JOURNAL OF CONTROLLED RELEASE
·
2010
·
IF 5.949
Yanzhuo Zhang,Zhuangzhi Zhi,Tongying Jiang,Jinghai Zhang,Zhanyou Wang,Siling Wang
The purpose of this study was to develop mesoporous silica nanoparticles (MSNs) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loading capacity. Spherical MSNs were synthesized using an organic template method in an oil/water phase, and large pore diameter MSNs were functionalized with aminopropyl groups through postsynthesis. MSNs as well as the resulting functionalized MSNs were investigated as matrices for loading and release of the model drug telmisartan (TEL). The effects of different pore sizes and surface chemical groups on TEL uptake and release were systematically studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption , X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC. The total pore volume and the pore diameter of MSNs were the two main factors limiting the maximum drug load capacity. MSNs allow a very high drug loading of about 60% in weight. The release rate of TEL from MSNs with a pore diameter of 12.9 nm was found to be effectively increased and the release rate of TEL from the functionalized MSNs was effectively controlled compared with that from the unmodified MSNs. We believe that the present study will help in the design of oral drug delivery systems for the dissolution enhancement and/or sustained release of poorly water-soluble drugs.
研究领域:
药剂学
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纳米医学
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DOI
高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2024
·Vol. 94
·期 1
·193-203
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IF 0.9
Lv J.,Yang S.,Zhang W.,Wei Y.,Qu Y.,Lv C.
Abstract Hollow mesoporous silica-based materials are ideal drug carriers applied in controlled drug delivery systems due to their unique hollow core and tunable shell composition. Two types of hollow mesoporous materials, hollow mesoporous silica nanoparticles (HMSNs) and hollow periodic mesoporous organosilicas (HPMOs), were synthesized and applied as drug carriers to regulate insoluble drug release. Fenofibrate (FNB) was used as a model drug to study the effect of framework difference for HMSNs and HPMOs materials on the drug loading and release processes. FNB/HPMOs had a higher drug loading (35.39%) than FNB/HMSNs (30.22%) because of hydrophobic bridging C 2 H 4 groups within the mesoporous skeleton. HMSNs showed fast release behavior, resulting from their hydrophilic surface with a large number of silanol groups favorable for dissolution media diffusion and drug dissolution. HPMOs showed sustained release behavior, attributed to their hydrophobic surface which possessed stronger hydrophobic-hydrophobic van der Waals attraction to drug molecules. The drug release of HMSNs and HPMOs in different dissolution media followed the first order kinetic model with decreased release rate vs . time. Regulation of the organic-inorganic skeleton structure of the mesoporous materials could change their surface properties especially hydrophilicity or hydrophobicity, furtherly controlling the loading capacity and release behavior of the loaded drugs.
研究领域:
材料科学
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药学
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纳米技术
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 5
·2559-2566
·
IF 3.049
Ting Tang,Xiao Sun,Xuedong Xu,Yifeng Bian,Xiaojie Ma,Ning Chen
The development of hollow ferrogadolinium nanonetworks has not been reported for nanomedicine application until now. In this study, we developed a hollow and porous ferrogadolinium nanonetwork structure using the one-pot solvothermal method. This nanoparticle could be simultaneously used as a T1 and T2 dual-modal magnetic resonance imaging (MRI) contrast agent. In addition, the hollow lumen and abundant pores of the nanonetworks maximized the loading capacity and conferred the nanoplatforms for suitable anticancer drug loading capacity. Using these nanonetworks, MRI and anticancer experiments were conducted in vitro and satisfactory dual-modal MRI and cancer chemotherapy results were obtained. Therefore, the nanonetworks with dual-modal MRI and drug loading abilities effectively complement the ferrogadolinium composites' library and hold great promise in nanomedicine for simultaneous cancer diagnosis and chemotherapy.
研究领域:
纳米医学
·
磁共振成像
·
癌症治疗
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 54
·28683-28690
·
IF 3.708
Jie Feng,Zhifei Wang,Bin Shen,Liming Zhang,Xia Yang,Nongyue He
Mesoporous silica-coated Au nanorods (Aurod@SiO2) have recently attracted considerable interest in nanomedicine, and the template removal procedure is crucial for the preparation of such hybrid nanostructure. Herein, two kinds of typical extraction solvents, i.e., NH4NO3–CH3OH and HCl–CH3OH, were separately used to extract the surfactant cetyltrimethylammonium bromide (CTAB) from the obtained Aurod@SiO2. The results show that CTAB molecules could be completely removed from the pores of Aurod@SiO2 without damaging the internal Au nanorod by NH4NO3–CH3OH, while Aurod@SiO2 treated with HCl–CH3OH suffered from both poor extraction efficiency and the shape transformation of Au nanorod due to selective etching in the presence of oxygen. In addition, the consequent drug loading experiment shows that Aurod@SiO2 extracted by NH4NO3–CH3OH possesses a larger drug loading capacity with a loading efficiency of 82.5%. Furthermore, the in vitro photo-thermal therapy experiment shows that Aurod@SiO2 extracted by NH4NO3–CH3OH is more efficient in killing the YCC-2 gastric cancer cells as compared with that extracted by HCl–CH3OH.
研究领域:
纳米医学
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材料科学
·
生物医学工程
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癌症研究
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Liping Luo,Wensheng Gong,Xiaojun Yang,Xiang Qin,Weilin Liu,Lingling Liu,Lijun Ji
An aligned porous polystyrene (PS) template with a pore diameter of 20 µm and millimeter scale length was prepared for the first time. Super-long aligned mesoporous bioactive glass tubes (AMBGTs) were prepared with this new PS template as an example. AMBGTs had a millimeter scale length, a specific surface area of 240.98 m 2 ·g −1 , a mesoporous volume of 0.3 cm 3 ·g −1 and an average mesoporous diameter of 5.4 nm. They showed excellent in vitro bioactivity. The drug loading capacity of ibuprofen (IBU) reached 50.7% and the encapsulation efficiency was 63.4%. The kinetics fitted a first-order kinetic model and Fick diffusion mechanism. AMBGTs could be a potential material for preparing bone tissue engineering and drug delivery. More importantly, the successful preparation of AMBGTs confirmed that replicating the aligned porous PS template was an effective strategy to prepare super-long aligned one-dimensional materials. More aligned one-dimensional materials could be obtained by this strategy.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Lin Wang,Feiyu Wang,Bo Xu,Man Zhou,Yuanyuan Yu,Ping Wang,Qiang Wang
Pure silk fibroin (SF) hydrogel exhibits poor elasticity and low water retention ability, owing to the compact crystalline structure and high content of hydrophobic amino acids. Herein, a composite double-network hydrogel of SF and tyramine-modified hyaluronic acid (mHA) was constructed, via the laccase-catalyzed coupling reactions between the phenolic hydroxyl groups from SF and mHA chains. The obtained hydrogel exhibits improved structural stability and flexibility compared to pure SF hydrogel. Meanwhile, the swelling ratio, mechanical property, drug loading, and release behaviors can be readily regulated by alcoholization, altering pH value, and ionic strength of soaking solutions. Increasing pH values promoted the swelling capacity of SF/mHA hydrogel, resulting in an efficient loading of cationic drugs and sustained release of anionic drugs as well. The addition of inorganic salts reduced electrostatic repulsion in the hydrogel scaffold, accompanying with a noticeable improvement of toughness. Furthermore, alcohol treatment induced conformation changes of fibroin protein, and the composite hydrogel achieved a higher fracture and improved elasticity. The present work provides a biological alternative to regulate the mechanical behavior, drug loading, and sustained release capacity of the SF-based hydrogel.
研究领域:
材料科学
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生物医学工程
·
化学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Song Chen,Hao Li,Yajia Bai,Jianan Zhang,Toshiyuki Ikoma,Di Huang,Xiaona Li,Weiyi Chen
Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications. In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution. The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100–300 μm. Their surface was mainly constructed by numerous HAp NWs with the diameter of 80–120 nm and showed a hierarchical and urchin-like nanofibrous architecture. It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs. In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture. Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus . Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
研究领域:
生物材料
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生物医学工程
·
药剂学
·
纳米技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiaqing Chen,Jingsheng Chen,Zelin Zhu,Tianyi Sun,Mingxian Liu,Lu Lu,Changren Zhou,Binghong Luo
Current artificial periostea mainly focus on osteogenic activity but overlook structural and mechanical anisotropy, as well as the importance of antibacterial and anti-inflammatory properties. Here, inspired by the anisotropic structure of wood, the delignified wood (named white wood, WW) with a porous and highly oriented cellulose fiber skeleton was obtained, which was further filled with polyvinyl alcohol (PVA) hydrogel loaded with curcumin (Cur) and phytic acid (PA). The prepared wood-derived hydrogel composite membranes can not only exhibit an obvious anisotropic structure and good mechanical properties but also sustainably release loaded drugs to obtain long-term biological activities. Creatively, PA can effectively improve the bioavailability of Cur; more importantly, Cur and PA play an obvious synergistic effect in antibacterial, anti-inflammatory, and osteogenic activities. Compared with the wood-derived hydrogel composite membranes without drug loading, as well as loaded with Cur or PA only, these loaded with Cur and PA are significantly more conducive to inhibiting the growth of bacteria and inflammatory response and facilitating the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. This kind of anisotropic wood-derived hydrogel composite membrane with fantastic antibacterial, anti-inflammatory, and osteogenic activities is expected to be ideal artificial periostea.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaoning Zhang,Jingxian Zhu,Xiaoya Kang,Xiaoqing Hu,Qiang Gao,Ming Li,Jingyao Sun,Jian Zhuang
The healing of linear skin wounds is a complex biological process, and traditional treatment methods have certain limitations. This study proposes a wireless power supply near-infrared light drug-loaded microneedle system (NIR-LED-NG-R1-MN), which utilizes microneedles (MNs) to achieve targeted delivery of the active component of traditional Chinese medicine, Notoginsenoside R1 (NG-R1), and combines the biological regulatory effect of near-infrared light (NIR) to achieve efficient synergistic treatment for linear skin wounds. Experimental results show that the device can significantly promote the wound closure rate and reduce the levels of inflammatory factors and the risk of scar formation. By comparing the wound repair conditions of different treatment groups, it was found that the group treated with the NIR-LED-NG-R1-MN patch for NG-R1 and NIR synergistic treatment (MN@NG-R1@LED group) showed superior wound repair effects compared to other groups, thus confirming the synergistic therapeutic advantages of NG-R1 and NIR in skin wound healing. In addition, the application of wireless power supply technology used in this system eliminates the dependence on external power sources, enhancing the convenience of treatment. This study clearly demonstrates that the NIR-LED-NG-R1-MN has the potential to become a new clinical method for the treatment of linear skin wound healing.
研究领域:
生物医学工程
·
药学
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Xianhua He,Yi Deng,Yue Yu,Hao Lyu,Li Liao
Bone restoration and related infection in bone defect repair remain thorny problems in clinical practice. Herein, a drug-loaded (chlorogenic acid, CGA)/grafted peptide (BFP) hydrogel system supported on a sulfonated polyetheretherketone (SPEEK) surface is constructed to address the problem of large-scale defects and related infections in clinical bone implantation. Briefly, the encapsulated chlorogenic acid is released during hydrogel degradation and can inhibit the growth of bacteria and provide a bacteria-free environment for new bone formation. In vitro experiments and cell adhesion/proliferation evaluation reveal that the chlorogenic acid-sodium alginate-peptide bridging system shows better bioaffinity than the control groups due to the BFP peptide on the surface of the hydrogel. In addition, bacterial experiments suggest that the released chlorogenic acid has excellent antibacterial activity against gram-negative and gram-positive bacteria. Therefore, the hydrogel bridging system has a prospective application in clinical applications for bone repair.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Xiumei Zhu,Yan Peng,Liyan Qiu
Carboplatin is one of the few platinum-based antitumor drugs used worldwide. Unfortunately, systemic carboplatin therapy is limited by its dose-related myelosuppression. In this study, a viable way to reduce the serious myelotoxicity of carboplatin while improving its therapeutic efficacy using amino-functionalized polyphosphazene vesicles is reported. First, three polyphosphazenes with different amino content were synthesized by amidating hydrophobic side groups; these polyphosphazenes could self-assemble into polymersomes with similar particle size and morphology. Based on FTIR analysis, hydrogen bonding interactions between the polymeric carriers and carboplatin were validated and shown to predominantly contribute to the significant improvement of drug loading in polymersomes. Therefore, it turned out that the amino level of polymers played a substantial role in carboplatin encapsulation. Then, PEAP-2-C polymersomes were optimized for further experimental verification to achieve depressed carboplatin-induced myelotoxicity as well as promote curative effects against CT-26 colon adenocarcinoma. These results in vitro and in vivo proved that amino-functionalized polyphosphazene vesicles have great potential for carboplatin delivery in the application of cancer therapy.
研究领域:
药学
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Miaomiao Han,Longqian Zhu,Jianbin Mo,Wei Wei,Biao Yuan,Jing Zhao,Chongjiang Cao
Borophene has emerged as a type of two-dimensional monoelemental nanomaterials with excellent drug loading capacity and photothermal properties. Here, we demonstrated the adsorption of plasma proteins onto borophene nanosheets (B NSs) and the promoted immune responses of macrophage by the B NS–corona complex. We discovered that plasma proteins changed the surface identities of B NSs. Using proteomics analysis, 46.5% of the proteins bound to B NSs (94 plasma proteins) were immune-relevant proteins. Uptake of B NSs by phagolysosomes was observed, and the plasma corona promoted the uptake. In comparison with graphene and phosphorene, we found that 32 plasma proteins appeared on all of the three nanosheets. The proportion of immune-relevant proteins in graphene–corona and phosphorene–corona was 41.3% and 75.6%, respectively. The components of the adsorbed immune-relevant proteins show diversity, which influence the immune responses of these nanosheets. Phosphorene–corona showed the most remarkable immunoregulatory behavior in these nanosheets. For the first time, we compared the highly complex protein corona at the nanosheet–plasma interface of three key 2D monoelemental nanosheets. Our study helps to understand the interaction between borophene and biological systems and provides a theoretical basis for the development and application of borophene in the biomedical field.
研究领域:
材料科学
·
生物医学工程
·
免疫学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
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