JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Fangduo Huang,Tingting Sun,Junliang Liu,Hao Yu,Qisheng Zang,Xinyan Feng,Xuefan Feng,Andrej Atrens,Ming-Chun Zhao,Fuqin Zhang
The commercial application of lithium-sulfur batteries has been delayed due to problems associated with the Li metal anodes. This work fabricated a β-LiAl+α-Al composite alloy anode by electrodeposition, and investigated the following three aspects: safety, LiAl||Li half-cell performance and LiAl||Sulfur full-cell performance. Diffusional lithium trapping enabled the electrode to withstand water immersion without undergoing complete reaction. There was growth of flat LiAl mounds during cycling in both cell types attributed to lithium diffusion in the LiAl electrodes, leading to the improved stability. The shifted working voltage in the LiAl||S full-cell was attributed to the higher electrode potential of LiAl, which did not affect the reaction pathway of the Li-S battery. These unexpected aspects could offer valuable guidance for future investigations into anodes with similar mechanisms of lithium storage through diffusion.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Chem
·
2020
·
IF 19.735
Qunqun Bao,Ping Hu,Weiwei Ren,Yuedong Guo,Jianlin Shi
Summary Surgery and subsequent chemotherapy are still the most adopted clinical modalities for bladder cancer treatments with the inevitable operation risks, chemotherapy toxicity, and high recurrence rate. Here, we report an unprecedented tumor cell dissociation strategy for malignant bladder tumor removal without the needs of conventional surgery and chemotherapy. A common metal ion chelator, ethylene diamine tetraacetic acid (EDTA), has been loaded into the interlayers of neurotensin (NT)-modified Zn-Al layered double hydroxide (LDH). Under the targeting by NT, such a nano-platform shows high affinity to bladder tumor cells, leading to the highly selective and efficient accumulation at the bladder tumor site. The released EDTA molecules deprive Ca 2+ from the intercellular calcium-dependent connexin by EDTA-Ca 2+ chelation, resulting in the tumor disaggregation that is then safely excreted out of body rather than killed using toxic chemodrugs, thus, ensuring excellent biosafety and extraordinarily high effectiveness.
研究领域:
肿瘤学
·
药理学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Jin Deng,Nan Ma,Yuze Jia,Lu Dong,Yan Zhang,Yi Ren,Xiaolu Shi,Yingshuang Lu,Shuo Wang
This study investigated the impact of oxygen concentrations during baking on flavor, sensory perception, and acrylamide content in butter cookies. Cookies were baked at 190 and 210 °C under three oxygen levels (5, 10, and 21%). Key quality parameters, including moisture content, texture, color, flavor volatiles, and acrylamide content, were measured, and sensory evaluation was conducted using 55 judges. Principal component analysis was implemented to elucidate relationships among physicochemical properties, aroma profiles, and safety metrics. Results demonstrated that baking under low oxygen concentrations significantly reduced acrylamide formation, exemplified by a reduction from 95.8 to 58.5 μg/kg at 190 °C and 116.6 to 53.1 μg/kg at 210 °C, respectively. Notably, baking at 190 °C with 5% oxygen was identified as the optimal condition, balancing sensory quality and safety by minimizing the formation of harmful substances. These findings provide a promising strategy for improving the safety and quality of baked goods through controlled oxygen levels during processing.
研究领域:
食品科学
·
营养学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Jing Zhong,Zhixing Wang,Xiaoli Yi,Xinhai Li,Huajun Guo,Wenjie Peng,Hui Duan,Jiexi Wang,Guochun Yan
Lithium (Li) metal is considered an attractive anode for high-energy Li secondary batteries, but it suffers from a short cycle life and serious safety hazards due to its high reactivity and dendritic growth. A potential approach is to construct a stable artificial SEI film. Herein, we report a polymer coating that is composed of LiTFSI and PVDF-HFP, which is spread onto the Li foil (25 μm) by the blade coating method (abbreviated as Li-PH@Li). During drying, LiTFSI reacts with Li metal to form LiF that is distributed evenly in the coating layer, thus improving the mechanical strength of the coating. In addition, the coating layer could selectively transport the Li-ions and delay the transport of solvent and PF6–, alleviating the side reaction between Li metal and electrolyte. Therefore, a dense Li deposition layer is obtained during a long cycle. Consequently, the Li-PH@Li||LFP coin cell with a low N/P ratio (3:1) could maintain 355 cycles at 0.5 C (0.79 mA cm–2), while only 240 cycles for the bare Li||LFP cell. Moreover, a lean Li-PH@Li||LFP pouch cell, whose N/P ratio is 1.9:1, can also sustain more than 200 cycles. This work paves a new approach to protect Li metal anodes for high-performance Li metal batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE CHINESE INSTITUTE OF ENGINEERS
·
2025
·
IF 1.2
Songbo Cheng,Hang Hu,Defeng Xu
Pyriminobac-methyl is an important herbicide widely used for weed control in direct-seeding rice fields. The traditional synthetic methods usually involve n-butyl lithium or diazotization reaction, resulting in serious safety issues or environmental problems. In this work, 3-chlorophthalic anhydride was used as a raw material to synthesize pyriminobac-methyl. 3-chlorophthalic anhydride was first reacted with potassium hydroxide in the presence of cuprous chloride and then reacted with acetic anhydride to give 3-hydroxyphthalic anhydride with a total yield of 66%. 3-hydroxyphthalic anhydride was then reacted with diethyl malonate (yield 60%) and subsequently hydrolyzed to obtain 2-acetyl-6-hydroxybenzoic acid with a yield of 80%. After esterification with methanol (yield 90%) and imidization with methoxamine hydrochloride (yield 88%), 2-hydroxy-6-(1-methoxyiminoethyl)benzoic acid methyl ester was obtained. Finally, 2-hydroxy-6-(1-methoxyiminoethyl) benzoic acid methyl ester was reacted with 2-methylsulfonyl-4,6-dimethoxypyrimidine in the presence of potassium carbonate to obtain pyriminobac-methyl with a yield of 87%. Compared to the traditional synthetic processes of pyriminobac-methyl, our new synthetic process is safer, more facile, and environmental-friendly.
研究领域:
有机化学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2024
·
IF 4.4
Shuailiang Xu,Mingqiang Li,Haochen Weng,Jingwen Li
Because of the high capacity, natural abundance, and safety of aluminum (Al), the Al–Li alloy formed by combining it with lithium (Li) is an attractive anode material. In this paper, we propose a new type of lithium battery that works in an open system and does not require sealing, the “Lithium-Aluminum” soft pack battery (LAB). Al foil is applied to the anode of the LAB, LiCl is used for the electrolyte, and LiFePO 4 is used as the cathode. LAB incorporated Al–Li alloy into lithium batteries in a new way. During charging, lithium deposits in the anode undergo an electrochemical synthesis reaction with Al to produce Al–Li alloys, which decompose during discharge. The LAB has a discharge voltage plateau of about 2.8 V and a discharge capacity of 0.48 mAh/cm 2 (145.5 mAh/g), with the Coulombic efficiency remaining above 90 %. The capacity retention rate is 95.9 % after 600 cycles and still reaches 65.2 % after 800 cycles. Notably, the battery remains functional when bent at will and in a broken or punctured state. Compared to traditional lithium metal batteries (LMBs), our work demonstrates superior cycle stability, a safer operational environment, increased versatility in application scenarios, and reduced costs.
研究领域:
材料科学
·
电化学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2019
·
IF 3.78
Wenzong Xu,Xiaoling Wang,Xiongjie Wu,Wu Li,Chuanming Cheng
Fire safety is very important in the application of epoxy resin (EP). To study the effect of fire safety, a new kind of double-modified graphene (F-RGO-CuMoO 4 ) was synthesized in this work. Firstly, GO was modified with 3-Triethoxysilylpropylamine (KH550) through the amidation reaction between the amino and carboxyl group to obtain organic functionalized graphene F-RGO. Subsequently, CuMoO 4 was introduced onto the surface of F-RGO by the electrostatic interaction . Then the prepared F-RGO-CuMoO 4 was added into EP to prepare an EP composite. The TEM test results of the EP/F-RGO-CuMoO 4 ultrathin section showed that F-RGO-CuMoO 4 was well dispersed in EP, indicating that the dispersion of graphene in EP was obviously improved after double modification. In addition, F-RGO-CuMoO 4 also effectively improved the fire safety of EP. Specifically, the total heat release (THR), peak heat release rate (PHRR), total smoke production (TSP) and smoke production rate (SPR) values of the EP/F-RGO-CuMoO 4 composite were reduced to 33.4 MJ/m 2 , 504 kW/m 2 , 24.5 m 2 and 0.27 m 2 /s, which were 43.7%, 59.9%, 62.3% and 66.7% lower than those of pure EP, respectively. The main fire safety mechanism of F-RGO-CuMoO 4 was explored according to the char residue analysis.
研究领域:
材料科学
·
火灾安全工程
✓ 已验证
产品关联
DOI
高影响因子
FOOD CONTROL
·
2020
·
IF 4.258
Zhouli Wang,Rui Cai,Xiandong Yang,Zhenpeng Gao,Yahong Yuan,Tianli Yue
Stir-fried pork slices are kinds of traditional pork processing products in China, which are usually cooked at high temperature with different seasonings. Because of their special quality and flavor, these products gain consumers' preference. However, there are few studies on their physicochemical properties, aroma composition and safety. In this study, the changes in basic components, aroma components and potentially hazardous substances during the stir-frying of pork slices were determined. The effects of the different ratios of fat meat to lean meat and vinegar on these indicators were evaluated, and the formation of potential Maillard reaction products was also analyzed. The results indicated that water content, chrominance values of L * and b * exhibited decreasing trends; a * value displayed a trend of decline first and then rising, while the fat content showed a rising trend during the processing. Appropriate stir-frying can promote the formation of aldehydes, while the content of acids, ketones, and terpenes decreased during processing. The change of alcohols has no obvious rule. Some sulfur compounds not found in raw meat were also detected. Different ratios of fat meat and lean meat changed the kinds of aroma components, while vinegar altered the types and their contents. Besides, the contents of acrylamide and 5-HMF changed significantly, and that of benzo(a)pyrene remained at a low level. The addition of vinegar can enhance the amount of acrylamide and 5-HMF but has no obvious effect on benzo(a)pyrene. Besides, 8 kinds of Maillard reaction products (acrylamide, 5-HMF, benzo(a)pyrene, 5-methylfurfural, pyrazine, 4-methylimidazole, pyrraline, and 5- hydroxymethyl - 2-furancarboxylic acid) were determined, and some of them were harmful to product quality and human health. The results showed that the processing time of pork slices should be controlled within 60 min.
研究领域:
食品科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2015
·Vol. 35
·期 11
·1415-1426
·
IF 2.982
Xu Wang,Ziqiang Tan,Yuanhu Pan,Awais Ihsan,Qianying Liu,Lingli Huang,Guyue Cheng,Dongmei Chen,Yanfei Tao,Zhenli Liu,Zonghui Yuan
Aditoprim (ADP), a new developed dihydrofolate reductase (DHFR) inhibitor, has great potential in clinical veterinary medicine because of its greater pharmacokinetic properties than structural analogs. Preclinical toxicology studies were performed to assess the safety of ADP including an acute oral toxicity test, a subchronic toxicity test and five mutagenicity tests. In the acute oral toxicity test, ADP was administered singly by oral gavage to Wistar rats and Kunming mice. The LD 50 calculated was 1400 mg kg –1 body weight (BW) day –1 in rats and 1130 mg kg –1 BW day –1 in mice. In a subchronic study, Wistar rats were administered ADP at dose levels of 0, 20, 100 and 1000 mg kg –1 diet for 90 days. Significant decreases were observed on body weight and food efficiency in the high-dose group. Treatment-related changes in clinical serum biochemistry were found in the medium- and high-dose groups. Significant increases in the relative weights of livers and kidneys in females and testis in males in the 1000 mg kg –1 diet, and significant decrease in relative weights of livers in males in the 100 mg kg –1 diet were noted. Histopathological observations revealed that the 1000 mg kg –1 ADP diet could induce lymphocytic infiltration and hepatocytic necrosis near the hepatic portal area. The genotoxicity of ADP was negative in tests, such as the bacterial reverse mutation assay, mice bone marrow erythrocyte micronucleus assay, in vitro chromosomal aberration test, in vitro cho/hgprt mammalian cell mutagenesis assay and mice testicle cells chromosome aberration. Based on the subchronic study, the no-observed-adverse-effect level for ADP was a 20 mg kg –1 diet, which is about 1.44-1.53 mg kg –1 BW day –1 in rats. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
药理学
·
毒理学
·
兽医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2016
·
IF 6.333
Tianqiao Yong,Lingzhi Zhang,Jinglun Wang,Yongjin Mai,Xiaodan Yan,Xinyue Zhao
Three choline-based ionic liquids functionalized with trimethylsilyl, allyl, and cynoethyl groups are synthesized in an inexpensive route as safe electrolytes for high-voltage lithium-ion batteries. The thermal stabilities, viscosities, conductivities, and electrochemical windows of these ILs are reported. Hybrid electrolytes were formulated by doping with 0.6 M LiPF6/0.4 M lithium oxalydifluoroborate (LiODFB) as salts and dimethyl carbonate (DMC) as co-solvent. By using 0.6 M LiPF6/0.4 M LiODFB trimethylsilylated choline-based IL (SN1IL-TFSI)/DMC as electrolyte, LiCoO2/graphite full cell showed excellent cycling performance with a capacity of 152 mAh g -1 and 99% capacity retention over 90 cycles at a cut-off voltage of 4.4 V. The propagation rate of SN1IL-TFSI)/DMC electrolyte is only one quarter of the commercial electrolyte (1 M LiPF6 EC/DEC/DMC, v / v / v = 1/1/1), suggesting a better safety feature.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2016
·
IF 6.333
Yi Liu,Shaohua Fang,Pei Shi,Dong Luo,Li Yang,Shin-ichi Hirano
New mixtures of 3-(2-methoxyethoxy)propanenitrile, fluoroethylene carbonate and 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether are introduced as safe electrolytes for lithium-ion batteries. The electrolytes with 30 wt% 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether can own high safety and better wettability to separator and electrodes than the conventional electrolyte. The oxidation potentials of these electrolytes are about 4.8 V versus Li/Li + , and their conductivity can reach 5.42 mS cm −1 at 25 °C. Graphite/LiMn 2 O 4 coin cells are used to evaluate the electrochemical performances, and this kind of safe electrolytes can exhibit better rate and cycle performances than the conventional electrolyte. These results indicate that such ternary electrolytes have a great potential for practical application.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Yuewen Lu,Jin Chen,Ruihao Wang,Pengfei Xu,Xingquan Zhang,Bing Gao,Changping Guo,Guangcheng Yang
Simultaneous improvement of the safety performance and thermal decomposition properties of ammonium perchlorate (AP) remains a significant challenge. Therefore, based on inspiration from biological materials, we have prepared a novel copper alginate/ammonium perchlorate (Cu-alginate/AP) composite by facile air atomization. The evaluation of the safety performance and thermal decomposition indicates that these properties were significantly improved. In addition, the possible catalytic mechanism of thermal decomposition of AP is proposed herein. It should be noted that Cu-alginate is a three-dimensional network structure and was uniformly coated on the surface and inside of the AP. When the composite is stimulated by external forces, this unique structure plays a buffering role, absorbing energy and greatly improving safety performance. With increasing temperature, the Cu-alginate easily decomposed and renascent Cu-based nanoparticles were generated by in situ growth. These renascent nanoparticles exhibited excellent catalytic activity for the thermal decomposition of AP. As expected, the bio-inspired material can smartly improve both the safety performance and thermal decomposition of AP. Therefore, these findings provide a promising strategy for the development of composite solid propellants.
研究领域:
材料科学
·
推进剂化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）