JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2021
·Vol. 21
·期 12
·5912-5919
·
IF 0
Feng Zhi-Yuan,Wang Chen-Di,Park Soo-Jin,Meng Wan,Meng Long-Yue
Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility. However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which
is an efficient method of fabricating nanofibers for drug carriers. To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning. The PA/CS/TEOS
ratios significantly influenced the nanofiber morphology. As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM). The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was
smoother with less beads and uniform fiber diameter. Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2016
·Vol. 122
·期 7
·1-8
·
IF 1.444
Sun Huanghui,Zhang Lingfan,Xia Wei,Chen Linxiao,Xu Zhizhen,Zhang Wenqing
Functionalized graphene oxide with its unique physical and chemical properties is widely applied in biomaterials, especially in drug carrier materials. In the past few years, a number of different drugs have been loaded on functionalized graphene oxide via π–π stacking and hydrophobic interactions. The present report described a new approach, dexamethasone phosphate successfully loaded onto graphene oxide–chitosan nanocomposites as drug carrier materials by covalent bonding of phosphate ester linkage. Compared with the graphene oxide–chitosan nanocomposites that dexamethasone phosphate was loaded on via simple physical attachment, covalently linked composites as drug carrier materials were more biocompatible which effectively reduced the burst release of drug, and controlled the release of drug in different pH conditions.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2017
·Vol. 19
·期 35
·5244-5250
·
IF 3.474
Jun Wang,Deyun Ma,Weilin Liao,Shujun Li,Manfei Huang,Huimin Liu,Yifei Wang,Rui Xie,Jun Xu
A hydrostable anionic porous drug carrier MOF with a bcu topology constructed from trinuclear clusters, [(Me2NH2)2Zn3(fdc)4]n·DMA (1) (fdc = 2,5-furandicarboxylate, DMA = dimethylacetamide), was synthesized and structurally characterized. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. 1 exhibits a 3D framework with rectangular channels of 10.0 × 7.7 and 6.1 × 7.8 Å2 along the b axis. Desolvated 1 adsorbs around 17.2 wt% 5-fluorouracil and the cumulative release value of 5-fluorouracil at 72 h was about 93.3% in PBS (pH 7.4) at 37 °C. Results of in vivo zebrafish toxicity tests and in vitro MTT assays of 1 at different concentrations reveal that 1 is nontoxic.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2016
·
IF 4.556
Jingfu Jia,Yanzhe Gai,Wucong Wang,Yaping Zhao
Ultrasound-induced synthesis of chitosan-modified nano-scale graphene oxide (CS-NGO) hybrid nanosheets, which has great potential pharmaceutical applications, in supercritical CO 2 without catalyst was presented for the first time. The preparation process does not require organic solvent and post-processing, and CO 2 easily escapes from the product. The morphology and structure of the CS-NGO, characterized using scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, X-ray photoelectron spectroscopy and thermogravimetric analysis, confirms that it was combined via the amide linkage, and had excellent dispersibility and stability toward acidic and physiological aqueous solution, which implies that it could be used as a drug-carrier. The sonication power played a crucial role in inducing forming amidation, and the conversion rate increased with the sonication time. The mechanism of this reaction was explained.
研究领域:
材料科学
·
药学
·
纳米技术
✓ 已验证
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 12
·2752
·
IF 3.267
Lili Qin,Yiwei He,Xinyu Zhao,Ting Zhang,Yao Qin,Ai Du
Silica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, resveratrol-loaded silica aerogel (RSA) as a drug delivery system was prepared by the sol-gel method. Before gelling, resveratrol was added into the hydrolyzed tetraethyl orthosilicate (TEOS) ethanol solution then dispersed by stir and ultrasound. The results showed that RSA has a high loading rate of 19% with low cost and excellent biocompatibility. The SEM images showed that silica aerogel wraps up outside the resveratrol. Sustained releasing effect could be observed in RSA after 1 h, while pure resveratrol did not display this. The release of RSA lasted for over 6 h, and the release amount reached over 90% and 80% in either simulated gastric fluid (pH = 2.0) or phosphate-buffered saline (pH = 7.4) at 37 °C. Preliminary in vitro toxicity test revealed RSA to be biocompatible and stable; and when coupled with the anti-inflammatory effects of resveratrol, showed good potential for osteoarthritis treatment.Keywords:resveratrol;silica aerogel;drug carrier;characterization;release kinetics
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Kun Ge,Cuimiao Zhang,Wentong Sun,Huifang Liu,Yi Jin,Zhenhua Li,Xing-Jie Liang,Guang Jia,Jinchao Zhang
The rare earth hollow spheres with up-conversion luminescence properties have shown potential applications in drug delivery and bioimaging fields. However, there have been few reports for the degradation properties of rare earth oxide drug carriers. Herein, uniform and well-dispersed Y2O3:Yb3+,Er3+ hollow spheres (YOHSs) have been fabricated by a general Pechini sol–gel process with melamine formaldehyde colloidal spheres as template. The novel YOHSs with up-conversion luminescence has good drug loading amount and drug-release efficiency; moreover, it exhibits pH-responsive release patterns. In particular, the YOHSs sample exhibits low cytotoxicity and excellent degradable properties in acid buffer. After the sample was loaded with anticancer drug doxorubicin (DOX), the antitumor result in vitro indicates that YOHS-DOX might be effective in cancer treatment. The animal imaging test also reveals that the YOHSs drug carrier can be used as an outstanding luminescent probe for bioimaging in vivo application prospects. The results suggest that the degradable drug carrier with up-conversion luminescence may enhance the delivery efficiency of drugs and improve the cancer therapy in clinical applications.
研究领域:
生物医学工程
·
纳米医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Jun Wang,Na Huang,Qi Peng,Xiaoyan Cheng,Wuke Li
In this paper, the luminescent temperature/pH dual-responsive nanoparticles based on lanthanide-polyoxometalates were fabricated as a controllable drug delivery system. In the drug delivery carrier, the mesoporous silica acted as the core, and the poly (N-isopropylacrylamide-co-methacrylic acid) and lanthanide-polyoxometalates served as the dual-responsive shell and luminescent labeling, respectively. Composite hydrogels exhibited red luminescence under UV irradiation, which was visible to the naked eye. The releases of doxorubicin hydrochloride (DOX) from the composites were temperature/pH-dependent. DOX can be quickly released in an acidic environment and at high temperatures. Moreover, the drug delivery carrier showed minimal toxicity to HeLa cells and exhibited good biocompatibility. However, DOX loaded drug-delivery system showed the significant toxicity to HeLa cancer cells in vitro. Cell imaging has shown that lanthanide polyoxometalates composites can be used as bioimaging materials for cell monitoring. As a result, the drug delivery systems based on lanthanide-polyoxometalates have potential applications in the field of biomedical science.
研究领域:
生物医学
·
材料科学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Zhiya Sun,Mei Long,Xinxuan Liu,Yi Zhang,Shunxiang Li,Limei Bai,Huaming Yang
Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy.
研究领域:
医学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 44
·20818-20824
·
IF 3.591
Xilin Bai
Herein an injectable self-healing hydrogel via dynamic linkage of an imine bond based on a novel multi-aldehyde polyethylene glycol crosslinker was reported. The biocompatible crosslinker could be synthesized via easy chemistry on a large scale. After cross-linking with glycol chitosan, the self-healing hydrogel could be easily obtained in ∼1 h under mild conditions. The prepared hydrogel showed satisfactory mechanical properties and ideal biocompatibility and was successfully used in an in vivo mouse model as a drug carrier just like a “Trojan Horse”. It could deliver a highly concentrated anti-tumor drug (DOX) to the desired position for sustainable controlled release at a safe level. Compared with intravenous or intratumoral injection, the hydrogel drug carrier achieves an admirable therapeutic effect and collectively prevents the recurrence of colon cancer during the whole treatment process. Due to its excellent biocompatibility and good operability, this injectable self-healing hydrogel might be a promising drug carrier for surgical adjuvant treatment and other medical applications. This strategy may provide more insights for the design, study and application of new biomaterials.
研究领域:
生物材料学
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 48
·31497-31505
·
IF 4.036
M. R. Ali,M. S. Bacchu,D. D. Ridoy,P. L. Mozumder,M. N. Hasan,S. Das,M. F. H. Palash,S. Akter,N. Sakib,A. Khaleque,D. Chakrobortty,M. Z. H. Khan
In this study, hematite nanotube (HNT) and tyramine-based advanced nano-drug carriers were developed for inhibiting the growth of Klebsiella pneumoniae (K. pneumoniae). The HNT was synthesized by following the Teflon line autoclaved assisted hydrothermal process and tyramine was incorporated on the surface of the HNT to fabricate the formulated nano-drug. The nano-drug was prepared by conjugating meropenem (MP) on the surface of Tyramine-HNT and characterized using different techniques, such as scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), etc. Furthermore, the drug-loading efficiency and loading capacity were measured using a UV-vis spectrometer. The pH, amount of Tyr, and HNT required for drug loading were optimized. A controlled and gradual manner of pH-sensitive release profiles was found after investigating the release profile of MP from the carrier drug. The antibacterial activity of MP@Tyramine-HNT and MP was compared through the agar disc diffusion method which indicates that antibacterial properties of antibiotics are enhanced after conjugating. Surprisingly, the MP@Tyramine-HNT exhibits a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of K. pneumoniae lower than MP itself. These results indicate the nanocarrier can reduce the amount of MP dosed to eradicate K. pneumoniae.
研究领域:
材料科学
·
微生物学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 3
·202
·
IF 4.421
Lan Zhang,Min Yan,Kun Chen,Qikang Tian,Junying Song,Zijuan Zhang,Zhishen Xie,Yong Yuan,Yaquan Jia,Xin Zhu,Zhenqiang Zhang,Xiangxiang Wu,Huahui Zeng
A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS could relieve TP-induced inhibition on RAW264.7 cells and apoptosis, respectively. Compared with the TP group, TP-CMCS could effectively alleviate the toxicity injury of TP and decreased the mortality rate of the mice (p< 0.05). TP-CMCS did not cause much damage to the liver (AST and ALT) and kidney (BUN and CRE) (p< 0.05). After administration, the levels of IL-6, IL-1β, and TNF-α decreased, and the arthritis detumescence percentages increased significantly, and the bony erosion degree was distinctly decreased in the TP-CMCS groups and TP group. Our results suggested that TP-CMCS was a useful carrier for the treatment of RA, which enhanced aqueous solubility of free TP and reduced drug toxicity in vitro and in vivo.Keywords:triptolide;toxicity;water solubility;carboxylmethyl chitosan;drug carrier system
研究领域:
药理学
·
生物医学工程
·
风湿病学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 11
·2286
·
IF 4.967
Meiyan Wu,Wangfang Deng,Yidong Zhang,Chao Chen,Zhexuan Liu,Pedram Fatehi,Bin Li
It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.Keywords:cellulose nanofibrils;chitosan;drug carrier;tetracycline hydrochloride;drug release
研究领域:
材料科学
·
药学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）