ANALYST
·
2024
·
IF 3.6
Yating Rui,Qunyong Tang,Liyi Chen,Juan Pu,Wangpeng Wang,Shou-Nian Ding
Baijiu, as a traditional Chinese alcoholic beverage, carries China's rich historical and cultural heritage. Consumers experience varying levels of relaxation and pleasure after consuming different Baijiu, with the biological basis of delectation influenced by serotonin and dopamine. In this study, we prepared carbon fiber electrodes modified with surface decorated gold nanoparticles to directly measure the electrochemical response signals in the serum of mice before and after gavage different types of Baijiu. It was observed that the serum signal change in mice after consuming Baijiu Sample 1 (J1) was higher than the other two types of Baijiu. Consequently, trace flavor compounds in the Baijiu samples were detected using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS), revealing the highest content of L-lactic acid in J1. Mice were intraperitoneally injected with 200 mg/kg of L-lactic acid. The changes in dopamine and serotonin in the serum of injected mice were monitored using a biosensor, and the results were compared with results from high performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS). The findings confirmed that L-lactic acid could indeed stimulate both neurotransmitters' secretion in mice, suggesting that the trace components in J1 may even exhibit synergistic effects. The study contributes to a deeper under-standing of the effects of Baijiu on body and provides a scientific basis for the production and consumption of Baijiu.
研究领域:
生物化学
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神经科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2021
·Vol. 178
·期 24
·4808-4825
·
IF 8.74
Yan-Fei Yang,Hui Dong,Yan Shen,Lei Li,Michael Lazarus,Wei-Min Qu,Zhi-Li Huang
Background and Purpose Modafinil is a potent eugeroic (wakefulness-promoting) drug that is prescribed to treat narcolepsy and has a low incidence of abuse. Although previous studies have shown that modafinil-induced arousal depends on the dopamine receptors and transporters, the specific part/s of the dopamine transmitter system underlying this mechanism remained unclear. Here, we investigated the role of mesencephalic dopamine neurons in modafinil-evoked arousal. Experimental Approach A dopamine indicator (dLight1.1) was employed to detect dopamine changes in the nucleus accumbens (NAc) and dorsal striatum. We specifically lesioned mesencephalic dopamine neurons via diphtheria toxin (DTA) in the dopamine transporter (DAT)-Cre mice. Then, the sleep–wake states were recorded to evaluate the effect of modafinil on arousal. Finally, the extent of DTA-induced lesions was determined by immunohistochemistry. Key Results Modafinil promptly increased dopamine levels in the NAc and dorsal striatum in a dose-dependent manner. Lesioning of dopamine neurons in the substantia nigra pars compacta (SNc) or ventral tegmental area (VTA) had no significant effects on physiological sleep–wake cycles. Modafinil at 90 mg·kg −1 increased continuous wakefulness for 355 min in control mice. However, these effects were slightly decreased by 6.7% in the SNc-lesioned mice and were prominently diminished by 32.8% in VTA-lesioned mice. Furthermore, the modafinil-induced arousal was completely blocked in the SNc-VTA-lesioned mice, whereas lesions of the dorsal raphé nucleus had no effect. Conclusion and Implications Taken together, our findings indicate that mesencephalic dopamine neurons are essential for modafinil-induced arousal. Graphical
研究领域:
神经科学
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药理学
·
睡眠医学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 138
·期 3
·49698
·
IF 2.52
Yao Xu,Jinhao Sun,Lijun Qian,Juan Li
Polydopamine (PDA) was prepared by using dopamine which has good charring ability. The PDA was used as an environmentally friendly flame retardant and combined with 9,10-dihydro-9-oxo-10-phosphaphenanthrene-10-oxide (DOPO) to improve the flame retardancy of epoxy (EP) resin. The flame retardancy and thermal stability of EP composites were researched by UL-94 vertical burning, limiting oxygen index (LOI), cone calorimetry tests, and thermal gravimetric analyzer. Adding DOPO alone requires 6% to make EP obtain the UL-94 V0. If DOPO and PDA are combined, only 4% is needed to make EP obtain the UL-94 V0, which suggests that there is good synergistic effect between them. Moreover, the peak of heat release rate of EP/DOPO/PDA composites is less than that of EP/DOPO composites. The reactions among EP, DOPO, and PDA reduce the release of combustible gases at the early stage of degradation; at the same time, DOPO volatilize to the gas phase, quench the free radicals, and the combustion can be stopped. In addition, due to the decrease of the amount of PDA/DOPO, the EP composite can get a higher glass transition temperature, but due to the aggregation of PDA in EP, the tensile property of EP composite decreases.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 35
·29279-29287
·
IF 3.289
Mei Liu,Wanquan Jiang,Qian Chen,Sheng Wang,Ya Mao,Xinglong Gong,Ken Cham-Fai Leung,Jie Tian,Huijuan Wang,Shouhu Xuan
A facile one-step method was developed to synthesize core–shell structured SiO2@polydopamine (PDA) nanospheres. During the synthesis, a PDA shell was simultaneously coated on the SiO2 nanospheres to form the core–shell nanostructure. The PDA shell thickness was tunable by varying the concentration of the starting dopamine precursor. After dispersing the core–shell nanospheres into poly(ethylene glycol) 200 (PEG200), a SiO2@PDA based shear thickening fluid (STF) was obtained. In comparison to pristine SiO2, the SiO2@PDA based STF presented better ST effects and its maximum viscosity could reach as high as 194.6 Pa s. A possible enhancement mechanism was proposed in order to investigate the structural dependence of the ST effect. This high performance SiO2@PDA based STF could be widely applied in body armor and other safe-guarding areas.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2021
·
IF 8.742
Lan Hao,Zexu Chi,Jianyou Wang
Hyperbranched polyethyleneimine (PEI) holds great potential for membrane-separation materials owing to the dendritic structure. However, their utilization in constructing antifouling anion exchange membranes (AEMs) remains significant challenge. Herein, a novel strategy of employing hyperbranched PEI to design antifouling AEMs was demonstrated. Hyperbranched PEI and dopamine were co-deposited on the surface of AEMs to prepare antifouling AEMs. Dopamine can easily form polydopamine (PDA) and enhance the hydrophilicity and electronegativity of membrane surface. The hydrophilic and electronegative membrane surface enabled the ability to block foulants, endowing the AEMs with improved antifouling performance. Meanwhile, the dendritic structure of hyperbranched PEI tended to assemble the low-barrier pathway for ion transport and maintained the desalination performance of AEMs. Thus, the obtained PEI-1800&PDA/AEM achieved 1.93 times variation of the electrical conductivity for diluted solution of commercial AEM after antifouling experiment, while the variation is close to that of commercial AEM after desalination experiment. This study offers new insight into fabricating hyperbranched PEI-based membranes for high-performance materials.
研究领域:
材料科学
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化学工程
·
环境科学
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产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Ying Zhou,Min Tian,Ruichun Li,Yan Zhang,Guomei Zhang,Caihong Zhang,Shaomin Shuang
An electrochemical sensor applied for dopamine (DA) detection was constructed. An easy static way was used to synthesize bimetallic CoNi-MOF. Next, it was mixed with graphene oxide (GO) under ultrasound to get a uniform suspension. Subsequently, the solution was coated on the glassy carbon electrode (GCE) to form CoNi-MOF@ERGO/GCE by the electrochemical reduction method. The interaction between CoNi-MOF and electrochemically reduced graphene oxide (ERGO) enhances the electrocatalytic performance for DA detection. CoNi-MOF@ERGO/GCE has a wider linear range (0.1–400 μM) and a lower detection limit (0.086 μM) under optimum conditions. Furthermore, it has been applied to test DA in human serum samples. The results reveal that the DA sensor shows excellent performance, which will provide a novel idea for more sensitive and quicker DA detection.
研究领域:
生物化学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2016
·
IF 2.74
Cuiping Zhai,Fang Sun,Ping Zhang,Huiting Ma,Aixin Song,Jingcheng Hao
Cyclic voltammetry (CV), density functional theory (DFT) calculations, and atoms in molecules (AIM) analyses were performed to investigate the hydrogen bonding in dopamine-ethanol and dopamine hydrochloride-ethanol mixtures. CV results show that the anodic/cathodic peak potential of dopamine hydrochloride in ethanol is influenced by the hydrogen bonding formed in the mixtures. The DFT and AIM results indicate that the hydrogen atoms of NH 3 + in dopamine hydrochloride-ethanol system are easier to interact with ethanol by hydrogen bonding than those in dopamine-ethanol system. On the contrary, the hydrogen atoms on phenolic hydroxyl groups can form stronger hydrogen bonding with ethanol in dopamine-ethanol system than in dopamine hydrochloride-ethanol system.
研究领域:
生物化学
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药物化学
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计算化学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 134
·期 10
·
IF 1.866
Yuanyuan Liu,Xueqin Li,Yun Qin,Ruili Guo,Jianshu Zhang
Novel facilitated-transport mixed-matrix membrane (MMM) were prepared through the incorporation of polydopamine (PDA) microspheres into a poly(amide- b -ethylene oxide) (Pebax MH 1657) matrix to separate CO 2 –CH 4 gas mixtures. The Pebax–PDA microsphere MMMs were characterized by Fourier transform infrared spectroscopy, scanning electron microcopy, X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. The PDA microspheres acted as an adhesive filler and generated strong interfacial interactions with the polymer matrix; this generated a polymer chain rigidification region near the polymer–filler interface. Polymer chain rigidification usually results in a larger resistance to the transport of gas with a larger molecular diameter and a higher CO 2 –CH 4 selectivity. In addition, the surface of PDA microspheres contained larger numbers of amine, imine, and catechol groups; these were beneficial to the improvement of the CO 2 separation performance. Compared with the pristine Pebax membrane, the MMM with a 5 wt % PDA microsphere loading displayed a higher gas permeability and selectivity; their CO 2 permeability and CO 2 –CH 4 selectivity were increased by 61 and 60%, respectively, and surpassed the 2008 Robeson upper bound line. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44564.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Chengzhuo Yu,Jin Xu,Li Xiong,Yarui Wang,Silong Wang,Fanglan Geng,Zesen Shang,Huasheng Wu,Lixia Zhao,Yawei Wang
Luminol-based chemiluminescence (CL) systems, as a powerful tool for bioanalysis, are limited owing to their weak CL intensity and self-decomposition of the classic oxidant H2O2. Herein, we introduced a new luminol CL enhancer, the natural light-driven photocatalyst MIL-100(Fe)/TiO2, for the selective determination of dopamine (DA). By employing MIL-100(Fe)/TiO2 for the first time as an efficient enhancer, the MIL-100(Fe)/TiO2-luminol CL intensity was 100 times higher than that of the classical H2O2-luminol system. The CL spectrum, UV–vis absorption spectroscopy, radical scavenger experiments, and electron spin resonance spectroscopy were utilized to investigate the possible CL mechanism of the MIL-100(Fe)/TiO2-luminol system. All of the results indicated that MIL-100(Fe)/TiO2 can generate reactive oxygen species under mild natural light, which could react rapidly with the luminol anion radical and result in direct CL emission. The sensitive plate for DA was developed based on its inhibiting effect on CL intensity, and the linear range between CL intensity and DA concentration was 100 nM–1000 μM with a detection limit of 16.7 μM (S/N = 3). This study successfully achieved a stable reactant that can directly trigger the CL of luminol without the need for additional oxidizing agents under mild natural light and offers new possibilities for photoinduced amplification technology.
研究领域:
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Shanshan Zhan,Hongying Liu,Lihua Li,Zhengzhi Yin,Chunchuan Gu
Developing fast and sensitive methods to simultaneously analyze neurotransmitter and drug is of scientific significance for diagnosing and treating neurological diseases. Acupuncture can adjust and balance the blood gas, yin and yang and other physiological states through inserting acupuncture needle into the patient’s body, so as to treat diseases, care health and strengthen body. In this study, the stainless-steel needle was used as electrode matrix for the sensor. Gold nanoparticles (Au NPs), polydopamine (PDA) and multi-wall carbon nanotubes (MWCNTs) were layer-by-layer modified onto the bare acupuncture needle (AN) through green and environment-friendly method, and the new interface showed efficient performance for simultaneous monitoring dopamine (DA), acetaminophen (AC) and chlorpromazine (CPZ). It was interesting that the synergistic interface of MWCNTs, PDA and AuNPs exhibits effect conductivity, and high electrocatalytic activity for three molecules. The sensor optimally exhibits wide linear ranges of 0.08–100 and 100–1000 μM for DA, 0.07–100 and 100–1000 μM for AC, 0.1–100 and 100–450 μM for CPZ, respectively. The low detection limits are 0.015, 0.012, and 0.022 µM correspondingly, which are competitively compared to previous reports. In addition, the sensor exhibits good anti-interference ability in the presence of excessive interference. The sensor can successfully monitor DA, AC and CPZ in human serum and urine with the recovery rates from 97.2 % to 102.6 %. The sensor showed good repeatability, stability, and reproducibility. The simultaneous detection of needlelike sensor should play important roles in biomedicine.
研究领域:
分析化学
·
生物医学工程
·
神经科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Bo Gu,Xinghua Zhu,Guohong Pu,Fangfang He,Peng Wang,Guansong He,Ren He,Kai Zhang,Wenbin Yang
In this work, anilino-methyl-triethoxysilane (AMTS) was used as a modifier to secondary modified carbon fiber (CF). Firstly, the CF was pretreated by immersing it in a dopamine (DA) solution so that a certain amount of polydopamine (PDA) particles were attached to its surface to obtain modified carbon fiber (m-CF). Next, m-CF was immersed in a solution of ethanol with AMTS. m-CF@AMTS was obtained by hydrolytic bonding of AMTS to the surface of m-CF. Finally, a silicone rubber/carbon fiber composite (SR/m-CF@AMTS) was prepared from m-CF@AMTS and silicone rubber (SR) matrix. Meanwhile, γ-Aminopropyltriethoxysilane (KH550), 3-Glycidoxypropyltrimethoxysilane (KH560), and 3-(Trimethoxysily)proply methacrylate (KH570) were used as controls for the AMTS secondary modified carbon fiber. The resultant of transverse fiber bundle tests (TFBT) shows that the SR/m-CF@AMTS compared with untreated silicone rubber/carbon fiber (SR/CF) and dopamine (DA) modified silicone rubber/carbon fiber (SR/m-CF) composites, the TFBT strength of SR/m-CF@AMTS was improved by 135.5 % and 51.6 %, and the elongation at break was improved by 177.9 % and 63.8 %, respectively. The above results show that secondary modification of CF by AMTS is a successful and efficient method. Secondary modification of CF by AMTS was first proposed and applied to the experiment.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 19
·10346
·
IF 4.9
Jiadong Hu,Jiaxin Li,Qunqun Guo,Guicai Du,Changming Li,Ronggui Li,Rong Zhou,Hongwei He
Dopamine (DA) is a widely present, calcium cholinergic neurotransmitter in the body, playing important roles in the central nervous system and cardiovascular system. Developing fast and sensitive DA detection methods is of great significance. Fluorescence-based methods have attracted much attention due to their advantages of easy operation, a fast response speed, and high sensitivity. This study prepared hydrophilic and high-performance CdS/ZnS quantum dots (QDs) for DA detection. The waterborne CdS/ZnS QDs were synthesized in one step using the amphiphilic polymer PEI-g-C14, obtained by grafting tetradecane (C14) to polyethyleneimine (PEI), as a template. The polyacrylonitrile nanofiber membrane (PAN-NFM) was prepared by electrospinning (e-spinning), and a metal organic frame (ZIF-8) was deposited in situ on the surface of the PAN-NFM. The CdS/ZnS QDs were loaded onto this substrate (ZIF-8@PAN-NFM). The results showed that after the deposition of ZIF-8, the water contact angle of the hydrophobic PAN-NFM decreased to within 40°. The nanofiber membrane loaded with QDs also exhibited significant changes in fluorescence in the presence of DA at different concentrations, which could be applied as a fast detection method of DA with high sensitivity. Meanwhile, the fluorescence on this PAN-NFM could be visually observed as it transitioned from a blue-green color to colorless, making it suitable for the real-time detection of DA.
研究领域:
生物化学
·
材料科学
·
医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）