ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Liwei Wu,Jiawen Fan,Hengxi Yao,Tong Wei,Jia Li,Jiawei Yan,Tianyi Wang,Canlin Zhou,Yingdong Han,Linyang Li,Dong Tu,Dongling Geng
Photoluminescence (PL) and mechanoluminescence (ML), serving as core mechanisms of emerging intelligent luminescent materials, hold momentous promise for applications in information security, display technologies, and self-powered sensing. However, conventional intelligent luminescent materials face critical limitations, including the difficulty in constructing multiplexing systems, dependence on ultraviolet (UV) pre-irradiation, and constraints of monochromatic emission. To address these limitations, a series of Er 3+ mediated piezoelectric Ca 3 Ga 4 O 9 :Eu 3+ samples is designed and developed, establishing a four-wavelength-excitation optical multiplexing platform, where each excitation source selectively activated distinct lanthanide energy transfer pathways while enabling tricolor PL tuning from orange-red to yellow to green. Simultaneously, intriguing ML is also achieved, featuring non-pre-irradiation and multicolor (continuous red-to-green emission) tunability characteristics. More importantly, combining systematic experimental investigations and density functional theory calculations, the underlying mechanism of the ML has been elucidated as the synergistic contribution of triboelectric and piezoelectric effects. The developed Ca 3 Ga 4 O 9 :Eu 3+ embellished by Er 3+ displayed intriguing potential application in grayscale analysis anti-counterfeiting films, and self-powered cipher lock system.
研究领域:
材料科学
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发光材料
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智能响应材料
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信息加密
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自供电系统
·
纳米能源
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固态物理化学
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防伪技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xuheng Chen,Hongbin Zhang,Yong Liu,Feiyu Zhao,Bowen Li,Run Yang,Niansong Qian,Yang Bai,Liang Zhao,Bin Zheng,Shanlong Zhang
Prodrugs enable targeted and precise release through chemical modifications, optimizing pharmacokinetics, minimizing side effects, and enhancing therapeutic efficacy, making them a powerful tool in precision medicine. However, prodrug activation systems face clinical translation challenges, such as off-target activation, metabolic variability, and imprecise external triggering, which reduce therapeutic precision and limit their clinical potential. Here, we have designed an engineering graphene oxide (GO)/Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O₃ (BCZT/GO) energy nanoconverter, which can achieve precise prodrug resurgence through precise external ultrasound triggering. The system initiates the proton sponge effect via the transformation of a pH-responsive structure, which disrupts the integrity of the lysosomal membrane and facilitates the escape of nanoparticles from lysosomal entrapment. Upon ultrasound (US) irradiation in the acidic tumor microenvironment (TME), BCZT/GO generates hydrogen (H 2 ), converting the Pt (IV) prodrug into a bioactive Pt (II) compound. This catalytic transformation results in the formation of cytotoxic DNA-cisplatin cross-links, thereby inhibiting DNA replication and repair in cancer cells and significantly suppressing tumor growth in tumor-bearing mouse models. This gas reduction strategy demonstrates that ultrasonically activated piezoelectric materials can serve as an effective mechanism for precise drug delivery and controlled release. This innovative approach holds great promise for the treatment of advanced cancer and provides a versatile platform for targeted therapeutic interventions.
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DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Linlin Liang,Xin Li,Kai Hu,Pingqiang Cai,Jianwu Wang,Jing Yu,Shasha Wang,Yuwei Zhao,Changgeng Xu,Siwei Li,Hong Liu,Changyong Wang,Jin Zhou
Secondary traumatic brain injury (TBI) induces a pro-inflammatory microenvironment that hampers neural stem cells (NSCs) therapy and tissue regeneration. To address this challenge, an immuno-piezoelectric transducer have been developed to create an anti-inflammatory immune microenvironment, deliver wireless electrical stimulation, and facilitate multimodal NSCs therapy. The immuno-piezoelectric transducer drives the polarization of microglia towards the anti-inflammatory M2 phenotype and secretion of anti-inflammatory cytokines. This modulation significantly reduces the inflammatory response, creating an optimal microenvironment for NSCs survival. Furthermore, the wireless electrical stimulation generated by ultrasound facilitates NSCs differentiation into glutamatergic and GABAergic neurons, enhances neurite complexity, upregulates synaptic proteins expression and neural integration in injured regions. The multimodal therapy demonstrates superior outcomes in restoring structural integrity, improving functional, and enhancing behavioral action in TBI rat models. This study integrates piezoelectric with immunomodulation to reprogram the neuroimmune microenvironment, providing novel therapeutic paradigm for brain injury repair.
研究领域:
神经科学
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免疫学
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生物医学工程
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干细胞治疗
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转化神经病学
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组织工程
·
生物材料
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Tianchan Jia,Shengbin Cao,Xiaosong Liu,Lei Li,Kai Dong
Traditional power technologies are constrained by size and endurance, whereas nanogenerators offer lightweight, environmentally friendly, and sustainable energy solutions. In this study, an MXene/BaTiO3/PAN composite nanofiber membrane was developed using electrospinning technology. The incorporation of BaTiO3 nanoparticles and two-dimensional MXene flakes significantly enhanced the piezoelectric properties of the PAN matrix, resulting in an output voltage of 6.45 V and a current of 308 nA-approximately four times higher than that of pure PAN. Notably, piezoelectric nanogenerators (PENGs) and triboelectric nanogenerators (TENGs) were integrated into one single device, addressing the low output and stability issues of traditional PENGs. The integrated device achieved a higher stable output voltage of 12–14 V and retained stable performance over 5000 cycles. Moreover, the MXene component endowed the nanofiber membrane with excellent photothermal properties, achieving a temperature rise of 42 °C under 1 W cm−2 solar irradiation. This demonstrates its potential for human joint photothermal therapy and underscores its value for developing high-performance self-powered sensors and wearable electronic devices.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shi-Zheng Liu,Wen-Jing Ding,Peng-Fei Li,Zhi-Lin Liao,Fang-Xin Zhao,Ren-Yan Bai,Man-Di Lu,Hui-Peng Lv,Xiao-Gang Chen,Yong Ai
The power source material applied in wearable electronic devices should be soft, flexible, stretchable, and biocompatible. Organic piezoelectric materials, with their unique combination of these properties, show great promise as innovative energy-harvesting materials. Herein, we present an enantiomeric organic piezoelectric material, R/S-MP-TFSA (MP = 2-Methylpiperazine, TFSA = Trifluoromethanesulfonimide), which crystallizes at room temperature in the polar space group P1 and exhibits a pronounced second-harmonic generation (SHG) response. With a piezoelectric coefficient (d33) of 20 pC/N, the R/S-MP-TFSA- based piezoelectric device demonstrates a stable piezoelectric output voltage of approximately 16 V under simple finger-tapping conditions, a representative example of human mechanical motion. These characteristics highlight its considerable potential for applications in piezoelectric sensors for energy harvesting and self-powered low-voltage electronic devices.
研究领域:
材料科学
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有机电子学
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生物医学工程
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纳米能源
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柔性传感器
·
可穿戴设备
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Xi Cui,Yizhu Shan,Jiaxuan Li,Meng Xiao,Yuan Xi,Jianying Ji,Engui Wang,Baokun Zhang,Lingling Xu,Mingzhu Zhang,Zhou Li,Yingzi Zhang
Prevention of aseptic loosening, the main reason for secondary surgery of bone implants, is of great crucial clinical importance. As a promising bioactive material to promote bone regeneration, the piezoelectric materials for preventing aseptic loosening has not been reported. Here, a surface coating is presented for implants based on piezoelectric poly(L-lactic acid) (PLLA). The coating ingeniously utilizes zoledronic acid (ZA), a drug used to treat osteoporosis, as a nucleating agent to enhance the piezoelectricity of PLLA. The coating can not only provide a continuous porous piezoelectric environment to stimulate osteogenic differentiation without intervention, but also effectively inhibit the osteolytic activity of osteoclasts through the slow release of ZA, achieving long-term effectiveness with a single implantation. The rat femur cavity implantation experiment suggests that, the PLLA/ZA coating can rapidly initiate osseointegration of the implant and effectively mitigate the risk of aseptic loosening, even in the presence of metal submicroscopic particles that induce aseptic loosening. This strategy of piezo-enhanced PLLA drug-loaded coating may provide a new idea for the surface modification of bone implants.
研究领域:
生物医学工程
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材料科学
·
骨科
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DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Yu Chen,Yangfei Ou,Chunxing Xian,Hao Wu,Guoqing Pei,Wei Li,Ling Wang,Lei Shi
Osteonecrosis of the femoral head (ONFH) is a common condition that greatly affects patients’ quality of life, yet current treatments often have limited effectiveness. This study aimed to explore how a porous titanium alloy scaffold coated with barium titanate (BaTiO3) could promote bone regeneration in ONFH. We employed various research methods including cell culture, piezoelectric property measurements, tissue-engineered scaffold fabrication, and in vitro and in vivo biocompatibility assessments. Our results showed that macrophages had better attachment and growth on the BaTiO3-coated porous titanium alloy (PTB) scaffold than on the uncoated porous titanium alloy (PT) scaffold, with no significant differences in apoptosis rates between the two groups. Furthermore, the PTB scaffolds reduced the expression of bone resorption markers, such as Cathepsin K, TRAP, and RANK, under dynamic loading conditions. This finding indicates their potential to inhibit osteoclast differentiation. Moreover, the BaTiO3 coating enhanced the mechanical properties and biocompatibility of the scaffolds, evidenced by significantly higher alkaline phosphatase activity and calcium nodule formation in MC3T3-E1 osteoblasts cultured on PTB scaffolds. These findings underscore the dual role of BaTiO3 in facilitating cellular responses and modulating signaling pathways involved in bone metabolism. Our study highlights the promise of BaTiO3-coated titanium alloy scaffolds as an innovative approach to enhance bone regeneration in ONFH, paving the way for future clinical applications and the development of advanced biomaterials for bone healing.
研究领域:
骨科学
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生物材料学
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组织工程
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再生医学
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生物力学
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分子生物学
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转化医学
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Chao Yan,Liang Wang,Xiangming Li,Xiaopei Wang,Ye Tang,Hongmiao Tian,Chunhui Wang,Xiaoliang Chen,Jinyou Shao
Piezoelectric pressure sensors often suffer from low sensitivity due to limited compressive stress or mismatched piezoelectric modes. Additionally, achieving controllable adjustment of their sensitivity and sensing range remains a significant challenge. Here, spider web-inspired flexible piezoelectric pressure sensors with a high sensitivity and adjustable sensing range are proposed. First, a radially polarized piezoelectric biomimetic film with 3D-architectured spiral microelectrodes is developed, achieving the d 33 mode under radial stress. Second, low-stiffness soft substrates are introduced to convert small axial compressive stress into significantly increased radial stress. The developed sensors with a cavity soft substrate exhibit high sensitivities of 3.356 V N −1 (0.01–0.5 N) and 2.524 V N −1 (0.5–10 N), which represent 55- and 41-fold improvements over conventional sensors, respectively, far surpassing previously reported strategies. Third, a simple method is proposed for altering sensor stiffness to tune sensitivity and sensing range. By increasing the bending stiffness, the pressure sensors achieve an extended sensing range (0.5–40 N) and an 11-fold enhancement in sensitivity. Furthermore, the proposed sensors not only demonstrate excellent cyclic stability (up to 50 000 cycles) and scalability but also enable highly sensitive detection of airflow velocity, breathing state, and distributed pressure.
研究领域:
生物医学工程
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柔性电子学
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传感技术
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仿生材料
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可穿戴设备
·
生理信号监测
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 26
·1-14
·
IF 2.8
Li Chenglong,Si Jingxiang,Yuan Xiufang,Wang Wenxuan,Wang Guoguo,Lin Xiujuan,Huang Shifeng,Yang Changhong
With the development of new sensor technology, flexible piezoelectric materials possessing exceptional mechanical-to-electrical energy conversion capabilities hold great promise for application in a variety of sectors, including biomedicine, flexible robotics, and wearable electronic devices. This work reports the successful growth of an all-inorganic transparent Bi(Fe 0.95 Mn 0.05 )O 3 (BFOMn) film on the Mica substrate using a straightforward one-step sol–gel method. The prepared BFOMn thin film enables the optimum electrical properties with a saturated polarization of ~ 92 μC/cm 2 , a remanent polarization of ~ 74 μC/cm 2 , and a high piezoelectric constant d 33 of ~ 405 pm/V. Concurrently, the film exhibits exceptional adaptability without compromising its electrical performance, as evidenced by its capacity to undergo a tight curve with a radius of just 2 mm. Utilizing this BFOMn film, the fabricated flexible piezoelectric energy harvester (FPEH) has exceptional energy collecting capabilities, producing an output voltage of 15 V, a short current of 130 nA, and a notable force sensitivity of 4 V·N −1 before poling. It can also be employed to monitor human actions, such as hand hammering, hand clapping, and foot stepping. This work demonstrates the potential of the BiFeO 3 -based FPEH/sensor in the field of new intelligent electronics.
研究领域:
材料科学
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纳米技术
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能量转换
·
柔性电子学
·
传感器技术
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Guanbo Min,Yue Peng,Wenjun Wang,Tingyu Wang,Yaqi Zhang,Zetao Yin,Fujie Lv,Xuanli Dong,Shuxing Xu,Kun Xu,En Zhao,Chengyu Li,Ke Wang,Xin Zhao,Jessica M Rosenholm,Weiguo Wang,Cheng Huang,Wei Tang
Critical bone defects require interventional treatment as they exceed the body's natural repair capacity. The emerging approaches involve implantable biomaterial or devices, but persist challenges in biodegradability, low cell migration, and differentiation efficiency, complex surgery procedures. This study presents a biodegradable piezoionic hydrogels assembly scaffoldoid composed of piezoelectric glycine-based hydrogel and Li + -contained injectable conductive hydrogel. Upon ultrasound stimulation, the piezoelectric hydrogel generates an electric field that propagates through the conductive hydrogel. The regulation of Li + concentration to enhance the electrical conductivity of conductive hydrogels facilitates the recruitment of bone marrow mesenchymal stem cells (BMSCs) by the assembly. Under the synergistic stimulation of electrical signals and Li + , namely, dual-stimuli, the recruited BMSCs activated their PI3K/AKT and β-catenin/TCF7/CCN4 signaling pathways, thereby promoting the high expression of osteogenic genes such as RUNX2. Moreover, the conductive hydrogel is injectable, serving as a conformal scaffoldoid for full wound coverage, and the piezoelectric hydrogel can be seamlessly attached upon with the conductive hydrogel at the wound site, thereby simplifying the interventional repair procedures.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
骨科学
·
分子生物学
·
生物材料学
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DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
An Zhang,Zhiyong Liu,Bing Xie,Jinshan Lu,Kun Guo,Shanming Ke,Longlong Shu,Huiqing Fan
Excellent vibration-electricity conversion in various piezoelectric materials is frequently restricted, thus hardly generates high mechanochemical potential eliciting by ferroelectric polarization for advanced catalysis processes. Herein, we propose a phase boundary in Li modified Na 0.5 K 0.5 NbO 3 (NKN) materials to improve the piezocatalytic activity, and the relationships among the composition, phase structure, electrochemical and catalytic performances were systematically investigated. An outstanding piezocatalytic performance was exhibited in the LNKN6 (6 mol % Li doped NKN) with coexistence of orthorhombic and tetragonal phases, and the piezocatalytic activity showed a superior repeatability and universal applicability for the degradation of organic pollutants. The reaction rate constant of the LNKN6 was up to 25.16 × 10 −3 min −1 , which was 3.20 times than that of pristine NKN. The enhancement of piezocatalytic activity was confirmed by Landau-Ginsburg-Devonshire phenomenological theory and the transfer efficiency of force-generated electrons and holes, and then an appropriate mechanism of the ultrasonic vibration driven piezocatalysis was speculated. This work provides an alternative strategy to enhance the catalytic efficiency of piezocatalyst and the high activity of the NKN-based piezoelectrics has an important application for environmental remediation.
研究领域:
材料科学
·
环境科学
·
催化
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Daojian Su,Linlin Jiang,Zijun Pan,Changhong Yang,Chang Liu,Rongxiao Liu,Tong Liu,Xin He,Shifeng Huang,Zhenxiang Cheng
Disentangling complex, concurrent dynamic and static mechanical stimuli remains a challenge for next-generation wearable devices. Here, we propose a vertically integrated flexible dual-modal pressure sensor that synergistically combines a lead-free flexibility piezoelectric sensor (FPS) and a bioinspired iontronic capacitive sensor (ICS) to address this limitation. The FPS employs a three-dimensional interwoven potassium sodium niobate piezoceramic textile embedded in polydimethylsiloxane, achieving efficient stress transfer for dynamic sensing with high piezoelectricity (piezoelectric constant d 33 = 38 pC N −1 , S Vmax = 0.7 kPa −1 ). In parallel, the ICS incorporates a peak-valley microstructured ionogel dielectric layer, enabling ultrahigh static sensitivity ( S Cmax = 2599.65 kPa −1 ) through pressure-modulated interfacial contact area. This dual-mode architecture generates complementary signals: transient piezoelectric voltage for high-frequency dynamics and capacitive displacement for static/quasi-static loads. This capability overcomes the single-mode limitation in disentangling concurrent static and dynamic sensing, achieving exceptional accuracy in discriminating loads, recognizing sound, analyzing high-pressure gait, and identifying handwriting. This study not only establishes an innovative strategy for dual-mode pressure sensor design but also bridges the critical gap between complex mechanical stimuli decoding, medical diagnostics, and adaptive human-machine interaction (HMI).
研究领域:
生物医学工程
·
柔性电子学
·
智能传感
·
可穿戴医疗设备
·
人机交互
·
生理信号解码
·
转化医学
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DOI
高影响因子
危险品化学品经营许可证（带存储）