COMPOSITES PART B-ENGINEERING
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2023
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IF 13.1
Yi Hou,Mengmeng Jin,Dan Sun,Junfeng Li,Ruiye Bi,Li Zhang,Songsong Zhu
This study reports for first time the development of bone-regenerative nanocomposite microspheres re-engineered from chicken eggs. We deployed a novel hybrid crosslinking technique combining chemical and thermal crosslinking to produce highly cross-linked microspheres consisting of organic egg white matrix and bioactive inorganic egg shell nanofillers . The nanocomposite microspheres exhibit enhanced mechanical properties and prolonged degradation profile. Ca 2+ released from the microspheres are found to accelerate the biomineralization process, facilitate the stem cell differentiation , and promote the osteogenesis process. In addition, antibiotic drug levofloxacin has been loaded onto the proposed microspheres and the dual function of the microspheres in bacterial infection control and bone regeneration has been successfully demonstrated in animal models. Results show that our nanocomposite microspheres can serve as a promising multifunctional platform for bone repair applications.
研究领域:
材料科学
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生物医学工程
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组织工程
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纳米技术
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产品关联
DOI
高影响因子
CHEMOSPHERE
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2023
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IF 8.8
Qixun Nian,Huan Yang,Erqiong Meng,Chunmin Wang,Qian Xu,Qiuping Zhang
Aminoglycoside antibiotics (AGs) in environmental water are emerging pollutants that must be removed to protect human health and the ecosystem. However, removing AGs from environmental water remains a technical challenge due to high polarity, stronger hydrophilicity and unique characteristics of polycation. Herein, a thermal-crosslinked polyvinyl alcohol electrospun nanofiber membrane (T-PVA NFsM) is synthesized and firstly leveraged as the adsorptive removal of AGs from environmental water. The thermal crosslinking strategy is demonstrated to enhance both the water resistance and hydrophilicity of T-PVA NFsM, thereby effectively interacting with AGs with high stability. Experimental characterizations and analog calculations indicate that T-PVA NFsM utilizes multiple adsorption mechanisms, including electrostatic and hydrogen bonding interactions with AGs. As a result, the material achieves 91.09%–100% adsorption efficiencies and a maximum adsorption capacity of 110.35 mg g −1 in less than 30 min. Furthermore, the adsorption kinetics follow the pseudo-second-order model. After eight consecutive adsorption-desorption cycles, T-PVA NFsM with a simplified recycling process maintains a sustainable adsorption capability. Compared with other forms of adsorption materials, T-PVA NFsM has significant advantages such as less consumption of adsorbent, high adsorption efficiency and fast removal speed. Therefore, T-PVA NFsM-based adsorptive removal holds promise for eliminating AGs from environmental water.
研究领域:
环境科学
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水处理
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材料科学
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DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
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2022
·Vol. 22
·期 5
·2100441
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IF 5.859
Yongyao Tan,Dan Chen,Yunming Wang,Wei Wang,Lingjuan Xu,Rong Liu,Chunxiu You,Guigang Li,Huamin Zhou,Dequn Li
Constrained by the existing scaffold inability to mimic limbal niche, limbal bio-engineered tissue constructed in vitro is challenging to be widely used in clinical practice. Here, a 3D nanofiber-aerogel scaffold is fabricated by employing thermal cross-linking electrospinned film polycaprolactone (PCL) and gelatin (GEL) as the precursor. Benefiting from the cross-linked (160 °C, vacuum) structure, the homogenized and lyophilized 3D nanofiber-aerogel scaffold with preferable mechanical strength is capable of refraining the volume collapse in humid vitro. Intriguingly, compared with traditional electrospinning scaffolds, the authors’ 3D nanofiber-aerogel scaffolds possess enhanced water absorption (1100–1300%), controllable aperture (50–100 µm), and excellent biocompatibility (optical density value, 0.953 ± 0.021). The well-matched aperture and nanostructure of the scaffolds with cells enable the construction of limbal bio-engineered tissue. It is foreseen that the proposed general method can be extended to various aerogels, providing new opportunities for the development of novel limbal bio-engineered tissue.
研究领域:
组织工程
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生物材料
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再生医学
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产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
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2019
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IF 4.511
Ying Wang,Ranjith Kumar Kankala,Kai Zhu,Shi-Bin Wang,Yu Shrike Zhang,Ai-Zheng Chen
Gelatin methacryloyl (GelMA) hydrogels have been commonly used in fabricating cannular tissue constructs due to their excellent cytocompatibility, as well as amenity to migration and proliferation of encapsulated cells. Here, we present a simple yet efficient approach for fabricating hollow structures with gelatin-based hydrogels using a modified microfluidic-based biofabrication technology. Hollow microfibers were generated using a customized coaxial nozzle by soft templating against a polyvinyl alcohol solution core. Reversible thermo-cross-linking and irreversible photo-cross-linking were achieved successively through gelatin (Gel) mixed into the GelMA solution and by irradiating with UV light, resulting in stable and continuous generation of hollow structures. Furthermore, in vitro evaluations confirmed good proliferation of multiple cell types in the GelMA/Gel hollow microfibers. Together, we believe that this approach holds great potential in engineering cannular constructs for applications in regenerative medicine and tissue modeling.
研究领域:
生物医学工程
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组织工程
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再生医学
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生物制造
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产品关联
DOI
PubMed
高影响因子
CELL TRANSPLANTATION
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2022
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IF 4.139
Wan Wei,Qiuhong Yang,Jing Hu,Yong Yao,Huayuan Yang
The physicochemical stimulation of acupoints is a widespread treatment strategy for different diseases, such as sciatica. Its efficacy is mainly based on the temporal and spatial modulation of the physicochemical properties of the acupoints. The existing therapies based on the stimulation of acupoints have certain disadvantages. Therefore, in this study, injectable dexamethasone (DXM)- and magnetic Fe3O4 nanoparticles-loaded chitosan/β-glycerophosphate (CS/GP) thermal crosslinking hydrogels were prepared, thereby improving the performance of embedding materials. The sciatica rat models were established to compare the therapeutic effects of hydrogels and catgut. The DXM or Fe3O4-loaded CS/GP hydrogels were compared in terms of their gelation kinetics, release kinetics, magnetic responsiveness in-vitro, and biocompatibility as well as their analgesic effects on the chronic constriction injury of the sciatic nerve (CCI) rats in-vivo. The CS/GP/Fe3O4/DXM hydrogel showed comparable gelation kinetics and good magnetic responsiveness in-vitro. This hydrogel could relieve sciatica by reducing the expression levels of inflammatory factors in serum, inhibiting the p38MAPK (p38, mitogen-activated protein kinase) phosphorylation, and decreasing the expression level of the P2X4 receptor (P2X4R) in the spinal dorsal horn. In conclusion, the DXM or Fe3O4-loaded CS/GP hydrogels can be considered as a treatment option for the physiochemical stimulation therapy of acupoints to improve sciatica.
研究领域:
药理学
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材料科学
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神经科学
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生物医学工程
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中医
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2023
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IF 6.6
Chang-An Xu,Zhuangzhuang Chu,Xingchi Li,Heng Fang,Weijian Zhou,Yang Hu,Xudong Chen,Zhuohong Yang
Epoxy vinyl ester resin is widely used in the field of corrosion protection because of its excellent corrosion resistance and mechanical properties . However, due to the ease of hydrolysis of the ester group in the ester resin, the barrier ability of the coating is reduced, which will accelerate metal corrosion. The existing literature shows that the use of nano-sheet materials such as graphene oxide (GO) can effectively enhance the barrier properties of the coating. In order to solve the poor compatibility and electrical corrosion phenomenon of GO, in this work, renewable vanillin and silicone with excellent anti-corrosive properties were grafted to GO (APGO) by insertion reaction and D-A reaction. Subsequently, a series of new APGO-based epoxy vinyl ester resin composites with excellent mechanical properties and anti-corrosion properties were prepared by thermal crosslinking polymerization. The results showed that when the additive amount of APGO was 0.1 wt%, the comprehensive performance of the composite was the best: the conductivity (1.9 × 10 −13 –5.6 × 10 −13 S/cm) of the composite was far lower than the critical electrical insulation value (10 −9 S/cm), the breaking strength was improved by 38.0 %, the contact angle was increased by 65.7 %, and its anti-corrosion efficiency was up to 99.03 %. After 70 days of immersion in 3.5 wt% salt water, the impedance modulus of the composite at low frequency (Z f = 0.01 Hz) remained 2.23 × 10 10 Ω cm 2 , which was 2 orders of magnitude higher than that of pure epoxy vinyl ester resin (2.43 × 10 8 Ω cm 2 ). The above results were not only related to the maze effect formed by APGO, but also related to the increased crosslinking density of the system. This work provided a novel strategy for preparing GO-based composites with excellent comprehensive properties.
研究领域:
材料科学
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腐蚀科学
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高分子化学
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涂料技术
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2023
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IF 9.5
Yongyue Zhang,Lei Wang,Lin Li,Hua Wang,Xinyu Dong,Yanqiu Pan,Tonghua Wang
In this work, polyacrylonitrile (PAN) based organic solvent nanofiltration (OSN) membranes were prepared by combining nonsolvent-induced phase separation (NIPS) and thermal crosslinking methods. The structure and morphology changes of the PAN membrane during thermal crosslinking were investigated by Fourier transform infrared spectrometer (FTIR), X-ray photoelectron spectrometer (XPS), X-ray diffractometer (XRD) and scanning electron microscope (SEM). The thermal crosslinking reaction of PAN chains and fusion of pore structure occurred simultaneously, which were conducive to the transformation of an asymmetric PAN ultrafiltration (UF) membrane into OSN membrane. The influences of thermal crosslinking temperature and time on the structure evolutions and nanofiltration performance of PAN based crosslinked membranes were systematically investigated. The formation mechanisms of OSN membrane were discussed in terms of the evolutions of chemical structure and pore structure. The resultant thermally crosslinked membranes showed excellent thermal stability and solvent resistance in different organic solvents. Furthermore, a remarkable stability of OSN performances in long-term test was exhibited due to the formation of crosslinked ladder structure of PAN. This work showed that thermal crosslinking is an encouraging and promising method to transform UF membranes into OSN membranes.
研究领域:
膜科学
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材料科学
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化学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）