant metal coordination strategy. The cluster framework comprises 26 Ti atoms linked by binuclear units, with 10 Pb 2+ ions anchored through distinct coordination: 2 embedded and 8 surface exposed. Ti 26 Pb 10 displays a piezoelectric constant 5.5 times higher than PbTiO 3 , as confirmed by piezoresponse force microscopy. Density functional theory simulations reveal stress-induced lattice distortion and bandgap shifts. Critically, leveraging piezo-photocatalytic synergy, Ti 26 Pb 10 enables ultraefficient tetracycline degradation, achieving a rate 15 times faster than PbTiO 3 under combined light and ultrasound, with a superior synergy factor. Mechanistic studies indicate that local electric fields coupled with light excitation promote 1 O 2 generation. This work extends titanium-oxide clusters into piezo-photocatalysis and provides a rational design paradigm for multifield synergistic catalysis and atomic-level structure-activity insights.
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