ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Jiezhao Zhan,Lin Wang,Yuchen Zhu,Huichang Gao,Yunhua Chen,Junjian Chen,Yongguang Jia,Jingcai He,Zhou Fang,Ye Zhu,Chuanbin Mao,Li Ren,Yingjun Wang
Modification of implants by antimicrobial peptides (AMPs) can improve the antimicrobial activity of the implants. However, AMPs have some cytotoxicity in vivo when they are exposed at body temperature. To tackle this challenge, we propose to develop a new approach to generating a smart antimicrobial surface through exposure of AMPs on the surface. A polydopamine film was first formed on the substrates, followed by the conjugation of a temperature-sensitive polymer, poly(N-isopropylacrylamide) (pNIPAM), to the film through atom transfer radical polymerization (ATRP). Then, AMPs were conjugated to the NIPAM on the resultant pNIPAM-modified surface through a click chemistry reaction. Because of the temperature-sensitive property of pNIPAM, the AMPs motif was more exposed to the external environment at room temperature (25 °C) than at body temperature (37 °C), making the surface present a higher antimicrobial activity at room temperature than at body temperature. More importantly, such a smart behavior is accompanied with the increased biocompatibility of the surface at body temperature when compared to the substrates unmodified or modified by AMPs or pNIPAM alone. Our in vivo study further verified that pNIPAM-AMP dual modified bone implants showed increased biocompatibility even when they were challenged with the bacteria at room temperature before implantation. These results indicate that the implants are antibacterial at room temperature and can be safely employed during surgery, resulting in no infection after implantations. Our work represents a new promising strategy to fully explore the antimicrobial property of AMPs, while improving their biocompatibility in vivo. The higher exposure of AMPs at room temperature (the temperature for storing the implants before surgery) will help decrease the risk of bacterial infection, and the lower exposure of AMPs at body temperature (the temperature after the implants are placed into the body by surgery) will improve the biocompatibility of AMPs.
研究领域:
生物材料
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医学工程
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微生物学
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产品关联
DOI
PubMed
高影响因子
Materials
·
2021
·Vol. 14
·期 22
·6793
·
IF 3.623
Xiaofei Yan,Chenkai Zhu,Ju Huang,Dongmin Qi,Jiawei Li
The growth and reproduction of microorganisms on fabrics could not only affect the wearability of textiles but also cause harm to human health, and it is an important problem that should be solved to reduce the adsorption and growth of microorganisms on the surface of the fabric. A series of ω-vinyl betaine copolymers were synthesized by catalytic chain transfer polymerization (CCTP) and were modified by mercapto-vinyl click chemistry to synthesize silane-modified betaine copolymers, which were used to treat the cotton fabric. The hydrophilic–hydrophobic transition performance and anti-protein specific adhesion performance of cotton fabric with the betaine copolymer were systematically investigated. The copolymer was confirmed to be successfully finished on the cotton fabric via1H–NMR and FTIR. The cotton fabric, which was treated by the betaine copolymer, presented temperature response performance in the range of 30–55 °C and had excellent anti-protein adsorption performance. The treated fabric had the best temperature-sensitive and anti-protein specific absorption performance among all the specimens when the mass fraction of G06B in DMAPS was 6 wt.%.Keywords:betaine copolymer;cotton fabric;temperature-sensitive response;anti-protein specific adhesion
研究领域:
材料科学
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纺织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Zhengang Xie,Qiuyu Xiong,Yun Fang,Qi Zhang,Wenlong Liang,Jingli Cheng,Wenxuan Shang,Wei Zhao,Jinhao Zhao
Soil-borne diseases have caused substantial economic losses to agricultural production due to their rapid onset and few means of control. Here, pyraclostrobin (Pyr) microcapsules (Pyr@MCC) with temperature-responsive pesticide release capability were prepared using temperature-sensitive phase-change materials as capsule cores. Then, the Pyr@MCC was organically combined with poly(vinyl alcohol)-starch film (PVA/ST) to prepare a composite mulch film (PM/PVA/ST) with intelligent control of pesticide release rate according to external temperature change, which realized sustainable and efficient control of Phytophthora root rot (PRR) on soybean. Tensile tests showed that the PM/PVA/ST film exhibited good tensile deformation ability (134.9%) and high tensile stress (18.0 Mpa). The water vapor transmission rate test showed that the PM/PVA/ST film exhibited good barrier performance to H2O, CO2, and O2. The release test data proved that the PM/PVA/ST film could slowly release Pyr at lower temperatures (15 °C) and release Pyr rapidly at higher temperatures (35 °C), corresponding to the high temperature at which the Phytophthora root rot outbreak. In vitro antifungal and pot experiments showed that the PM/PVA/ST film had a good control efficiency on Fusarium spp. These results show that the functional pesticide microcapsules loaded onto the film have good application potential for controlling PRR on soybean. In general, this composite mulch film provided some innovative research ideas for optimizing the pesticide delivery pathway and thereby efficiently controlling soil-borne pests and diseases, reducing the frequency and amount of pesticide use and minimizing white pollution from traditional plastic mulch films.
研究领域:
农业科学
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植物病理学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·
IF 4.3
Zou Zhi,Xu Xiang,Zhao Hai-Tao,Cheng Jian-Nan,He Wei-Wei,Zhang Li-Fen,Cheng Zhen-Ping
Temperature-responsive polymers have garnered significant attention due to their ability to respond to external stimuli. In this work, dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization (RAFT) polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine (SBMA) and N -isopropyl acrylamide (NIPAAm) as monomers. The thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate (BN) or hydrophilic monomer acrylic acid (AA), adjusting concentration or pH, or varying the degree of polymerization of the block chain segments. The cloud points of the copolymers are determined by UV-Vis spectrophotometry, and these copolymers exhibit both controlled upper and lower critical solubility temperatures (LCST and UCST) in aqueous solution. This study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation laws. It is very interesting that the introduction of poly-acrylic acid (PAA) segments in the middle of di-block copolymer PSBMA 55 - b -PNIPAAm 80 to form PSBMA 55 - b -PAA x - b -PNIPAAm 80 results in a reversal of temperature-responsive behaviors from ‘U’ (LCST < UCST) to ‘n’ (LCST > UCST) type, while the copolymer PSBMA 55 - b -P(NIPAAm 80 - co -AA x ) not. This work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2020
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IF 3.616
Meifeng Liu,Weichi Chen,Xingyu Zhang,Pengwen Su,Feng Yue,Shaoqun Zeng,Song Du
Madecassoside (MA) exhibits excellent therapeutic effects in wound healing and scar management. However, its high hydrophilic nature and low permeability through skin tissue limits its topical application. Liposomes are widely used to deliver drugs due to their high structural similarity and biocompatibility with cell membranes. However, normal liposome formulations are too fluid to maintain sufficient adhesion to the wound surface. In this study, in order to make an MA formulation conducive to topical administration, poly(ethylene glycol)-poly( ε -caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE), a biodegradable and temperature-responsive copolymer material, was synthesized and applied to improve the adhesion properties of MA liposomes. The mean particle size of the PECE-modified MA liposomes was 213.43±4.68 nm, and the zeta potential was −23.80±15.37 mV under the optimal conditions of EPC (egg yolk lecithin) to PECE at a mass ratio of 1:1. Additionally, PECE-modified MA liposomes maintained a hydrogel state for better adhesion until the temperature reached 43°C. Furthermore, the PECE-modified MA liposomes showed superior wound contraction effects relative to the MA liposomes in second-degree burn experiments using a rat model. These results indicated that PECE-modified MA liposomes have better surface adhesion performance and healing effects than unmodified MA liposomes.
研究领域:
药剂学
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材料科学
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生物医学工程
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2015
·Vol. 26
·期 11
·1-13
·
IF 2.587
Wu Yukun,Yang Chengling,Lai Quanyong,Zhang Qian,Wang Wei,Yuan Zhi
To ideally solve the contradiction between enhanced cellular uptake and prolonged blood circulation, reversible targeting polymeric micelles based on the expanding and shrinking behavior of a temperature-responsive polymer were developed. The micelle contained a hydrophobic PCL core and a mixed shell consisting of poly( N -isopropylacrylamide) (PNIPAAm) and biotin-terminated poly(ethylene glycol) (Biotin-PEG), and its targeting ability could be switched on/off by temperature. The cellular uptake of the complex polymeric micelles was studied. The results from a quantitative enzyme-linked immunosorbent assay (ELISA) indicated that the surface biotin content increased by as much as 11.6-fold when the temperature increased above the lower critical solution temperature (LCST). More importantly, the ELISA confirmed that biotin-mediated targeting on the surface was reversibly switched on and off for at least five cycles. In addition, the results from quantitative flow cytometry and confocal spectroscopy indicated that the cellular uptake of the targeted micelles at temperatures above the LCST was much higher than that at temperatures below the LCST. This complex polymeric micelle with reversible targeting property could be a promising alternative for drug delivery.
研究领域:
药剂学
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生物材料学
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DOI
PubMed
高影响因子
Pigment & Resin Technology
·
2021
·Vol. 52
·期 1
·123-133
·
IF 1.263
Jun Zhang,Xiaojian Ou,Lin Li,Qianqian Chen,Zifan Zhang,Ting Huo,Xiaoyu Lin,Fangfang Niu,Shengyuan Zhao,Fang We,Hui Li,Chunli Liu,Zhenbin Chen,Sujun Lu,Peng Zhang,Jinian Zhu
Purpose A novel grafted temperature-responsive ReO 4 − Imprinted composite membranes (Re-ICMs) was successfully prepared by using polyvinylidene fluoride (PVDF) resin membranes as substrates, this study aimed to separate and purify ReO effectively. Design/methodology/approach Re-ICMs were synthesized by PVDF resin membranes as the substrate, acrylic acid (AA), acrylamide (AM), ethylene glycol dimethacrylate (EGDMA) were functional monomers. The morphology and structure of Re-ICMs were characterized by scanning electron microscope and Fourier transform infrared spectroscopy. Findings The maximum adsorption capacity toward ReO 4 − was 0.1,163 mmol/g and the separation decree had relation to MnO 4 − was 19.3. The optimal operation conditions were studied detailedly and the results as follows: the molar ratios of AA, AM, EGDMA, ascorbic acid, NH4ReO 4 , were 0.8, 0.96, 0.02, 0.003 and 0.006. The optimal time and temperature were 20 h and 40°C, respectively. The Langmuir and pseudo-second-order models were fit these adsorption characteristics well. Practical implications Rhenium (Re) is mainly used to chemical petroleum and make superalloys for jet engine parts. This study was representing a technology in separate and purify of Re, which provided a method for the development of the petroleum and aviation industry. Originality/value This contribution provided a novel method to separate ReO 4 − from MnO 4 − . The maximum adsorption capacity was 0.1163 mmol/g at 35°C and the adsorption equilibrium time was within 2 h. Meanwhile, the adsorption selectivity rate ReO 4 − /MnO 4 − was 19.3 and the desorption rate was 78.3%. Controlling the adsorption experiment at 35°C and desorption experiment at 25°C in aqueous solution, it could remain 61.3% of the initial adsorption capacity with the adsorption selectivity rate of 13.3 by 10 adsorption/desorption cycles, a slight decrease, varied from 78.3% to 65.3%, in desorption rate was observed.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
ACS Applied Polymer Materials
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2025
·
IF 4.7
Shaobo Ren,Zhiming Li,Ju Lv,Pengfei Han,Xinyue Zhang,Lang Pan,Ying You,Xueqiong Yin,Xingqing Xiao
The ion imprinting technique was applied in this work to prepare a thermosensitive biomass-based polymeric hydrogel, termed UITB, which exhibits unique temperature-dependent swelling behavior: it shrinks at high temperatures but swells at low temperatures. The reversible swelling property enables the UITB polymer gel to capture and release UO22+ ions by adjusting the temperature within a moderate range of 20°C–45°C. A high adsorption selectivity of UITB for the target UO22+ ions was observed in the presence of decoy metal ions. Rinsing with pure water for the elution of the absorbed UO22+ greatly extends the lifetime of the polymer gel. Subsequently, various thermodynamic models were used to theoretically study the adsorption equilibrium and kinetics of UITB. A monolayer adsorption was identified, with the adsorption dynamics being controlled by both the diffusion process and electron transfer. To explore the molecular mechanism of UO22+ adsorption at the microscale level, atomistic molecular dynamics simulations were performed to investigate the adsorption behavior of UO22+ in two computationally modeled hydrogel network units of different pore sizes. Analysis of the energies showed that the negative intermolecular ELE+EGB energy is responsible for the adsorption and desorption of UO22+ on the polymer gel, while the positive intermolecular VDW energy indicates that the UO22+ ions are prevented from being absorbed anywhere except within the cavities. Finally, testing of the application revealed that our UITB polymer gel demonstrates effective adsorption capabilities for UO22+ in natural seawater, highlighting its potential for practical use.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tiantian Gong,Jiahui Jiang,Cheng Chen,Yangbo Lv,Tao Cao,Peng Cao,Qichen Zhan
Temperature-responsive hydrogels are advanced materials that exhibit significant physical or chemical changes in response to temperature variations. When the temperature reaches a specific threshold, these hydrogels alter their properties accordingly. They offer significant advantages in cancer therapy, including precise control over drug release, minimized toxicity, improved therapeutic efficacy, and biodegradability. Advancing the development of novel temperature-responsive hydrogels is crucial for enhancing therapeutic strategies. Herein, two-dimensional polydopamine (2D PDA) was first combined with chitosan (CTS) to create a temperature-responsive hydrogel for the control and release of anticancer drugs. Leveraging the carbonyl-rich nature of 2D PDA, we initiated a reversible cyclization reaction between CTS and the carbonyl groups on the surface of 2D PDA, resulting in a temperature-responsive CTS@2D PDA (CP) hydrogel. Furthermore, the CP hydrogel template was incorporated with the photosensitizer zinc phthalocyanine (ZnPc) and sodium percarbonate (SPC), an oxygen (O 2 ) donor, to form a composite hydrogel (CSZP hydrogel). O 2 released from the CSZP hydrogel mitigated solid tumor hypoxia and suppressed the expression of hypoxia-inducible factor-1α (HIF-1α), thereby augmenting the efficacy of photodynamic therapy (PDT). This temperature-responsive hydrogel represented a highly promising platform for the precise and controlled release of various therapeutics, thereby advancing the field of targeted disease treatment.
研究领域:
材料科学
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生物医学工程
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Shengwei Zhang,Bo Peng,Weijie Wang
As an effective anionic surfactant for chemical flooding, petroleum sulfonate (PS) is often used in conjunction with alkalis to reduce the adsorption loss of PS onto rock and clay surfaces. However, alkali injection can lead to scaling, aggravate the water-sensitive effect of clays, and accelerate polymer hydrolysis. Here, a temperature-responsive biohydrogel-based carrier (XLK) was designed to protect PS from adsorption onto geological features. XLK, an aqueous mixture containing 0.5% xanthan gum, 0.5% locust bean gum, and 2% KCl, was a gel at room temperature and transformed gradually into a sol above 50 °C (sol/gel transition temperature, Tsol/gel). Below the Tsol/gel, most PS was retained in the gel, preventing the adsorption of PS onto quartz sand. Above the Tsol/gel, PS was released into the surrounding medium. After it had been loaded with PS, the storage modulus (G′, Pa) of XLK increased from 102 to 103 and the loss modulus (G″, Pa) increased from 101 to 102. Environmental scanning electron microscopy micrographs showed that PS filled gaps within the cross-linked network structure of XLK. Compared with the aqueous XLK formulation, the addition of hydrolyzed polyacrylamide (HPAM) decreased the melt rate of XLK and the interfacial tension (IFT) of PS. Among the constituents of XLK loaded with PS, KCl had the most obvious effect of lowering the shear modulus of HPAM. Sufficient amounts of KCl were effective in reducing the IFT of PS to ultralow levels (10–3 mN/m).
研究领域:
石油工程
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材料科学
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化学工程
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DOI
高影响因子
Journal of Physical Chemistry C
·
2012
·
IF 4.805
Longcheng Xu,Jianming,Pan,Qianfang Xia,Fenfen Shi,Jiangdong Dai,Xiao Wei,Yongsheng Yan
We report on the fabrication of silica/zinc oxide/zinc sulfide nanoparticles (SiO2/ZnO/ZnS NPs) wrapped with thermoresponsive molecularly imprinted polymers (TMIPs) for photocatalysis (PC) applications. TMIPs were prepared via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization of N-isopropylacrylamide (NIPAm) and ethylene glycol dimethacrylate (EGDMA), rendering the material solution accessible and temperature sensitive. Photodegradation of sulfadiazine (SD) was used as a probe to evaluate the effect of coated TMIPs on the PC performance of SiO2/ZnO/ZnS NPs. The results showed that TMIPs made SiO2/ZnO/ZnS NPs have an outstanding specific affinity PC activity toward template SD. Modification of SiO2/ZnO/ZnS NPs with Ag2S resulted in a tunable PC ability of the prepared material. For SI-RAFT conducted in a controlled manner, a thin layer of polymers (∼100 nm) formed around NPs was measured by a transmission electron microscopy (TEM). Also the polymers were characterized by Fourier transform infrared spectrometer and thermogravimetric analysis. Due to the specific binding of imprinted polymers, thermoresponsiveness of poly-NIPAm shells, and tunable PC ability of NPs cores, the obtained material catalyzed the original template SD with an appreciable selectivity over other structurally related antibiotics and the PC ability could be tunable by changing thte environmental temperature or NPs cores.
研究领域:
材料科学
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环境科学
·
生物化学
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DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 1
·172-176
·
IF 3.708
Weixiao Ji,Bolun Jiang,Fangxing Ai,Hanxi Yang,Xinping Ai
Safety issues have severely retarded the commercial applications of high-capacity and high-rate lithium ion batteries (LIBs) in electric vehicles and renewable power stations. Thermal runaway is a major cause for the hazardous behaviors of LIBs under extreme conditions. In this paper, a new thermal shutdown separator with a more reasonable shutdown temperature of ∼90 °C is developed by coating thermoplastic ethylene-vinyl acetate copolymer (EVA) microspheres onto a conventional polyolefin membrane film and tested for thermal protection of lithium-ion batteries (LIBs). The experimental results demonstrate that owing to the melting of the EVA coating layer at a critical temperature, this separator can promptly cut off the Li+ conduction between the electrodes and thus shut down the battery reactions, so as to protect the cell from thermal runaway. In addition, this type of the separator has no negative impact on the normal battery performance, therefore providing an internal and self-protecting mechanism for safety control of commercial LIBs.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）