Cancer Medicine
·
2026
·Vol. 15
·期 8
·e72212
·
IF 3.5
Yanmin Zhang,Yaxi Shi,Wenlong Bai
Advanced epithelial ovarian cancer responds poorly to current treatments, creating an urgent need for novel therapeutic strategies. 1,25-dihydroxyvitamin D 3 (1,25D 3 ) exerts potent anti-proliferative effects on ovarian cancer cells in vitro, but the concentrations required for growth suppression in cell culture are not readily achievable in vivo, and higher doses induce hypercalcemia, which hinders its clinical translation. Sodium selenite (Na 2 SeO 3 ) has been identified as a chemopreventive agent that inhibits the growth of multiple cancer types. In this study, we demonstrated that combined treatment with Na 2 SeO 3 and 1,25D 3 exerts enhanced anti-proliferative efficacy against ovarian cancer cells both in vitro and in vivo. Specifically, 1,25D 3 upregulated the expression of vitamin D receptor (VDR) and Selenoprotein-P1 (SEPP1), and this effect was further enhanced by Na 2 SeO 3 co-treatment. Consistently, Na 2 SeO 3 augmented the suppressive effect of 1,25D 3 on ovarian cancer cell proliferation, demonstrating synergistic inhibitory activity. Notably, knockout (KO) of either VDR or SEPP1 abrogated this synergistic effect. Mechanistic investigations confirmed that SEPP1 is a direct target gene of VDR, and functional vitamin D response elements (VDREs) are present within its genomic locus. In vivo, low-dose 1,25D 3 (0.3 μg/kg) combined with Na 2 SeO 3 outperformed 1,25D 3 monotherapy, with no significant hypercalcemia, ascites formation, or metastasis observed throughout the treatment period. These findings indicate that Na 2 SeO 3 acts in combination with 1,25D 3 to induce SEPP1 expression, thereby enhancing the antitumor efficacy of low-dose 1,25D₃ against ovarian tumors. This study provides a promising strategy for the safe and effective application of 1,25D 3 in ovarian cancer therapy.
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Acta Biomaterialia
·
2026
·
IF 10.4
Hao Zhang,Yining Wang,Tian Deng,Jiahui Peng,Xiaxin Ye,Xing Zeng,Jingjing Zhu,Linzhe Huang,Xiaoming Zheng,Yun Li,Yang Kang
Sepsis is a serious syndrome characterized by acute dysfunction of multiple organs, and there is a notable lack of effective preventive strategies and interventions. As a natural anti-inflammatory and antioxidant feedback regulator in the body, itaconic acid can precisely and synergistically modulate anti-inflammatory and antioxidant effects through various mechanisms, providing a metabolic regulation strategy for inflammatory diseases and diseases related to oxidative damage. Previous studies primarily utilized small molecule derivatives of itaconate, such as dimethyl itaconate (DMI) and itaconate 4-octyl ester. However, their in vivo stability and tissue targeting capabilities are often suboptimal, significantly reducing their anti-inflammatory and antioxidant efficacy in disease treatment. Poly itaconic acid (pIA) was synthesized through a one-step polymerization method, and pIA NPs were prepared using nanoprecipitation, effectively addressing the current challenges associated with itaconic acid delivery. Through comprehensive in vitro and in vivo evaluations, the nanoparticles have demonstrated good biocompatibility in the inflammatory microenvironment and can specifically release, thereby enhancing its targeting at the sites of inflammation. In contrast to dimethyl itaconate, pIA NPs exhibited enhanced anti-inflammatory and antioxidant properties, which more effectively safeguard against multi-organ dysfunction caused by sepsis and increase the survival rate in mice. Mechanistic investigations demonstrated that these therapeutic benefits mainly occurred through the facilitation of nuclear factor erythroid 2-related factor 2 nuclear translocation and the reprogramming of macrophages by pIA NPs. Furthermore, the preparation process of the nanoparticles are simple and cost-effective, providing a foundation for the clinical translational application of itaconic acid. Statement of significance This work innovatively developed a simple, safe esterase-responsive polymer delivery system for itaconic acid, solving defects of complex preparation, poor stability and targeting of conventional systems. It advanced sepsis therapy and macrophage metabolic regulation research. For journal readers, it links nanomedicine, immunometabolism and sepsis treatment, providing valuable insights for researchers in inflammatory diseases and drug delivery. Download: Download high-res image (236KB) Download: Download full-size image
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TALANTA
·
2026
·
IF 6.7
Ning Liu,Haishen Zeng,Junhao Lin,Jiewei Deng,Chunyan Hao,Tiangang Luan,Yunyun Yang
Elucidating the effects of pollutants at the level of primary single cells is of great significance for an in-depth understanding of their health risks and toxicological mechanisms. N,N ′-bis (1,4-dimethylpentyl)-p-phenylenediamine quinone (77PDQ) is an emerging environmental contaminant with multiple biological toxicities; however, its toxic effects at the primary single-cell level remain unexplored. In this study, we established a high-throughput single-cell metabolomics platform based on label-free CyESI-MS and applied it to the analysis of freshly isolated primary mouse liver cells for toxicological assessment of 77PDQ exposure at single-cell resolution. This strategy enabled us to capture cell-to-cell metabolic heterogeneity that was lost in conventional bulk measurements. Analysis of primary mouse liver cells revealed 181 significantly altered metabolites (|Log 2 FC|>1, p < 0.05) following 77PDQ exposure. Pathway analysis demonstrated substantial disruptions in glycerophospholipid, arginine-proline, and beta-alanine metabolism. Eight lipid biomarkers (PC (41:6), PS (31:4), Cer (d41:1), TAG (53:2), LPG (18:1), SM (d42:3), FA (23:0), PA (36:2)) showed excellent diagnostic capacity (AUC>0.9). Our study provides the single-cell metabolomics evidence of 77PDQ hepatotoxicity and offers new mechanistic insights into this emerging environmental contaminant.
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Scientific Reports
·
2026
·
IF 4.9
Wang Ying,Zhang Qi,Liu Jiahui,Kuang Hongying,Feng Xiaoling
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder among women of childbearing age and the leading cause of anovulatory infertility worldwide, with the death of granulosa cells implicated in its pathogenesis. However, the mechanisms underlying granulosa cell death remain unclear. Limited research has explored the association between GATA binding factor 1 (GATA1) and adverse pregnancy outcomes, yet its role in PCOS is still elusive. This study established an in vivo PCOS model via dehydroepiandrosterone administration in mice and used ovarian-like KGN cells to explore granulosa cell function. Results showed elevated ovarian GATA1 expression in PCOS mice. Functionally, GATA1 overexpression in KGN cells increased lipid reactive oxygen species, malondialdehyde, and iron, while reducing glutathione. Notably, all these effects of GATA1 were mitigated by a ferroptosis inhibitor Ferrostatin-1. Furthermore, GATA1 knockdown alleviated lipid peroxidation and iron overload in KGN cells induced by a ferroptosis inducer Erastin. Mechanistically, GATA1 directly bound the transferrin receptor (TFRC) promoter to enhance its transcription. Additionally, TFRC overexpression counteracted GATA1 knockdown’s protective effects against Erastin-induced ferroptosis. Collectively, GATA1 promotes granulosa cell ferroptosis via TFRC transcriptional activation, contributing to PCOS pathogenesis. GATA1 regulatory pathways may serve as potential therapeutic targets for PCOS.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 29
·13771-13782
·
IF 5.8
Tian Ying,Yu Shirong,Yu Xuebin,Kang Yongyin
Quantum
dots (QDs) have attracted considerable attention in wearable
electronics owing to their excellent optical properties, including
tunable bandgaps, narrow emission line widths, and high quantum yields.
Nevertheless, the weak chemical interaction between the surface ligands
of QDs and the polar moieties in polymer matrices impairs interfacial
compatibility, leading to ligand desorption and particle aggregation
during electrospinning. Herein, we report a viable strategy for creating
highly luminous QD/polymer nanofibers. Polar solvent processability
was achieved by replacing the pristine ligands with shorter-chain
6-mercaptohexanol (MCH). Through rational optimization of electrospinning
parameters and concentration, the QDs were effectively encapsulated,
achieving a photoluminescence quantum yield (PL QY) of 86.6%. Owing
to the dual protection of the polymer matrix and ligand-engineered
compatibility, the nanofibers exhibited significantly improved stability,
with the QY remaining as high as 84.0% after 36 days under ambient
conditions. Furthermore, a red light-emitting diode was fabricated
based on the nanofiber membranes, exhibiting a color purity exceeding
92.4%. This study provides a practical strategy for developing highly
luminescent and flexible nanofibers, highlighting their great potential
for applications in smart displays, intelligent textiles, and anticounterfeiting.
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Food Science & Nutrition
·
2026
·Vol. 14
·期 8
·e72200
·
IF 5
Fanke Zeng,Yuxiang Zhu,Xiaoyan Li,Ruyi Li,Lei Pan,Yaping Dai,Shaodan Peng,Lei Fang,Jihua Li,Wei Zhou
Litchi seeds are by-products produced from the fruit consumption, which contain rich phenolic compounds and have been traditionally used in inflammatory pain relief. This study sought to reveal phenolic profiles in the litchi seeds from different cultivars and explore their contributions to anti-inflammatory, analgesic potentials. Purified polyphenols were derived from five cultivars of litchi seeds, including Baitangying (BTY), Baila (BL), Feizixiao (FZX), Heiye (HY), and Huaizhi (HZ). Fifteen flavonoids, two phenolic acids, one coumarin, and two tannins were characterized using UPLC-Q/TOF-MS, while procyanidin A 1 , procyanidin A 2 , and phlorizin were identified as major phenolic compounds in HPLC. HY contained relatively higher phenolic contents. The polyphenols from different cultivars effectively inhibited LPS-induced generation of ROS, NO, IL-6, TNF- α , and PGE 2 in RAW 264.7 macrophages, which was tightly associated with the contents of procyanidin A 1 , procyanidin A 2 , and phlorizin. Procyanidin A 1 played a relatively significant role, which could strongly bind to iNOS, COX-2 and their mixture with procyanidin A 2 and phlorizin exhibited better effect in the NO inhibition. Furthermore, the litchi seed polyphenols were demonstrated to inhibit xylene-induced ear edema and acetic acid-induced abdominal writhing in mice. Thus, the litchi seed polyphenols possessed potentials to be utilized as anti-inflammatory and analgesic agents.
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BIOCHEMICAL PHARMACOLOGY
·
2026
·
IF 6.5
Qigen Fang,Xu Zhang,Junhui Yuan,Liyuan Dai,Mingwei Su
Achaete-scute homolog 2 (ASCL2), as a transcription factor, is overexpressed in various tumors and considered to be associated with malignant progression and poor prognosis of tumors. However, whether ASCL2 affects head and neck squamous cell carcinoma (HNSCC) progression has not been studied. We reported that ASCL2 was up-regulated in HNSCC tumor tissues compared to normal tissues, and that this increase was associated with adverse clinical outcomes. Cell-based characteristics revealed the pro-oncogenic effect of ASCL2 overexpression in cell proliferation, colony formation, sphere growth and migration/invasion through facilitating epithelial-mesenchymal transition (EMT). Knocking down ASCL2 resulted in growth arrest of HNSCC cells and the inhibition of malignant behaviors. The xenograft tumor model of ASCL2-expressing cells was larger, more prone to lymph node metastasis (LNM), and exhibited more significant characteristics of cancer stem cells (CSCs) (upregulated CD44, OCT4, and NANOG and increased stem cell frequency). Analysis between mRNA-seq and ChIP-seq showed that ASCL2 regulated the function of SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH). SHPRH was inhibited in ASCL2-expressed HNSCC cells. Mechanistically, ASCL2 suppressed the transcriptional activity of SHPRH, subsequently leading to a weakened ability of SHPRH in inhibiting the proliferation, migration, invasion. Overexpressing SHPRH in ASCL2-expressed HNSCC cells alleviated the malignant behavior of tumor cells. In conclusion, our research revealed that ASCL2 promoted the proliferation, EMT and CSC characteristics of HNSCC cells by transcriptionally inhibiting the expression of SHPRH. Targeting this process might be a promising approach for HNSCC therapy.
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Foods
·
2025
·Vol. 14
·期 12
·2116
·
IF 5.1
Xianghui Yan,Ting Peng,Zheling Zeng,Pengbo Wang,Yifang Gao,Xuefang Wen,Jiaheng Xia,Deming Gong,Ping Yu
Medium chain triglycerides (MCTs) are regarded as an important ingredient for functional foods and nutraceuticals.Cinnamomum camphoraseed kernel oil (CCSKO) contains more than 95% medium chain fatty acids (MCFAs), which is a significantly higher level than palm kernel oil (62%) and coconut oil (55%). However, the safety assessment of CCSKO, as the only natural MCT oil rich in capric acid and lauric acid found so far in the world, has not been fully verified. The study aimed to investigate the 90-day sub-chronic oral toxicity and teratogenicity of CCSKO. In the sub-chronic oral toxicity study, no clinically significant adverse events occurred in male or female Sprague–Dawley (SD) rats with CCSKO daily administration for 13 weeks. Moreover, there were no dose–response relationships between CCSKO and body-weight gain, food intake and food utilization in male or female SD rats. No significant differences (p> 0.05) were found in the hematological properties or organ weights between the male and female SD rats. In the teratogenicity test, no toxicological signs were observed in either Wister pregnant rats or fetuses. The no-observed-adverse-effect level of CCSKO was determined to be more than 4 mL/kg body weight. These results suggested that CCSKO may be an excellent edible oil with high oral safety.
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Boyin Yang,Zilong Jiang,Yang Yang,Bo Jiang,Hong Gao,Yingshuang Shang,Haibo Zhang
Interface thermal resistance is the key factor in influencing the thermal conductivity of filler-reinforced composites. Building a covalent-bond bridge between the resin and filler effectively reduces the interface thermal resistance by creating thermal transmission pathways. A covalent-bonded poly (ether-ether-ketone)/boron nitride (PEEK/BN) composite (i-PEEK/BNNS-FOH) was prepared by functionalizing BN and incorporating it into the in situ polymerization process. With an addition of 30 wt% functionalized BN, the thermal conductivity of i-PEEK/BNNS-FOH reached 1.79 W m −1 K −1 , an increase of 12% over ungrafted PEEK/BN. Foygel's model calculations proved that the modification of BN reduced interface thermal resistance by 48%. Additionally, the improved interface contributed to better mechanical properties, reaching a tensile strength of 97 MPa with a 10 wt% filler addition. This covalent-bond bridging strategy highlights modified BN fillers for high-temperature applications and an efficient method for the preparation of thermally conductive special engineering plastics.
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CHIRALITY
·
2025
·Vol. 37
·期 7
·e70043
·
IF 3
Min Wei,Yinxin Yang,Ruoxi Huang,Linxu Dong,Haikuan Yuan,Lijuan Zhang,Jie Lu
In this work, a novel pair of chiral ionic liquids (CILs) based on cis- and trans-myrtanol was designed, synthesized, and applied in the enantioselective liquid–liquid extraction (LLE) of DL-3-phenyllactic acid (DL-3-PLA). DL-3-PLA, a naturally occurring broad-spectrum antimicrobial compound, exhibits distinct biological activities in its enantiomeric forms, making its separation of significant interest for pharmaceutical and food applications. The CILs were synthesized starting from (1S)-(−)-β-pinene via oxidative hydroboration, followed by subsequent functional group modifications, and were fully characterized using 1 H NMR, FTIR, DSC, and TGA. Optimization of the LLE parameters (0.10-M CILs in n-octanol, 0.10-M DL-3-PLA in water, pH 6.8, 298.15 K) yielded a single-stage enantiomeric excess ( ee ) of 15.68%. Using five consecutive extractions with the trans-CILs isomer, a cumulative ee of 95.18% was achieved. Quantum mechanical calculations, including electrostatic potential analysis, IGMH isosurface mapping, and binding energy evaluations, revealed that both the cis- and trans-CILs isomers exhibited strong chiral recognition toward D-3-PLA, with the trans-CILs isomer showing superior recognition performance compared to the cis-CILs isomer. These results underscore the potential of the designed CILs as effective chiral selectors for the DL-3-PLA separation and provide a promising strategy for practical applications in enantioselective separations.
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Yang Zheng,Guanghong Du,Yi Sun,Jiachen Wang,Wei Liu,Guanghui Cui,Zhanpeng Wu
Carbon fiber-reinforced polymer composites are commonly used in ablative materials, but achieving a balance between thermal insulation, mechanical strength, and anti-ablation performance is challenging. This study presents a series of polyphosphazenes with trichloroethoxy substituents, which enhance the mechanical and thermal properties of the synthesized polyphosphazenes. The effects of different types and amounts of fiberized carbon fillers, including carbon fibers, carbon fiber powder, and carbon nanofibers, on the poly[(2,2,2-trichloroethoxy)/(aryloxy)] phosphazene composites were investigated. The composite reinforced with 10 phr (parts per hundred rubber) of fiberized carbon fillers showed a 49.1% reduction in linear ablation rate and 31.4% in charring ablation rate, compared with the baseline. The mechanical properties of the composite and charred layer improved by 57.5% and 215%, respectively. This is due to the fact that the carbon filler facilitates the formation of dense charred layers with low porosity and high graphitization, which prevent heat and flame penetration. The fiberized carbon-reinforced polyphosphazene composites exhibit excellent ablation resistance and mechanical performance, making them ideal for high-performance thermal insulation in extreme conditions.
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AQUATIC TOXICOLOGY
·
2025
·
IF 4.3
Xue Yang,Qiwei Zhang,Lihua Yang
The subchronic cardiotoxicity of 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ), an unregulated disinfection byproduct with high environmental detection rates, remains poorly characterized. Using integrated multi-omics (transcriptomics, proteomics, phosphoproteomics) and histopathological analyses in zebrafish, this study systematically elucidated its dose-dependent (low-dose, 10 nM; medium-dose, 100 nM; high-dose, 1000 nM) cardiotoxicity, from adaptive remodeling to failure, over a 35-day exposure period. A reduction in atrioventricular inflow ranging from 81.4 % to 93.9 %, along with lipid droplet accumulation and Z-disc rupture, indicate a dose-dependent cardiac crisis induced by 2,6-DCBQ. Multi-omics analyses, revealed that the kinase cascade involving braf (Myhpc2_T1545), camk2a (Mybpc3_S291), and mark3b (Ttn.1_S28131) arranged dose-dependent cytoskeletal remodeling. High-dose exposure initiated an inflammation-cytoskeleton vicious cycle, wherein chemokine-driven collagen degradation exacerbated Z-disc rupture, while lipotoxic lipid droplets recruit inflammatory infiltrates, collectively escalating irreversible cardiac decompensation. These findings demonstrate that subchronic exposure to 2,6-DCBQ initiates cardiac remodeling, escalating cardiovascular susceptibility in exposed populations.
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