Materials Today Chemistry
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2026
·
IF 6.7
Bo Wang,Maosheng Wan,Li Hua,Feiqing Rao,Jialin Liang,Zejie Zhao,Chunquan Li
HDPE has attracted significant attention owing to its outstanding corrosion resistance, ease of processing, and cost effectiveness. Nevertheless, it has low toughness and is prone to aging, which results in a decline in mechanical properties and restricts its application in special fields. Using diethanolamine, boric acid, phenol, 2,4,6 -trichloro- 1,3,5 -triazine and long chain primary amines as raw materials, a series of multifunctional double chain tricyclic borate coupling agents 8a-f with novel structures were designed and synthesized. The structure of the target compounds was characterized by FT-IR and 1 H NMR. Thermal analysis showed that the double long chain tricyclic coupling agents had high thermal stability and the thermal decomposition temperature was as high as 270 °C. The oil absorption value of GCC powder treated with compound 8f decreased from 30.4 g/100 g– 13.6 g/100 g, and the contact angle increased from 0° to 135.4° . Compared with the unmodified composite, the mechanical properties of the modified GCC/HDPE composite were significantly enhanced, and its impact strength, tensile strength and bending strength were increased by 48.7 %, 48.6 % and 58.2 %, respectively. After 1000 h of UV aging, the tensile strength of the modified composite decreased by only 0.6 %, and there was no yellowing phenomenon, indicating that it has excellent aging resistance. This study provides a reference strategy for the development of functional coupling agents and high-performance composite materials.
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JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 3.9
Wang Rong,Tian Xiao-Li,Li Jin,Chen Jia-Jia,Hu Yue,Zhang Ji
Ferroptosis is a non-apoptotic form of cell death that offers unique advantages in various cancer therapies. Gene therapy, on the other hand, involves transferring therapeutic genes into cancer cells to regulate related proteins and exert therapeutic effects. Nanomaterials that combine the ability to induce ferroptosis in cancer cells with gene delivery functionality hold great potential for tumor therapy. Herein, we designed and synthesized a series of ferrocene-containing (Fc) cationic lipids (NFC-1~4) based on the Ugi reaction. Fc, as a typical Fenton reaction catalyst, can effectively trigger ferroptosis in cancer cells. The results showed that NFC-1~3 lipoplexes could be efficiently taken up by A549 cells and exhibit excellent gene transfection capabilities, with the best transfection efficiency surpassing that of Lipofectamine 2000. Reactive oxygen species (ROS) detection experiments revealed that NFC-2 possesses Fenton characteristics, enabling it to induce the Fenton reaction and produce ROS. In vitro antitumor experiments demonstrated that NFC-2 LNPs could inhibit tumor cell growth to some extent, with its efficacy significantly enhanced after DNA encapsulation. Mechanistic studies indicated that the Fenton reaction mediated by NFC-2@DNA lipoplexes converted endogenous H 2 O 2 into highly toxic ·OH, leading to increased intracellular ROS levels, glutathione (GSH) depletion, and inactivation of glutathione peroxidase 4 (GPX4). The disruption of the cellular redox balance caused excessive accumulation of lipid peroxides (LPOs), ultimately inducing ferroptosis. NFC-2 holds promise as an efficient ferroptosis agent and a dual-function lipid for co-delivering DNA, offering potential for combined gene therapy and ferroptosis-based cancer treatment. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 13.2
Hongyang Li,Zelin Guo,Zhan Liu,Changda Nie,Sijia Wang,Menghan Li,Zhonghao Rao
The performance and safety of lithium-ion batteries (LIBs) are highly dependent on the operating temperature. Therefore, it is of utmost importance to establish an efficient and reliable battery thermal management (BTM) system to regulate the battery temperature. Latent heat storage technology, as an efficient passive thermal management solution, has attracted much attention in BTM. However, the commonly used phase change materials (PCMs) have problems such as easy leakage, poor thermal stability, and flammability, which always hinder their practical application. In this study, a polyimide@1-tetradecanol@graphene oxide (PI@TD@GO) composite PCM was synthesized and used for BTM. It not only achieves efficient heat storage and thermal management, but also exhibits a fire alarm function in an extreme thermal situation, providing a new idea for the thermal management of LIBs. In the BTM experiment, the surface temperature of the battery loaded with the PI@TD@GO5 decreases from 80.1 °C to 61.6 °C at a 3C discharge rate. In the fire alarm experiment, the PI@TD@GO5 triggered a fire alarm after 14 s contacting with flame and maintained the alarm for more than 200 s. This research proposes an innovative solution for battery thermal management, flame retardant, and fire alarm, which has great application potential.
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Acta Pharmaceutica Sinica B
·
2026
·
IF 14.6
Juntao Lin,Rulong Cai,Shaobing Li,Zhixiang Peng,Yupeng Wang,Yan Chen,Dongfang Zhou
Osteoarthritis (OA) remains a major clinical challenge due to its complex pathogenesis and the current lack of effective therapies capable of halting the progressive degradation of cartilage. Our bioinformatics analysis reveals that synovial inflammation precedes cartilage degeneration in early-stage OA, and chondrocyte pyroptosis present in both early and late stages, further promoting cartilage degeneration. Based on these findings, we developed a novel pathological progression-guided biphasic drug delivery supramolecular hydrogel (SP Gel/DS@cLip) featured by dual cross-linking where both spermidine (SP) and disulfiram (DS)-loaded cationic liposomes (DS@cLip) actively participate in hydrogel network formation. SP Gel/DS@cLip demonstrated favorable injectability, self-healing capacity, lubrication performance and biocompatibility. Notably, the hydrogel system enables rapid SP release to target early synovial inflammation and sustained DS release to inhibit chondrocyte pyroptosis, exerting significant cartilage protective effects both in vitro and in vivo . This pathological progression features-guided biphasic drug delivery system offers a promising therapeutic approach with strong potential for clinical translation in OA treatment.
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Gels
·
2025
·Vol. 11
·期 10
·806
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IF 5.3
Qinglong Liu,Dewei Ma,Haoze Cheng,Keke Yang,Bo Hou,Ziwen Heng,Yu Qian,Wei Liu,Siyuan Chen
Oral administration remains the most patient-friendly drug delivery route, yet its efficacy is limited by physiological barriers including gastric degradation and inefficient cellular uptake. pH-responsive nanogels have shown promise for gastrointestinal drug delivery, though their effectiveness is often constrained by poor membrane interaction. Inspired by natural membrane-anchoring mechanisms, a series of comb-like anionic polymers were designed via grafting alkylamines of different chain lengths (C10, C14, C18) at varying densities (10–30%) onto a biodegradable poly(L-lysine isophthalamide) (PLP) backbone. These pH-responsive comb-like polymers self-assembled into nanogels for loading the hydrophobic chemotherapeutic agent camptothecin. The alkyl length and grafting density significantly influenced pH-responsive behavior, membrane disruption, and drug release profiles. The optimal formulation—the nanogel prepared with PLP grafted 30% C14—achieved a high drug-loading capacity, ideal particle size and stability, and offered superior protection in acidic conditions (only 7 ± 5% release at pH 1.2 over 24 h), while enabling rapid intestinal release (78 ± 2% at pH 7.4 within 24 h). The nanogels significantly enhanced cellular uptake, cytoplasmic delivery, and cytotoxicity against colorectal carcinoma cells. This study demonstrates the key role of hydrophobic modification in designing effective oral nanocarriers, providing a promising platform for the treatment of intestinal diseases.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-17
·
IF 12.6
Bai Ge,Liu Hongwen,Li Wei,Chen Sijia,Wang Lishan,Wang Zhangding,Zhou Yue,Pan Yani,Liu Yu,Chen Qi,Zhang Nannan,Wei Jingjing,Fu Xueni,Zhou Yaru,Zhu Yun,Xu Lei,Wang Lei
Background The remodeling of extracellular matrix often fails chemotherapeutic agents to fight intrahepatic cholangiocarcinoma (ICC). The cGAS/STING pathway can trigger the innate immune response to obtain better immunotherapeutic outcomes. Results A cLipG/CuET nanocomposite was designed and synthesized based on glycyrrhizic acid (GA) and copper diethyldithiocarbamate (CuET). GA can open mitochondrial permeability transition pores (MPTPs), allowing Cu (II) to interrupt mitochondrial function through copper toxicity. By activating the cGAS-STING signaling pathway in macrophages, this mitochondrial-targeting polymer (cLipG/CuET) significantly boosted the production of mitochondrial reactive oxygen species (mtROS), and promoted the escape of damaged mitochondrial DNA (mtDNA) from ICC cells. Consequently, M1 polarization of cancer-associated macrophages enhanced the immune response against ICC. In the mouse model, the intravenous administration of cLipG/CuET transformed the ICC from “cold” into “hot”. Conclusions With a high biosafety, cLipG/CuET exerted a synergistic effect on the immune checkpoint inhibitor αCTLA-4 against ICC, and their combination provided a new therapeutic strategy. Graphical abstract
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Caiyun Zhao,Yaokun Pang,Yunmeng Li,Tao Zhou,Yan Wang,Cong Du,Binbin Fan,Hanlin Ou,Hua Yuan
Wearable electronics have become a hot research field of next-generation electronics. Despite significant progress in the advancement of wearable electronics, powering these devices with sustainable energy sources and equipping them with special functions remain formidable challenges. Herein, a multifunctional all-nanofiber-based TENG prepared by a simple electrospinning technique is reported, which exhibits good biodegradability, antibacterial activity, UV-protective, flame retardant properties, and hydrophobicity for human motion sensing and biomechanical energy harvesting. This TENG is fabricated by sandwiching a silver nanowire (AgNW) between a sodium alginate (SA) nanofiber membrane-based triboelectric layer and a modified multifunctional substrate layer. Due to the added poly(ethylene oxide) (PEO) and BaTiO3 nanoparticles (BTO) in the SA nanofiber membrane, the output voltage and transferred charge of the TENG are increased by about 4.95 and 3.89 times, and it exhibits a high output power density of 654 mW m–2. Additionally, after modification with phytic acid, octadecylamine, and TiO2 nanoparticles, the nanofiber membrane exhibits special properties, such as UV-protective, hydrophobicity, flame retardancy, antibacterial capabilities, and degradability. Finally, the constructed TENG device is utilized to monitor various human motions in a self-powered manner and harvest energy from body movements to power wearable sensors. Given the outstanding features, the fabricated TENG paves a new and practical pathway to develop next-generation wearable electronics.
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JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Xuening Feng,Huanyu Liu,Hanjun Liu,Xuebin Jiang,Liwei Shen,Yuqi Tang,Qian Qu,Dong Xiang,Xuemin Yan,Yuanzhu Mi
A new type of ionic liquid demulsifier with double hydrophilic and hydrophobic chains (HDEA-TFA) was synthesized through the quaternization and replacement reaction. The chemical structure of HDEA-TFA was identified by 1 H NMR and FT-IR. It could be applied as an excellent demulsifier for two water-in-crude oil (W/O) emulsions (m water :m oil = 70:30 and m water :m oil = 30:70). The effect of demulsification conditions such as concentration of HDEA-TFA, settling time, demulsification temperature, pH value and salinity on the demulsifying efficiency (DE) of the W/O emulsions were discussed in detail. The results showed that the demulsifying efficiency (DE) of HDEA-TFA in the two W/O emulsions could reach 100 % with the concentration of 500 mg/L at 60 °C within 120 min. Also, HDEA-TFA had excellent acidic, alkaline and salt resistance. Moreover, several commercial demulsifiers were compared to evaluate the demulsifying performance of HDEA-TFA. The dynamic interfacial tension (IFT), surface tension (ST), three-phase contact angle (CA), elasticity modulus (EM) and zeta potential were used to investigate the demulsifying mechanism. The current study developed a new type of ionic liquid demulsifier with excellent performance and provided a reference for the research of demulsification mechanism.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Zhaohua Zhang,Zejian He,Tianhang Weng,Laifa Tong,Yongcheng Liu,Yulong Chen,Mi Zhou
In this paper, a series of fluorescent starches were prepared simply and effectively by Hantzsch multi-component reaction (MRC). These materials showed bright fluorescence emission . Notably, due to the existence of polysaccharide skeleton, starch molecules can effectively inhibit the common aggregation induced quenching effect caused by the aggregation of conjugated molecules in traditional organic fluorescent materials. Meanwhile, the stability of this material is so excellent that the fluorescence emission of the dried starch derivatives would not destroy after boiling at a high temperature in some common solvents, and even brighter fluorescence can be stimulated in alkaline solution. In addition to fluorescence, starch was also endowed with hydrophobic property by one-pot method connecting long alkyl chains. Compared with native starch, the contact angle of fluorescent hydrophobic starch increased from 29° to 134°. Furthermore, the fluorescent starch can be prepared into film, gel and coating by different processing methods. The preparation of these Hantzsch fluorescent starch materials provide a new way for the functional modification of starch materials and has great application potential in detecting, anti-counterfeiting, security printing and other related fields.
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RSC Advances
·
2023
·Vol. 13
·期 12
·7848-7856
·
IF 3.9
Hao Yang,Yinmeng Ding,Ya Ding,Jing Liu
Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous and persistent organic compounds that are significantly teratogenic, carcinogenic and mutagenic. Rubber stoppers commonly used in sterile formulation packaging materials often contain carbon black as the additive to enhance mechanical strength. However, PAHs may be formed during the production of carbon black, which could cause the drug formulations to be contaminated when contacting with the rubber stopper, and then enter the patient's body. The determination of PAHs in drug formulations is challenging, due to their trace amounts and matrix interference. Therefore, sample pretreatment is necessary and important. In this work, a novel technique, named in-vial solid-phase extraction (IVSPE), was developed for the selective extraction and enrichment of 16 PAHs in pharmaceuticals. The coated sample vial was directly used as the container for the whole process of sample pretreatment. As the solid-phase adsorbent, the coating was prepared by successively modifying the inner surface of a sample vial with polydopamine film and octadecylamine. PAHs could be selectively extracted through π–π stacking interaction and hydrophobic interaction, and then desorbed and enriched by a small amount of organic solvent. After systematic optimization of the coating preparation and the extraction process, the limits of detection and quantification of 16 PAHs were in the range of 0.002–0.60 ng mL−1 and 0.007–2.00 ng mL−1, respectively. Good linearities and precision of six repeated injections were obtained. The recoveries at three spiked concentration levels in normal saline were in the range of 62.72–106.90% with the relative standard deviation between 0.83% and 6.78%. Finally, PAHs in normal saline and powders for injection were extracted by established IVSPE, followed by separation and detection with high-performance liquid chromatography with a fluorescence detector and diode array detector (HPLC-FLD/DAD). It is worth noting that the preparation conditions of the adsorbent in the IVSPE method are mild, simple and green. Moreover, IVSPE has the advantages of having few work steps and avoiding the risk of contamination, because no special instrumentation or sample transfer is required. IVSPE could also be used for the pretreatment of multiple samples at the same time, which is beneficial to practical applications.
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MINERALS ENGINEERING
·
2023
·
IF 4.8
Xueshan Yu,Zhenhai Fu,Yanfang Ma,Chengbao Li,Shichun Zhang,Zhihong Zhang
Currently, the “crystallization-flotation” process is widely used for the industrial production of KCl. However, the significant aggregation of KCl and NaCl in the decomposition-crystallization stage of carnallite leads to inefficient separation of the two particles in the flotation stage, which restricts the production of high-grade KCl. In this study, environmentally friendly polyethylene glycol (PEG) was used to regulate the decomposition-crystallization of carnallite for the first time, and the high-grade KCl was successfully prepared by reducing the degree of crystal aggregation. The crystals were characterized by SEM-EDS, FT-IR, XRD and AFM, and it was found that PEG which average Mn 800 (PEG 800) could adsorb on the crystal surface and effectively disperse NaCl and KCl. It was also found that there are two mechanisms by which PEG 800 achieves dispersion. On the one hand, PEG 800 micelles contain polyoxyethylene chains with large steric repulsion, which can prevent the adhesion of particles. On the other hand, PEG 800 can weaken the electric potential on the surface of KCl and NaCl and reduce the electrostatic interaction force between the particles. Finally, the behavior of Na, K, and Cl before and after the addition was simulated by molecular dynamics, and molecular dynamics calculations showed that PEG 800 could weaken the effect of NaCl on KCl.
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Asian Journal of Pharmaceutical Sciences
·
2023
·
IF 10.2
Run Han,Zhuyifan Ye,Yunsen Zhang,Yaxin Cheng,Ying Zheng,Defang Ouyang
Liposome is one of the most widely used carriers for drug delivery because of the great biocompatibility and biodegradability. Due to the complex formulation components and preparation process, formulation screening mostly relies on trial-and-error process with low efficiency. Here liposome formulation prediction models have been built by machine learning (ML) approaches. The important parameters of liposomes, including size, polydispersity index (PDI), zeta potential and encapsulation, are predicted individually by optimal ML algorithm, while the formulation features are also ranked to provide important guidance for formulation design. The analysis of key parameter reveals that drug molecules with logS [-3, -6], molecular complexity [500, 1000] and XLogP3 (≥2) are priority for preparing liposome with higher encapsulation. In addition, naproxen (NAP) and palmatine HCl (PAL) represented the insoluble and water-soluble molecules are prepared as liposome formulations to validate prediction ability. The consistency between predicted and experimental value verifies the satisfied accuracy of ML models. As the drug properties are critical for liposome particles, the molecular interactions and dynamics of NAP and PAL liposome are further investigated by coarse-grained molecular dynamics simulations. The modeling structure reveals that NAP molecules could distribute into lipid layer, while most PAL molecules aggregate in the inner aqueous phase of liposome. The completely different physical state of NAP and PAL confirms the importance of drug properties for liposome formulations. In summary, the general prediction models are built to predict liposome formulations, and the impacts of key factors are analyzed by combing ML with molecular modeling. The availability and rationality of these intelligent prediction systems have been proved in this study, which could be applied for liposome formulation development in the future.
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危险品化学品经营许可证（带存储）