POLYMERS FOR ADVANCED TECHNOLOGIES
·
2015
·Vol. 26
·期 8
·953-959
·
IF 1.757
Shuting Wang,Lan Cen,Qihao Wu
Maleated glycidyl 3-pentadecenyl phenyl ether with styrene (MGS) was synthesized from glycidyl 3-pentadecenyl phenyl ether (GPPE), maleic anhydride (MAH) and styrene (St) in the presence of AIBN initiator at 80°C, and then the resultant MGS was applied as a compatibilizer to prepare SBR/silica composites. Meanwhile, the commercial compatibilizer bis-(triethoxysilylpropyl) tetrasulfide (named Si69) added into composite was also prepared for comparison purpose. The synthetic MGS structure was characterized by GPC and FTIR, and SBR/silica compounds with different compatibilizer were analyzed using RPA, DMA and so on. The results showed that M̄n and M̄w of MGS were 19,538 g/mol and 23,790 g/mol, respectively. The curing time of compounds with MGS increased, whereas the maximum and minimum torques decreased. The addition of MGS decreased Payne effect of SBR/silica compounds, which implied an improvement of silica dispersion in the compounds. Bound rubber content of compound with MGS was about 1.7 times higher than the absence and 1.5 times higher than that with Si69. The tensile strength of the composites was improved by increasing compatibilizer loading, and the optimum value was observed at 6 phr of MGS. Meanwhile the use of MGS can improve the anti-aging property of composite. According to DMA, the tanδ value at 0°C of composite with MGS was higher than composite without compatibilizer suggesting that MGS can improve the wet skid resistance of composite. The SEM analysis revealed that introduction of MGS enhanced the compatibility between SBR and silica. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
高分子化学
·
橡胶复合材料
·
材料界面科学
·
功能高分子
·
聚合物改性
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 112
·111217-111225
·
IF 3.289
Sijie Zhao,Huiru Yang,Cai Zuo,Lu Sun,Liwei Ma,Hua Wei
Star-shaped polymers are attractive as drug carriers due to the integration of relatively easy synthesis compared to the preparation of hyper-branched dendrimers and their potential ability to form unimolecular nanoparticles with enhanced stability to survive the high dilution-associated deformation and subsequently premature drug release in the body fluids and blood during circulation. Clearly, the star structure exerts a significant effect on their bioproperties and potential applications. In this study, three star-shaped amphiphilic copolymers with the same polymer compositions but different star structures were synthesized to investigate the effect of star architecture on their properties as well as potential applications as drug carriers. Three different branched alcohols, 2-(hydroxymethyl) propane-1,3-diol, pentaerythritol and dipentaerythritol with 3, 4, and 6 respective hydroxyl groups were chosen as the starting core to generate the target star-shaped amphiphilic block copolymers composed of hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(oligoethyleneglycol methacrylate) (POEGMA) with 3, 4, and 6 corresponding star arms by a combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Dynamic light scattering (DLS) measurements and pyrene fluorescence probe technique confirmed the capability of the resultant star-shaped amphiphilic copolymers to form unimolecular micelles with average diameters smaller than 50 nm in an aqueous phase. A comparison of the drug loading capacity revealed that the micelles of 4-star-PCL–POEGMA (4s-PCL–POEGMA) exhibited the highest drug loading content (DLC) of all the three formulations. More importantly, in vitro doxorubicin (DOX) release study showed unique pH-mediated drug release behaviors, i.e., dramatically accelerated release at pH 6.0 but a much slower profile at pH 7.4, from these generally recognized “pH-insensitive” 4-arm star-shaped micelles. An acid-triggered degradation and an acid–base titration were performed to further reveal that such interesting pH-responsive drug release behaviors were attributed primarily to the hydrophilic corona of OEG brushes. This study is believed to provide a new insight into the structure–bioproperties relationship of star-shaped polymers, thus should be useful for the future design and development of novel star-shaped polymers for controlled drug delivery.
研究领域:
高分子药剂学
·
纳米医学
·
药物控释
·
生物材料
·
药剂学
·
肿瘤治疗
·
纳米载体
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Ming Li,Xiaohong Liu,Ning Liu,Zihe Guo,Puneet Kumar Singh,Shiyu Fu
Cellulose nanocrystals (CNCs) is a kind of natural, renewable, and biocompatible materials that can be functional via the surface modification. A covalently bonded CNCs-g-PDMAEMA was prepared by grafting 2-(dimethyl-amino) ethyl methacrylate (DMAEMA) on the CNCs’ surface via atom transfer radical polymerization (ATRP). Subsequently, the tertiary amino groups of the CNCs-g-PDMAEMA were transferred to quaternary ammonium groups by adding alkyl bromides with different carbon chain lengths (C10-C18). It was found that the antibacterial activity of the prepared materials is related to the quaternary group structure. The material containing C10 alkyl in quaternary group exhibited the best antibacterial efficiency, which was closely associated with the wettability of the quaternary CNCs-based polymers. The lower wettability of materials with higher hydrophobicity may impose a restriction on the polymeric antibacterial groups’ accessibility to the cytoplasmic membrane of bacteria. The antimicrobial CNCs-based composites may be potential to apply as coating agents for aseptic packaging.
研究领域:
高分子科学
·
生物材料
·
表面化学
·
抗菌材料
·
包装材料
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2013
·
IF 3.458
Ziwei Zhang,Xiaole Qi,Xiangbo Li,Jiayu Xing,Xuehua Zhu,Zhenghong Wu
Multilayer-coating technology is the traditional method to achieve pulsatile drug release with the drawbacks of time consuming, more materials demanding and lack of efficiency. The purpose of this study was to design a novel pulsatile drug delivery system based on the physiochemical interaction between acrylic copolymer and organic acid with relatively simpler formulation and manufacturing process. The Enalapril Maleate (EM) pulsatile release pellets were prepared using extruding granulation, spheronization and fluid-bed coating technology. The ion-exchange experiment, hydration study and determination of glass transition temperature were conducted to explore the related drug release mechanism. Bioavailability experiment was carried out by administering the pulsatile release pellets to rats compared with marketed rapid release tablets Yisu ® . An obvious 4 h lag time period and rapid drug release was observed from in vitro dissolution profiles. The release mechanism was a combination of both disassociated and undisassociated forms of succinic acid physiochemically interacting with Eudragit ® RS. The AUC0-τ of the EM pulsatile pellets and the market tablets was 702.384 ± 96.891 h ng/mL and 810.817 ± 67.712 h ng/mL, while the relative bioavailability was 86.62%. These studies demonstrate this novel pulsatile release concept may be a promising strategy for oral pulsatile delivery system.
研究领域:
药剂学
·
药物递送
·
生物药剂学
·
药物代谢
·
制剂工程
·
药动学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Haihua Wang,Bei Li,Guiqiang Fei,Yiding Shen,Ke Zhu
We reported herein the synthesis of block copolymers and their application in the in-situ emulsion polymerization of waterborne poly (urethane-acrylate) (WPUA) nanoemulsions based on phase inversion process. The polymerizable surfmers containing terminal unsaturated double bonds (MSA-r) were successfully synthesized via catalytic chain transfer polymerization (CCTP). Random copolymer (MSA-t) prepared through radical polymerization was utilized as control. The structure, surface tension and aggregation behavior of surfmers were characterized. The phase inversion, formation and stability of WPUA nanoemulsions were systematically investigated. Effects of MSA-r surfmer content and BMA/MMA ratio on the water resistance and thermal stability of the corresponding films were also discussed. It was found that the phase inversion mechanism of PUA prepolymer in the presence of MSA-r surfmers is different from conventional polyurethane prepolymer. The addition of MSA-r and MSA-t surfmers alters the rheological behaviors of PUA prepolymer via PUA-surfmer interactions, as well as the phase inversion process. Compared with WPUA/MSA-t emulsion, WPUA/MSA-r nanoemulsion displayed improved stability at higher solid content. The minimum particle size of WPUA/MSA-r nanoemulsion was 88.7 nm and kept almost constant after 12-month storage, while the particle size of WPUA/MSA-t emulsion was 131.3 nm and increased to 178.9 nm. Moreover, the WPUA/MSA-r film possessed improved water resistance and thermal stability.
研究领域:
高分子化学
·
胶体与界面科学
·
材料化学
·
纳米材料
·
功能高分子
·
水性涂料
·
聚合物乳液
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 68
·55048-55058
·
IF 3.84
Aizhao Pan,Shao Yang,Ling He
Polyhedral oligomeric silsesquioxane (POSS) tethered fluorinated diblock copolymers including linear-shaped ap-POSS–PMMA-b-PDFHM and star-shaped s-POSS–(PMMA-b-PDFHM)16 are synthesized by octakis(dibromoethyl)POSS (POSS-(Br)16) and aminopropylisobutyl POSS (ap-POSS) initiating methylmethacrylate (MMA) and dodecafluoroheptylmethacrylate (DFHM). In THF solution, both diblock copolymers could self-assemble into 200 nm core/shell micelles with a POSS/PDFHM core and 70–80 nm PMMA shell. These micelles are able to produce typical films with a fluorine-rich top-surface and POSS-gathered sub-surface. Although PDFHM segments and POSS cages are competitively migrating onto the film surface, the migration of the PDFHM segments is actually improved by the POSS cages. Comparatively, the surface of the ap-POSS–PMMA-b-PDFHM film is much more rough and fluorine-rich than the s-POSS–(PMMA-b-PDFHM)16 film, therefore, the ap-POSS–PMMA-b-PDFHM film has higher viscoelasticity and higher oleophobicity, but a little lower hydrophobicity than the s-POSS–(PMMA-b-PDFHM)16 film. The hydrophobic application of both linear- and star-shaped topologies to glass, cotton fabric and stone substrates reveals that the treated samples exhibit superhydrophobicity for the cotton fabric (>150°) and obvious hydrophobicity for the stone and glass (>135°) in terms of resistance to water and other liquids like coffee, milk, coke and green tea. It is believed that the properties of self-assembled films and the hydrophobic applications are related closely to the topologies of block copolymers.
研究领域:
高分子化学
·
材料科学
·
表面科学
·
纳米技术
·
功能材料
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haoyu Gu,Tong Lv,Qiankun Zhang,Dequan Chi,Yang Zhang,Zhongjun Cheng,Zhimin Xie,Yongjun Xu,Dongjie Zhang,Yuyan Liu
Smart reconfigurable metamaterials can better adapt to changing electromagnetic environments and broaden the range of applications. However, constructing electromagnetic reconfigurable metamaterials, especially those with large areas or applied to complex surfaces via a universal approach, is still a challenge. Here, we introduce a smart reconfigurable metamaterial consisting of a thermadapt shape memory polymer ethylene vinyl acetate copolymer (EVA) matrix and a flowable liquid–metal resonant unit. Based on the excellent self-healing properties of EVA, large-area metamaterials can be constructed by thermal assembly of metamaterial units. In addition, the original shape of the metamaterial can be reprogrammed to apply to complex three-dimensional surfaces with the reprocessing properties of EVA. Moreover, by utilizing the shape memory performance of the EVA, the temporary resonant frequency of the metamaterial can be set by programming and the resonant frequency tuning of the metamaterial can be controlled under external temperature stimulation, achieving noncontact tuning. In the future, this concept can be broadly applied in fields such as complex structure stealth layers and multifunction filters.
研究领域:
材料科学
·
电磁学
·
高分子化学
·
智能材料
·
功能材料
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 17
·7456-7468
·
IF 4.5
Zhang Ning,Wang Zongliang,Zeng Yuqi,Guo Yueming,Wang Liqiang,Liu Jianguo,Wang Yu,Zhang Peibiao
Preformed three-dimensional scaffolds with insufficient mechanical properties, poor surgical performance, and morphological mismatch to defects with irregular shape have shown drawbacks in animal evaluations and clinical applications. This motivates the development of novel injectable systems to ideally fill bone defects, allowing in situ solidification within the host tissues while retaining high initial mechanical strength and appropriate porosity. In this study, an in situ forming scaffold with time-dependent pore formation inspired by the metamorphosis of a butterfly was fabricated by incorporating gelatin microspheres (GMs) into a poly(lactic-co-glycolic acid) (PLGA)-based injectable implant. After optimizing solvent, molecular weight and solution concentration of PLGA matrix, the injectable mixture could be easily injected into both aqueous solution and random-shaped grooves while in situ solidified instantaneously. The injectability enabled an in situ morphological match within an irregular bone defect, providing high initial strength in the early period. The toughness of the injectable implant also allowed them to be easily bent into a ring without breaking. Time-dependent pore formation was accomplished by gradual degradation of GMs, generating appropriate space for tissue ingrowth in the scaffold. It is expected that the injectable in situ forming implant would aid the bone healing process by maintaining initial mechanical support and creating a spatiotemporally evolutionary microstructure during bone tissue regeneration.
研究领域:
生物材料学
·
组织工程
·
骨科学
·
再生医学
·
高分子科学
·
药物递送系统
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 50
·期 24
·5177-5184
·
IF 3.919
Yonggang Gao,Lin Gu,Yusheng Qin,Xianhong Wang,Fosong Wang
Low-molecular weight oligo(carbonate-ether) diols are important raw materials for polyurethane formation, which with tunable carbonate unit content (CU) may endow new thermal and mechanical performances to polyurethane. Herein, facile synthesis of oligo(carbonate-ether) diols with number average molecular weight ( M n ) below 2000 g mol −1 and CU tunable between 40% and 75% are realized in high activity by immortal copolymerization of CO 2 /propylene oxide (PO) using zinc-cobalt double metal cyanide complex (Zn-Co-DMCC) in the presence of sebacic acid (SA). M n of the oligomer is in good linear relationship to the mole ratio of PO and SA (PO/SA) and hence can be precisely controlled by adjusting PO/SA. Besides, the molecular weight distribution is quite narrow due to the rapid reversible chain transfer in the immortal copolymerization. High pressure and low temperature are favorable for raising CU. In all the reactions, the weight fraction of propylene carbonate ( W PC ) can even be controlled as low as 2.0 wt %, and the catalytic activity of Zn-Co-DMCC is above 1.0 kgg −1 cat. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
研究领域:
高分子化学
·
催化化学
·
绿色化学
·
功能材料
·
聚合物合成
·
二氧化碳利用
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 34
·1802848
·
IF 13.325
Zhenguang Wang,Yu-e Shi,Xuming Yang,Yuan Xiong,Yanxiu Li,Bingkun Chen,Wing-Fu Lai,Andrey L. Rogach
A water-soluble, positively charged polymer is obtained by copolymerizing chitosan with hypromellose, and the evaluation of its biocompatibility and the capacity for the loading of exogenous agents is performed. Films based on hypromellose grafted chitosan (HGC) are employed as a matrix to fabricate composite films by dehydration-triggered aggregation of copper nanoclusters (NCs). The resulting HGC/Cu NC films are transparent and exhibit an aggregation-induced emission enhancement of copper NCs, with a resulting photoluminescence quantum yield of 42%. The application of these orange emitting films as color converters for fabrication of remote light-emitting devices is demonstrated.
研究领域:
高分子科学
·
生物材料
·
纳米医学
·
药物递送
·
光电子学
·
生物医学工程
·
荧光成像
·
转化医学
✓ 已验证
DOI
高影响因子
POLYMER
·
2022
·
IF 4.432
Hui Wang,Chongrui Zhang,Lusha Jiang,Shan Tong,Yu-Chao Li,Hefu Pu,Qiang Zhao
Calcium bentonites (CaB), rich in European and Asian countries, are potential barrier materials for landfill leachate containment. However, CaB has to be converted into sodium bentonite (NaB) by Na-activation so as to facilitate intercalation modification. In this study, salt-resistant poly(acrylic acid-N, N-diethyl acrylamide) [P(AA-DEA)] was designed to intercalate and graft CaB by in situ polymerization without prior Na-activation. By this design, acrylic acid monomers were first adsorbed into interlayers of Ca-montmorillonite (Ca-MT) through the electrostatic complexation with Ca 2+ , dislodging Ca 2+ from montmorillonite surfaces. Then, ammonium ions of N, N-diethyl acrylamide were adsorbed into Ca-MT interlayers. Swelling index of the obtained CaB/P(AA-DEA) nanocomposite in aggressive coal combustion product (CCP) leachate is 15.8 mL/2g, which is as high as 3.4 times that of CaB. CaB/P(AA-DEA)-based geosynthetic clay liners (GCLs) exhibit very low hydraulic conductivity (1.6✕10 −12 m/s) to CCP leachate, which is as low as 3.3% that of the U.S. standard requirement and ∼4 orders of magnitude lower than that of CaB-based GCL. Polymer elution of CaB/P(AA-DEA)-8% in CCP leachate is as low as 1.9% that of the dry mixed samples.
研究领域:
环境工程
·
材料科学
·
土木工程
·
高分子化学
·
地质屏障材料
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Li Wang,Ya Liu,Hongsheng Lu,Zhiyu Huang
Plastic waste has caused severe environmental problems. Some additives in plastics, like organophosphates, enter the environment with plastic waste, causing significant harm to plants and creatures. However, the primary method of recycling phosphorus-containing plastic, especially polycarbonate and acrylonitrile-butadiene-styrene copolymer (PC/ABS), is a mechanical method, which not only does not effectively separate plastics and organophosphates but also tends to cause polymer degradation during recycling. In order to overcome these problems, we proposed an efficient and sustainable approach to recycle of phosphorus-containing plastic. In this method, N, N -dimethylcyclohexylamine (DMCHA), a switchable hydrophilicity solvent (SHS), was used to react with and extract organophosphates in plastic, achieving the goal of complete separation of plastic and organophosphates. PC/ABS can be recovered by precipitation. Dissolved organophosphates can also be easily recovered due to the switching characteristics of SHS. Both of recovered materials were of high purity and were close to virgin materials. This technique is an easy and efficient approach to separate plastic and organophosphates, which has excellent application prospects in recycling phosphorus-containing plastic.
研究领域:
环境科学
·
高分子化学
·
绿色化工
·
资源循环利用
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）