JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Li Wang,Wanwan Wang,Shumin Zhang,Jie Wei,Qingmin Chen,Tianhui Jiao,Anhui Lin,Quansheng Chen,Xiao-Mei Chen
In this study, we present an intelligent electromagnetic-actuated microfluidic chip integrated with a G-quadruplex DNAzyme-based biocatalysis platform for rapid and sensitive tetracycline (TC) detection. In this sensing system, TC significantly quenches fluorescent magnetic carbon dots (M-CDs) via the internal filtration effect and dynamic quenching (the excitation and emission wavelength at 350 and 440 nm, respectively). Then, the G-quadruplex on the M-CDs-Aptamer is exposed and bound with hemin to form hemin-G-quadruplex DNAzyme, catalyzing the conversion of 3,3′,5,5′-tetramethylbenzidine to produce blue color. This enables the fluorescence/colorimetric detection of TC. Importantly, an automatic electromagnet-integrated microfluidic chip was designed to control the shuttling of magnetic materials in each function slot according to a programmed sequence. Under the optimal conditions, the detection limits of TC for fluorescence and colorimetric methods were 11 and 43 μmol/L, respectively. The detection results for tilapia (Oreochromis nilotica) were comparable to those of traditional high-performance liquid chromatography. This platform offers excellent performance for TC determination and potential for portable, intelligent detection of trace pollutants in food and the environment.
研究领域:
生物化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Nature Biomedical Engineering
·
2025
·
IF 26.6
Wang Ben,Shen Jie,Huang Chenyang,Ye Zhicheng,He Jiajun,Wu Xinyu,Guo Zhiguang,Zhang Li,Xu Tiantian
Small materials with pliability and untethered mobility are particularly suitable for minimally invasive medical interventions inside the body. However, the capabilities and applicability of such soft ‘robots’ are restricted by foreign-body responses to them and by the need to get them cleared from the body after the intervention. Here we report the development of biodegradable magnetized biohybrid blood hydrogel fibres that evade immune recognition, and their applicability for targeted intracranial tumour therapy with real-time tracking through X-ray fluoroscopy. The gel fibres can be made of the patient’s own blood mixed with a small amount of magnetic particles and can be produced in about 15 min. We show that the locomotion of intracranially injected gel fibres through cerebrospinal fluid can be remotely controlled under a magnetic field and fluoroscopically tracked, and that a drug encapsulated in the gels can be released on demand under magnetic control, as we show for the delivery of doxorubicin to intracranial tumours in the minipigs. Biodegradable soft actuatable materials that avoid foreign-body responses may aid the development of personalized targeted interventions.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
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IF 19
Ye Tian,Xiaojun Lu,Tingbin Wang,Aiping Liu,Lisha Fan,Huaping Wu
Soft microactuators leveraging biomimetic designs and microfabrication advances show substantial promise for soft robotics, precision sensing, and targeted drug delivery. However, simultaneously achieving rapid deformability with mechanical robustness in such systems remains a significant challenge. Herein, a hybrid microactuator with heterogeneous materials is fabricated via femtosecond laser two-photon polymerization. Incorporating acrylic acid as a functional monomer imparts pH-responsive behavior to the hydrogel, whereas the rigid photoresist ensures structural integrity. Moreover, embedded magnetic nanoparticles enable contactless and precise locomotion under an external magnetic field. As a proof-of-concept, a scorpion-inspired microactuator with dual pH/magnetic responsiveness demonstrates programmable functions including capture, transport, and release. This strategy provides a versatile platform for adaptive microrobots with localized responsiveness and remote motion, paving the way for precision therapeutics and cellular micromanipulation.
研究领域:
生物医学工程
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微纳制造
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智能材料
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软体机器人
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靶向给药
✓ 已验证
产品关联
DOI
高影响因子
Device
·
2025
·
IF 8
Jiyang Wu,Yuxuan Sun,Yifan Peng,Xingxiang Li,Shutong Nong,Boxi Sun,Zhengqing Zhu,Dongxiao Li,Mengting Wang,Weihua Li,Shiwu Zhang,Gang Pei,Mujun Li
Programmable functional surfaces face a tradeoff between fast reprogrammability and stable self-maintainability. The integration of field-responsive materials offers convenience for repeated programming of functional surfaces but necessitates continuous energy input to maintain the programmed functions. Meanwhile, technologies such as shape memory and functional coatings enable stable maintenance of surface states but result in a time-consuming reprogramming process. This tradeoff limits the demonstration of surface properties. We present a magnetic mini flap (at the millimeter scale) that can self-maintain its surface state and a pulsed magnetic tip to enable local fast reprogramming of the mini flaps within 100 ms. The mini flaps are arranged in a pixel array, where each pixel can be customized for specific surface properties, such as wettability and reflectivity.
研究领域:
材料科学
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应用物理
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微加工
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表面工程
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DOI
高影响因子
Small
·
2021
·Vol. 18
·期 5
·2105198
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IF 13.281
Xiangyi Zhang,Lipei Ren,Jie Xu,Bin Shang,Xin Liu,Weilin Xu
Structural design of the solar-absorbing layer has been considered as one of the most direct and effective approaches for improving the solar steam generation performance by maximizing the absorption of sunlight, but great challenges in manipulation simplification and structure controllability still remain. Herein, a polyester (PET) fabric covered with a vertically aligned 3D tower-like ferrosoferric oxide (Fe 3 O 4 ) array via a convenient magnetically driven spray-coating method is reported, and both the spatial density and height of the Fe 3 O 4 array are tunable upon spraying time. It shows an extremely high solar absorbance (98.6%) in the entire solar spectrum, which is superior to the corresponding 2D Fe 3 O 4 structure (91.1%). Combining the obtained 3D Fe 3 O 4 /PET with a yolk-shell hydrophobic/superhydrophilic modified melamine-formaldehyde (mMF) sponge, the carefully designed and fabricated 3D Fe 3 O 4 /PET-mMF evaporator can realize a high water evaporation rate of 1.59 kg m −2 h −1 under 1 kW m −2 solar illumination, outperforming most related solar steam generation systems. With the advantages of cost-effectiveness, high evaporation rate, reliable endurance, and structural controllability, this 3D structural design provides an avenue to build up high-performance solar energy-driven water steam generation systems.
研究领域:
材料科学
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能源科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-8
·
IF 17.694
Li Ming-Ding,Shen Xiao-Quan,Chen Xin,Gan Jia-Ming,Wang Fang,Li Jian,Wang Xiao-Liang,Shen Qun-Dong
With speeding up development of 5 G chips, high-efficient thermal structure and precise management of tremendous heat becomes a substantial challenge to the power-hungry electronics. Here, we demonstrate an interpenetrating architecture of electrocaloric polymer with highly thermally conductive pathways that achieves a 240% increase in the electrocaloric performance and a 300% enhancement in the thermal conductivity of the polymer. A scaled-up version of the device prototype for a single heat spot cooling of 5 G chip is fabricated utilizing this electrocaloric composite and electromagnetic actuation. The continuous three-dimensional (3-D) thermal conductive network embedded in the polymer acts as nucleation sites of the ordered dipoles under applied electric field, efficiently collects thermal energy at the hot-spots arising from field-driven dipolar entropy change, and opens up the high-speed conduction path of phonons. The synergy of two components, thus, tackles the challenge of sluggish heat dissipation of the electroactive polymers and their contact interfaces with low thermal conductivity, and more importantly, significantly reduces the electric energy for switching the dipolar states during the electrocaloric cycles, and increases the manipulable entropy at the low fields. Such a feasible solution is inevitable to the precisely fixed-point thermal management of next-generation smart microelectronic devices.
研究领域:
材料科学
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电子工程
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热能工程
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纳米技术
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jingang Wang,Jianchen Zheng,Chengzhi Zhang,Ya Duan,Yuzhao Zhang,Hongji Guo,Ye Qiu,Xiaoduo Wang,Lianqing Liu,Haibo Yu
Soft microrobots exhibit distinct advantages in biomedical applications, with their exceptional maneuverability in confined spaces and environmental adaptability offering innovative solutions for targeted theranostics. However, current systems are inherently constrained by the physical separation of sensing and actuation modules, leading to inadequate integration and operational efficiency that hinder practical implementation. To overcome this challenge, a micro-nano 4D printing design paradigm is proposed. Through spatial programming of multi-responsive materials and biomimetic microstructural engineering, a microrobotic system is fabricated with synergistic perception-actuation capabilities. By integrating gradient magnetic field-responsive composites and pH-sensitive hydrogels, a 150-µm-scale biomimetic fish-shaped microrobot is developed, innovatively integrating three functionalities: magnetic-actuation, pH-triggered joint actuation, and diffractive optical sensing. Specifically, its tail joint enables adaptive modulation of doxorubicin release kinetics via pH-mediated mechanical deformation, while the head-mounted diffractive spectral sensor provides dynamic optical feedback of pathological microenvironment pH (5.0–6.5). Proof-of-concept experiments demonstrate the system's precise drug release control and environmental monitoring capabilities in gastric cancer cell therapy. This work provides a 4D printing design approach for next-generation intelligent therapeutic microrobots capable of environmental perception, intelligent response, and precise execution.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗学
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智能材料
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转化医学
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微纳机器人
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药物控释
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Tian Guan,Dayu Liu,Xiangmei Li,Bowen Shu,Mengting Li,Yingju Liu,Zhenlin Xu,Yudong Shen,Yuanming Sun,Hongtao Lei,Xing Shen
Simplicity, sensitivity and high throughput are the qualities researcher always difficultly pursue in the screening surveillance assay for food contaminants. Herein, coupled with a common gel imager as a signal reader, a novel magnet-actuated droplet microfluidic immunosensor without any complicated manipulation system was successfully fabricated for the convenient and sensitive detection of cyanobacteria toxin microcystin-LR (MC-LR) in aquatic products. The proposed sensor demonstrated three superiorities compared to the extensively used microfluidic systems: 1) simple but effective operation only by magnetic force rather than inconvenient actuating devices; 2) high throughput parallel detection on a 15-channels chip; 3) convenient signal readout on an ordinary laboratorial gel imager. This gel imager-assisted magnet-actuated droplet microfluidic immunosensor exhibited a limit of detection as low as 6.0 × 10 −4 μg/L with high specificity. The average recoveries were ranged from 92.0% to 96.6% in spiked fish and prawn samples, and showed a good agreement with confirmation method LC-MS/MS, suggesting the proposed method to be an ideal surveillance assay tool for the MC-LR monitoring in aquatic products.
研究领域:
环境科学
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分析化学
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食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2024
·Vol. 14
·期 4
·186
·
IF 4.9
Yanpeng Wang,Zhaoyang Wang,Haotian Sun,Tong Lyu,Xing Ma,Jinhong Guo,Ye Tian
Nano-doped hollow fiber is currently receiving extensive attention due to its multifunctionality and booming development. However, the microfluidic fabrication of nano-doped hollow fiber in a simple, smooth, stable, continuous, well-controlled manner without system blockage remains challenging. In this study, we employ a microfluidic method to fabricate nano-doped hollow fiber, which not only makes the preparation process continuous, controllable, and efficient, but also improves the dispersion uniformity of nanoparticles. Hydrogel hollow fiber doped with carbon nanotubes is fabricated and exhibits superior electrical conductivity (15.8 S m−1), strong flexibility (342.9%), and versatility as wearable sensors for monitoring human motions and collecting physiological electrical signals. Furthermore, we incorporate iron tetroxide nanoparticles into fibers to create magnetic-driven micromotors, which provide trajectory-controlled motion and the ability to move through narrow channels due to their small size. In addition, manganese dioxide nanoparticles are embedded into the fiber walls to create self-propelled micromotors. When placed in a hydrogen peroxide environment, the micromotors can reach a top speed of 615 μm s−1and navigate hard-to-reach areas. Our nano-doped hollow fiber offers a broad range of applications in wearable electronics and self-propelled machines and creates promising opportunities for sensors and actuators.
研究领域:
材料科学
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生物医学工程
·
传感器技术
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Mengyao Zhu,Xiangyi Zhang,Junhao Chen,Xiang Fu,Huiyu Yang,Dongzhi Chen,Pei Lyu,Shaojin Gu,Xin Liu,Bin Shang
Cactus spinelike materials have attracted much attention due to high fog harvesting efficiency, but great challenges in structure fabrication and structural controllability still remain. In this study, we proposed a magnetically driven spray-coating method to fabricate a cactus spinelike superhydrophobic Fe3O4 vertical array on nonwoven cotton fabric. This method is simple and controllable; a mixture containing magnetic Fe3O4 particles and organosilicon resin was atomized into tiny droplets and arranged along the magnetic field lines. Different from the traditional method to prepare a cactus spinelike structure via liquid flow under magnet, which is usually accompanied with a big structure size and an unobvious structure feature due to the high viscosity of magnetic liquid. However, if the magnetic liquid is transformed into tiny magnetic droplets by a spraying method, it is promising to prepare micrometer-scale conical structures, and the reduction degree of bionic structures is high. When the fabricated structure is used for fog harvesting, it shows an extremely high efficiency of approximately 6.33 g cm–2 h–1, which is superior to most state-of-the-art fog harvesting materials. Considering the advantages of simplicity, structure controllability, and high fog harvesting rate, the reported strategy provides an avenue to build up high-performance fog harvesting materials.
研究领域:
材料科学
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环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2024
·
IF 3.4
Sida Peng,Xiaonan Lei,Shengzhi Sun,Yi Zhu,Jianrong Qiu,Huayong Yang
Gear transmission holds paramount significance for intricate mechanical systems. However, when the size of the driving gear is miniaturized to less than 50 microns, both manufacturing and control meet challenges. Here, a magnetic-driven micro-gear pair (MMGP) and its manipulation strategy are proposed. The MMGP is composed of two micro-gears fabricated by the two-photon polymerization (TPP) and its manipulation strategy depends on the gear engagement. The driving gear was processed with a magnetic photoresist and can rotate stably with a rapid rotation response (<100 ms) under the control of an external magnetic field. The driven gear can be driven by the driving gear through the meshing relationship of the gear teeth. As a proof of concept, number counters and the delivery of drugs are achieved by specially designed MMGPs. This development establishes a pivotal foundation for micro-gear transmission in complex intelligent systems, microfluid operation, and biological manipulation. This article is protected by copyright. All rights reserved.
研究领域:
微工程
·
微机械
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Linsen Li,Ying Zhang,Liping Zhao,Yueguang Lv,Feng Qu,Qiang Ma
The rapid on-site mass spectrometry (MS) analysis of biofluids is of immense significance for point-of-care scenarios. In this study, an innovative magnetically driven capture-and-release strategy for in-capillary cyclical transfer enrichment of analytes of interest is reported. A dispersive magnetic solid-phase microextraction protocol is developed based on aptamer-functionalized polymer-modified magnetic nanoparticles, enabling specific recognition, fast transportation, and dynamic enrichment of target analytes within the capillary. Furthermore, a dicationic ionic liquid (DIL)-based charge inversion reaction is integrated with extraction nanoelectrospray ionization and miniature MS analysis to achieve significant signal amplification. The sensitivity of the analysis for typical per- and polyfluoroalkyl substances was enhanced by 6.3–28.9 times in the positive ion mode following the DIL-based charge inversion strategy, compared to that in the negative ion mode without any DILs used. The proposed method underwent validation, demonstrating good linearity with correlation coefficients exceeding 0.99, acceptable recoveries ranging from 89.6% to 111.1%, and satisfactory sensitivity with limits of detection and quantitation in the ranges of 0.05–0.2 and 0.2–2 ng/mL, respectively. This methodology demonstrates appealing analytical performance and environmental friendliness, which is of great importance for clinical and point-of-care applications.
研究领域:
分析化学
·
医学检测
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）