ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Yuqian Liu,Qingsheng Guo,Xiaojun Qu,Qingjiang Sun
The combination of functional nucleic acids and nanomaterials enables the continuous development of hybrid nanosystems that have found wide applications including chemo/biosensing. Herein, we report the supramolecular assembly of a “sesame biscuit”-like superstructural nanosystem based on aptamer, quantum dot (QD), and graphene oxide (GO), and its diverse applications in Pb2+ and pH sensing. The nanosystem was assembled via adsorbing silica-encapsulated green-emitting QD onto the edge of GO by ionic interaction, followed by absorbing aptamer-modified red-emitting QD onto the GO surface via the π-stacking interaction. The nanosystem showed the characteristic of the nonquenched green fluorescence due to silica encapsulation and quenched red fluorescence owing to nanomaterial surface energy transfer. The nanosystem responded to Pb2+/pH in ratiometric fluorescence: the red fluorescence varied upon analyte-driven conformational changes of the aptamer, whereas the green one remained constant. Under optimized conditions, the nanosystem was demonstrated to be capable of quantifying Pb2+ with a detection limit of 11.7 pM, as well as pH with a sensing resolution of 0.1 pH unit. More importantly, the ratiometric nanosystem facilitated visualization of analytes in a distinct “traffic light” manner, which was exemplified by semiquantification of exogenous Pb2+ in living cells. To demonstrate practicality, fluorescent test strips were fabricated by immobilizing the nanosystem on paper. The fluorescent test strips displayed traffic light-type fluorescence color changes, with the capacity for on-site, naked-eye detection of Pb2+ in real samples, as well as point-of-care pH testing in routine urinalysis.
研究领域:
分析化学
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纳米技术
·
生物传感
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2024
·
IF 6.4
Sai Wang,Xunchang Yan,Tong Zhang,Lin Li,Ru Li,Seeram Ramakrishna,Yun-Ze Long,Wenpeng Han
Wearable multi-functional sensor with practical features is crucial for applications in many areas such as e-skin, health monitoring, and human-computer interaction. Herein, an all-nanofiber flexible breathable iontronic sensor based on polyacrylonitrile (PAN) nanofiber membrane doped with ionic liquid (IL) is prepared by electrospinning technique. Compared to the traditional capacitor's electrode-dielectric-electrode sandwich structure, an undoped PAN nanofiber membrane is added between the electrode and the dielectric layer as the spacer. The iontronic sensor demonstrated an impressive linear response in pressure ranges of 0–50 and 50–300 kPa, with linearity values of R 1 2 = 0.992, R 2 2 = 0.998 by adjusting the thickness of the spacer. Additionally, the iontronic sensor demonstrates excellent temperature response attributed to the thermal sensitivity of the IL. It exhibits high sensitivities of 8.5, 31.8, and 71.1% °C −1 , along with low detection limits of 0.5°C, across temperature ranges of 20–40, 40–55, and 55–80 °C, respectively. To validate the sensor for practical applications, its uses are demonstrated in various scenarios, such as body joint flexion, heartbeat monitoring, encrypted messaging, and temperature-sensitive gloves. This study enables the integration of pressure and temperature sensing functions to develop diverse and integrated designs for wearable electronic devices.
研究领域:
材料科学
·
生物医学工程
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yun-Fan Wang,Xiao-Yang Zhang,Jun-Yang Liu,Yuan-Jun Song,Yu-Qing Ni,Ze-Xian Chen,Yuan-Chun Li,Tong Zhang
The widespread use of human–computer interaction has generated enormous interest in stretchable and wearable electronic devices, such as smart gloves, wearable mice, electronic skins, and other sensors capturing deformation signals on human skins. The main challenge of such devices lies in monitoring multi-level human motions such as bending, stretching, and pressing. Developing new materials and fabrication methods is indispensable to tackle this challenge. In this paper, we propose a multi-model and naked-hand wearable sensing system based on Ag and thermoplastic polyurethane (Ag-TPU) composite with porous microstructure and direct writing technology which implements pressure sensing and strain sensing simultaneously. Dynamic response test illustrates that motion frequencies from 0.24 s −1 to 0.88 s −1 can be detected, covering the typical frequency of clicking operation on a mouse, with the response time between 156 ms and 609 ms at the frequency of 0.88 s −1 . Due to the protection of TPU polymer, this material remains stable and effective in1400 bends at a bending curvature from 0.17 to 0.2. These characteristics, along with the low cost, high sensing sensitivity, simple production procedure, biocompatibility, and wearability on the naked hand, make our material match the actual requirements of human–computer interaction mice. With an extra inertial measurement unit, the mouse can distinguish different gestures and finger movements in various frequencies. Through our test, it can control the cursor and paint on computers with the multi-model characteristic. Therefore, our wearable virtual mouse demonstrates a new way to match flexible materials with human–computer interaction interfaces, extending the application of Ag-TPU composite with multi-model sensing while ensuring the timeliness and accuracy of information transfer in the process of human–computer interaction.
研究领域:
材料科学
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电子工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscience and Nanotechnology Letters
·
2020
·Vol. 12
·期 9
·1079-1086
·
IF 1.128
Hao Haitao
At present, chemical biosensors still have poor reproducibility and stability due to that the density of nanomaterials particles is not ideal. Therefore, an optimal design method of electrochemical biosensor based on gold nanomaterials is proposed. Two types of sensors, namely DNA biosensor
and immune biosensor, were designed in this work. A DNA biosensor with gold nanorod nanocomposite modified electrode was prepared, and its electrical activity was measured by Methylene blue. In contrast, an electrochemical immune sensor with gold nanorod-modified electrode was prepared and
used for detection of alpha fetoprotein. The experimental results show that the designed DNA biosensor and electrochemical immune sensor have the advantages of simple preparation, high sensitivity, good selectivity and good stability.
研究领域:
生物传感技术
·
纳米生物学
·
医学检测
✓ 已验证
DOI
高影响因子
Nano Energy
·
2023
·
IF 17.6
Jin Xu,Hanfang Feng,Jinwei Cao,Binran Zhang,Wandi Bao,Luohaoran Wang,Yiming Yin,Huayang Li,Guang Zhu
Wearable sensing electronics capable of detecting and differentiating multiple mechanical stimuli are promising devices in the applications of healthcare monitoring, robotics, etc. However, most wearable sensors are developed for detecting only uniaxial mechanical stimuli, which severely hinders their practical applications that usually involve complex mechanical stimuli. Here, a wing-like multifunctional sensor (WMS) consisting of pressure sensing module in the middle and stretching sensing module in both wings is developed with the capability of detecting and differentiating pressure, stretching, convex and concave bending through distinct electrical signals variation trends. The hierarchical in-situ filling porous as pressure sensing layer and micro-wrinkled carbon nanotubes (CNTs)/Ag nanoflakes as stretch sensing layer achieve high sensitivity over a broad range in both pressure (sensitivity of 0.25 kPa −1 at 500 kPa) and strain sensing (Gauge factor of 140 at 150%). The pressure and stretch sensing module can work without interfering with each other, which is realized by structural design of lower Young’s modulus stretch sensing module and higher thickness and compressibility pressure sensing module. Then WMS is demonstrated in accurate detection of human kinesthesia, human-computer interface, identification of objects of various hardnesses and sizes by robotic gripper , and perception of environmental information through a crawling robot.
研究领域:
生物医学工程
·
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yan Zhu,Dahu Yao,Xiping Gao,Jing Chen,Hui Wang,Tianyan You,Chang Lu,Xinchang Pang
Multimodal flexible sensors, consisting of multiple sensing units, can sense and recognize different external stimuli by outputting different types of response signals. However, the recovery and recycling of multimodal sensors are impeded by complex structures and the use of multiple materials. Here, a bimodal flexible sensor that can sense strain by resistance change and temperature by voltage change was constructed using poly(vinyl alcohol) hydrogel as a matrix and poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) as a sensing material due to its conductivity and thermoelectric effect. The plasticity of hydrogels, along with the simplicity of the sensor’s components and structure, facilitates easy recovery and recycling. The incorporation of citric acid and ethylene glycol improved the mechanical properties, strain hysteresis, and antifreezing properties of the hydrogels. The sensor exhibits a remarkable response to strain, characterized by high sensitivity (gauge factor of 4.46), low detection limit (0.1%), fast response and recovery times, minimal hysteresis, and excellent stability. Temperature changes induced by hot air currents, hot objects, and light cause the sensor to exhibit high response sensitivity, fast response time, and good stability. Additionally, variations in ambient humidity and temperature minimally affect the sensor’s strain response, and temperature response remains unaffected by humidity changes. The recycled sensors are essentially unchanged for bimodal sensing of strain and temperature. Finally, bimodal sensors are applied to monitor body motion, and robots to sense external stimuli.
研究领域:
材料科学
·
传感器技术
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生物医学工程
·
纳米技术
·
机器人学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Electronic Materials
·
2025
·
IF 4.7
Jifeng Pan,Yunsong Li,Tian Tian,Zilong Tang,Zichao Lian,Nan Ma
The development of advanced humidity sensors is becoming increasingly essential for the progression of various industries, particularly for integration with IoT devices. Consequently, the creation of high-performance humidity sensors is of paramount importance. In this study, we present a highly sensitive humidity sensor based on the ferroelectric oxide BiFeO3, which is further enhanced by the incorporation of the hydrophilic inorganic salt NaCl. By optimizing the NaCl content and the thickness of the sensing film, the 15 wt % NaCl-BiFeO3 sensor with a film thickness of 68 μm demonstrated an exceptional response of 10,073 as the relative humidity was varied from 13 to 86% RH at room temperature, representing a 46.3-fold enhancement compared to pure BiFeO3-based sensors. The sensor also exhibited rapid response and recovery times of 0.27 and 5.73 s, respectively. The excellent humidity sensing performance can be attributed to the increased electrical conductivity, which results from the generation of free ions due to NaCl dissolution in adsorbed water under high humidity conditions. Furthermore, this highly sensitive sensor is well-suited for noncontact applications, such as human respiratory monitoring and contactless control. This work underscores the potential of NaCl-BiFeO3 as a highly promising material system for high-performance humidity sensors in smart sensing applications.
研究领域:
材料科学
·
物联网技术
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Donghui Kou,Ruicheng Lin,Chang Li,Shufen Zhang,Wei Ma
Bioinspired adaptive coloring strategies advance the investigation of responsive photonic crystal (PC) colors for environmental visual sensing, but are being encumbered by inherent strong angle-dependent structural colors of their highly ordered photonic microstructures. Herein, imitating hexagonal pit array on the elytral surface of a male beetle- Chlorophila obscuripennis and utilizing optically isotropic features of the unique concave axisymmetric geometry, biomimetic micro-sized bowl-array enabled angle-independent and flexible one-dimensional PC colors are first demonstrated based on transfer printing technique which is certified as a facile, energy efficient and universal nanofabrication strategy. The photonic films assembled by functional copolymers and inorganic oxides are successfully transferred onto bowls on the surface of polydimethylsiloxane, exhibiting flexible and brilliant pixel array-like non-iridescent colors. Even after being twisted and stretched, water-washing and rubbing, the nanomaterial-based photonic films on the bowls still show glossy and stable angle-independent colors, presenting powerful strengths for practical visual sensing. In practical terms, functional copolymers based PC films on the bowls are developed as humidity and organic solvents colorimetric sensors free of angles with desirable sensitivity, remarkable durability and repeatability. And integrating photonic multilayered films with different response features, multi-mode pattern displays are realized. The remarkable sensing and display applications reflect the high values of the novel bowls enabled angle-independent photonic color building strategy.
研究领域:
材料科学
·
光学工程
·
生物仿生学
✓ 已验证
DOI
高影响因子
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
·
2025
·
IF 4.5
Zheng Gong,Xiang Chen,Shanaz X. Chen,Jun Hu,Yifan Chen
Electromagnetic nanosensor network (ENSN) is an innovative technological concept that focuses on using electromagnetic technologies like microwaves and millimeter-waves for advanced biomedical applications. ENSNs enable highly sensitive detection of a phenomenon of interest (POI) through electromagnetic radiation. ENSNs are composed of interconnected nanoscale sensors that utilize electromagnetic principles to sense and communicate useful low-level physiological signals within the body. This article presents a novel microgels-based ENSN for microwave glucose monitoring, and the research contributions can be summarized into two main aspects. First, a new type of microgel-based sensor (MBS) sensitive to microenvironmental conditions is manufactured, and a comprehensive material characterization of dielectric constant is performed. The corresponding models provide critical insights into the potential biomedical applications of the microgels. Second, a microgels-oriented ENSN system is proposed to enable the acquisition of human physiological signals, including manufactured implantable and external sensors (i.e., MBSs and antennas), related circuits, and miniaturized signal transceivers. Moreover, a novel sensing strategy based on machine learning is proposed for accurate disease feature recognition using multiple pairs of sensors, which includes a differential sensing step to eliminate unwanted interference due to tissue heterogeneity and a data fusion step to improve system reliability. To verify the proposed ENSN, the feasibility of classifying blood glucose between hyperglycemia and hypoglycemia is investigated. By incorporating the microgels-based sensor, the proposed system significantly outperforms traditional microwave medical sensing (MMS) methods using only the external electromagnetic sensor (EMS), achieving remarkable 46% and 53% improvements in numerical and experimental classification performance.
研究领域:
生物医学工程
·
材料科学
·
医学信号处理
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Fei Wang,Xiaojing Wu,Wenao Liao,Ting Li,Yidan Hu,Yan Zhu,Chang Lu,Junwei Feng,Xilin Liu
Bimodal flexible strain–temperature sensor arrays, capable of simultaneously detecting mechanical and thermal stimuli, show great potential in wearable electronics and human–machine interaction applications. However, existing hydrogel-based bimodal sensors commonly suffer from signal crosstalk, insufficient sensitivity, and poor structural reconfigurability. To address these challenges, this work proposes a modular “building-block” assembly strategy to construct a flexible multimodal hydrogel sensor array with effective strain–temperature signal decoupling and high sensitivity. The strain sensing units are composed of polyacrylamide/chitosan (PAM/CS) hydrogels, while the temperature sensing units are fabricated by sequentially coating chitosan (CS) and poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) on polyacrylamide/sodium alginate (PAM/SA) hydrogels. Electrostatic interactions among CS, SA, and PEDOT:PSS ensure stable interfacial bonding, while Ca 2+ crosslinking enhances the rigidity of PAM/SA, inducing strain concentration in the PAM/CS region to achieve signal decoupling. The strain concentration effect significantly improves strain sensitivity with a gauge factor up to 8.82, and the constructed energy-filtering interface elevates the Seebeck coefficient to 128.59 μV/K, endowing the device with excellent temperature sensing performance (detection limits for strain and temperature difference are 0.1 % and 0.3 °C, respectively). Moreover, the hydrogel materials exhibit good cytocompatibility and hemocompatibility, further ensuring their safe integration into wearable systems. This sensor array is applicable in sign language recognition, intelligent password input, and other scenarios, demonstrating broad application prospects.
研究领域:
生物医学工程
·
柔性电子
·
可穿戴设备
·
传感器技术
·
人机交互
·
材料科学
·
转化医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zichun Lu,Lingke Liu,Runtian Miao,Ning Zhang,Minjuan Gao,Xingyu Fan,Yueqin Li
The ultrafast preparation of electrically conductive hydrogels to endow high sensing performance and temperature tolerance remains a critical challenge. Herein, lignosulfonate sodium-templated polypyrrole (LS-PPy) nanofillers were rapidly introduced into polyacrylic acid (PAA) hydrogel through ultrafast free radical polymerization in a glycerol/water binary solvent system. The resultant LS-PPy/PAA electrically conductive organohydrogel possesses satisfactory mechanical performance (strength of 56 kPa at a tensile strain of 800 %), strong adhesion, and a desirable low freezing point (−35 °C). Furthermore, this organohydrogel exhibits high strain sensitivity (gauge factor = 2.65), fast response time (∼160 ms), low signal hysteresis, and excellent cyclic stability (over 1200 cycles). And the wearable LS-PPy/PAA organohydrogel sensor could accurately and real-time monitor various intense or subtle human movements, such as joint bending, facial expression and hand writing. Besides, the developed LS-PPy/PAA temperature sensor can respond to environmental temperature variations over a wide range of −20–100 °C. High resolution of 0.5 °C with remarkable sensitivity (−0.80 %/°C and linearity of R 2 = 0.99) and repeatability were achieved within 36.5–40 °C, which makes it suitable for human body temperature monitoring. All these results demonstrate the substantial prospective value of the LS-PPy/PAA hydrogel in wearable sensors and other associated fields.
研究领域:
材料科学
·
传感器技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Jie Chen,Xiaolu Xia,Xiaoqian Yan,Wenjing Wang,Xiaoyi Yang,Jie Pang,Renhui Qiu,Shuyi Wu
Flexible piezoresistive sensors are core components of many wearable devices to detect deformation and motion. However, it is still a challenge to conveniently prepare high-precision sensors using natural materials and identify similar short vibration signals. In this study, inspired by microstructures of human skins, biomass flexible piezoresistive sensors were prepared by assembling two wrinkled surfaces of konjac glucomannan and k-carrageenan composite hydrogel. The wrinkle structures were conveniently created by hardness gradient-induced surface buckling and coated with MXene sheets to capture weak pressure signals. The sensor was applied to detect various slight body movements, and a machine learning method was used to enhance the identification of similar and short throat vibration signals. The results showed that the sensor exhibited a high sensitivity of 5.1 kPa–1 under low pressure (50 Pa), a fast response time (104 ms), and high stability over 100 cycles. The XGBoost machine learning model accurately distinguished short voice vibrations similar to those of individual English letters. Moreover, experiments and numerical simulations were carried out to reveal the mechanism of the wrinkle structure preparation and the excellent sensing performance. This biomass sensor preparation and the machine learning method will promote the optimization and application of wearable devices.
研究领域:
材料科学
·
生物医学工程
·
人工智能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）