Aggregate
·
2025
·
IF 13.7
Yingping Tong,Birong Wang,Dongyu Zhao,Min Li,Ben Zhong Tang
Parathyroid hormone (PTH) is an important factor in maintaining blood calcium levels in the human body. Therefore, monitoring PTH levels is essential for assessing the various diseases progression and managing overall health. In this study, a fluorescence and optical sensor based on an aggregation-induced emissive liquid crystal photopolymer (AIE-LC-Poly) film was established for the qualitative and quantitative detection of PTH. The specific interaction between PTH and anti-PTH on the substrate surface was utilized, and variations in orientation and aggregation state of the fluorescent LCs were evaluated by both optic and fluorescent means. The detection limit for PTH using optical image was above 10 µg/mL, while fluorescence detection achieved a much lower limit of 1 ng/mL. Additionally, the photopolymer further amplified the detection signals by strengthening the AIE effect of the fluorescent LCs in initiate state, and enhancing the disturbance of LCs ordered orientation upon PTH addition. Ultimately, the detection limits for PTH were reduced to 0.01 µg/mL for optical detection and 50 pg/mL for fluorescence detection. The quantitative and sensitive AIE-LC-Poly biosensing technology presented here sets the stage to develop LC-based sensor for biomedical applications without labeling.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Zhicai Xing,Jingqi Tian,Abdullah M. Asiri,Abdullah H. Qusti,Abdulrahman O. Al-Youbi,Xuping Sun
In this article, for the first time, two-dimensional hybrid mesoporous Fe 2 O 3 –graphene (mFe 2 O 3 –G) nanostructures were developed as a peroxidase mimetic with catalytic activities superior to those of mFe 2 O 3 , G, and previously reported Fe-based peroxidase mimetics. The high-surface-area mFe 2 O 3 not only offers a large number of catalytically active sites, but also facilitates the diffusion of 3,3,5,5-tetramethylbenzidine (TMB) and H 2 O 2 toward G surface. On the other hand, G is π-rich and thus favors the adsorption and enrichment of TMB within these pores. These synergistic effects lead to highly improved catalytic performances. Based on these findings, a simple, rapid, and highly sensitive and selective optical detector of glucose has been developed and demonstrated in buffer solution with a pretty low detection limit of 0.5 μM. In addition, this nanosensor is reusable and can also be used for glucose detection in diluted serum.
研究领域:
生物医学工程
·
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 37
·5494-5501
·
IF 1.9
Min Zhu,Nuerguli Kari,Yin Yan,Abliz Yimit
A m-Cresol Purple-polyvinylpyrrolidone (m-CP-PVP) composite-film was immobilized on the surface of a potassium ion-exchanged glass optical waveguide using the spin-coating method. The optical properties of the film were probed by UV-visible Spectroscopy and Fourier Transform Infrared Spectroscopy. The transmittance variation and the structural properties of the m-CP-PVP composite film/K+-exchanged glass optical waveguide sensor were studied before and after reaction with an amine and volatile organic gases. When the sensing film was exposed to an amine gas, the color changed from yellow to purple/blue. This simply designed sensor was able to measure trimethylamine (TMA) gas down to a concentration of 0.1 ppb at room temperature, and its response and recovery times were 1.4 s and 5.6 s, respectively.
研究领域:
光学传感
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生物医学工程
·
分析化学
·
纳米材料
·
环境监测
✓ 已验证
DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Yun Wu,Meiqi Wang,Ying Gu,Kun Ge
Herein, the miniaturized thermal purge-and-trap (MTPT) device combined with self-calibration colorimetric/surface-enhanced Raman spectroscopy (SERS) dual-model optical sensors were designed for effective analysis of sulfur dioxide (SO 2 ) in wine. The SO 2 can be rapidly separated from wine and enriched by MTPT device, ensuring colorimetric/SERS dual-model optical sensing based on Karl Fischer reaction. The high separation efficiency of miniaturized MTPT device combined with self-calibration of dual-model optical sensors significantly alleviate matrix interference and improve the detection accuracy. The satisfactory linear range of 0.1–200.0 mg/L and 0.1–500.0 mg/L with limit of detection of 0.03 mg/L can be obtained. Finally, the MTPT-colorimetric/SERS method was applied to determine the content of SO 2 in different kinds of wine to verify the practicality. These results provide an ideal strategy in construction of MTPT device combined with self-calibration dual-model optical sensors for quantification of gaseous hazards in complex food samples with high rapidity, anti-interference and accuracy.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IEEE SENSORS JOURNAL
·
2021
·Vol. 21
·期 10
·12146-12152
·
IF 3.301
Haijin Chen,Xuehao Hu,Xiaoyong Chen,Qianqing Yu,Zhenggang Lian,Heng Wang,Hang Qu
In this paper, we proposed an in-fiber Mach-Zehnder temperature sensor based on a dual-core fiber (DCF) in which one core, working as the sensing arm, is suspended in an embedded fluidic channel filled with silicone oil, while the other one, working as the reference arm, locates eccentrically in the DCF. Temperature variations would change the refractive index of silicone oil infiltrated as well as the effective index of the guided mode in the suspended core, thus shifting the interference spectra. Both experiments and numerical simulations were carried out to characterize the sensor. The spectrum shifts measured experimentally agreed well with the theoretical results. Experimental sensitivity of the sensor using a DCF infiltrated with ~20 cm-long silicone oil was found to be as high as −1.42 nm/°, comparable to those of the SPR fiber sensors and other interferometric sensors. The measuring range of the sensor was more than 120°. The proposed sensor could be easily fabricated with good robustness and stability, which makes the sensor promising for applications such as environment and architecture monitoring.
研究领域:
光学工程
·
传感器技术
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生物医学工程
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精密测量
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光纤通信
✓ 已验证
DOI
高影响因子
ACS Sensors
·
2024
·
IF 8.2
Fangkun Yang,Ning Huangfu,Jiaxi Shen,Jiajun Ying,Hengyi Mao,Yongfang Yin,Pengpeng Su,Ruochi Zhao,Xiao Chen,Hailiang Zhu,Wenming He,Hanbin Cui,Kai Wang
Cardiovascular diseases (CVDs) are a major global health concern, highlighting the need for effective diagnostic tools. Zinc ions (Zn2+) play a role in CVDs, but their detection is challenging. This study presents a multifunctional optical sensor, HD-Zn, designed to detect Zn2+ in relation to CVDs. We developed a novel fluorescence probe, HD-Zn, by conjugating N,N-di(2-picolyl)ethylenediamine (DPEN) to HD via an amide bond, which results in fluorescence quenching due to photoinduced electron transfer (PeT). Adding Zn2+ significantly increased fluorescence intensity in the near-infrared region (NIR-I). The probe showed a linear response to varying Zn2+ concentrations, with a detection limit of 9.8 nM, appropriate for physiological conditions. Fluorescence imaging in RAW264.7 macrophages indicated lower intracellular Zn2+ levels in foam cells compared to healthy cells, linked to CVDsprogression. In vivo imaging in mouse models showed decreased fluorescence intensity in the aorta with disease progression. Our findings confirm that HD-Zn is a reliable tool for measuring Zn2+ levels in plaques and demonstrate its biosafety for detecting Zn2+ in serum and urine, offering potential for clinical applications in CVDs diagnosis and monitoring.
研究领域:
医学诊断
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光学传感
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心血管研究
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分子生物学
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jingang Wang,Jianchen Zheng,Chengzhi Zhang,Ya Duan,Yuzhao Zhang,Hongji Guo,Ye Qiu,Xiaoduo Wang,Lianqing Liu,Haibo Yu
Soft microrobots exhibit distinct advantages in biomedical applications, with their exceptional maneuverability in confined spaces and environmental adaptability offering innovative solutions for targeted theranostics. However, current systems are inherently constrained by the physical separation of sensing and actuation modules, leading to inadequate integration and operational efficiency that hinder practical implementation. To overcome this challenge, a micro-nano 4D printing design paradigm is proposed. Through spatial programming of multi-responsive materials and biomimetic microstructural engineering, a microrobotic system is fabricated with synergistic perception-actuation capabilities. By integrating gradient magnetic field-responsive composites and pH-sensitive hydrogels, a 150-µm-scale biomimetic fish-shaped microrobot is developed, innovatively integrating three functionalities: magnetic-actuation, pH-triggered joint actuation, and diffractive optical sensing. Specifically, its tail joint enables adaptive modulation of doxorubicin release kinetics via pH-mediated mechanical deformation, while the head-mounted diffractive spectral sensor provides dynamic optical feedback of pathological microenvironment pH (5.0–6.5). Proof-of-concept experiments demonstrate the system's precise drug release control and environmental monitoring capabilities in gastric cancer cell therapy. This work provides a 4D printing design approach for next-generation intelligent therapeutic microrobots capable of environmental perception, intelligent response, and precise execution.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗学
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智能材料
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转化医学
·
微纳机器人
·
药物控释
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2025
·
IF 5.2
Haichao Yu,Yan Xu,Jinfeng Zhao,Jiayue Huang,Jianjun Li,Xiaojun Liu,Yanfen Liu,Xiaohua Liu
Industrial and agricultural development has contributed to increased heavy metal pollution. Consequently, efficient heavy metal ion detection technologies are essential for comprehensive environmental monitoring and for safeguarding ecosystems and human health. We developed a rapid, user-friendly, and highly sensitive label-free sensing platform based on 4-cyano-4′-pentylbiphenyl (5CB) droplets for heavy metal ions detection. Five representative heavy metal ions and four light metal ions were chosen for feasibility testing. By varying solution pH and heavy metal ion concentration, we observed stearic-acid-mediated optical responses in the 5CB droplets. At 400 pM Cu(II), the sensor exhibited a rapid response, stabilizing within approximately 30 s, while at 30 pM the response time increased to around 330 s. Similarly, at 800 pM Fe(III) the response stabilized within about 40 s, whereas at 100 pM stabilization required approximately 420 s. The sensor's detection limits were 10–30 pM for Cu(II) and 80–100 pM for Fe(III). Compared to hemispherical designs, spherical 5CB microdroplets offer more uniform molecular alignment and improved optical clarity, thereby enhancing sensitivity and reducing detection time. Furthermore, the sensor can differentiate between heavy metal ions and light metal ions.
研究领域:
环境科学
·
分析化学
·
材料科学
·
传感器技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Shuting Xie,Ri He,Qifan Zhu,Mingliang Jin,Ruizhi Yang,Shitao Shen,Jiayi Cui,Yiying Zou,Minmin Zhang,Lingling Shui
A sessile droplet array of 4’-pentyl-biphenyl-4-carboxylic acid (PBA) doped 5CB sessile droplets (12 −104 µm) is prepared by inkjet printing and applied for label-free sensing of penicillin G according to the configuration transition from axial to windmill based on the molecular alignment of 5CB at the LC-aqueous interface. Selective determination of penicillin G is achieved according to the target-selective enzymatic hydrolysis catalyzed by penicillinase, exhibiting sensitive detection and fast response with a detection limit of 0.178 ng/mL within 3–5 min. The sensitivity is linear depending on LC droplet size. Under the optimized conditions, the linear detection range is 1.78–178.0 ng/mL. Such a droplet array sensor has also been successfully applied to determine penicillin G in real river and lake water samples with RSD of 102–119%. Such a platform possesses the advantages of simple and cheap construction of an ordered array for multiplex sensing, and easy characterization via a polarizer . The quantification range of this proposed label-free optical penicillin G sensor covers the maximum residue limits in raw milk and river water defined in the European Union Regulation, and thus being applicable for food and environmental monitoring. By engineering LC-based probes, this approach could be extended to sense various molecules and ions in biomedical and chemical scenarios. And the sessile droplets on polymer substrates would also bring the possibility for employing in flexible and wearable devices in the future.
研究领域:
光学传感
·
分析化学
·
环境监测
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Mengdan Yan,Haoyang Tian,Zhong Liu,Xiangbing Wu,Li Yu,Zhiyun Ma,Yongxia Gu,Wenzhong Wang,Shaoze Yan,Xuemei Chen,Jieliang Zhao
Multilayered soft underwater robots achieve superior performance in deep-sea environments through enhanced environmental adaptability and structural dexterity. However, the insufficient interfacial bond strength of conventional multilayer structure designs is often compromised by interface layering and limited drive modes, leading to the interlayer peeling and poor reconfigurability. Here, a novel programmable functional gradient hydrogel is developed based on a magnetic field-guided gradient distribution, the structure-function integrated design of which is achieved by the gradient distribution of Fe 3 O 4 /polydopamine hybrid nanoparticles (FPHPs) with photo-thermal responsive properties into a temperature-sensitive hydrogel network. This hydrogel effectively avoids interfacial failure issues in traditional multilayer materials due to its seamless gradient structure. Upon 808 nm near-infrared (NIR) irradiation, the localized heating to 59.6 °C underwater creates a temperature gradient, which in turn induces a asymmetric swelling force for actuation. Experimental results demonstrate that the hydrogel can achieve controllable bending deformation of 180° within 5 s while maintaining initial deformation capability after more than 50 deformation cycles. We developed an underwater smart optical sensor utilizing hydrogel deformation to precisely modulate infrared tube exposure area, enabling RGB-LED multicolor tunable display for enhanced deep-sea optical communication. Furthermore, exploiting the programmable magnetization of FPHPs, we constructed various soft robots including an integrated jellyfish-inspired prototype with precisely controlled locomotion. This work advances flexible underwater robotics by solving interfacial stability problems and pioneering hydrogel-based underwater optical sensors, enabling intelligent deep-sea exploration.
研究领域:
生物医学工程
·
智能材料
·
软体机器人
·
海洋工程
·
纳米复合材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2020
·
IF 4.189
Zhiguang Suo,Xialing Hou,Jingqi Chen,Xiaowei Liu,Yu Liu,Feifei Xing,Yingying Chen,Lingyan Feng
Circularly polarized luminescence (CPL) as an intriguing luminescence phenomenon has attracted significant research interests for their chiroptical application, and CPL-active materials have been extensively explored in recent years. Herein, a highly chiroptical sensor was fabricated by the coassembly of G-quartet nanofiber and gold–silver bimetallic nanoclusters. In this, the adenosine 5′-monophosphate (AMP) templated gold–silver bimetallic nanoclusters (AuAg NCs) exhibited an enhanced fluorescence (λex = 356 nm, λem = 475 nm), a 9.42% quantum yield, and a 3.8 μs decay time compared with AMP stabilized Au NCs. In addition, a helical G-quartet-based nanofiber structure (g-fiber) was formed based on the self-assembly of guanosine 5′-monophosphate (GMP). The g-fiber was employed as chiral template for CPL emission by decorating AuAg NCs. Most interesting, the opposite CPL emission was regulated by K+ ion. The dissymmetry factor (glum) of this CPL-active material was up to 10–2. Furthermore, a CPL sensor based on the CPL emission has been developed for l-cysteine detection due to the quenching effect on AuAg NCs. The limit of detection (LOD) was as low as 95.7 nM, ranging from 0.1 to 8 μmol L–1, which was comparable with other analytical methods and materials. Our design presents a new horizon for nanoclusters and provides an entirely new approach for bioassay application.
研究领域:
纳米材料科学
·
分析化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Wen-Shuai Jiang,Wei Xin,Shuang Xun,Shao-Nan Chen,Xiao-Guang Gao,Zhi-Bo Liu,Jian-Guo Tian
A sensitive and selective optical biosensor based on reduced graphene oxide (RGO), which uses the polarization-dependent absorption effect of graphene under total internal reflection, is reported for determination of rabbit IgG. RGO sheets with the thickness of about 8.1 nm are fabricated by high temperature reduction and used as a sensing film, because of its strong polarization dependent absorption. This RGO-based optical sensor shows a satisfactory response to rabbit IgG with a minimum concentration of 0.0625 μg/ml. As a contrast, commercial SPR apparatus is used to investigate rabbit IgG with a minimum concentration of 0.3125 μg/ml. Moreover, with antigen–antibody binding, this sensor can also achieve label-free and real-time detection. Taking into account these factors, the RGO-based optical sensor may be a potential candidate for biosensing.
研究领域:
材料科学
·
生物传感器
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）