ANALYTICAL LETTERS
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2024
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IF 1.6
Jin-Wen Liu,Tingting Chen,Meiqun Cai,Yingfeng Qin,Mei Li
Accurate, rapid, and quantitative detection of D-penicillamine (D-PA) in pharmaceutical formulations is imperative for drug quality and clinical medication guidance. Various colorimetric and fluorescent assays have been constructed for D-PA based on nanomaterials. However, the reliable and rapid detection of D-PA in pharmaceutical formulations remains a challenge because these methods suffer from shortcomings such as time-consuming procedures, poor uniformity, and complicated nanomaterial preparation. In this work, an effective and facile homogeneous dual-mode optical sensing strategy was established based on the strong complexation between D-PA and Cu2+ and catalyzed the oxidation of O-phenylenediamine. This platform displayed a sensitive response to D-PA from 5 to 100 µmol/L, with a detection limits of 0.54 µmol/L (fluorescence) and 0.76 µmol/L (colorimetry). As expected, the method was successfully applied to the determination of D-PA in pharmaceutical formulations with satisfactory results. Overall, this developed strategy provides a facile and rapid dual-mode optical platform for D-PA and has great potential in D-PA-related pharmaceutical quality control.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Shaofeng Huang,Dongxu Li,Xipeng Xu,Jing Lu,Yaning Li
The rough surface grains of polycrystalline diamond (PCD) pose significant grinding difficulties, rendering traditional processing methods inefficient and time-consuming for achieving the desired surface quality for chip cooling substrates. To overcome this problem, a novel composite abrasive wheel capable of inducing reaction with PCD’s surface grains for rapid diamond removal is introduced. The performance of the wheel is optimized through a series of experiments considering sintering temperature, pore-forming agent content, and grinding particle size. Upon sintering under vacuum, the optimal formulation, consisting of 30 wt% Fe and 15 wt% PMMA, yields a tool characterized by high microhardness, bending strength, and porosity. The presence of amorphous carbon and iron carbide is confirmed using various characterization techniques. During processing, Fe particles interact with diamond to form iron carbide, reducing the PCD surface hardness and enhancing the removal efficiency. The PCD film achieves an smooth surface with a roughness as low as 0.49 nm and the thickness of the subsurface damage layer is 2.96 nm. Because the mechanical action of diamond collaborates with the chemical action of iron, subsurface damage is minimized and grinding efficiency is maintained.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Junda Huo,Dongxu Zhang,Debin Ni,Shan Wang,Qianyou Wang,Li Yang
The crystal morphology of energetic materials significantly affects their sensitivity, initiation capability, and flowability, which directly determine the performance of weapons and equipment. Despite great efforts having been devoted to the morphological control of primary explosives, the mechanism insights into morphological modification are still in infancy stage. Herein, combining experimental results with theoretical calculations, we elucidated the morphological control process of a novel environmentally friendly lead-free primary explosive named bis-(ethylenediamine) copper (II) 5-nitrotetrazolate [Cu(EDA) 2 (NT) 2 ]. Through directional suppression/induction by different surfactants on crystal face growth, three completely different shaped crystals of Cu(EDA) 2 (NT) 2 (lamellar, hollow rhombic toroidal, and uniform rhombic block) were prepared, ultimately achieving precise control over the crystal morphology. Among them, the block-shaped crystals of CMC-Cu(EDA) 2 (NT) 2 , modified with carboxymethyl cellulose, exhibited significantly improved stacking density, thermal stability, and initiation capability. This work not only significantly optimized the modification of Cu(EDA) 2 (NT) 2 , but also revealed the complex interaction mechanism between surfactants and crystal surfaces, laying an important scientific foundation for tailoring morphology, and enhancing performance of primary explosives crystals.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Pengpeng Zhang,Zihao Li,Wenbao Liu,Mingyang Li,Fanfei Min
Achieving selective flotation separation between chlorite and specularite is inherently difficult, primarily because of their overlapping surface characteristics and analogous reactivity toward commonly used depressants. In this work, we propose a novel pre-adsorption strategy using two phosphonic acid reagents—bisphosphonomethyl glycine (BPMG) and aminotrimethylene phosphonic acid (ATMP)—to selectively modify chlorite surfaces. Systematic flotation experiments, combined with contact angle and zeta potential analyses, FTIR and XPS spectroscopy, and density functional theory (DFT) simulations, revealed that both reagents strongly chelate with Al³ ⁺ and Mg²⁺ sites on chlorite. Such targeted surface modification impedes the subsequent adsorption of depressants while promoting collector interaction, thereby creating a more pronounced difference in flotation behavior between the two minerals. ATMP demonstrated enhanced efficacy compared to BPMG, a consequence of its structurally enriched phosphonate functionalities and more stable complexation with Mg²⁺ and Ca²⁺. Under optimized conditions, the recovery difference between chlorite and specularite exceeded 70 %, and artificial mixed mineral tests confirmed enhanced Fe grade and recovery. This study introduces phosphonic acid pre-adsorption as an innovative route to overcome the limitations of traditional depressants and provides new surface chemistry insights for designing selective reagents in complex iron ore flotation.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yu Chen,Zihui Yu,Yihan Wang,Chengliang Ma,Quanli Jia,Ye Li
Based on the degradation mechanism of refractory saggar involving penetration and corrosion by Li-ion battery (LIB) cathode materials, developing refractory composites with a contiguous corrosion resistant materials network structure are considered one of the most promising ways to simultaneously achieve enhanced penetration resistance and corrosion resistance in saggar materials. Here, a mullite-based composites with a contiguous K 2 O-Al 2 O 3 -SiO 2 amorphous phase (KASp) network structure were simply prepared by incorporating potassium feldspar. The resulting material features a contiguous KASp network structure and exhibits low connectivity pores. This structure significantly enhances the composites resistance to penetration and corrosion by LIB cathode materials, primarily due to the combined effects of the KASp physical barrier and reduced pore continuity. Additionally, the strong KASp and mullite/corundum interfacial bonding reinforce the composites, leading to exceptional mechanical strength.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2025
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IF 4.1
Hongxun Wang,Tao Yang,Yanping Li,Guosheng Wen,Cheng Zhang,Dazhou Yan
An intensive attention is paid to silicon (Si), due to its high theoretical specific capacity (4200 mAh g −1 ) and natural abundance, among the anode materials for lithium-ion batteries. However, bonding failure and structural fracture of the anodes caused by the huge volume expansion (300 %) of Si during repeated lithiation-delithiation cycles, results in dramatic capacity degradation and lifetime attenuation of lithium-ion batteries. Herein, a modified starch binder (TADS) was synthesized by introduction of different polar groups to enhance the hydrogen bonding and adhesion among the binder, Si anodes and the current collector. The Si electrode with the TADS binder (Si-TADS) exhibited superior mechanical integrity and electrochemical performance, delivering a high reversible specific capacity of 2005.9 mAh g −1 at 0.1C after 100 cycles, more than twice that of the counterpart with the unmodified starch binder (Si-TA, 947.5 mAh g −1 ). Furthermore, a Si-based anode with an initial capacity of 1000 mAh g −1 sustained over 600 stable cycles when using the TADS binder, whereas only 150 cycles were achieved with the unmodified TA binder.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yunchuan Li,Xiaolei Ye,Shenghui Guo,Ming Hou,Li Yang,Lei Gao,Kaihua Chen,Mingxu Li,Ziyue Xue
As an innovative material synthesis strategy, high-entropy design offers a novel approach for the development of solid oxide fuel cell cathodes. In this study, we employed microwave heat treatment combined with solution combustion to synthesize five-component, cobalt-free high-entropy spinel oxides, specifically (Ni 0.2 Fe 0.2 Cr 0.2 Zn 0.2 Mg 0.2 ) 3 O 4 , where the molar ratio of the metal elements is nearly equal. The synthesized (Ni 0.2 Fe 0.2 Cr 0.2 Zn 0.2 Mg 0.2 ) 3 O 4 exhibits a porous network structure with a notably high specific surface area of 25.013 m 2 /g, enhancing its effectiveness in facilitating the oxygen reduction reaction. The high-entropy strategy, combined with microwave heat treatment, facilitates the formation of oxygen vacancies in (Ni 0.2 Fe 0.2 Cr 0.2 Zn 0.2 Mg 0.2 ) 3 O 4 , thereby enhancing its oxygen ion conductivity. The synergistic interactions among multiple metal cations significantly enhance the activity of the oxygen reduction reaction. (Ni 0.2 Fe 0.2 Cr 0.2 Zn 0.2 Mg 0.2 ) 3 O 4 exhibits excellent chemical compatibility with GDC, SDC, and YSZ. Electrochemical impedance spectroscopy analysis reveals that the high-entropy spinel, synthesized through microwave heat treatment at 800 °C, exhibits a polarization impedance as low as 0.12 Ω cm 2 and a power density of 611.53 mW cm −2 . These findings underscore its considerable potential for application as a cathode material in intermediate-temperature SOFCs. This study highlights the potential of the high-entropy strategy and microwave synthesis to improve the performance of spinel oxide cathodes. These approaches offer innovative directions for developing cobalt-free, intermediate-temperature SOFCs cathodes.
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高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2025
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IF 3.9
Fangru Zhou,Mi Zhou,Yuqian He,Yang Yuan,Zhuowei Zhang,Yingjie Zhang,Jun Ma,Linlin Yan,Xiquan Cheng
As a cutting-edge method, membrane separation technology effectively addresses high-algae water, mitigating the threats posed by it to public health and environmental sustainability, especially ceramic membranes. Ceramic membranes with stable physical and chemical properties exhibit remarkable permeance and superior rejection performance in algae-laden water treatment, yet their large-scale deployment is impeded by serious membrane fouling. Here, we propose a facile strategy to prepare anti-fouling ceramic membranes by depositing multifunctional coatings on the surface through soaking in a blend solution of PDA and KH560 to tailor the surface structure and hydrophilicity. The introduction of multi-functional coating optimized the physical and chemical structure of the surface, thereby increasing the hydrophilicity of the membrane and reducing surface roughness and pore size. As a result, the pure water flux of the modified membrane increased by 38.4 % compared with the original membrane, and the modified membrane exhibited a reduction in irreversible fouling from 5.0 % to 2.5 % and also an increase in flux recovery from 79.7 % to 98.6 %. Interestingly, the dissolved organic carbon (DOC) and the UV 254 removal rates of the filtrate decreased by 63.2 % and 75.6 %, respectively. Notably, dead algae cells and extracellular organic matter (EOM) were identified as the main factors inducing irreversible fouling of the membrane during the filtration process, and furthermore, the modified membrane alleviated the irreversible fouling via multiple mechanisms including the Donnan effect and pore size screening. Overall, the study provides a new solution and theoretical basis for the development of anti-fouling ceramic membranes.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Jiasen Zhang,Lin Zhang,Xufei Liu,Bokun Jia,Kai Xie
To mitigate the environmental pressures associated with waste management, it is crucial to adopt scientific and rational approaches to solid waste treatment. This study introduces a novel gravity-driven membrane (GDM) that utilizes industrial solid waste as its structural framework, significantly enhancing algae removal efficiency. The industrial solid wastes examined include bayer red mud (BRM), sintered red mud (SRM), fly ash (FA), and gangue (GA). Notably, the adsorption energy (E ads ) of modified iron atoms on BRM was found to be −0.532 eV, indicating robust interaction forces. The adsorption efficiency of the GDM is primarily governed by the Lewis acid-base interactions ( Δ U fwm AB ). Further analysis combining interaction energy with fluorescence characteristics demonstrates the effectiveness of the Fe–O network in BRM at extracting tryptophan protein-like substances from the membrane pores. The algae removal efficiency of the GDM incorporating BRM reached 66.71 %, suggesting a promising application for filtering algal-rich waters at the molecular level within ceramic matrices.
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高影响因子
MOLECULAR IMMUNOLOGY
·
2024
·
IF 3.2
Nini Jia,Yun Meng,Jing Li,Mengyao Cui,Yaqing Li,Dayuan Jiang,Xiaoqin Chu
Objective To study the therapeutic effect and mechanism of Shaoyao Gancao Decoction (SGD) on ulcerative colitis (UC) mice based on the perspective of intestinal barrier, and this study provides a new consultation for the clinical application of SGD. Methods The chemical composition of SGD was characterized by HPLC. The UC mouse model was constructed by 3 % dextran sodium sulfate (DSS), which were randomly divided into the model group (DSS), the positive drug group (5-ASA), the Shaoyao group (SYD), Gancao group (GCD), and the Shaoyao Gancao Decoction group (SGD) at low, medium, and high dosages, respectively. The effects of each drug treatment group on UC were evaluated by the rate of body weight loss, disease activity index (DAI), colon length, spleen index, histopathological evaluations, and the levels of serum inflammatory factors (IL-1β, IL-6, IL-10, IL-21, and TNF-α). The goblet cell was observed by Alcian blue/periodic acid-Schiff (AB/PAS) straining, ELISA was used to detect the content of LPS in serum, and Western blot was used to detect the changes in the expression of tight junction proteins ZO-1, occludin, and the pathway proteins TLR4 and NF-κBp65 in the colonic tissues, to explore the protective effect of SGD on the intestinal barrier of UC mice. The vivo absorption process of the main active ingredients in the SG, SY and GC groups was determined by LC-MS. Results The contents of albiflorin, paeoniflorin, liquiritin apioside, liquiritin and glycyrrhetinic acid were 6.1227 mg/g, 20.8993 mg/g, 4.0054 mg/g, 3.6140 mg/g and 8.2515 mg/g, respectively. Compared with DSS group, SGD reduced weight loss(P<0.01) and DAI scores(P<0.05), prevented colon shortening(P<0.01), and ameliorated histopathological damage of the colon in UC mice(P<0.01). SGD also protected the intestinal barrier to alleviate UC by significantly reducing serum LPS and inflammatory factor levels, altering the number of goblet cells, promoting tight junction proteins (ZO-1 and occludin) and decreasing the expression of TLR4 and NF-κB in colonic tissues. Pharmacokinetic results showed that there was no significant difference in C max , AUC 0-t (μg/L . h) and T max of albiflorin and paeoniflorin between the SY and SG groups, the T max was within 1 h; the AUC 0-t (μg/L . h) of liquiritin and glycyrrhizic acid were about 1.6 and 1.9 times higher in the SG group compared to the GC group, respectively. The C max , T max and AUC 0-t (μg/L . h) of glycyrrhizinic acid were significantly reduced to 0.73, 0.68 and 0.68 times of that of the GC group. Conclusion SGD may have a therapeutic effect on DSS-induced UC mice by repairing the damaged intestinal barrier through the TLR4/NF-κB pathway. The combination of Shaoyao and Gancao increased the absorption of liquiritin and glycyrrhizic acid in vivo. The combination of Shaoyao and Gancao could promote the absorption of Gancao, and that the pairing of the two herbs could have a synergistic effect.
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PubMed
高影响因子
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