ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 32
·79423-79436
·
IF 5.8
Zhang Jingni,Wang Hongjuan,Chen Huan,Liu Yong,Wang An,Hou Hongwei,Hu Qingyuan
Long-term use of alcohol and cigarettes is associated with millions of deaths each year, directly or indirectly. The carcinogen acetaldehyde is both a metabolite of alcohol and the most abundant carbonyl compound in cigarette smoke, and co-exposure of them is usual and primarily leads to liver and lung injury, respectively. However, few studies have explored the synchronic risk of acetaldehyde on the liver and lung. Here, we investigated the toxic effects and related mechanisms of acetaldehyde based on normal hepatocytes and lung cells. The results showed that acetaldehyde caused significant dose-dependent increases of cytotoxicity, ROS level, DNA adduct level, DNA single/double-strand breakage, and chromosomal damage in BEAS-2B cells and HHSteCs, with similar effects at the same doses. The gene and protein expression and phosphorylation of p38MAPK, ERK, PI3K, and AKT, key proteins of MAPK/ERK and PI3K/AKT pathways regulating cell survival and tumorigenesis, were significantly upregulated on BEAS-2B cells, while only protein expression and phosphorylation of ERK were upregulated significantly, the other three decreased in HHSteCs. When either the inhibitor of the four key proteins was co-treated with acetaldehyde, cell viabilities were almost unchanged in BEAS-2B cells and HHSteCs. Thus, acetaldehyde could synchronically induce similar toxic effects in BEAS-2B cells and HHSteCs, and MAPK/ERK and PI3K/AKT pathways seem to be involved in different regulatory mechanisms.
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Small Methods
·
2021
·Vol. 5
·期 12
·2100964
·
IF 14.188
Juan Meng,Yongzhuang Liu,Qinqin Xia,Shi Liu,Zhihan Tong,Wenshuai Chen,Shouxin Liu,Jian Li,Shuo Dou,Haipeng Yu
Phosphorus-doped carbon materials are promising alternatives to noble metal-based catalysts for the highly selective oxidation of benzyl alcohol to benzaldehyde, but it is challenging to achieve high loadings of high-activity P dopants in metal-free catalysts. Here, the preparation of high-loading and well-dispersed P atoms confined to the surfaces of cellulose-derived carbon via a dissolving-doping strategy is reported. In this method, cellulose is dissolved in phosphoric acid to generate a cellulose-phosphoric supramolecular collosol, which is then directly carbonized. The as-prepared carbon possesses a high specific surface area of 1491 cm 3 g −1 and a high P content of 8.8 wt%. The P-doped nanoporous carbon shows a superior catalytic activity and cyclic stability toward benzyl alcohol oxidation, with a high turnover frequency of 3.5 × 10 −3 mol g −1 h −1 and a low activation energy of 35.6 kJ mol −1 . Experimental results and theoretical calculations demonstrate that the graphitic C 3 PO species is the leading catalytic active center in this material. This study provides a novel strategy to prepare P dopants in nanoporous carbon materials with excellent catalytic performance.
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CHEMOSPHERE
·
2023
·
IF 8.8
Zegang Fu,Ye Shui Zhang,Guozhao Ji,Aimin Li
Supercritical water (SCW) treatment of plastics is a clean technology in the ‘waste-to-energy’ path. In this work, PP and PET plastics were processed by sub-/supercritical water. The results showed that temperature was the most important factor of the PP and PET degradation. The influence of factors on the degradation of plastics follows the following order: temperature > residence time > plastic/water ratio. These factors influenced the yield of gas products by promoting or inhibiting various reactions (such as reverse water gas shift reaction, methylation reaction, and Fischer-Tropsch synthesis reaction). Besides, the composition of liquid oil was also analyzed. The main composition of the liquid oil produced by PET was benzoic acid and acetaldehyde, which were generated from the decarboxylation of terephthalic acid (TPA) and dehydration reaction of ethylene glycol (EG). The liquid oil from PP was mainly long-chain olefins , long-chain alkanes, cycloalkanes , etc., which were formed by the interaction of various methyl, alkyl, hydroxyl, and other free radicals . This study could build fundamental theories of plastic mixture treatment.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Guihong Zhao,Siyu Tian,Yuhang Li,Weixuan Dong,Hao Jiang,Jiaxiang Kuang,Feiao Wang,Sijia Li,Yanjun Li
Engineered autonomous ethylamine biosynthesis via dual-pathway strategy, eliminating the need for exogenous ethylamine. • Achieved record-breaking L-theanine titer of 118.2 g/L in fed-batch fermentation, the highest reported production to date. • Elucidated the ethylamine preference mechanism of L-theanine synthetase Mm GMAS, providing insights for enzyme engineering. • Developed systematic metabolic engineering combining precursor enhancement, pathway knockout, and adaptive evolution. L-Theanine, the most abundant free amino acid in tea, is a non-proteinogenic amino acid widely used in food and cosmetics, with documented health benefits and therapeutic potential. To circumvent the reliance on hazardous exogenous ethylamine in L-theanine production, we engineered an integrated and efficient strategy for high-level L-theanine production in Escherichia coli via dual-pathway ethylamine biosynthesis. First, by enhancing the expression and elucidating the ethylamine preference mechanism of the L-theanine synthetase Mm GMAS, the obtained strain THE-3 produced 15.8 g/L L-theanine. Building on this, the knock-out of L-theanine degradation pathway combined with bolstered precursors supply further increased the titer to 16.8 g/L and 22.8 g/L in strain THE-6 and THE-9, respectively. Then, developing the ethylamine intracellular biosynthesis via Cs AlaDC-mediated decarboxylation pathway in THE-13 resulted in the production of 19.5 g/L L-theanine and 5.4 g/L L-alanine without exogenous ethylamine. Subsequently, by synergizing the Pp SpuC-mediated transamination pathway with L-alanine as the amino donor, and subjecting this strain to evolution for acetaldehyde resistance, the final engineered strain, THE-17, achieved a record-breaking titer of 118.2 g/L in fed-batch fermentation, with a yield of 0.389 g/g glucose and a productivity of 2.46 g/L/h. This study establishes the highest reported L-theanine production to date and provides a transformative approach for industrial L-theanine production, shifting the paradigm from reliance on exogenous ethylamine addition to autonomous ethylamine supply.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Busheng Zhang,Liangcai Lin,Canjie Zheng,Xuan Liu,Wanjing Cui,Xin Li,Xiaotong Lyu,Cuiying Zhang
“Empty cup aroma” is an important characteristic and quality evaluation standard of Jiangxiang-type Baijiu (JXB). In this study, an in situ detection method for the empty cup aroma of JXB was established, and the authenticity and origin information of JXB were identified with an untargeted flavoromics strategy. The complex composition of JXB leads to slow ethanol volatilization, which is a potential method for identifying artificial JXB. The results of the sensory analysis showed that acidic, sauce, burnt and qu in the empty cup of JXB were the strongest at the 45 min stage. A total of 155 compounds were detected in the empty cups of 15 JXB from different regions during 45 min of standing, and 34 compounds were identified as key aroma compounds in the empty cups of JXB. Eleven potential markers were screened (VIP > 1), which can be used to distinguish JXB produced in Guizhou/Sichuan and other regions.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yanmei Zhu,Fushuang Xiang,Yuanyuan Su,Xue Jiang,Yipeng Cang,Wanjun Long,Wei Lan,Gaoqiong Deng,Hengye Chen,Yuanbin She,Haiyan Fu
High - temperature Daqu Baijiu faces a challenge from illegal adulteration of high-grade Baijiu bottles with low-grade Baijiu, affecting its quality and value. This study developed a rapid identification method for high temperature Daqu Baijiu with the same aroma type using a four-channel visual array sensor and detection of color changes caused by competition coordination with Zn 2+ and color-changing organic dyes. The array sensor demonstrated high stability and repeatability in targeting flavor components and achieved 97.78 % or more accuracy combined with dd -SIMCA model in detecting adulteration across the Baijiu with same aroma type. The results of GC–MS and Quantum Chemical Calculation showed that esters, acids, and pyrazines played a crucial role. The smart phone App could quickly identify the authenticity of Baijiu with accuracy achieved 93 %. This research provides a foundation for rapid and reliable assessment of Baijiu quality and authenticity, enabling the industry to combat fraudulent practices effectively.
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CATALYSIS LETTERS
·
2021
·Vol. 152
·期 8
·2524-2532
·
IF 3.186
Jiang Haoxi,Jiang Angjiong,Gao Qiang,Yang Guochao,wang Lingtao
In this work, Ta was firstly reported as an efficient promoter of MgO–SiO 2 for the conversion of ethanol and acetaldehyde to 1,3-butadiene. The doping of Ta into MgO–SiO 2 forms Ta–O–Si bonds and generates more strong Lewis acid sites, which not only promote the aldol condensation reaction but also significantly facilitate the Meerwein–Ponndorf–Verley reduction, the total conversion around 80% which drops to 65% after 24 h. In addition, the catalyst showed desirable stability in 24 h long-term stability evaluation, the selectivity remained stable at 80%. Graphic Abstract
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SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Yawen Rong,Md Mehedi Hassan,Qin Ouyang,Li Wang,Tianhui Jiao,Quansheng Chen
The current work puts forward a turn-off ratiometric upconversion fluorescence nanosensor for the quantification of furfural (FUR). Upconversion nanoparticles (UCNPs) containing Y 3+ , Yb 3+ , and Er 3+ were synthesized; mesoporous SiO 2 and amino groups were subsequently conjugated and functioned as the signal component. The p-toluidine molecule played the role of recognition molecules, which coupled with UCNPs to form a unique detection system. An absorption peak appeared when the FUR was combined with p-toluidine resulted in an obvious quenching of upconversion emission at 539 nm via inner filter effects (IFE), while the fluorescence peak at 653 nm maintained constant. Therefore, the FUR concentration was quantified by the record of fluorescence ratio I 539 / I 653 . Under optimal conditions, the proposed UCNPs-p-toluidine coupled nanosystem achieved the ratiometric fluorescence sensing toward FUR in the linear range of 0.01–100 μg/mL with a detection limit as low as 0.003 μg/mL. The accuracy of the sensor was validated by the HPLC method with preferable accuracy. Finally, the overall nanosystem showed excellent application potential in adulterated foodstuff (e.g., cookie, honey, fruit wine, milk tea, and potato chips).
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Analytical Methods
·
2021
·Vol. 13
·期 26
·2989-2996
·
IF 2.896
Yiwen Cao,Shenjie Zhu,Lin Zhang,Qun Cui,Haiyan Wang
Aiming at the difficulty in qualitative and quantitative analysis of trace compositions in food preservative propionic acid, the trace compositions and the key components influencing the total aldehyde content in propionic acid were analyzed by gas chromatography-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC) and gas chromatography (GC) in this paper. The results show that the food preservative propionic acid contains 18 trace compositions. The main compositions affecting the total aldehyde content in propionic acid are acetaldehyde, propionaldehyde, 1-cyclopropyl-1-propanone and 2-methyl-2-pentenal, which account for ∼90% of the total aldehyde content in propionic acid. The total aldehyde content in propionic acid can be quickly determined by iodometric titration. However, the impurity compositions, solution oxygen content and pH value of propionic acid may affect the stability of NaHSO3, which lead to a higher titration value of the aldehyde content. The total aldehyde contents in propionic acid determined by GC (148.535–337.890 mg L−1) and HPLC (157.730–335.780 mg L−1) are close and reliable with a relative deviation of 0.31–3.00%. The volatile low-carbon aldehydes and ketones including formaldehyde, acetaldehyde and acetone have a weak response and a high detection limit in GC. The derivation conditions of all aldehydes and ketones in propionic acid should affect the determination results of HPLC. It provides the basic data for quality improvement and ultra-deep purification of food-grade propionic acid.
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JOURNAL OF FOOD SCIENCE
·
2021
·Vol. 86
·期 7
·2978-2989
·
IF 3.167
Jiaman Liu,Bo Teng,Xiaofeng Zhang,Minghui Dai,Yue Lin,Yang Liu,Jacqui M. McRae
Passion fruit rind is a waste product from the beverage industry that is rich in anthocyanins that can be potentially applied as a natural colorant. However, the inherent instability of anthocyanins causes rapid discoloration. In this study, the cyanidin-3-glucoside (C-3-G) in passion fruit rind was extracted using 50% ethanol and converted into nonbleachable pigments by reaction with Oolong tea extracts and acetaldehyde. Reactions over 70 days formed high concentrations of stable nonbleachable pigments (3.07–6.68 absorbance unit [A.U.], in total) such as pyranoanthocyanins, as well as oligomeric and polymeric pigments with ethyl-linked bridges. In C-3-G and acetaldehyde reaction, positive relations were found among acetaldehyde concentration, color density, and nonbleachable pigment concentrations. As for reactions with C-3-G and Oolong tea extract combined with acetaldehyde, greater color density and greater concentrations of nonbleachable pigments (10.80–12.34, 4.25–4.40 A.U., respectively) were formed compared with acetaldehyde alone. In addition, the antioxidant capabilities of the extracts were enhanced after reaction with Oolong tea extracts. The results of this study show a useful method to enhance the stability of anthocyanins from passion fruit rind and also provide greater economic value to this waste product. Practical Application Ripened passion fruits contain a high concentration of anthocyanins in their rind. These anthocyanins can be optimally extracted by ultrasonic assisted solvent extraction to provide stable pigments by inducing acetaldehyde (a volatile compound often found in foods and beverages) into the anthocyanins. These stable pigments have a greater reddish hue in solution than the anthocyanin extracted from the rind and are more stable over a greater pH range. In addition, these stable pigments can be potentially used as colorant throughout the food and cosmetic industry to provide high economical values.
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ADVANCES IN ATMOSPHERIC SCIENCES
·
2021
·Vol. 38
·期 7
·1238-1251
·
IF 3.158
Zhang Hailiang,Xu Yongfu,Jia Long,Xu Min
Acetaldehyde is one of the important VOC species of O 3 precursors in the atmospheric environment. The influences of relative humidity (RH) and initial VOC/NO x ratio ( R CN ) on the formation of O 3 are studied in smog chamber experiments, and the MCM v3.3.1 mechanism of acetaldehyde is modified based on the experimental results. In low-RH conditions (RH = 11.6%±1.1%), the O 3 concentration at 6 h increases first and then decreases with the increase of R CN , and the R CN at the inflection point of O 3 concentrations is 3.2. In high-RH experiments (RH = 78.8%±1.0%), variation of the O 3 concentration at 6 h with R CN is similar to that in low-RH experiments, but the R CN at the inflection point is 2.8. RH has no significant effect on the O 3 concentrations under low R CN (< 3), whereas it has a negative effect under high R CN (> 3). Compared with the experimental results, original MCM v3.3.1 greatly underestimates the O 3 concentrations. Addition of both the photolysis process of peroxyacetyl nitrate and the photolysis process of HNO 3 on the reactor surface into the original MCM can reduce the difference between the simulated O 3 concentrations and the experimental results at 6 h from 24%−35% and 17%−49% to 6%−26% and 10%−42% under low- and high-RH conditions, respectively. The maximum incremental reactivity (MIR) of acetaldehyde simulated with the modified MCM is 4.0 ppb ppb −1 without considering the effect of other VOCs.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Yanhui Zhong,Zhaoxia Shi,Taoxiao Wen,Xiaohua Xiao,Gongke Li,Yufei Hu
In this work, a novel cataluminescence(CTL) strategy was developed for fast differentiation of sunscreen cosmetics. The CTL reactions occurring on the surface of sunscreen cosmetics whose characteristic composition served as catalyst. Normalization methodology was utilized to process sensor array signals, we developed a dimensionless quantity called “relative signal ( S kr )” to characterize the sensor response. Firstly, aldehydes are eligible for triggering CTL reactions on the surface of TiO 2 , so they served as probe in the CTL sensor. Then, with four aldehydes as sensor elements, the obtained four S kr of a catalytic material constitute as digital code for rapid screening of nanomaterials. Further, the CTL S kr of different brands and colors of sunscreen cosmetics were obtained. The CTL S kr functioned as digital code which can be used to distinguish sunscreen cosmetics. Intersecting, the CTL signals of the array could be applied to normalize, and identify sunscreen cosmetics of different brands and colors through linear discrimination analysis (LDA). It provides a rapid and convenience platform for distinguishing sunscreen cosmetics, and avoid cumbersome sample preparation. The strategy is a new idea for rapid distinguishing the complex samples based on its special ingredient.
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危险品化学品经营许可证（带存储）