EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2020
·
IF 3.616
Fang Liu,Ling-Yang Wang,Ming-Chao Yu,Yan-Tuan Li,Zhi-Yong Wu,Cui-Wei Yan
With the purpose of overcoming the serious hepatotoxicity of antituberculosis drug isoniazid (INH), a cocrystallization strategy based on complementary advantages was implemented by choosing the hepatoprotective nutraceutical quercetin (QCT) as the cocrystal former. The strategy plays the solubility advantage of INH to improve the bioavailability of the insoluble QCT, thereby significantly enhancing the QCT's hepatoprotective effects. The optimized protective effects of QCT, in turn, feed back to INH to reduce its hepatotoxicity. Along this line, a novel INH-QCT cocrystal was successfully prepared and structurally characterized. The systematic evaluation results of the in vitro/in vivo revealed that, due to the advantage of INH's solubility, the dissolution efficiency of QCT from the cocrystal was increased 51.67-fold compared with that of coarse quercetin, and the oral bioavailability of the cocrystal in rats was enhanced by 28.91 times. As a result, the INH-QCT cocrystal almost removed INH induced serious hepatotoxicity, which has been demonstrated by the hepatotoxicity studies in rats. These findings present new opportunities for the advantageous solid forms of low-toxic antituberculosis drugs, and open new avenues against toxic side effects of drugs through the cocrystallization mean.
研究领域:
药学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2015
·Vol. 8
·期 2
·316-325
·
IF 1.821
Fugang Xu,Ying Liu,Shi Xie,Li Wang
In this study, a sensitive hydrazine sensor based on CuxO decorated three dimensional poly(3,4-ethylene-dioxythiophene) (3D-PEDOT) was developed. A 3D-PEDOT–CuxO hybrid was prepared through a facile electrochemical deposition and cyclic voltammetry treatment process. The hybrid material was characterized by scanning microscopy (SEM), X-ray energy dispersive spectroscopy (EDS), Raman, and electrochemical methods. It was found that 3D-PEDOT not only acts as a matrix to increase the loading amount of CuxO and enhances the conductivity, but also directly contributes to the catalytic oxidation of hydrazine. Owing to the synergistic interaction between 3D-PEDOT and CuxO, the 3D-PEDOT–CuxO hybrid displayed obviously enhanced catalysis for hydrazine oxidation with lower overpotential and stronger oxidation current compared to single component CuxO or 3D-PEDOT. The hydrazine sensor based on the 3D-PEDOT–CuxO hybrid exhibited a one order of magnitude wider linear range (0.5 μM to 53 mM), ten-fold lower detection limit (0.2 μM) and higher stability compared to those of the sensor based on CuxO. The proposed sensor was also used for the determination of hydrazine in real water samples with a satisfactory recovery.
研究领域:
材料科学
·
分析化学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2013
·Vol. 31
·期 8
·987-991
·
IF 0.917
Lei Huang,Pingfei Luo,Man Xiong,Rizhi Chen,Yong Wang,Weihong Xing,Jun Huang
Commercial MoS 2 was found to be a highly selective catalyst for the reduction of nitrobenzenes to the corresponding anilines with hydrazine under mild conditions. MoS 2 is not only much cheaper, but also more selective than noble metal catalysts for the reduction of functional nitrobenzenes to the corresponding anilines. Nitrobenzenes with halides (F, Cl, Br and I) were reduced selectively, and the corresponding anilines were obtained in excellent yields, and no dehalogenation was detected. Functional groups such as NH 2 , OH, alkene groups were tolerated during the reduction of the nitro compounds. The reduction of p -chloronitrobenzene was studied over MoS 2 and Pd/C respectively with hydrazine. The yield of p -chloroaniline was much higher with MoS 2 than that with Pd/C at full conversion.
研究领域:
化学
·
催化材料科学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 13
·2207
·
IF 5.719
Xin Li,Xiaobin Wang,Wei Guo,Feng Luan,Chunyuan Tian,Xuming Zhuang,Lijun Zhao
In this paper, the SQDs@MnO2NS as the probe was applied to construct a novel “turn-on” fluorescent sensor for sensitive and selective detection of hydrazine (N2H4). Sulfur quantum dots (SQDs) and MnO2nanosheets (MnO2NS) were simply mixed, through the process of adsorption to prepare the architectures of SQDs@MnO2NS. The fluorescent emissions of SQDs@MnO2NS play a key role to indicate the state of the sensor. According to the inner filter effect (IFE) mechanism, the state of the sensor at the “off” position, or low emission, under the presence of MnO2NS, is which the ultraviolet and visible spectrum overlaps with the fluorescence emission spectrum of SQDs. Under the optimal conditions, the emission was gradually recovered with the addition of the N2H4, since the N2H4as a strong reductant could make the MnO2NS converted into Mn2+, the state of the sensor at the “on”. Meanwhile, the fluorescent sensor possesses good selectivity and high sensitivity, and the detection concentration of N2H4with a wide range from 0.1 µM to 10 mM with a detection limit of 0.072 µM. Furthermore, actual samples were successful in detecting certain implications, indicating that the fluorescent sensor possesses the potential application ability to monitor the N2H4in the water.Keywords:sulfur quantum dots;MnO2nanosheet;hydrazine;fluorescence probe
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Yi He,Wei Huang,Yun Liang,Haili Yu
A novel, label-free, and low-cost colorimetric assay is developed for the detection of hydrazine with high-selectivity and excellent sensitivity using MnO 2 nanosheets as probes. It is first time demonstrated that MnO 2 nanosheets can be used as colorimetric probes for environmental analysis. In the absence of hydrazine, MnO 2 nanosheets exhibit a strong ultraviolet–visible (UV–vis) absorption peak at 370 nm due to the d-d transition. Once hydrazine is introduced, MnO 2 nanosheets will be reduced to Mn(OH) 2 nanoparticles, and the absorbance at 370 nm decreases remarkably. In this case, a distinct color change from yellow to colorless can be observed, which is dependent on the concentration of hydrazine. The signal change can allow colorimetric detection of hydrazine. The assay offers a good linear range from 0.5 μM to 20 μM and a detection limit of 0.4 μM for hydrazine. The lowest detection concentration by the naked eye is as low as 11 μM. Additionally, the developed assay was successfully applied for the colorimetric detection of hydrazine in environmental water samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Yang Liu,Hongqian Xi,Jinhu Wang,Jie Fu,Tiesheng Shi
Oxidations of the antitubercular drug isoniazid (INH) and its analogy hydrazides, nicotinic hydrazide (NH), picolinoyl hydrazide (PH), and benzohydrazide (BH), by ClO 2 were investigated with a focus on the kinetics and reaction mechanisms. In buffered solutions of a wide pH range (from 0.51 to 10.35), the oxidation reactions strictly followed the second-order kinetics, and the apparent second-order rate constant k app versus pH profiles were established at 25.0 °C and 1.0 M ionic strength. Excess ClO 2 could rapidly oxidize the hydrazides to their corresponding aryl acids which were identified by mass spectrometry. For each of the hydrazides, the proposed reaction mechanism involves parallel rate-determining reactions between ClO 2 and various protolysis species of the hydrazide, rendering two types of hydrazyl free radicals; the free radicals are quickly oxidized by 3 more equivalents of ClO 2 to aryl acids. The derived rate constants for the rate-determining reactions revealed that for each hydrazide a huge reactivity difference existed among the protolysis species (>10 8 times) and that the enolate form (or its resonant structures) was extremely reactive. Two possible modes of electron transfer in the rate-determining reactions are discussed based on the observed reaction characters. In buffered solution of pH 7.0 and 25.0 °C, the measured values of k app are 6.20×10 4 , 7.8×10 3 , 2.57×10 3 , and 1.83×10 3 M −1 s −1 for INH, NH, PH, and BH, respectively, imparting an important data set as a reference to the water treatment. This work may open a new door for resolving water pollution caused by INH and its derivatives.
研究领域:
药理学
·
环境科学
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2018
·Vol. 34
·期 11
·1297-1302
·
IF 1.355
Wang Hao,Wu Xiaoming,Tao Feiyan,Yang Shaoxiang,Tian Hongyu,Liu Yongguo,Sun Baoguo
A new highly selective and visible colorimetric fluorescent probe (probe 1) was developed to detect hydrazine (N2H4) concentration in real water samples. As different concentrations of N 2 H 4 were added, the color of the probe solution was graded gradually from colorless to pink, which could be observed by the naked eye under UV light at 365 nm. Our research indicates that probe 1 offers a certain practical significance for use as a visible detection agent to detect N2H4 efficiently by distinct color response. Furthermore, our work showed that probe 1 can be successfully applied to detect N2H4 concentrations in real water samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 25
·37316-37325
·
IF 0
Liu Yanping,Wang Xiaonan,Wang Siwei
Litchi and longan pests significantly affect crop yield and quality. Chemical prevention and control are very effective for production; therefore, it is crucial to study fate assessment and appropriate field efficacy before pesticide application on crops to appropriately assess the health and ecological risks linked with these agents. This study conducted Good Agricultural Practice (GAP) field trials and laboratory experiments to elucidate the dissipation, terminal residues, and efficacy of methoxyfenozide on litchi and longan in six locations throughout China. To detect methoxyfenozide residues on litchi and longan, a QuEChERS/UPLC-MS/MS-based method was designed. The initial methoxyfenozide levels in litchi and longan ranged from 2.21–2.86 to 0.83–0.95 mg kg −1 and indicated half-lives of 5.1–5.3 and 5.3–5.7 days, respectively. After 7 days of foliage treatment, the concentrations of terminal methoxyfenozide residue were 0.78–2.61 and 0.02–1.01 mg kg −1 , which were less than the established maximum residue limit for methoxyfenozide in litchi and longan. The chronic (acceptable daily intake = 0.0055–0.0331%) dietary intake risk analysis for methoxyfenozide in longan and litchi indicated acceptable concentrations of terminal residue for the general population. Methoxyfenozide in litchi and longan was readily degraded in first-order kinetics models, the degradation rate on longan was higher than that on litchi, and their dietary risks were negligible to consumers. Two hundred forty grams per liter of methoxyfenozide suspension concentrate (SC) represents a highly efficacious insecticidal dose to control litchi and longan pests and indicates a significant application potential as it is rapidly degraded and linked with reduced post-treatment residue levels.
研究领域:
农业科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
POLYHEDRON
·
2017
·
IF 1.926
Rui Cheng,Lihong Qian,Dejuan Fa,Yuqing Miao
Hydrazine (N 2 H 4 ) reduction is one of the simplest and most widely used method for the synthesis of various metal element-based micro-/nano-materials. However, the roles of N 2 H 4 during the chemical reaction are often diversified and subjected to further analysis. Here, Ni in turn produced its coordination compounds, hydroxide and pure metal with an increase in N 2 H 4 content, where N 2 H 4 plays diversified roles as a complexant, alkali resource and reductant, respectively. The elements Pr, Nd, Sm and Y exhibited high hydroxylation ability and formed their respective hydroxides. Their formation mechanisms are discussed and summarized. This study is useful for N 2 H 4 to be employed for material synthesis.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Nuclear Engineering and Technology
·
2023
·
IF 2.7
Guanghui Wang,Yaorui Li,Mingjian He,Meng Zhang,Yang Gao,Hui He,Caishan Jiao
In spent fuel reprocessing, UO 2 (DBP) 2 (U-DBP) can be deposited in stainless steel equipment. U-DBP must be removed by dissolution and the process must not cause corrosion to stainless steel. This study was conducted to find the best scheme for dissolution. U-DBP was manufactured by the titrimetric sedimentation method. The effects of different factors on the dissolution of U-DBP were investigated. For example, solid-liquid ratio, hydrazine carbonate solutions with different mass components, mixed solutions containing different concentrations of H 2 O 2 , and different carbonates. The results indicated that U-DBP does not have a regular crystal morphology. With the increase of the solid-liquid ratio and the mass fraction of hydrazine carbonate, the concentration of U(VI) at the dissolution equilibrium increases gradually. The addition of H 2 O 2 has a great promotion effect on the dissolution. However, when the concentration of H 2 O 2 is greater than 0.5 M, the dissolution solution may have an erosive effect on the stainless steel. (NH 4 ) 2 CO 3 can increase the dissolution capacity of dissolved U-DBP, but it may also accelerate the corrosion of stainless steel.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2022
·
IF 4.598
Panpan Xu,Tingting Xu,Mingguang Ma,Xia Qiu,Yue Wang,Yinggui Zhu
This work presents a method for the establishment of a highly sensitive and selective nalidixic acid and S 2 O 8 2− (NA/S 2 O 8 2− ) electrochemiluminescence (ECL) system using isonicotinic (INH) as a co-reaction accelerator. After optimizing the experimental conditions including scan rate, pH value of buffer solution, concentration, etc., the chemiluminescence mechanism of the system was studied in detail using fluorescence spectroscopy, ECL spectroscopy and cyclic voltammetry (CV). The results show that INH is an efficient co-reaction accelerator, which interacts with the co-reactant S 2 O 8 2− but not the luminophore NA to promote the production of more oxidant SO 4 ·– , which then further reacts with NA to generate excited state species NA* with strong ECL signal, indicating that co-reaction accelerators can provide a simple, efficient, and low-cost method for signal amplification. Based on the great ECL enhancement of INH for the NA/S 2 O 8 2− system, under the optimal experimental conditions, highly sensitive and selective electrochemiluminescence detection of tetraethylenepentamine (TEPA) was achieved.
研究领域:
分析化学
·
药物分析
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2019
·Vol. 20
·期 1
·140
·
IF 3.031
Yaqi Lu,Dan Wu,Ziyin Li,Quanjie Lin,Xiuling Ma,Zhangjing Zhang,Shengchang Xiang
It very important to be able to efficiently detect hydrazine hydrate in an aqueous medium due to its high toxicity. Here, we have proposed a new idea: to construct a sensor for the rapid determination of hydrazine hydrate based on the nano-CuO derived by controlled pyrolysis of HKUST-1 [Cu3(BTC)2(H2O)3]. The as-prepared CuO at 400 °C possesses a uniform appearance with nano-structure via SEM images, and the nano-CuO-400 has exhibited excellent electrocatalytic activity towards hydrazine oxidation. Amperometrici-tcurves shows the peak current as linearly proportional to the hydrazine concentration within 1.98–169.3 μmol L−1and 232–2096 μmol L−1with the detection limit of 2.55 × 10−8mol L−1and 7.01 × 10−8mol L−1, respectively. Moreover, the sensor constructed in the experiment shows good selectivities, and it is feasible to determining actual water samples.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）