LANGMUIR
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2025
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IF 3.9
Weijie Jiang,Xin Guan,Liang Wang,Yuqian Mao,Panfei Ma,Wei Liu,Yunxing Li,To Ngai,Hang Jiang
Methods based on double emulsions for producing porous microspheres have gained popularity as an effective and adaptable strategy. However, these microspheres are frequently composed of organic polymers that lack sufficient mechanical strength. Additionally, the conventional two-step process and the use of surfactants present notable challenges. A promising solution is to replace traditional surfactants with inorganic particles, utilizing a Pickering emulsion approach. Herein, we introduced a one-step approach for creating Pickering double emulsions, followed by a straightforward solvent evaporation process to produce porous proteinaceous microspheres. By harnessing the enhanced stability of Pickering emulsions, we can manipulate the morphology and pore structure of the microspheres by varying the oil-(ethanol/water) volume ratio, the size and type of emulsifier, ripening time, rotary evaporation temperature, and the addition of enzymes. Furthermore, we innovatively proposed the coencapsulation of glucose oxide (GOx) and horseradish peroxidase (HRP) for interfacial cascade catalysis, showing excellent catalytic activity, recovery, and reusability. This study presents a new, scalable approach for producing porous microspheres using a one-step Pickering double emulsion. It demonstrates significant potential for interfacial biocatalysis, and is expected to be applied in fields such as medicine, drug delivery, and biotechnology due to their suitability for encapsulating bioactive materials.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
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IF 3.8
Yibo Yan,Ruilin Yang,Yanan Wang,Yinan Wu,Xiaofei Gu,Xiaoqiang Qiao
Styrene-maleic acid (SMA) copolymer has received much attention for its excellent solubilization characteristics. In this work, SMA copolymer brush-based chromatographic stationary phases were exploited and developed for the first time. First, SMA copolymer brush was in situ grown on the surface of spherical silica via living/controlled reversible addition-fragmentation chain transfer (RAFT) polymerization method. Subsequently, as a proof-of-concept demonstration, the copolymer was esterified by diethylene glycol mono-2-ethylhexyl ether (DGME) and 2-(2-ethylhexyloxy) ethanol (EHOE), respectively. The obtained Sil-SMA-DGME and Sil-SMA-EHOE copolymer-brush chromatographic stationary phases were characterized by transmission electron microscopy, Fourier transform infrared spectrometer, X-ray photoelectron spectroscopy, and thermogravimetric analysis, respectively. The chromatographic retention mechanism indicated that both the two packed columns exhibited hydrophilic/reverse mixed-mode retention modes. The maximum column efficiency was up to 71,000 N/m. The chromatographic separation performance evaluation indicated that the novel kind of stationary phases had excellent separation capabilities for hydrophilic, hydrophobic compounds and phospholipid standards. In addition, by combination with mass spectrometry identification, the Sil-SMA-DGME column was further exploited for separation and identification of phospholipids in human lung cancer cells. Totally, 9 classes including 186 phospholipid species were successfully identified. The results demonstrated the promising application prospects of the novel kind of SMA copolymer-brush chromatographic stationary phases.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-9
·
IF 14.7
Qi Cheng,Ma Xudong,Zeng Qi,Huang Zhangwei,Zhang Shanshan,Deng Xiaokang,Kong Tiantian,Liu Zhou
Hierarchical compartmentalization, a hallmark of both primitive and modern cells, enables the concentration and isolation of biomolecules, and facilitates spatial organization of biochemical reactions. Coacervate-based compartments can sequester and recruit a large variety of molecules, making it an attractive protocell model. In this work, we report the spontaneous formation of core-shell cell-sized coacervate-based compartments driven by spontaneous evaporation of a sessile droplet on a thin-oil-coated substrate. Our analysis reveals that such far-from-equilibrium architectures arise from multiple, coupled segregative and associative liquid-liquid phase separation, and are stabilized by stagnation points within the evaporating droplet. The formation of stagnation points results from convective capillary flows induced by the maximum evaporation rate at the liquid-liquid-air contact line. This work provides valuable insights into the spontaneous formation and maintenance of hierarchical compartments under non-equilibrium conditions, offering a glimpse into the real-life scenario.
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ACS Nano
·
2025
·
IF 16
Xue-Mei Dong,Chen Chen,Yin-Xiang Li,Hong-Chao Sun,Bin Liu,Zi-Fan Li,Kai-Li Wang,Zi-Xi He,Meng-Na Yu,Wei Huang,Ju-Qing Liu
Neuromorphic vision sensors capable of multispectral perception and efficient recognition are highly desirable for bioretina emulation, but their realization is challenging. Here, we present a cocrystal strategy for preparing an organic nanowire retinamorphic vision sensor with UV–vis–NIR perception and fast recognition. By leveraging molecular-scale donor–acceptor interpenetration and charge-transfer interfaces, the cocrystal nanowire device exhibits ultrawide photoperception ranging from 350 to 1050 nm, fast photoresponse of 150 ms, high specific detectivity of 8.2 × 1012 Jones, and responsivity of 15 A W–1, as well as retina-like photosynaptic plasticity behaviors. Utilizing the sensor nerve and convolutional neural network, the architecture achieves 90% accuracy in recognizing colorful images. The cocrystal design offers an effective method for constructing nanowire photosynases with high performance in artificial visual systems.
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Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 15
·4131-4139
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IF 5.976
Shaobo Tan,Jie Xiong,Yifei Zhao,Jingjing Liu,Zhicheng Zhang
The grafting of poly(methacrylate ester) or polystyrene onto the side chain of poly(vinylidene fluoride) (PVDF)-based fluoropolymers maintains their high energy density and remarkably reduces the energy loss due to the confinement (or insulation) effect, which has potential application in high-pulse capacitors. The graft copolymers were previously synthesized from C–Cl bonds via the transition metal-catalyzed atom transfer radical polymerization (ATRP) process. To overcome the negative influence of the residual metal ions from the catalyst on the dielectric properties of the resultant copolymers, in the present contribution, a facile strategy is reported for photo-mediated ATRP using organic-based photoredox catalysts to directly synthesize a poly(methyl methacrylate) (PMMA)-grafted copolymer from the commercial poly(vinylidene fluoride-co-chlorotrifluoroethylene) (P(VDF–CTFE)). The graft copolymerization is efficiently activated and deactivated with light and exhibits first-order kinetics. The detailed structural information of the graft copolymer, including average grafting density and side chain length, are also determined by converting the uninitiated Cl atoms into H atoms. When compared with the traditional Cu-catalyzed ATRP process, the current photo-induced ATRP method used for preparing the graft copolymer results in improved dielectric performances such as reduced dielectric loss at low frequency and high temperature, decreased conduction loss, and enhanced breakdown strength.
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CHEMISTRY OF MATERIALS
·
2018
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IF 9.89
Xin Ye,Yang Liu,Quanxiang Han,Chao Ge,Shuangyue Cui,Leilei Zhang,Xiaoxin Zheng,Guangfeng Liu,Jie Liu,Duo Liu,Xutang Tao
Organic single crystals manifest the intrinsic physical properties of materials. However, traditional growth of organic single crystals is limited by low solubility from solutions or complexity from physical vapor deposition. Here we report a new method to grow organic single crystals by microspacing in-air sublimation, which avoids costly vacuum system and time-consuming procedures and is practical for a wide range of organic crystals. In situ crystal growth observation revealed an unprecedented vapor-to-melt-to-crystal mechanism, resulting from the micrometer scale spacing distance between the source and the growth position. FET devices based on the rubrene crystals directly grown on Si/SiO2 substrate exhibited higher mobility than the best record using SiO2 as the gate dielectric. This effective organic crystal growth technique can be affordable and handled for almost every lab, which may be beneficial for future research and application of organic crystals.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 2
·1-7
·
IF 5.705
Yang Meiding,Zhou Huipeng,Zhang Yunyi,Hu Zhenzhen,Niu Niu,Yu Cong
A new water soluble fluorescent coronene probe (CTCA) was synthesized and is shown to display strong fluorescence (with excitation/emission maxima at 313/450 nm) in aqueous solution. Dopamine was oxidized under air to form polydopamine (PDA) which quenches the fluorescence of CTCA. The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Thiocholine inhibits the polymerization of DA, and this leads to recovery in CTCA fluorescence. These findings form the basis for a new method for detection of AChE activity. The assay has a detection limit as low as 0.05 mU·mL −1 of AChE. It is highly selective, and other enzymes do no noticeably interfere. It was applied to the determination of AChE activity in (spiked) human serum, and of AChE inhibitors in (spiked) lake water samples.
Controlled synthesis of polydopamine for the highly sensitive and selective sensing of AChE activity is reported for the first time.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Jian Wei,Jianjun Sun,Yucui Hou,Zhuosen He,He Li,Shuhang Ren,Weize Wu
The structural analysis of lignin is highly significant in practical terms. We investigated the presence of fused aromatic multirings (FARs) distinct from conventional phenylpropane units in seven lignin types using synchronous fluorescence spectroscopy (SFS) and quantified their relative proportions. Our findings reveal that FARs are present in all lignin samples, primarily composed of 2–6 rings. The relative distribution of FARs in lignin is ranked as follows: 2 rings > 1 ring > 4 rings > 3 rings > 6 rings > 5 rings. The relative contents of these FARs (1–6 rings) exhibit slight variations across all lignin samples. Notably, FARs with 2 rings are the highest at 35 %−53 %, while those with 5 and 6 rings are the lowest, collectively accounting for less than 1.37 %. Moreover, the relative contents of FARs with 1 and 2–6 rings range approximately 24 %−32 % and 68 %−76 %, respectively. Furthermore, the catalytic hydro-depolymerization of lignin was performed and the experimental results demonstrate that the hydro-liquefied oil from lignin contains aromatic compounds with 1–7 rings, and the relative contents of aromatic compounds with 1 ring and 2–7 rings in the oil are 29 % and 71 %, respectively, which is consistent with that of lignin SFS. These findings are also consistent with the existing literature and experimental results. This study offers an explanation for the low yields observed in current depolymerization processes targeting small molecules within lignin and establishes a theoretical foundation for achieving high yields in the preparation of multiring aromatic hydrocarbons.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Shuyue Zheng,Jihong Dong,Quan Chen,Min Wu,Dong Zhu,Li Cui,Philippe Frangois-Xavier Corvini,Hong-Zhe Li,Bo Pan
Polycyclic aromatic hydrocarbons (PAHs) are widespread contaminants that can accumulate in microorganisms, posing significant ecological risks. While previous studies primarily focused on PAH concentrations, the impacts of PAH self-clustering have been largely overlooked, which will lead to inaccurate assessments of their ecological risks. This study evaluates the toxic effects of four prevalent PAH clusters on microbes with an emphasis on comparing the cluster sizes. Results revealed that over 95% of PAHs can form clusters in the aquatic environment, with smaller clusters more likely to form at lower concentrations and with fewer benzene rings. To quantify the toxic effects and understand underlying mechanisms, single-cell Raman-D2O was employed to link bacterial phenotypes with transcriptomic profiles. Bacteria exposed to smaller PAH clusters showed a 1%–10% reduction in metabolic activity, which was associated with a 1.8–2.9-fold increase in intracellular reactive oxygen species (ROS). Furthermore, when exposed to smaller PAH clusters, the expression of genes related to the ROS response and efflux pumps was upregulated by up to 6.33-fold and 4.97-fold, respectively, suggesting that smaller PAH clusters pose greater toxicity to microbes. These findings underscore the potentially overlooked risks of PAH clusters in environmental systems and deepen our understanding of the environmental fate and ecological risks of these contaminants.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
·
IF 4.3
Junmei Fan,Ruitao Zhu,Wei Han,Hongfei Han,Liping Ding
Flavonoids are a kind of natural polyphenols which are closely related to human health, and the identification of flavonoids with similar structures is an important but difficult issue. We herein easily constructed a powerful fluorescent sensor ensemble by using surfactant cetyltrimethylammoniumbromide (CTAB) encapsulating two commercially available fluorescent probes ( F1 and F2 ) with multi-wavelength emission. Fluorescence measurements illustrate the present sensor ensemble exhibits turn-off responses to flavones and flavonols but ratiometric responses to isoflavones, owing to different FRET processes. The heat map and linear discriminant analysis (LDA) results show that this single sensor can effectively distinguish 6 flavonoids belong to three subgroups by collecting the fluorescence variation at four typical wavelengths. Moreover, it can be applied to identify different flavonoids even in biofluids like serum and urine, providing potential practical application.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Feilin Lin,Siyu Wang,Bernard P. Binks,Jianzhong Jiang
High internal phase Pickering emulsions (HIPPEs) have attracted increased interest due to their diverse applications in fields such as food and material science. The pH value may vary in different application fields; however, maintaining the stability of HIPPEs at various pH levels presents a notable challenge. Here we describe photo-responsive HIPPEs tolerant to different pH values (pH = 2–12) with up to 96 % internal phase through one-step emulsification without pre-treatment (such as ultrasonic dispersion). The emulsifier was formed by the host–guest interaction between chitosan-grafted cyclodextrin (CS-CD) and azobenzene (C 4 AzoC 6 N). The microstructure of the porous materials prepared from the HIPPEs can be regulated by the photo-triggered adsorption of supramolecular polymers at the oil–water interface. Moreover, due to the photochromism properties of C 4 AzoC 6 N, a colour-changing writing ink can be obtained without any additive, making it an ideal candidate for 4D printing. This strategy provides a simple and efficient method for preparing pH-tolerant HIPPEs in a one-step process, expanding the range of applications in 4D printing and functional materials.
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Polymers
·
2024
·Vol. 16
·期 5
·647
·
IF 4.7
Lin Qi,Teng Hang,Weijie Jiang,Sinong Li,Hui Zhang,Xiang Liang,Le Lei,Qiangqiang Bi,Hang Jiang,Yunxing Li
Microalgae are highly regarded as ideal materials for the creation of liquid biofuels and have substantial potential for growth and utilization. However, traditional storage and culture methods for microalgae are plagued by challenges such as uncontrolled growth, bacterial contamination, and self-shading among algae. These issues severely impede the photosynthetic process and the efficient extraction of biomass energy. This study tackles these problems by utilizing magnetic hydrophobic protein particles to stabilize water-in-oil Pickering emulsions. This allows for the micro-compartment storage and magnetic transfer of algae. Additionally, the successful encapsulation of Chlorella cells in high-internal-phase water-in-oil Pickering emulsions effectively mitigates the settling problem of Chlorella cells in the liquid phase, thereby enabling the potential use of Pickering emulsions for the confined cultivation of microalgae.
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