ADVANCED MATERIALS
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2023
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IF 29.4
Ying Chen,Zeyu Liang,Qiyue Wang,Lin Xiao,Shangzhi Xie,Shengfei Yang,Xun Liu,Daishun Ling,Fangyuan Li
The alpha-synuclein (α-syn) oligomers hold a central role in the pathology of Parkinson's disease (PD). Achieving accurate detection of α-syn oligomers in vivo presents a promising avenue for early and accurate diagnosis of PD. Magnetic resonance imaging (MRI), with non-invasion and exceptional tissue penetration, offers a potent tool for visualizing α-syn oligomers in vivo. Nonetheless, ensuring diagnostic specificity remains a formidable challenge. Herein, a novel MRI probe (ASOSN) is introduced, which encompasses highly sensitive antiferromagnetic nanoparticles functionalized with single-chain fragment variable antibodies, endowing it with the capacity for discerning recognition and binding to α-syn oligomers and triggering a switchable T1–T2 MRI signal. Significantly, ASOSN possesses the unique capability to accurately discriminate α-syn oligomers from neuroinflammation in vivo. Moreover, ASOSN facilitates the non-invasive and precise visualizing of endogenous α-syn oligomers in living systems. This innovative design heralds the development of a non-invasive visualization strategy for α-syn oligomers, marking a pivotal advancement for early and accurate diagnosis of PD.
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JOURNAL OF THE ENERGY INSTITUTE
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2021
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IF 6.186
Lin Hu,Xian-Yong Wei,Yu-Hong Kang,Xian-Hou Guo,Mei-Ling Xu,Zhi-Ming Zong
Recently high yield of cycloalkanes originates from selective hydrodeoxygenation (HDO) of lignin-derived bio-oil under mild conditions, which still encounters the great challenges. Herein, mordenite-supported ruthenium bifunctional catalyst (Ru 3% /M) was prepared by using the deposition-precipitation (DP) method for the HDO reaction of the petroleum ether-extractable portions (PEEP) from alkali catalytic ethanolysis of lignin (CEOL). Ru 3% /M catalyst was characterized systematically by XRD, XPS , FTIRS , NH 3 -TPD, N 2 -adsorption, SEM , and TEM, indicating that it had the moderate acid sites and uniform Ru nanoparticles dispersion. The synthesized catalyst was further tested for the HDO performance of diphenyl ether, oxybis(methylene)dibenzene, and anisole, respectively. Results showed that three lignin model compounds can be converted to high yield of cycloalkanes under 160 °C and 3 MPa H 2 in n -hexane. This catalyst showed the high catalytic activity for diphenyl ether HDO reaction, the conversion decreased slightly to 87.6% after five recycle times. Furthermore, catalyst feed mass was the key factor for HDO reaction of raw PEEP from CEOL, promoting the HDO reaction process to produce high yield of cycloalkanes. Interestingly, the mass ratio between catalyst feed and raw PEEP was 1, thus 74.36% relative content (RC) of cycloalkanes can be obtained. The upgraded PEEP from CEOL has potential to be used as clean liquid fuels.
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FUEL PROCESSING TECHNOLOGY
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2021
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IF 7.033
Xiangchen Kong,Chao Liu,Weicong Xu,Yue Han,Yuyang Fan,Ming Lei,Ming Li,Rui Xiao
Stubborn lignin (SL) is the thermochemically stable fragment generated from biomass utilization (e.g., pyrolysis , hydrolysis, fermentation, pulping), which is comparatively difficult to be further depolymerized into value-added bio-products. The cleavage of the stubborn linkages within the structure of SL, such as C C, α -O-4, and 4-O-5 linkages, is the key for its valorization. Herein, we investigated the depolymerization of SL through catalytic hydroprocessing in supercritical methanol with Cu/CuMgAlO x catalyst. The yield of monomers reached 37.76C% with 240 min at 300 °C. Cyclohexanols were identified as the major monomeric products, indicating the occurrence of hydrodeoxygenation and hydrogenation. GPC , quantitative 13 C NMR, HSQC NMR, and HMBC NMR analyses evidenced the depolymerization of SL and upgrading of its derivatives. Furthermore, the mechanistic studies were carried out to provide insights to the stubborn linkage cleavages. The degrees of difficulty to break up the three involved linkages obeyed the sequence of β -5 > 4-O-5 > α -O-4. The apparent activating energies ( E a ), chemisorption energies ( E c ), and bond dissociation energies (BDE) were determined computationally to support the experimental results from the perspectives of kinetics, chemisorption, and thermodynamics, respectively. This research provides a reliable way for the utilization of SL.
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ACS Applied Energy Materials
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2021
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IF 6.024
Xiangchen Kong,Chao Liu,Baolong Wang,Weicong Xu,Yuyang Fan,Ming Li,Rui Xiao
A complex copper acid catalyst (SA-Cu/CuMgAlOx) was developed with boosted catalytic activity for the hydrodeoxygenation (HDO) of lignin-derived phenolics. Remarkably, the yields of total monomers and cyclohexanes from the HDO of lignin pyrolysis bio-oil were significantly improved after the catalyst modification with salicylic acid, which increased by 17 and 40%, respectively, at 300 °C for 8 h. The catalyst characterizations revealed that acidic oxygen-containing functional groups (−OH and −COOH) were introduced onto the catalyst surface without corrosion to the metallic framework. The acidic groups contributed to the formation of surface Brønsted acid sites, which participated in the hydrogenolysis and dehydroxylation reactions of the phenolics in bio-oil. The catalyst was deactivated after four cycles of bio-oil HDO and could be recovered after the removal of carbon deposits and the reactivation of Cu species. The results offered appealing opportunities for tailoring more efficient copper-containing catalysts for the HDO of lignin-based phenolics.
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JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-14
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IF 10.435
Liu Qinmin,Liu Lijuan,Mo Chunwei,Zhou Xiao,Chen Dongming,He Yu,He Hailu,Kang Wei,Zhao Yongfeng,Jin Guanqiao
Background Nasopharyngeal carcinoma (NPC) is a type of head and neck malignant tumor with a high incidence in specific regional distribution, and its traditional therapies face some challenges. It has become an urgent need to seek new therapeutic strategies without or with low toxicity and side effects. At present, more and more researchers has been attracting attention by nanotheranostic platform. Therefore, our team synthesized the polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X (USPIO-PEG-sLex) nanotheranostic platform with high temperature pyrolysis.Results The USPIO-PEG-sLex nanoparticles had excellent photothermal conversion property, and the temperature of USPIO-PEG-sLex nanoparticles solution increased with its concentration and power density of near-infrared (NIR) on 808 nm wavelengths. Five USPIO-PEG-sLex nanoparticles with different concentrations of 0 mg/ml, 0.025 mg/ml, 0.05 mg/ml, 0.1 mg/ml and 0.2 mg/ml were prepared. The biological toxicity results showed that the viability of NPC 5-8F cells is related to the concentration of USPIO-PEG-sLex nanoparticles and the culture time (P < 0.001). The results of photothermal therapy (PTT) in vitro indicated that the viability of 5-8F cells decreased significantly with the concentration of USPIO-PEG-sLex nanoparticles increases (P < 0.001), and the viability of NPC 5-8F cells were 91.04% ± 5.20%, 77.83% ± 3.01%, 73.48% ± 5.55%, 59.50% ± 10.98%, 17.11% ± 3.14%, respectively. The USPIO-PEG-sLex nanoparticles could target the tumor area, and reduce the T2* value of tumor tissue. The T2* values of tumor pre- and post-injection were 30.870 ± 5.604 and 18.335 ± 4.351, respectively (P < 0.001). In addition, USPIO-PEG-sLex nanoparticles as a photothermal agent for PTT could effectively inhibit tumor progression. The ratio of volume change between tail vein injection group, control group, nanoparticles without laser irradiation group and blank group after 5 treatments were 3.04 ± 0.57, 5.80 ± 1.06, 8.09 ± 1.96, 7.89 ± 2.20, respectively (P < 0.001).Conclusion sOur synthesized USPIO-PEG-sLex nanotheranostic platform, and it may be become a new strategy for the treatment of NPC.Graphic Abstract
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-11
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IF 14.919
Liang Zeyu,Wang Qiyue,Liao Hongwei,Zhao Meng,Lee Jiyoung,Yang Chuang,Li Fangyuan,Ling Daishun
Histopathological level imaging in a non-invasive manner is important for clinical diagnosis, which has been a tremendous challenge for current imaging modalities. Recent development of ultra-high-field (UHF) magnetic resonance imaging (MRI) represents a large step toward this goal. Nevertheless, there is a lack of proper contrast agents that can provide superior imaging sensitivity at UHF for disease detection, because conventional contrast agents generally induce T2 decaying effects that are too strong and thus limit the imaging performance. Herein, by rationally engineering the size, spin alignment, and magnetic moment of the nanoparticles, we develop an UHF MRI-tailored ultra-sensitive antiferromagnetic nanoparticle probe (AFNP), which possesses exceptionally small magnetisation to minimize T2 decaying effect. Under the applied magnetic field of 9 T with mice dedicated hardware, the nanoprobe exhibits the ultralow r 2 / r 1 value (~1.93), enabling the sensitive detection of microscopic primary tumours (<0.60 mm) and micrometastases (down to 0.20 mm) in mice. The sensitivity and accuracy of AFNP-enhanced UHF MRI are comparable to those of the histopathological examination, enabling the development of non-invasive visualization of previously undetectable biological entities critical to medical diagnosis and therapy.
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POLYMER TESTING
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2020
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IF 3.275
Lidong Feng,Sheng Xiang,Yanlong Liu,Xinchao Bian,Gao Li,Xuesi Chen
An analytical method was developed to quantitatively determine residual monomers, namely, lactide (LA) and ε -caprolactone (CL), in poly(lactide- co - ε -caprolactone) (PLCL) using an internal-standard method of gas chromatography (GC). PLCL and diphenyl ether (DPE) as an internal standard were initially dissolved in dichloromethane (DCM), and then PLCL was precipitated in cyclohexane. The residual LA and CL monomers in PLCL, as well as DPE, were extracted into cyclohexane from the polymer solution. The resulting solution was directly injected into a GC system. This method was practical for measuring the residual LA and CL contents in PLCL. The relative standard deviation ( RSD ) ( n = 5) denoting the repeatability of this method was less than 5.6% and 4.3% for the LA and CL measurements, respectively, indicating that the method was sufficiently precise. The recovery rate of standard addition was 96.5%–101.5% and 98.4%–104.2% for the determination of LA and CL in PLCL, respectively. The RSD of the recovery of standard addition ( n = 5) was not more than 2.0%, indicating that the method was sufficiently accurate.
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CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Beili Pang,Meili Zhang,Cheng Zhou,Hongzhou Dong,Shuai Ma,Jianguang Feng,Yingjie Chen,Liyan Yu,Lifeng Dong
The development of low cost electrocatalysts with excellent I − /I 3 − redox reaction efficiency is critically important for practical applications of dye-sensitized solar cells (DSSCs). Nevertheless, it is difficult to simultaneously improve the activity and stability of catalysts. Herein, heterogeneous FeNi 3 /NiFe 2 O 4 nanoparticles are successfully embedded in modified graphene (mGr) matrix with network structure. As-prepared FeNi 3 /NiFe 2 O 4 @mGr shows excellent electrocatalytic activities and high stability. The DSSCs with FeNi 3 /NiFe 2 O 4 @mGr as counter electrodes demonstrate a high power conversion efficiency of 12.14%, which is superior to that of platinum (Pt, 8.31%). Also, the FeNi 3 /NiFe 2 O 4 @mGr device remains 90% efficiency up to 42 days under ambient conditions without encapsulation. Therefore, the FeNi 3 /NiFe 2 O 4 @mGr composite can be further developed as an environmentally friendly, inexpensive, and efficient counter electrode material for DSSCs.
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ACS Applied Materials & Interfaces
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2020
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IF 8.758
Lei Zhang,Feng Wei,Qianqian Bai,Danhong Song,Zhuofan Zheng,Yafei Wang,Xin Liu,AL-Ammari Abdulrahman,Yingxin Bian,Xuran Xu,Chuntao Chen,Hongsong Zhang,Dongping Sun
Despite the widely explored biomaterial scaffolds in vascular tissue engineering applications lately, no ideal platform has been provided for small diameter synthetic vascular grafts mainly due to the thrombosis issue. Endothelium is the only known completely non-thrombogenic material; so, functional endothelialization onto vascular biomaterials is critical in maintaining the patency of vascular networks. Bacterial cellulose (BC) is a natural biomaterial with superior biocompatibility and appropriate hydrophilicity as potential vascular grafts. In previous studies, surface modification of active peptides such as Arg-Gly-Asp (RGD) sequences onto biomaterials has been proven to achieve accelerated and selective endothelial cell (EC) adhesion. In our study, we demonstrated a new strategy to remotely regulate the adhesion of endothelial cells based on an oscillating magnetic field and achieve successful endothelialization on the modified BC membranes. In details, we synthesized bacterial cellulose (BC), magnetic BC (MBC), and RGD peptide-grafted magnetic BC (RMBC), modified with the HOOC-PEG-COOH-coated iron oxide nanoparticles (PEG-IONs). The endothelial cells were cultured on the three materials under different frequencies of an oscillating magnetic field, including “stationary” (0 Hz), “slow” (0.1 Hz), and “fast” (2 Hz) groups. Compared to BC and MBC membranes, the cells on RMBC membranes generally show better adhesion and proliferation. Meanwhile, the “slow” frequency of a magnetic field promotes this phenomenon on RMBC and achieves endothelialization after culture for 4 days, whereas “fast” inhibits the cellular attachment. Overall, we demonstrate a non-invasive and convenient method to regulate the endothelialization process, with promising applications in vascular tissue engineering.
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POLYMER
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2020
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IF 4.231
Xian-Ling Yang,Wan-Xia Wu,Jun Li,Zu-E. Hu,Na Wang,Xiao-Qi Yu
Aliphatic polyesters have led to significant advancements in drug delivery systems spanning decades owing to their biocompatibility and biodegradability . A series of pH-sensitive aliphatic polyesters were synthesized by facile enzymatic polymerization , which could be post-modified by click chemistry to form multifunctional graft copolymers . Typically, the hydrophilic methoxy polyethylene glycol (mPEG) and fluorescent coumarin were grafted onto the polyester backbone to constitute a multifunctional amphipathic graft copolymer , serving as a trackable pH-responsive drug delivery vehicle . This amphipathic graft copolymer could encapsulate hydrophobic doxorubicin (DOX) via self-assembly in aqueous solutions and performed superior controlled drug release . And the in vitro cellular uptake and cytotoxicity results showed the feasibility of this system for drug delivery application. Collectively, this copolymer offers a potential route of constructing controlled drug delivery system.
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ACS Applied Energy Materials
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2020
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IF 4.473
Yueli Liu,Xizhu Zhao,Zifan Yang,Qitao Li,Wei Wei,Bin Hu,Wen Chen
Perovskite solar cells (PSCs) have developed rapidly in the past 10 years. However, they are faced with a huge challenge for stability improvement because of the volatile organic components in the light absorption and hole transporting layer. Herein, we fabricate all-inorganic PSCs with the structure of FTO/c-TiO2/m-TiO2/CsPbI3 quantum dots (QDs)/Cu12Sb4S13 QDs/Au to improve device stability. To enhance the photovoltaic performance of PSCs, the surface oleylamine ligands of Cu12Sb4S13 QDs with 3-mercaptopropionic acid are exchanged, as the enhanced electronic coupling and reduced band gap are realized after the ligands exchange. Cu12Sb4S13 QD based PSCs exhibit a PCE of 10.02%, approaching that of the spiro-MeOTAD based PSCs (12.14%). A high short-circuit current density of 18.28 mA cm–2 is achieved because of the enhanced light absorption and excellent hole extraction ability of Cu12Sb4S13 QDs. Moreover, Cu12Sb4S13 QD based PSCs exhibit the improved long-term stability and retain 94% of their initial PCE after storage in ambient air for 360 h.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2020
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IF 4.65
Guanjie Xing,Min Huang,Simeng Hao,Chuansheng He,Xiaohong Li,Louzhen Fan,Yunchao Li
To obtain high-capacity electrode materials and meanwhile actualize the reuse of scrap lead paste, a novel alkylamine-mediated thermolysis route is proposed herein for one-pot preparation of high-quality PbO nanomaterials , relying on the thermal decomposition of lead carboxylate in hot solvent in the presence of hexadecylamine (HDA). This synthetic route allows us to produce uniform PbO nanowires with a diameter of 7.1 nm and a length beyond 10 μm, and nanosheets and nanorings with a lateral size of ca. 310 nm on a gram scale, by simply tuning the alkylamine content or reaction time. In particular, we have employed various means to unveil the key role of HDA, i.e., precursor activation and surface passivation function, in the controlled preparation of such PbO nanomaterials. Impressively, when serving as the positive active materials for lead acid batteries (LABs), the anodes based on PbO nanowires displayed an excellent discharge performance: its discharge capacity and active material utilization ratios could reach 164.3 mA h/g and 68.5% respectively even at a discharge current density as high as 50 mA/g, which are superior to most of the previously-reported values. Such an excellent discharge performance was speculated to result from the synergization effect of the large ECSA, small charge transfer resistance and highly active exposed facets associated with the PbO nanowires.
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