SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Tingyan Shi,Zuorui Wen,Lijun Ding,Qian Liu,Yingshu Guo,Caifeng Ding,Kun Wang
A novel photoelectrochemical (PEC) aptasensor for diclofenac detection, based on visible/near-infrared (vis/NIR) light-responsive vanadyl-phthalocyanine/graphitic carbon nitrid nanosheet (VOPc/CN) nanocomposites, was successfully fabricated. In this work, the first coupling of CN and VOPc with a facile solution–phase method was prepared and applied to PEC sensing. The UV–vis diff ;use reflection spectra (DRS) indicated that VOPc is an excellent photosensitizer when applied to the surface of CN. It promoted CN light absorption to the visible-NIR region, which greatly enhanced the light excitation capability. The PEC signal of the VOPc/CN nanocomposites improved 2.7 and 12.42-fold compared with pure VOPc and CN, respectively, indicating that VOPc/CN nanocomposites have good photoelectric activity and enhanced photo-to-current conversion efficiency. As a result, VOPc sensitized CN was introduced as a covalent immobilizing PEC aptasensor for the sensitive and selective determination of diclofenac (DCF). Under optimal conditions, the fabricated PEC biosensor exhibited good PEC performances with high sensitivity, a low detection limit of 0.03 nM (S/N = 3) and a wide linear response, in the range of 0.1-500 nM. This was due to the specific interaction between DCF and the aptamer. It is concluded that VOPc/CN nanocomposites are potentially promising photoactive materials for applications in PEC biosensors, as well as for photocatalysis and other related fields.
研究领域:
分析化学
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环境科学
·
生物医学工程
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DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Zuxin Liang,Xuling Liu,Zhiran Qin,Jingshu Li,Jianhai Yu,Xiaoen He,Li Zhu,Hongying Fan,Yushan Hu,Jinxiu Yao,Chenguang Shen,Chengsong Wan,Bao Zhang,Wei Zhao
This study aimed to inactivate Shigella flexneri using curcumin-based photosensitization and determine the sensitivity of S. flexneri to the combination of epsilon (ε)-polylysine (ε-PL) and curcumin-based photosensitization for decontamination. Bacterial numbers were reduced by 4.65 log CFU/mL after incubation with 80 μM curcumin and illumination for 20 min. Photosensitization resulted in cell morphology changes and increased cell permeability and protein degradation. Oxidative stress gene ( oxyR ) and efflux pump genes ( marA , acrA ) were upregulated. Decontamination of S. flexneri after incubation with curcumin and ε-PL for 1 h followed by photoactivation for 60 s has been investigated. It was found that the growth of bacteria was completely inhibited. Additionally, the number of bacteria was reduced by > 6 log CFU/mL. Experiments on the uptake of curcumin molecules by bacteria showed that ε-PL promoted the penetration of bacterial cells by curcumin, thus enhancing the effects of photosensitization.
研究领域:
微生物学
·
食品科学
·
生物技术
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DOI
高影响因子
Catalysts
·
2025
·Vol. 15
·期 8
·739
·
IF 4
Xiao Ge,Hongrui Ding,Tong Liu,Yifei Du,Anhuai Lu
Photocatalytic redox processes significantly contribute to shaping Earth’s surface environment. Semiconductor minerals exhibiting favorable photocatalytic properties are ubiquitous on rock and soil surfaces. However, the sunlight-responsive characteristics and functions of TiO2, an excellent photocatalytic material, within natural systems remain incompletely understood, largely due to its wide bandgap limiting solar radiation absorption. This study analyzed surface coating samples, determining their elemental composition, distribution, and mineralogy. The analysis revealed enrichment of anatase TiO2and β-carotene. Informed by these observations, laboratory simulations were designed to investigate the synergistic effect of β-carotene on the sunlight-responsive behavior of anatase. Results demonstrate that β-carotene-sensitized anatase exhibited a 64.4% to 66.1% increase in photocurrent compared to pure anatase. β-carotene sensitization significantly enhanced anatase’s electrochemical activity, promoting rapid electron transfer. Furthermore, it improved interfacial properties and acted as a photosensitizer, boosting photo-response characteristics. The sensitized anatase displayed a distinct absorption peak within the 425–550 nm range, with visible light absorption increasing by approximately 17.75%. This study elucidates the synergistic mechanism enhancing the sunlight response between anatase and β-carotene in natural systems and its broader environmental implications, providing new insights for research on photocatalytic redox processes within Earth’s critical zone.
研究领域:
环境矿物学
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光催化化学
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地球化学
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表面科学
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环境功能材料
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产品关联
DOI
高影响因子
WATER RESEARCH
·
2022
·
IF 13.4
Yi Liu,Wenhua Dong,Shuyi Shen,Fanxu Meng,Jiajia Wang,Kun Yang,Daohui Lin
Cost-effective disinfection technology is urgently needed in poor rural areas. Erythrosine (ERY)-based solar disinfection (SODIS) provides a promising solution because of its effective inactivation of viruses and gram-positive bacteria at low cost. However, the poor gram-negative bacteria (G − , e.g., Escherichia coli ) inactivation of photosensitized ERY inhibits its application. Herein, for the first time, the protonation of ERY was found to greatly enhance its G − inactivation, and 99.99999% (7.0 log) of E. coli were completely inactivated within only 30 s using 2.5 mg/L ERY under 200 mW/cm 2 visible light irradiation. The inactivation rate constant ( k ) reached 17.5 min −1 at pH 4.0, which was 4730 times higher than that at pH 7.0. At a lower pH, more severe cell wall and genomic DNA damage was observed. A linear correlation between k and monoanionic ERY (HE − ) content was obtained, indicating that HE − rather than dianionic ERY (E 2− ) participated in the inactivation at pH 5.0–7.0, which was further explained by the higher production of reactive oxygen species and bacterial adsorption of HE − than E 2− . Both 1 O 2 and O 2 − • dominated bacterial inactivation, contributing 56.8% and 43.2%, respectively. O 2 − • but not 1 O 2 caused ERY photobleaching. OH • was not involved in either inactivation or photobleaching. Humic acid and salts (NaCl, Na 2 SO 4 , CaCl 2 , and MgCl 2 ) slightly inhibited inactivation, while NaHCO 3 accelerated inactivation. Complete inactivation (99.9999%) of E. coli was achieved within ∼30 min at pH 5.0 in ERY-based SODIS with good adaptation to various water matrices and weather (sunny or partly cloudy). This work will help to promote the application of ERY-based disinfection especially for SODIS in poor rural areas.
研究领域:
环境科学
·
水处理
·
微生物学
·
光化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yu Zheng,Wanqing Liang,Xinyi Li,Cheng Zhang,Kui Zhang
The incorporation of heavy atoms into fluorescent emitters can efficiently facilitate spin-orbit coupling and enhance the intersystem crossing process from excited singlet states to triplet states. However, the introduction of heavy atoms into carbon dots (CDs) materials still remains challenges. In this work, CDs synthesized from polyethyleneimine and itaconic acid were subjected to a mild bromination process, yielding bromine-doped carbon dots (Br-CDs). Bromine atoms significantly enhanced the intersystem crossing process, leading to a 155.1 % increase in the phosphorescence intensity of the CDs. Moreover, the enhanced generation of excited triplet states endowed the Br-CDs with photosensitization performance, enabling them to produce singlet oxygen and superoxide anion radicals upon light irradiation. Interestingly, it was found that Cu 2+ ions could effectively inhibit this photosensitization process. By integrating the color changes of photosensitization oxidation substrates, a colorimetric method was developed for the rapid determination of Cu 2+ ion concentrations in water samples. This proposed method offers a novel approach for the design of sensors based on luminescent nanomaterials.
研究领域:
纳米材料
·
光化学
·
传感器
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环境分析
·
荧光探针
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产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 4
·585-589
·
IF 0.875
Wei Qi,Wang Liyuan
Molecular glass resist has been considered as one of the best choices for a new generation of lithography. In this work, a new type of photoactive compound was obtained by the esterification of tannic acid with 2-diazo-1-naphthoquinone-4-sulfonyl chloride(2,1,4-DNQ-Cl) and ditertbutyl dicarbonate. The new obtained compound possessed both a photosensitive group of diazonaphthoquinone sulfonate(2,1,4-DNQ) and a group of acidolytic protection. Upon the irradiation of the compound under 365 nm light, the former group was photolyzed and converted into indene carboxylic acid along with a small amount of sulfonic acid, which could lead to the deprotection of the latter group. As a result, a novel i-line molecular glass photoresist was formed with the chemical modification of tannic acid. The experimental results show that the modificated compound had a fair solubility in many organic solvents. The lithographic performance of the resist was evaluated on an i-line exposure system with high photosensitivity and resolution as well.
研究领域:
材料科学
·
微纳加工
·
高分子化学
·
光电子学
·
半导体工艺
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DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2017
·Vol. 24
·期 11
·2602-2608
·
IF 5.317
Xinfeng Zhang,Li Deng,Chengpeng Huang,Jinyi Zhang,Xiandeng Hou,Peng Wu,Juewen Liu
Graphical Green ELISA : The photosensitizer phloxine B (PB) is explored for the activation of molecular oxygen to allow direct oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), eliminating the need for the unstable enzymes and H 2 O 2 required for traditional immunoassays. Visual detection of carcinoembryonic antigen (CEA) is possible for concentrations as low as 50 pg mL −1 (see figure). H 2 O 2 and horseradish peroxidase (HRP) are commonly used together in bioassays. HRP is required to accelerate the reaction between a chromogenic substrate (e.g., 3,3′,5,5′-tetramethylbenzidine, TMB) and H 2 O 2 , and thus amplifies the signal. Herein, molecular oxygen for enzyme-free and H 2 O 2 -free oxidation is explored, still using the same colorimetric reaction. Restricted by spin selection rules, the ground-state triplet oxygen needs to be converted to the singlet state to oxidize TMB. Phloxine B (PB) is used as the photosensitizer because of its excellent performance and safety. Under green light irradiation, each PB has a turnover of approximately 51 TMB molecules in 20 min, making PB a “molecular enzyme mimic” for signal amplification. With its small size, multiple PB molecules are loaded on a graphene oxide nanosheet to design a modified enzyme-linked immunosorbance (ELISA) assay (termed photosensitization immunosorbent assay, PISA), improving the 1:1 enzyme/target ratio to n :1. PISA is more sensitive for carcinoembryonic antigen than a commercial ELISA kit, and successfully measures the antigen in the serum of multiple cancer patients. This simple and green method of oxidation coupled with the small size of the photosensitizer and graphene oxide may enable many other applications in biosensor development, smart materials, and energy harvesting.
研究领域:
生物化学
·
生物技术
·
分析化学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Rui Ding,Zhuozhi Ouyang,Xue Zhang,Yankai Dong,Xuetao Guo,Lingyan Zhu
Tire wear particles (TWPs) exposed to the aquatic environment are rapidly colonized by microorganisms and provide unique substrates for biofilm formation, which potentially serve as vectors for tetracycline (TC) to influence their behaviors and potential risks. To date, the photodegradation capacity of TWPs on contaminants due to biofilm formation has not been quantified. To accomplish this, we examined the ability of virgin TWPs (V-TWPs) and biofilm-developed TWPs (Bio-TWPs) to photodegrade TC when exposed to simulated sunlight irradiation. V-TWPs and Bio-TWPs accelerated the photodegradation of TC, with rates (kobs) of 0.0232 ± 0.0014 and 0.0152 ± 0.0010 h–1, respectively (kobs increased by 2.5–3.7 times compared to that for only TC solution). An important factor of increased TC photodegradation behavior was identified and linked to the changed reactive oxygen species (ROS) of different TWPs. The V-TWPs were exposed to light for 48 h, resulting in more ROS for attacking TC, with hydroxyl radicals (•OH) and superoxide anions (O2•–) playing a dominant role in TC photodegradation measured using scavenger/probe chemicals. This was primarily due to the greater photosensitization effects and higher electron-transfer capacity of V-TWPs in comparison to Bio-TWPs. In addition, this study first sheds light on the unique effect and intrinsic mechanism of the crucial role of Bio-TWPs in TC photodegradation, enhancing our holistic understanding of the environmental behavior of TWPs and the associated contaminants.
研究领域:
环境科学
·
化学
·
微生物学
·
污染研究
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产品关联
DOI
PubMed
高影响因子
SURFACE AND INTERFACE ANALYSIS
·
2018
·Vol. 51
·期 2
·169-176
·
IF 1.263
Xuebin Hou,Yibing Cai,Xiaofei Song,Yue Wu,Junhao Zhang,Qufu Wei
Controlled polydopamine (PDA)-coated TiO 2 composite nanofibers (NFs) were successfully fabricated via a facile electrospinning process and exposing TiO 2 NFs into a slightly alkaline dopamine solution. Chemical composition, structural morphology, and photocatalytic degradation property of as-prepared TiO 2 NFs and PDA-coated TiO 2 composite NFs were characterized by Fourier transfer infrared, X-ray photoelectron spectra, transmission electron microscopy, UV-vis diffuse reflectance spectra, and photocatalytic degradation experiments. The results indicated that the core-shell TiO 2 @PDA composite NFs were successfully prepared and the thickness of PDA shell was highly controlled within several nanometers. And obtained TiO 2 @PDA composite NFs exhibited improved photocatalytic performance after PDA coating, which is attributed to the photosensitization of PDA shell. Moreover, with increased pH values of initial solution, both absorption capacity in the dark and photocatalytic performance of TiO 2 @PDA composite NFs showed significant improvement. Additionally, the obtained composite NFs showed different degrees of enhancement in photocatalytic performance based on different dyes, which is related to the “bait” effect of PDA shell. Comparing with anionic dyes, TiO 2 @PDA composite NFs tended to adsorb and degrade more cationic dye molecules. It is anticipated that the fabricated composite NFs with controlled core-shell structure have great potential to be applied for organic pollutants removal, especially cationic dyes.
研究领域:
材料科学
·
环境科学
·
纳米技术
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Zhongyu Wang,Li Wei,Junfeng Lin,Can Huang,Huitong Chen,Dong Fan,Weiyu Hu,Jing Liu,Huaiyi Huang,Zongming Wang,Xin Wang
Photodynamic therapy has been regarded as a noninvasive treatment for cancer with spatiotemporal control over drug activation. Bis-terpyridyl Ru(II) complexes exhibit a promising achiral structure but suffer from low photoreactivity due to deviation from the ideal octahedral geometry. Herein, we introduce the donor–acceptor–donor motif to construct a dinuclear bis-terpyridyl Ru(II) complex (Ru2). Ru2 exhibits superior light absorption properties compared with mononuclear complex Ru1. Importantly, upon 595 nm light excitation, Ru2 shows promising synergetic type I/II photosensitization and photocatalytic activity, while Ru1 is inactive. Anticancer mechanistic studies reflect that Ru2 induces intracellular redox imbalance and affects the biosynthetic and metabolic processes, leading to cell apoptosis. Overall, this work provides a simple strategy to rouse the PDT efficiency of bis-terpyridyl Ru(II) complexes.
研究领域:
癌症研究
·
无机化学
·
光化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2019
·
IF 3.261
Qiwen Du,Weichen Jia,Jingyu Dai,Chao Du,Aiyun Shao,Rongmin Zhang,Yuefei Ji
Natural organic matter (NOM) contains a large number of aromatic ketones and quinones, which can produce reactive oxygen species (ROS), such as 1 O 2 and HO·, through photosensitization. These ROS play important roles in the attenuation of organic pollutants in sunlit surface water. The NOM components fractionated with XAD-8 resin at different pH influence the photo-generation of ROS, which may be related to the degree of dissociation of functional groups. In this study, probe chemicals were used to investigate the effect of dissociation degree (p K a ) of NOM model compounds on ROS production under 254 nm UV irradiation. Experimental results showed that six model compounds with similar molecular weights and structures but different p K a values have different ROS production abilities in a pH 7.0 reaction system. The ability for DHB 2,5 (2.97), DHB 3,4 (4.48), and GUA (9.99) to photo-generate 1 O 2 increased with increasing dissociation. The ability for DHB 3,4 and GUA to photo-generate HO· followed the same trend. The correlation between NOM dissociation constant and ROS generation is preliminary established, which explains the influence of functional groups. Our results may provide some basic information for understanding the correlation between NOM structural features and ROS generation.
研究领域:
环境化学
·
光化学
·
水处理
·
环境科学
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产品关联
DOI
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2021
·Vol. 97
·期 4
·841-850
·
IF 3.421
Li Juan,Wei Diandian,Wang Jianfeng,Li Ning,Fan Yuchen,Li Na,Zhao Sijie,Li Kun,Sun Fengyuan
Tanshinone IIA (TanIIA) has multiple biological functions and already been clinically used to treat many cardiovascular diseases. TanIIA is a photoactive molecule and can be excited by light to generate 3 TanIIA*. Generation of 3 TanIIA* by TanIIA photosensitization indicates that TanIIA may serve as a photosensitizer to bring photodynamic damage to organisms. Therefore, human choroidal melanoma MUM-2B cell was chosen as a superficial tumor model and the photodynamic effect of TanIIA on tumor cells was evaluated in this study. The results showed that TanIIA photosensitization could generate singlet oxygen in noncellular system. MTT, clone formation and wound-healing assays showed that the survival and migration of MUM-2B cells could be efficiently inhibited by TanIIA photosensitization. And then, laser confocal microscope and flow cytometry were used to try to elucidate related mechanism. It was found that TanIIA could pass through cellular membrane and preferably accumulate in nucleus. TanIIA photosensitization could efficiently induce cell apoptosis and necrosis, increase intracellular ROS levels, decrease mitochondria membrane potential, and lead to cell cycle arrest in G2/M phase. Our findings indicate that TanIIA photosensitization can exert remarkable toxicity on choroidal melanoma cells.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
·
光化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）