POLYMER COMPOSITES
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2020
·Vol. 41
·期 5
·2094-2107
·
IF 2.265
Yujie Wang,Pei Zhang,Yuchun Zhao,Ruixin Dai,Miaoming Huang,Wentao Liu,Hao Liu,Suqin He,Chengshen Zhu
Polyurethanes are commonly used as shape memory materials due to their micro-phase separation structure. The degree of micro-phase separation is the key factor in the shape memory properties of materials. In this study, the shape memory polyurethane (SMPU) elastomer was prepared based on polycaprolactone diols, isophorone diisocyanate, and 1, 4-butanediol. And the branched structure is introduced by glycerol and hexamethylene diisocyanate to increase the degree of micro-phase separation. Moreover, nano-ZnO is also used to enhance micro-phase separation. Atomic force microscopy images clearly show that the nano-ZnO disperses uniformly in the polymer matrix and leads to significant change in the phase structure of SMPU. Dynamic mechanical analysis results indicate that the SMPU/ZnO nanocomposites possess two phase transition above 0°C, one is the melting transition of the soft segments, which is near the body temperature, and the other is the glass transition of hard segments. And with the addition of nano-ZnO, the difference in transition temperature between the hard and the soft segments is significantly increased. The relationship between shape memory properties and the micro-phase separation is explored and discussed. In vitro biocompatibility studies show that the SMPU/ZnO nanocomposites have good biosafety. Therefore, the obtained bionanocomposites have the potential application prospect as smart biomaterials.
研究领域:
材料科学
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生物医学工程
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纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Baozhan Zheng,Xiaoxia Liu,Jing Hu,Fengyi Wang,Xuan Hu,Yue Zhu,Xu Lv,Juan Du,Dan Xiao
For the pollution of radioactive materials, it is of great importance to develop efficient adsorbents for radioactive iodine adsorption in aqueous solution. In this work, a simple and green strategy was developed to construct hydrophobic surface on natural cotton fibers (n-CF) based on organic-soluble carbon dots (OCDs) for the first time. The results demonstrated the successful constructed hydrophobic n-CF@OCDs expressed excellent stability and selectivity for iodine (I 2 ) adsorption in water. The maximum adsorption capacity for I 2 on n-CF@OCDs is calculated to be 190.1 mg g −1 , which is about 6.8 times higher than that of n-CF (28.1 mg g −1 ), this highly I 2 adsorption efficiency should be attributed to the hydrophobic properties of adsorbent. The adsorption mechanism was also discussed in this work. In addition, the adsorbed I 2 could be desorbed easily with a simple reductive process at ambient conditions, which can lead to not only the restore of I 2 but also the recycling of adsorbent, illustrating their good practicability. Furthermore, this universal strategy can also be used for construction of hydrophobic surface on various natural biomaterials, demonstrating its potential application in constructing of hydrophobic surface and used for the adsorption and removal of nonpolar pollutions or radioactive waste in aqueous solutions.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
He Du,Quan Ji,Yacheng Xing,Xiaomei Ma,Yanzhi Xia
To promote the application extension of curdlan from food industry- dominant to advanced flexible biomaterials, a novel group of purely natural curdlan gels with noticeable performance was developed through a simple heating-cooling approach, i.e., heating the dispersion of pristine curdlan in mixed acidic natural deep eutectic solvents (NADESs) and water at 60–90 °C, and cooling at ambient temperature. The NADESs employed are composed of choline chloride and natural organic acids (lactic acid as the representative). The as-developed gels (called eutectohydrogels) are not only compressible and stretchable but conductive, which traditional curdlan hydrogels are not attainable. The compressive stress at 90 % strain exceeds 2.00 ± 0.03 MPa, the tensile strength and fracture elongation reach 0.131 ± 0.002 MPa and 300 ± 9 % respectively, attributed to the distinctive, reciprocally linked self-assembled layer-by-layer network structure formed during gelation . An electric conductivity up to 2.22 ± 0.04 S‧m −1 is achieved. The excellent mechanics and conductivity confer them good strain-sensing behavior. Additionally, the eutectohydrogels display high antibacterial activity against S. aureus (a model Gram-positive bacterium) and E. coli (a model Gram-negative bacterium). The outstanding comprehensive performance together with the purely natural attribute makes them broad application prospects in biomedical fields like flexible bioelectronics.
研究领域:
材料科学
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生物材料
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生物医学工程
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Rujian Jiang,Zhirong Xin,Shiai Xu,Hengchong Shi,Huawei Yang,Lingjie Song,Shunjie Yan,Shifang Luan,Jinghua Yin,Ather Farooq Khan,Yonggang Li
Biomaterial-associated infections critically compromise the functionality and performance of the medical devices, and pose a serious threat to human healthcare. Recently, natural DNase enzyme has been recognized as a potent material to prevent bacterial adhesion and biofilm formation. However, the vulnerability of DNase dramatically limits its long-term performance in antibacterial applications. In this work, DNase-mimicking polymer brushes were constructed to mimic the DNA-cleavage activity as well as the macromolecular scaffold of the natural DNase. The bacteria repellent efficacy of DNase-mimicking polymer brush-functionalized surface was comparable to that of the DNase-functionalized surface. More importantly, due to their inherent stability, DNase-mimicking polymer brushes presented the much better performance in inhibiting bacterial biofilm development for prolonged periods of time, as compared to the natural DNase. The as-developed DNase-mimicking polymer brush-functionalized surface presents a promising approach to combat biomaterial-associated infections.
研究领域:
生物医学工程
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材料科学
✓ 已验证
DOI
高影响因子
Biointerphases
·
2024
·Vol. 19
·期 4
·
IF 1.6
Yuan Bowei,Jiang Xue,Xie Zijun,Zhang Xuanjun,Zhang Jiaxin,Hong Jing
Retinal degenerative diseases, which can lead to photoreceptor cell apoptosis, have now become the leading irreversible cause of blindness worldwide. In this study, we developed an organic photovoltaic biomaterial for artificial retinas, enabling neural cells to detect photoelectric stimulation. The biomaterial was prepared using a conjugated polymer donor, PCE-10, and a non-fullerene receptor, Y6, both known for their strong near-infrared light absorption capabilities. Additionally, a fullerene receptor, PC61BM, was incorporated, which possesses the ability to absorb reactive oxygen species. We conducted a comprehensive investigation into the microstructure, photovoltaic properties, and photothermal effects of this three-component photovoltaic biomaterial. Furthermore, we employed Rat adrenal pheochromocytoma cells (PC-12) as a standard neural cell model to evaluate the in vitro photoelectric stimulation effect of this photovoltaic biomaterial. The results demonstrate that the photovoltaic biomaterial, enriched with fullerene derivatives, can induce intracellular calcium influx in PC-12 cells under 630 nm (red light) and 780 nm (near-infrared) laser irradiation. Moreover, there were lower levels of oxidative stress and higher levels of mitochondrial activity compared to the non-PC61BM group. This photovoltaic biomaterial proves to be an ideal substrate for near-infrared photoelectrical stimulation of neural cells and holds promise for restoring visual function in patients with photoreceptor apoptosis.
研究领域:
生物医学工程
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神经科学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
Gels
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2022
·Vol. 8
·期 6
·367
·
IF 4.432
Mengdie Xu,Nabila Mehwish,Bae Hoon Lee
For porous protein scaffolds to be employed in tissue-engineered structures, the development of cost-effective, macroporous, and mechanically improved protein-based hydrogels, without compromising the original properties of native protein, is crucial. Here, we introduced a facile method of albumin methacryloyl transparent hydrogels and opaque cryogels with adjustable porosity and improved mechanical characteristics via controlling polymerization temperatures (room temperature and −80 °C). The structural, morphological, mechanical, and physical characteristics of both porous albumin methacryloyl biomaterials were investigated using FTIR, CD, SEM, XRD, compression tests, TGA, and swelling behavior. The biodegradation and biocompatibility of the various gels were also carefully examined. Albumin methacryloyl opaque cryogels outperformed their counterpart transparent hydrogels in terms of mechanical characteristics and interconnecting macropores. Both materials demonstrated high mineralization potential as well as good cell compatibility. The solvation and phase separation owing to ice crystal formation during polymerization are attributed to the transparency of hydrogels and opacity of cryogels, respectively, suggesting that two fully protein-based hydrogels could be used as visible detectors/sensors in medical devices or bone regeneration scaffolds in the future.Keywords:bovine serum albumin methacryloyl;cryogels;hydrogels;porous biomaterials;mechanical properties
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2023
·
IF 17.1
Ying Wan,Huilong Liu,Zhengxing Chen,Chao Wu,Qixin Zhong,Ren Wang,Wei Feng,Xianfu Chen,Jinliang Zhang,Tao Wang,Zunmin Zhang,Bernard P. Binks
Construction of well-ordered two-dimensional (2D) and three-dimensional (3D) assemblies using one-dimensional (1D) units is a hallmark of many biointerfaces such as skin. Mimicking the art of difunctional properties of biointerfaces, which skin exhibits as defense and shelter materials, has inspired the development of smart and responsive biomimetic interfaces. However, programming the long-range ordering of 1D base materials toward vigorous control over 2D and 3D hierarchical structures and material properties remains a daunting challenge. In this study, we put forward construction of 3D enteric biomaterials with a two-strata 2D Janus interface assembled from self-adaptation of 1D protein–polysaccharide nanostructures at an oil–water interface. The biomaterials feature a protein dermis accommodating oil droplets as a reservoir for bioactive compounds and a polysaccharide epidermis protecting them from gastric degradation. Furthermore, the epidermis can be fine-tuned with different thicknesses rendering enteric delivery of a bioactive cargo (coumarin-6) with controllable retention in the intestinal tract from 6 to 24 h. The results highlight a skin-inspired construction of enteric biomaterials by self-adaptation of 1D nanostructures at the oil–water interface toward 2D Janus biointerfaces and 3D microdevices, which can be tailored for intestinal treatments with intentional therapeutic efficacies.
研究领域:
生物材料学
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纳米科学技术
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·
IF 29.4
Xiaoyu Yin,Lintao Wang,Yiming Niu,Daping Xie,Qingwen Zhang,Jian Xiao,Lei Dong,Chunming Wang
Hair loss affects over 50 million people worldwide with limited therapeutic options. Despite evidence highlighting the vital role of local immune cells in regulating the life cycle of hair follicles (HFs), accurate regulation of immunocytes to directly promote hair growth remains unachieved. Here, inspired by the physiological feedback in the skin immunity to suppress microbe-triggered inflammation, we develop an oligosaccharide biomaterial with “unmasked” specific activity to recruit T reg cells around HFs, leading to accelerated hair growth in mice. By processing the glucomannan polysaccharide via controllable enzymatic cleavage, we obtain a series of oligosaccharide fractions with more specific chemokine-inducing functions. Notably, a hexasaccharide-based fraction (OG6) stimulates macrophages to selectively express T reg -chemoattractant CCL5 through a mannose receptor-mediated endocytosis and NOD1/2-dependent signaling, as evidenced by molecular docking, inhibition assays, and a Foxp3 -reporter mouse model. Intradermal delivery of OG6 to the depilated mouse skin promotes T reg mobilization around HFs and stimulates de novo regeneration of robust hairs. Our study demonstrates that unmasking precise immunomodulatory functions in oligosaccharides from their parental polysaccharide can potentially solve the long-lasting dilemma with polysaccharide biomaterials that are widely renowned for versatile activities yet high heterogeneity, opening new avenues to designing glycan-based therapeutic tools with improved specificity and safety. This article is protected by copyright. All rights reserved
研究领域:
免疫学
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生物材料科学
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皮肤科
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药学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xianwen Hu,Peiyu Zhao,Peng Zhao,Youcun Zhu,Yifang Zhao,Lei Dai
In recent years, deep eutectic solvents (DESs) have garnered significant attention in the field of natural product extraction due to their eco-friendliness and tunable properties. In this work, six DES systems were utilized to extract chitin-glucan complex (CGC) from Shiitake mushroom (namely Lentinula edodes var. crispum) with choline chloride (ChCl) and betaine(Bet) as hydrogen bond acceptors (HBAs) and lactic acid (LA), malonic acid (MA), and urea (U) as hydrogen bond donors (HBDs). Through systematic experiments and calculations, the ChCl/LA (CLA) system exhibited the best overall performance in extracting chitin at 80 ℃, achieving a CGC yield of 32.3 %, the highest purity of chitin reached (47.5 %), a chitin acetylation degree (DA) of 65.16 %, excellent deproteinization (6.32 % residual protein) and demineralization capabilities (0.47 % residual CaCO₃). In comparation, the CGC yield of NaOH is only 21.2 %. Multiple testing analyses have confirmed that the CGC extracted by DES can maintain the composite structure of chitin and β-glucan, and has a certain degree of thermal stability, although its crystallinity is reduced and the surface is rough. Notably, the obtained CGC did not exhibit toxicity to L929 cells, with a survival rate above 80 %, which demonstrates its potential as biomaterial. This study provides a novel strategy for the green and efficient extraction of fungal chitin and its high-value utilization.
研究领域:
天然产物提取
·
绿色化学
·
高分子科学
·
生物材料
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真菌细胞壁处理
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2018
·Vol. 13
·期 1
·1-10
·
IF 3.125
Liang Chunyong,Luo Yongchao,Yang Guodong,Xia Dan,Liu Lei,Zhang Xiaomin,Wang Hongshui
Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young’s modulus of the 1.5 wt% GO incorporated scaffold is greatly increased compared to the control sample. The in vitro experiments show that the nHAC/PLGA/GO (1.5 wt%) scaffolds significantly cell adhesion and proliferation of osteoblast cells (MC3T3-E1). This present study indicates that the nHAC/PLGA/GO scaffolds have excellent cytocompatibility and bone regeneration ability, thus it has high potential to be used as scaffolds in the field of bone tissue engineering.
研究领域:
材料科学
·
生物材料
·
组织工程
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIO-MEDICAL MATERIALS AND ENGINEERING
·
2015
·
IF 1.091
Liu Xing,Xie Yi,Li Wei,Sheng Wen,Li Yinping,Tong Zan,Ni Hong,Huselstein Celine,Wang Xiong,Chen Yun
A series of composite films were prepared from glycerol-plasticized starch and zein by intensive mixing and hot press. The structure and physical properties of the starch/zein (SZ) composite films were characterized by scanning electron microscope (SEM), optical microscopy and water contract angle testing. The hemocompatibility and cytocompatibility of SZ films were evaluated by plasma recalcification time, hemolysis assay and cell culture experiment. SEM and optical observation showed that starch and zein domains can be differed in the films and in a two phase separation status. Glycerol affects the surface hydrophilicity/hydrophobicity of the films. The hemocompatibility and cytocompatibility evaluation showed that SZ composites are anticoagulant materials with no hemolysis and low cytotoxicity. The SZ composites maybe have potentials for applications as biomaterials.
研究领域:
生物医学工程
·
材料科学
·
生物学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Min Wang,Yuli Wang,Bingbing Gao,Yifeng Bian,Xiaojiang Liu,Zhenzhu He,Yi Zeng,Xin Du,Zhongze Gu
Paper, with advantages of low-cost, easy fabrication and disposal, flexibility and renewability, is a suitable substrate material for various applications. Functionalization and patterning on paper substrates are commonly required in many applications. Although many methods have been developed to achieve this, they typically suffer from some drawbacks such as time-consuming process, specific device dependence, lack of flexibility, low patterning resolution, and so forth. Herein, we present a general and fast method to functionalize paper sheets and create patterns. The whole modification process can be completed in 10 min and can be applied on various types of paper substrates and other natural materials such as natural fabrics. By our method, many commonly used functional groups can be covalently attached and patterned on paper substrates, while the characteristic features of the original paper substrates, for example, color, transparency, and conductivity, can be perfectly retained after modification to allow these properties to be incorporated into the resultant materials. High-resolution patterns can be created on paper by applying a photomask during the modification or controlling the time of modification to precisely control the functionality at any area on the obtained paper substrates. We also show the potential applications of our method in the fabrication of superhydrophobic coatings and biomaterials.
研究领域:
材料科学
·
表面化学
·
纳米技术
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）