COMBUSTION EXPLOSION AND SHOCK WAVES
·
2023
·Vol. 59
·期 3
·367-374
·
IF 1.2
Wang D.-W.,Li C.,Zhang L.,Zhu C.-G.
Abstract To develop a green primary explosive, we prepare an Al@KIO 4 nano-thermite using spray co-precipitation and then mix it with pentaerythritol tetranitrate (PETN) to form a PETN/Al@KIO 4 composite as a primary explosive. The thermite structure is characterized using X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy, which indicates that the thermite is about 200 nm and well distributed. The combustion performance is investigated using high-speed photography and confined combustion experiments. The results show that the detonation time of PETN/Al@KIO 4 composites is 60 \(\mu\) s earlier than that of pure PETN, indicating that the thermite accelerates the process of the deflagration-to-detonation transition of PETN. The detonation performance of the composites is investigated, and it is verified that PETN/Al@KIO 4 can initiate RDX successfully and be used as a primary explosive. Moreover, the safety performance and long-term storage performance of the composite are evaluated, which shows that the PETN/Al@KIO 4 composite performance is steady and the initiation effect does not change after 20 years of storage.
研究领域:
材料科学
·
爆炸化学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2025
·
IF 4.6
Wenyu Li,Yajun Wang,Qiang Gan,Zhengliang Deng,Junhan Gao
Developing efficient oxidizers is critical for advancing nano thermites. Titanium oxyfluoride (TiOF 2 ) with oxygen/fluorine dual-active centers is innovatively employed as an oxidizer in Al/TiOF 2 composites prepared via physical mixing. Structural and morphology characterization confirms uniform interfacial contact while preserving component stability. The system demonstrates exceptional reactivity: onset and peak reaction temperatures (409.4°C, 470.0°C) are reduced by 139.1°C and 130.7°C, respectively, versus Al/TiO 2 , with activation energy lowered to 84.35 kJ·mol −1 . Synergistic F–O interactions impair reaction barriers, yielding 3692.2J·g −1 heat release (120 % increase over Al/TiO 2 ). Combustion tests reveal vigorous ignition under low energy input, rapid flame propagation, and two-stage spark ejection. This work reveals the activation mechanism of oxyfluoride as an oxidizer for thermites: fluorine enhances the reaction kinetics through an interfacial modification effect, while oxygen guarantees the energy density of the system. The synergy of the two elements realizes the optimization and regulation of combustion performance.
研究领域:
材料科学
·
化学工程
·
含能材料
·
纳米技术
·
燃烧化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Jing Li,Wenjing Wang,Liang Zhao,Li Rong,Shijie Lan,Hongchen Sun,Hao Zhang,Bai Yang
Despite the success of galvanic replacement in preparing hollow nanostructures with diversified morphologies via the replacement reaction between sacrificial metal nanoparticles (NPs) seeds and less active metal ions, limited advances are made for producing branched alloy nanostructures. In this paper, we report an extended galvanic replacement for preparing branched Au–Ag NPs with Au-rich core and Ag branches using hydroquinone (HQ) as the reductant. In the presence of HQ, the preformed Ag seeds are replaceable by Au and, in turn, supply the growth of Ag branches. By altering the feed ratio of Ag seeds, HAuCl4, and HQ, the size and morphology of the NPs are tunable. Accordingly, the surface plasmon resonance absorption is tuned to near-infrared (NIR) region, making the branched NPs as potential materials in photothermal therapy. The branched NPs are further coated with polydopamine (PDA) shell via dopamine polymerization at room temperature. In comparison with bare NPs, PDA-coated branched Au–Ag (Au–Ag@PDA) NPs exhibit improved stability, biocompatibility, and photothermal performance. In vitro experiments indicate that the branched Au–Ag@PDA NPs are competitive agents for photothermal ablation of cancer cells.
研究领域:
材料科学
·
纳米技术
·
癌症研究
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Geyun Chen,Meng Wang,Liying Hao,Chaoliang Zhang,Chongyun Bao,Qiang Peng
As an antibiotic-independent approach, photothermal therapy (PTT) demonstrates significant efficacy in combating bacterial infections. Many nanoscale photothermal agents (nano-PAs), such as graphene-based nanomaterials, MXene and metal-based nanoparticles, have been reported for PTT. However, how protein corona surrounding 2D nano-PAs influences the antibacterial PTT is still unknown. Herein, we used graphene oxide (GO) as a model 2D nano-PA and investigated the effects of bovine serum albumin (BSA) corona on the antibacterial PTT of GO. We found BSA corona enhanced the photothermal effect of GO in terms of temperature increase. Despite the increased temperature, BSA corona significantly compromised the antibacterial PTT of GO against the model pathogen methicillin-resistant Staphylococcus aureus (MRSA) (viability loss rate 94.3 % for GO but 62.3 % for BSA-GO). Results from scanning electron microscopy suggested that the interactions of BSA-GO with MRSA cells were attenuated by BSA corona. This may be the reason for the compromised antibacterial PTT of BSA-GO. Our findings highlight the importance of considering the impacts of protein corona on the efficacy of antibacterial PTT. This is the first report regarding the compromised antibacterial PTT of 2D nano-PA caused by protein corona formation, which may guide the design and applications of other nano-PAs in PTT.
研究领域:
纳米医学
·
生物材料学
·
微生物学
·
感染性疾病
·
光热治疗
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Wangqing Bian,Zhenxing Pan,Yakun Wang,Wei Long,Zefeng Chen,Niping Chen,Yaoxun Zeng,Jiongpeng Yuan,Xujie Liu,Yu-Jing Lu,Yan He,Kun Zhang
Organic small molecules with near-infrared (NIR) absorption hold great promise as the phototheranostic agents for clinical translation by virtue of their inherent merits such as well-defined chemical structure, high purity and good reproducibility. Probes that happen to be based on cyanine dyes exhibit strong NIR-absorbing and efficient photothermal conversion, representing a new class of photothermal agents (PAs) for photothermal therapy (PTT), and taking into account the heat susceptibility of Mitochondria (Mito), we designed and prepared a mitochondria-targeted organic small molecule (Mito-BWQ) based on thiazole orange maternal unit that can effectively kill tumor cells through the hyperpyrexia generated in the lesions under exogenous laser irradiation. The Confocal laser scanning microscope was employed to determine the preferential targeting of Mito-BWQ to the mitochondria of MCF-7 cells and U87 cells. When subjected to 600 nm laser radiation, Mito-BWQ produced an increase in temperature in test systems and this increase was dependent on both the laser power and probe concentration. In vitro tests, cytotoxicity was observed when cells were incubated with Mito-BWQ and exposed to laser irradiation. The PTT in vivo also showed that Mito-BWQ performed remarkably in tumor inhibition. This study thus provides a vital starting point for the creation of thiazole orange-based PTT formulations and promotes further advances in the field of PAs-based anticancer research and therapy.
研究领域:
肿瘤学
·
药学
·
生物医学工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2018
·
IF 4.525
Yajie Chen,Wenchao Zhang,Chunpei Yu,Debin Ni,Kefeng Ma,Jiahai Ye
NiCo 2 O 4 has been selected as an oxidizer to realize the nanothermite film for the first time in this study. The NiCo 2 O 4 /Al core-shell nanowires (NWs) thermite film has been fabricated using a facile hydrothermal-annealing synthesis method and a controllable magnetron sputtering process. The as-obtained NiCo 2 O 4 /Al NWs thermite film shows a uniform structure and distribution on the substrate, with a favorable interfacial contact between the bimetallic oxide and the fuel at the nanoscale . It is found that the quantity of Al plays a key role in the total heat release magnitude. The maximal heat release of the NiCo 2 O 4 /Al nanothermite film has reached 2076.0 J/g at the optimal Al deposited thickness of 450 nm with the obtained optimum Al/NiCo 2 O 4 molar ratio of 4.9. Moreover, this design strategy is highly compatible with microelectromechanical systems (MEMs) and it can be applied to realize other nanothermites composed by bimetallic oxide and fuel.
研究领域:
材料科学
·
纳米技术
·
化学工程
·
能源材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xinjie Yin,Jie Wei,Jinhong Hou,Suying Xu,Leyu Wang
Bacteria-infected wound healing is one of the most challenging issues in health management that is attracting worldwide concerns. Despite great achievements with antibiotics, emergence of antibiotic-resistance retarded the wound healing process and also led to severe outcomes. Exploration of novel antibiotics together with amelioration of wound healing efficacy is desirable. Herein, a degradable microneedle patch (AAZH@MNs) was fabricated through incorporating near-infrared light responsive photothermal agents for sustained bacteria killing and prevention of biofilm formation. In addition, the antibacterial microneedle patch could even remold the microenvironment of bacteria-infected wounds through an antibacterial effect, significantly facilitating the wound healing process.
研究领域:
生物医学工程
·
伤口愈合
·
抗菌治疗
·
光热治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2024
·
IF 18
Hanchen Shen,Hongbin Wang,Jianlan Mo,Jianyu Zhang,Changhuo Xu,Feiyi Sun,Xinwen Ou,Xinyan Zhu,Lidong Du,Huaqiang Ju,Ruquan Ye,Guangfu Shi,Ryan T.K. Kwok,Jacky W.Y. Lam,Jianwei Sun,Tianfu Zhang,Shipeng Ning,Ben Zhong Tang
Ultrahigh dose-rate (FLASH) radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity. However, tumor recurrence largely impede the effectiveness of FLASH therapy. Overcoming tumor recurrence is crucial for practical FLASH applications. Here, we prepared an agarose-based thermosensitive hydrogel containing a mild photothermal agent (TPE-BBT) and a glutaminase inhibitor (CB-839). Within nanoparticles, TPE-BBT exhibits aggregation-induced emission peaked at 900 nm, while the unrestricted molecular motions endow TPE-BBT with a mild photothermy generation ability. The balanced photothermal effect and photoluminescence are ideal for phototheranostics. Upon 660-nm laser irradiation, the temperature-rising effect softens and hydrolyzes the hydrogel to release TPE-BBT and CB-839 into the tumor site for concurrent mild photothermal therapy and chemotherapy, jointly inhibiting homologous recombination repair of DNA. The enhanced FLASH radiotherapy efficiently kills the tumor tissue without recurrence and obvious systematic toxicity. This work deciphers the unrestricted molecular motions in bright organic fluorophores as a source of photothermy, and provides novel recurrence-resistant radiotherapy without adverse side effects.
研究领域:
肿瘤学
·
放射肿瘤学
·
纳米技术
·
药学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Gang Yang,Rongrong Deng,Yincheng Chang,Hongbo Li
Developing titanium-based dental implants with both excellent antibacterial properties and good osseointegration is crucial for the success of the implant operation and the long-term durability of the implant. In this study, a polydopamine-based coating was created by attaching TiO 2 nanosheets-cyanine composites onto the titanium surface, enabling the integration of effective photothermal antibacterial therapy with osseointegration. The exceptional dual-photothermal conversion abilities of polydopamine and cyanine in the coating resulted in outstanding photothermal antibacterial and antibiofilm therapy against four types of bacteria. Furthermore, TiO 2 nanosheets promoted the adhesion, proliferation and early osteogenic differentiation of osteoblasts. In an infected dental implant model in rats, the developed coating exhibited potent antibacterial activity and remarkable osteogenic differentiation in the bone, leading to increased bone formation around the implants. This innovative approach, combining photothermal therapy with osteogenic two-dimensional nanomaterials, presents a novel method for surface functionalization of implants to achieve effective antibacterial and osseointegration capabilities.
研究领域:
生物材料
·
牙科种植学
·
光热疗法
·
组织工程
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2022
·
IF 5.364
Kaiqing Yun,Juntong Guo,Renfang Zhu,Tianyi Wang,Xiaoyan Zhang,Hao Pan,Weisan Pan
Combining chemotherapy with photothermal therapy (PTT) for cancer treatment could overcome the inherent limitations of both single-modality chemotherapy and PTT. However, the obstacle of accurate drug delivery to tumor sites based on chemo-photothermal remains challenging. This article describes development of a reactive oxygen species (ROS)-responsive hyaluronic acid-based nanoparticle to overcome these drawbacks. Herein, HA-TK-MTX (HTM) was synthesized by a ROS-responsive cleaved thioketal moiety linker (TK) of methotrexate (MTX) and hyaluronic acid (HA). Through hydrophobic interaction and π–π stacking interaction, a photothermal agent IR780 was integrated into the HTM, and the IR780/HTM nanoparticles (IHTM NPs) were obtained. The IHTM NPs show high photostability, excellent photothermal performance, remarkable tumor-targeting ability, and ROS sensibility. Due to the accurate drug delivery ability and superior chemo-photothermal treatment effect of IHTM NPs, the tumor inhibition rate reached 70.95% for 4T1 tumor-bearing mice. This work serves as a precedent for the chemo-photothermal therapy of cancer by rationally designing ROS-responsive nanoparticles.
研究领域:
纳米技术
·
癌症研究
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gels
·
2022
·Vol. 8
·期 11
·754
·
IF 4.432
Yaqiong Wang,Haiyan Pan,Zhaowei Meng,Cai Zhang
Photothermal therapy (PTT) has been widely known as a promising therapeutic strategy for cancer treatment in recent decades. However, some organic and inorganic photothermal agents exhibit shortcomings including potential long-term toxicity and lack of biodegradability. Biocompatible extracts from plants and animals provide several alternatives for the reformation of photothermal agents. Bio-inspired products still have inherent problems such as low accumulation in tumors, easy diffusion, and fast elimination. Herein, we aim to develop a biocompatible photothermal agent with tumor enrichment. Enlightened by “parasitized snails”, in situ biosynthesis of photothermal agents and fluorescence imaging-guided PTT are achieved with the assistance of alginate–calcium–genipin (ACG) hydrogel. ACG hydrogel is a mixture of alginate (ALG), calcium (Ca), and genipin (GP). Given that the crosslinking product of GP and protein displays fluorescent/photothermal features, the constructed ACG hydrogel can gradually react with the tumor and then “light up” and “ignite” the tumor under specific light excitation. The ACG hydrogel can be seen as a photothermal parasite, eventually leading to the death of tumor. The photothermal therapeutic effects of ACG hydrogel reacting with tumors are successfully proven in vivo. The naturally derived GP and ALG ensure the biosafety of the ACG hydrogel-based bio-application. This work is another successful practice of nature-inspired methodological strategy for in situ biosynthesis of the photothermal agent.Keywords:alginate;hydrogel;genipin;biosynthesis;photothermal therapy
研究领域:
癌症治疗
·
生物材料
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Meng Chen,Bingbing Guo,Hui Cheng,Weiyi Wang,Junyi Jin,Yingyi Zhang,Xiaolian Deng,Wenjun Yang,Chenyao Wu,Xiang Gao,Dehong Yu,Wei Feng,Yu Chen
Collaboration between cancer treatment and inflammation management has emerged as an integral facet of comprehensive cancer care. Nevertheless, the development of interventions concurrently targeting both inflammation and cancer has encountered significant challenges stemming from various external factors. Herein, a bioactive agent synthesized by genetically engineering melanin-producing Bacillus thuringiensis ( B. thuringiensis ) bacteria, simultaneously achieves eco-friendly photothermal agent and efficient reactive oxygen/nitrogen species (RONS) scavenger benefits, perfectly tackling present toughies from inflammation to cancer therapies. The biologically derived melanin exhibits exceptional photothermal-conversion performance, facilitating potent photonic hyperthermia that effectively eradicates tumor cells and tissues, thereby impeding tumor growth. Additionally, the RONS-scavenging properties of melanin produced by B. thuringiensis bacteria contribute to inflammation reduction, augmenting the efficacy of photothermal tumor repression. This study presents a representative paradigm of genetic engineering in B. thuringiensis bacteria to produce functional agents tailored for diverse biomedical applications, encompassing inflammation and cancer therapy.
研究领域:
生物技术
·
基因工程
·
癌症生物学
·
炎症研究
·
药学科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）