npj Science of Food
·
2023
·Vol. 7
·期 1
·1-8
·
IF 6.4
Sun Yu-Long,Ge Bing-Qiang,Li Mi-Zhuan,Wang Lei,Chen Zhong-Xiu
Investigation on the physiochemical nature involved in the production of fatty acid catalyzed by the vesicles is of importance to understand the digestion of lipid. In this paper, the effects of crowding degree, which was constructed by polyethylene glycol (PEG), on the autocatalytic production of fatty acid with different chain lengths was studied. The results showed that the higher crowding degree led to the slower production rate of decanoic acid but the faster rate of oleic acid. The reason lies in that the presence of macromolecules resulted in the increased sizes of decanoic acid vesicles, but decreased sizes of oleic acid vesicles. Meanwhile, decanoic acid vesicles in more crowded medium exhibited viscous behavior, whereas oleic acid displayed elastic behavior. This research provides useful information for understanding the unusual autocatalyzed production of fatty acid in macromolecular crowding and may also draw an attention to the physiologically relevant lipid digestion.
研究领域:
生物化学
·
生理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Yang Gao,Guangli Liao,Shucong Wang,Ya Sun,Xin Long,Yan Ma,Hailong Zhang
This research aims to investigate the potential of N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine (SPM-NONOate) for promoting the absorption of poorly absorbed macromolecules delivered by intrapulmonary route. Influence of SPM-NONOate on the drug absorption was characterized by using a series of fluorescein isothiocyanate-labeled dextrans (FDs) as affordable models of hydrophilic macromolecules with established tools for quantitative analysis. SPM-NONOate increased concentration-dependently within 1–10 mM the pulmonary absorptions of FDs in rats. Moreover, this promoting effect varied with the molecular weight of FDs, and the largest absorption enhancement effect was obtained for FD70. SPM-NONOate also showed promising enhancement potential on the absorption of some therapeutic peptides, where obvious hypoglycemic and hypocalcemic effects were observed after intrapulmonary delivery of insulin and calcitionin, respectively, with SPM-NONOate to rats. The safety of SPM-NONOate was confirmed based on measurement of some biological markers in bronchoalveolar lavage fluid (BALF) of rats. Additionally, mechanism underling the absorption enhancement action of SPM-NONOate was explored by combinatorial administration of FD4 and SPM-NONOate with various scavengers and generator to rat lungs. Results indicated that NO released from SPM-NONOate induced the enhancement in the drug absorption, and peroxynitrate , a NO metabolite, possibly participated in the absorption enhancing action of SPM-NONOate.
研究领域:
药理学
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药物递送系统
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 10
·2305
·
IF 3.426
Dan Tian,Ji-Huan He
Mechanical property is one of the most important properties of nanofiber membranes. Electrospinning is widely used in the preparation of nanofibers due to its advantages such as good stability and easy operation. Compared with some nature silk, the mechanical properties of nanofibers prepared by electrospinning are poor. Based on the principle of vortex spinning and DNA structure, this paper designed an air vortex electrospinning device that can control the structure of macromolecular chains in nanofibers. When a weak air vortex is generated in the electrospinning process, the macromolecule chains will entangle with each other and form a DNA-like structure so as to improve the mechanical property. In addition, when a strong air vortex is generated during the electrospinning process, the nanofibers will adhere to each other, thereby enhancing the mechanical property and enlarging the pore size.
研究领域:
材料科学
·
生物工程
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Fei Wang,Xin Wang,Zhixing Li,Jinghong Ma,Weijiong Dai,Jiajun Zheng,Ruifeng Li
A novel zeolite-modified alumina-bead catalyst (ZSM-5/Al 2 O 3 -b) was prepared via calcining zeolite-coated alumina-bead material (Al 2 O 3 -b@ZSM-5) to graft zeolitic acid sites on the alumina-bead surface. The acid catalyst proved high activity and more 8 times catalytic efficiency than the corresponding ZSM-5(5 %) + Al 2 O 3 mechanically mixed catalyst for cracking of 1, 3, 5-triisopropylbenzene (TIPB) in the FCC simulation reactor with short contact time. The characterization results showed that the surface property of the alumina-beads has been modified and the interface connection of Si-O-Al bonds between zeolitic nanoparticles and alumina resulted in stable zeolite particles on the alumina surface and the structural stability in hot water. The excellent catalytic performances are ascribed to the decrease of diffusion limitation of reactants and intermediates and the increase of Brønsted acid sites on the ZSM-5/Al 2 O 3 -b catalyst. The grafted/modified alumina-bead catalyst can be directly used in practical catalytic cracking of large molecules without forming. This strategy can be extended to the preparation of other types of zeolite-containing catalysts and industrial applications.
研究领域:
催化化学
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材料科学
·
石油加工工程
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产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Zhaohui Guo,Christian M. Pedersen,Pengfei Wang,Minjun Ma,Yingqing Zhao,Yan Qiao,Yingxiong Wang
The isomerization of d-glucose to d-fructose plays a key role in the biochemical and chemical conversion of biomass, and it is therefore desirable to develop and improve catalysts for this reaction. In this study, the environmentally friendly polymer poly(amidoamine) (PAMAM) dendrimer’s properties as catalysts for this isomerization are investigated. The experimental results showed that the PAMAM dendrimers, which have basic terminal groups, can effectively promote the d-glucose isomerization reaction. Under the optimized reaction conditions, d-fructose was generated with a 20% maximum yield and above 90% selectivity. 13C and 2H isotope experiments by NMR were carried out to explore the reaction mechanism. When the reaction was performed in D2O, the C1 signal of d-fructose changed to a triplet, which confirmed that the C1 carbon binds to a deuterium atom, i.e., isotopic exchange. It was also found that the deuterium atom at the C2 position of d-glucose-2-d1 cannot transfer to d-fructose. These data indicate that PAMAM dendrimers catalyze d-glucose isomerization through a mechanism, which includes deprotonation, formation of ene-diol intermediate, and proton exchange with the solvent.
研究领域:
生物化学
·
绿色化学
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DOI
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 9
·3918-3925
·
IF 5.251
Hailin Cong,Liping Zhou,Qingye Meng,Yixin Zhang,Bing Yu,Youqing Shen,Hao Hu
Polymer gels can be classified as chemical and physical gels, depending on the type of cross-link. Physical gels usually form by physical cross-linking, such as hydrogen bonding, van der Waals and/or p–p interactions, which can avoid the use of additional cross-linking agents. Polyamidoamine (PAMAM) dendrimers possess abundant active groups on their surfaces. Modified dendrimers have been used as versatile linkers in some projects. In this work, polymer gels composed of PAMAM dendrimers without any covalent bonding cross-linking agents were prepared. The number of amino groups and ester groups on the surface of the dendrimers was precisely regulated to help form hydrogen bonds between adjacent dendrimers. The prepared dendrimer-based polymer gels retain the properties of PAMAM dendrimers such as antibacterial properties, and the unique structures make the gels exhibit high compressive strengths but relatively low tensile strengths. Interestingly, the prepared gels show good anti-inflammatory properties in acute inflammation models of mice with ear edema. The inflammatory inhibition rate and hematoxylin–eosin (H&E) staining method were used to confirm the anti-inflammatory effect. This present study demonstrates that the dendrimer-based polymer gels achieved through hydrogen bonding could be a versatile platform for tissue engineering.
研究领域:
材料科学
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生物医学工程
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药理学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
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2011
·
IF 7.883
Jingjing Hu,Yunzhang Su,Hongfeng Zhang,Tongwen Xu,Yiyun Cheng
In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2023
·
IF 6
Qingqi Zheng,Zhiyu Li,Tianyang Guo,Qingwen Fan,Song Hu,Jun Xiang,Peng Fu
To gain new insights into lignin pyrolysis, the synergistic development of carbon skeleton and pore networks in a wide temperature range of 200–800 °C was unraveled. The relative abundance of aromatic carbon structures increased exponentially with increasing temperature, as determined by 13 C NMR deconvolution. Additionally, the g-factor type of radicals changed from O-centered (g-factor <2.0030) to C-centered (g-factor >2.0040) radicals. The evolution of the char macromolecules structure from disorder to order was principally characterized by a decrease in aromatic spacing ( d 002 , 3.36→3.37 Å) an d an increase in stacking degree ( L c , 7.89→8.67 Å) and aromaticity ( f a , 75.19%→96.94%). f a h a s a strong negative linear correlation with d 002 ( R 2 = 0.965). Ternary quadratic polynomials can relate specific surface area, total pore volume, and relative carbon content to the pore fractal dimension. The hypothesized chemical reaction networks and synergistic development of carbon skeleton and pore networks are essential for lignin effective valorization by a pyrolysis-based biorefinery strategies.
研究领域:
生物质能
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2014
·Vol. 3
·期 3
·500-508
·
IF 0
Naimin Shao,Hui Wang,Bingwei He,Yu Wang,Jianru Xiao,Yitong Wang,Qiang Zhang,Yujia Li,Yiyun Cheng
Dendrimers have shown great promise in the design of efficient gene vectors. However, high transfection efficacy is usually associated with serious cytotoxicity for these cationic polymers. Here, we report a facile strategy to prepare surface-engineered dendrimers with a dramatic transfection efficacy and reduced cytotoxicity. Surface-engineered dendrimers with multiple hydrogen bonding ligands such as guanamine and nucleobase derivatives show superior efficacy and low cytotoxicity on commonly used cells as well as 3D tumor spheroids to representative transfection reagents such as Lipofectamine 2000. Complementary multiple hydrogen bonding interactions between the modified ligands and DNA nucleobases play essential roles in efficient gene transfection. The hydrogen-bond modulation strategy represents a promising tool in the design of highly efficient and less cytotoxic gene materials.
研究领域:
生物化学
·
基因治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 22
·
IF 1.86
Wenjian Wu,Hongqiang Li,Shuyan Yang,Xuejun Lai,Hongbo Fan,Haining Cai,Xingrong Zeng
Due to low thermal stability, poor migration, and extraction resistances, the antioxidant with low molecular weight is easy to physically lose during processing and long-term service, and its applications are severely restricted. To increase the molecular weight of antioxidant is one of the promising methods to overcome such drawbacks. In this study, the extraction resistance of a macromolecular antioxidant, namely polyhydroxylated polybutadiene containing thioether binding 2,2′-thiobis(4-methyl-6- tert -butylphenol) (PHPBT- b -TPH), was investigated by extraction resistance test and equilibrium swelling experiment. The results exhibited that the PHPBT- b -TPH offered much better extraction resistance in natural rubber (NR) than the low molecular weight antioxidant TPH. In addition, the extraction resistance of hydroxyl-terminated polybutadiene (HTPB), polyethylene glycol (PEG), and polypropylene glycol (PPG) in NR were also compared to study the extraction mechanism of the PHPBT- b -TPH. It was found that the higher molecular weight of PHPBT- b -TPH and the co-vulcanization between PHPBT- b -TPH and NR were the main reasons for the excellent extraction resistance. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44905.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2021
·
IF 3.981
Guanglan Ma,Xiao Du,Jianping Zhu,Feng Xu,Hua Yu,Juan Li
Liver cancer is one of the leading causes of cancer mortality worldwide. In this study, poly(lactide) (PLA) and hyaluronic acid (HA) co-modified half-generation of PAMAM G4.5 dendrimers (sPA) was chosen as the intelligent carrier for co-delivery of paclitaxel (PTX) and sorafenib (SOR) to treat liver cancer. The multifunctional micelle (HA-PALA@PTX + SOR) possessed a uniform size of 152.6 nm, good stability against serum medium, and a rapid in vitro drug release behavior under acidic condition in the presence of HAase. Cellular uptake study demonstrated an efficient intracellular delivery and drug accumulation in HepG2 cells. The antitumor and anti-metastasis efficacy of functionalized micelle was more obvious than that of free drugs. These data provided strong evidence that HA-PALA@PTX + SOR micelle could be utilized as a biocompatible and tumor targeted nano-carrier for the delivery of multiple anticancer drugs in liver cancer treatment.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Kexin Lu,Qian Ping,Yongmei Li
The abiotic interaction between ferric phosphate and major macromolecular organics (protein, saccharide, humic substance) in waste activated sludge (WAS) were studied, and the effect of phosphate on protein and the reaction mechanism were discussed in particular. With the addition of ferric phosphate, the concentration of protein was greatly reduced with a removal efficiency of 77.3%, accompanied by a remarkable increment of NH 4 + -N concentration (13.5 mg/L) when the release efficiency of NH 4 + -N reached 52.7%, while fulvic acid (FA) and glucose barely changed. PO 4 3 ‐ was the functional ion dominating the protein decomposition and NH 4 + -N release. The maximal release efficiency of NH 4 + -N (66.9%) occurred at pH 7, and the NH 4 + -N concentration mainly depended on the protein concentration, while the presence of FA and glucose would interfere the decomposition of protein. The analytical results of circular dichroism (CD) suggested that the reaction went through two stages: firstly, the process was relatively stable and phosphate showed a tendency to facilitate the transition from helices to β-sheets; then peptide chains on the helices were broken and deamination of amino acid residues occurred. Due to the loss of hydrophilic groups, hydrophobicity of the residue was further enhanced, resulting in its co-precipitation with protein. The results are applicable to proteins with similar structures to bovine serum albumin (BSA). This study provides a novel insight into the transformation of organic matters and phosphorus (P) in the anaerobic treatments of WAS.
研究领域:
环境科学
·
生物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）