JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2026
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IF 2.2
Yaohui Ni,Shicheng Tang,Haiyang Wu,Yufei Zhang,Saijiao Tang,Lexin Chen,Tianjian Lu,Defeng Xu,Hang Hu
Dimethylcurcumin (DMC) is a derivative of curcumin. Studies have shown that DMC can enhance the degradation of androgen receptors (AR), thereby inhibiting AR-related diseases. However, the extremely poor water solubility and fast metabolism in vivo of DMC greatly limit its clinical applications. In the present study, poly(ethylene glycol)-modified liposomes loaded with DMC (DMC@PEG-Liposomes) were prepared by an improved membrane hydration method. The prescription of the liposomes was optimized to obtain DMC@PEG-Liposomes with a particle size between 110 and 150 nm, moderate encapsulation efficiency and good freeze-drying stability. In vitro release studies showed that DMC@PEG-Liposomes displayed Fickian release at pH 7.4 and non-Fickian release at pH 5.0. Compared with free DMC, DMC@PEG-Liposomes were more toxic to 22Rv1 and HepG2 cells in vitro. DMC@PEG-Liposomes also exhibited enhanced AUC0-t as compared to free DMC in in vivo pharmacokinetic studies. These results suggest that DMC@PEG-Liposomes are a promising DMC formulation for anticancer DMC delivery.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Li Wang,Hengmei Yang,Zhongyou Lu,Lingchao Li,Yujing Zhang,Kun Xu,Yunqing Tang
This work reports a high-performance vertical organic electrochemical transistor (vOECT) for ultrasensitive sweat glucose monitoring via synergistic molecular and device engineering. The sensor integrates a hydrogen-bonded PEDOT:PSS-PVA channel, enabling record-high transconductance g m (102.5 mS) through enhanced phase separation and charge mobility, and a catalytic gate electrode with Prussian blue/chitosan/graphene/glucose oxidase multilayers for enzymatic signal amplification. It exhibits unprecedented sensitivity of 6.45 mA/dec in artificial sweat (over 5-fold higher than prior OECT-based glucose sensors), robust flexibility with >95% current retention at 1.5-cm bending radius, and a wide detection range (1 μM–5 mM) covering physiological sweat glucose levels with 95.5% accuracy in human trials. Validated in a wearable patch with wireless data transmission, this platform shows significant potential for non-invasive diabetes management, establishing a versatile material-device co-design strategy for multiplexed biomarker detection in personalized healthcare.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Wenjie Shi,Kai Wang,Taotao Li,Xin Guo,Hao Zhu,Xulin Jiang
Osteoarthritis is a chronic degenerative joint disease with local inflammation that needs sustained, localized anti-inflammatory therapy. In this study, a separable drug-loaded microneedle system based on thermosensitive hydroxypropyl chitin (HPCH) was developed via a green fabrication process without using organic solvents or chemical crosslinkers for prolonged transdermal piroxicam delivery. Each PrxC@HPCH microneedle contained a tip loaded with size-controlled piroxicam microcrystals (PrxC), prepared via an alkaline dissolution–acid neutralization antisolvent strategy, and a rapidly separating dissolving layer, could withstand a compressive force of approximately 1.22 N, sufficient for skin penetration. After insertion, the separation layer rapidly dissolved to detach the tips, which remained in the dermis and formed a physically cross-linked gel depot, enabling sustained piroxicam release in vitro for up to 192 h. Meanwhile, the PrxC@HPCH separable microneedles showed long-lasting anti-inflammatory effects for approximately five days after a single administration in vivo. Importantly, in an osteoarthritis rat model, PrxC@HPCH separable microneedles demonstrated superior and sustained therapeutic efficacy once per 3 days for continuous treatment, with effective suppression of synovitis, preservation of cartilage matrix, and alleviation of subchondral bone deterioration. Overall, this biodegradable HPCH-based separable microneedle platform offers a long-acting strategy for localized osteoarthritis therapy and other chronic inflammatory diseases.
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PubMed
高影响因子
Foods
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2026
·Vol. 15
·期 5
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IF 6
Zhiyuan Lin,Mei Chen,Bo Zhou,Junfeng Tan,Liang Zeng,Zhi Lin,Jinchi Tang,Weidong Dai
(1) Background: Primary metabolism is essential for tea quality formation, however systematic analysis of tea primary metabolites remains limited; (2) Methods: An orthogonal design was used to optimize the pre-column derivatization reaction conditions for the tea matrix. Using the optimized method, gas chromatography–mass spectrometry (GC–MS) was employed to analyze Longjing green tea (LJGT) samples from different processing stages and regions; (3) Results: Optimal derivatization was achieved with 75 μL of methoxamine hydrochloride pyridine solution at 30 °C for 1.5 h. A total of 52 primary metabolites were identified in LJGT. Processing analysis showed that 8 metabolites associated with carbohydrate metabolism significantly decreased during spreading. Five reducing sugars significantly decreased, while sucrose, turanose, and quinic acid significantly increased due to the thermal action during pan-fixation. Additionally, 15 key differential compounds were identified among three regions (Xihu, Qiantang, and Yuezhou) of LJGT. Quantitative analysis revealed that shikimic and quinic acid contents were significantly higher in the Xihu region compared to other regions; (4) Conclusions: This study established a pre-column derivatization GC-MS method for primary metabolite profiling, elucidated metabolic regulation during LJGT processing, and identified differences in primary metabolite content among LJGT from different geographical origins.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Weimin Fang,Wei Zeng,Yalan Huang,Anqi Chen,Yanbin Guo,Guanxi Wen,Jiayu Ye,Jinfeng Xu,Yingying Liu
Macrophage-driven oxidative stress and chronic inflammation play pivotal roles in the progression of atherosclerosis. Given the overactivation of poly (ADP-ribose) polymerase (PARP) in atherosclerosis, PARP inhibitors have potential therapeutic potential, but their efficacy is limited due to poor in vivo targeting. Platelet-rich plasma-derived extracellular vesicles (PEVs), which inherently target inflammatory sites and mitigate oxidative stress, offer a promising delivery platform. Here, we developed NGPPEVs, a nanoplatform that employs PEVs to deliver niraparib, a PARP inhibitor, followed by encapsulation of Ca(HCO₃)₂ to generate gas within cells, thereby combining targeted therapy with ultrasound imaging capabilities. In vitro, NGPPEVs significantly scavenged intracellular reactive oxygen species (ROS) and suppressed pathways related to oxidative stress and cholesterol metabolism. Mechanistically, NGPPEVs suppressed foam cell formation by inhibiting the PARP1–IL-6–CD36 axis, leading to significant downregulation of the key scavenger receptor CD36. In apolipoprotein E-deficient mice fed a high-fat high-cholesterol diet, NGPPEVs demonstrated superior therapeutic efficacy, effectively reducing atherosclerotic plaque area and enhancing plaque stability. Collectively, NGPPEVs have great potential in the precise diagnosis and treatment of atherosclerosis.
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Food Bioscience
·
2026
·
IF 6.2
Wanqi Zhang,Lu Han,Yanhao Yin,Yaoting Mou,Yuhang Tian,Zhicong Sun,Yanfang Wu,Dongfei Chen,Yemin Guo,Xia Sun,Falan Li
Excessive streptomycin (STR) residues pose significant risks to dairy product quality and safety. Thus, developing highly sensitive detection methods for STR is essential to safeguard dairy safety and public health. In this study, we present a dual signal amplification lateral flow strip (LFS) using enzyme-assisted cycling and composite probe composed of multiple gold nanoparticles (AuNPs) for STR detection. Through targeted mutation, an optimized aptamer (Apt52-0) with both high affinity for STR and recognition by nicking endonuclease was developed, exhibiting enhanced binding to STR with a K d value of 6.87 nM, compared to the original Apt52. Enzyme-assisted amplification was achieved using the hairpin structure of the Apt52-0, Vent (exo-) DNA polymerase, and Nt.Alwl nicking endonuclease, enabling dual cycling of the target and double-stranded DNA (dsDNA). The cyclic products were then isothermally amplified, and composite probe composed of multiple AuNPs was utilized to construct a dual signal amplification lateral chromatography sensor for STR detection. This aptamer-based LFS achieved a visual limit of detection (LOD) of 25 nM, and a LOD of 17.6 nM analyzed via ImageJ software. The test strip demonstrated promising sensing performance in practical application, with STR recovery rates of 95.8%–103.9% in milk samples. This dual signal amplification-based LFS offers an inexpensive, rapid and sensitive approach to STR detection.
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ACS Applied Polymer Materials
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2026
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IF 5.2
Yu Bai,Yi Ding,Guoquan Liao,Xiangchun Kong,Yucheng Wang,Mingshuo Dai,Yuandu Hu
Photonic microcapsules with dual stopbands hold great potential in sensing and wearable electronics. However, existing systems face limited deformability and responsiveness to physical stimuli. In this study, we fabricated fully deformable dual-stopband photonic microcapsules using microfluidics-enabled core–shell double-emulsion templates. The core and shell parts of the microcapsules were an aqueous suspension of PNIPAM-co-AAC hydrogel particles and a poly(ethylene glycol) phenyl ether acrylate (PEGPEA) resin suspension of silica particles, respectively. Given that the core and shell parts were both deformable components, the resultant photonic microcapsules featured full deformability. Their structural colors can be regulated by tuning the particles’ diameters and volume fractions. The resultant microcapsules exhibited isotropic reflection spectra, overcoming angle dependence, and showed reversible color changes under mechanical compression. This work offers a scalable approach for multifunctional photonic microcapsules, paving the way for applications in microsensors, stress visualization, and adaptive wearable devices.
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CONSTRUCTION AND BUILDING MATERIALS
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2026
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IF 8.9
Xueyu Pang,Kenedy Geofrey Fikeni,Xiujian Xia,Jiapei Du,Shenglai Guo,Huajie Liu,Kaihe Lv,Jinsheng Sun
To study the working mechanism of Portland cement retarders, the influences of various types of sugars (sucrose, glucose, and maltodextrin) on the hydration kinetics of oil well cement was evaluated primarily using isothermal calorimetry (IC) test method in the temperature range from 60 °C to 89 °C. By thorough analysis of the experimental data of this study and other relevant studies in the literature, a new retardation mechanism is proposed. Sugars inhibit the hydration of oil well cement by primarily retarding the hydration of silicate phases (mainly C 3 S). The hydration of aluminate phases, which is normally inhibited by the silicate hydration, can be accelerated when the silicate phases are strongly inhibited under high dosage of retarders. Indeed, strong aluminate hydration peaks are observed during the pre-induction period with sugar dosages of 0.2% and higher, and the effect intensifies at high temperatures. The initiation of the silicate hydration peak (main peak) is simultaneously controlled by the overall hydration extent of the cement (which can disrupt the retarder action) and the adsorption stability of the retarder (which is influenced by both retarder type and dosage). Therefore, high sugar dosages (≥0.3%) often causes strong inhibition of C 3 S hydration initially, but the resulted strong acceleration of aluminate hydration can cause earlier initiation of the main peak, resulting in decreased induction period with increasing sugar dosage, especially at elevated temperatures (≥80 °C). The proposed mechanism is further verified using thermogravimetric analysis (TGA) and quantitative XRD (QXRD) analysis of partially hydrated cement.
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ELECTROCHIMICA ACTA
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2026
·
IF 5.8
Longying Zhao,Jiayu Chen,Donglin Xiang,Mierban Dawuti,Laping He,Yuangen Wu,Han Tao
Residual organophosphorus pesticides (OPs) in food pose a severe threat to public health, necessitating simple and sensitive on-site analytical methods. In this study, a signal-off electrochemical sensing platform for OPs was constructed based on the OP-induced inhibition of silver deposition triggered by red kidney bean esterase (RKBE), coupled with the signal amplification of a CuNi dual-atom catalyst (CuNi-DAC). RKBE catalyzes the hydrolysis of α-naphthyl acetate to produce α-naphthol, which reduces Ag⁺ to Ag 0 deposited on the electrode. The electroactive Ag 0 undergoes oxidation to generate a prominent oxidation current, providing a sensitive sensing signal for detection. CuNi-DAC modification of the electrode accelerates charge transfer, provides more active sites, and effectively amplifies the sensing signal. Upon exposure to OPs, the activity of RKBE is inhibited, thereby suppressing the production of α-naphthol. This leads to a diminished Ag 0 generation and subsequent a weakened oxidation current. The decrease degree of current signal shows a positive correlation with pesticide concentration. Under optimized conditions, the fabricated sensing platform exhibits a good linear response range of 10 pmol/L-1000 pmol/L for fenthion with a low detection limit of 5.4 pmol/L. Spiked recoveries in cabbage and apple samples ranged from 93.3% to 108.5%, validating the sensing platform's practicality and reliability. This work offers a facile and cost-effective electrochemical sensing approach for on-site screening of OPs.
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Scientific Reports
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2026
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IF 4.9
Zhu Qingqing,Xie Fuwei,Zhao Ge,Yan Quanping,Hua Chenfeng,Shang Pingping,Chen Mantang,Chen Di,Ma Chengjie,Nie Cong
Sweet taste perception is primarily mediated by the T1R2/T1R3 receptor complex and plays a key role in dietary preference and human health. There is a growing significance in studying the relationship between sweet taste perception and metabolic responses. This study aimed to investigate metabolites changes associated with transient stimulation by different sweeteners (sucrose, neotame and sucralose) by a non-targeted metabolomic approach. The differential metabolite analysis and pathway enrichment revealed that different sweeteners activated distinct metabolic pathways and further impacted on cellular activity. As a nutritive sweetener, the transient stimulation by sucrose led to changes in numerous key intermediates in the tricarboxylic acid cycle within cells, suggesting the role of nutritive sweeteners in regulation of cellular energy metabolism. In contrast, many lipids were affected by neotame and sucralose transient stimulation, indicating that these non-nutritive sweeteners could impact cellular signaling and energy homeostasis. Additionally, we can effectively differentiate the metabolic profiles of these three sweeteners within 95% of the confidence interval through partial least squares-discriminant analysis. These findings offer insights into the diverse cellular metabolic responses induced by various sweeteners and provide a deeper understanding of receptor-mediated intracellular signaling.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Chenxia Zhen,Yinghua Che,Enqi Chen,Jian Zhao,Yanlong Luo,Xiujuan Wang
Dual heat-conduction pathways significantly enhance thermal transport. • In situ MOF growth is achieved on surface-modified BN fillers. • Interfacial functionalization improves filler-matrix compatibility. The heat transfer of electronic devices requires the use of thermal interface materials (TIM) with high heat dissipation capabilities and excellent thermal management performance to prevent overheating. However, in polymer-based thermal conductive phase-change composite systems, simple blending of functional nanofillers will lead to interface incompatibility, which cannot fully utilize the unique advantages of the fillers. Herein, a flexible polyurethane (PU)-based boron nitride/metal-organic framework/polyethylene glycol (BN/MOF/PEG) composite film (named BMP) is fabricated which integrates high latent heat and excellent thermal management capabilities via functional modification and the construction of dual heat conduction pathways. After sucrose treatment of BN, hydroxyl-functionalized BN (BN-OH) was obtained. Subsequently, MOF was in situ grown on the BN-OH surface to form BM, which was further deposited onto BN-OH/PU (TB) fibers for PEG adsorption, thereby yielding the BMP composite film. Among them, the thermal conductivity of the BMP-3 film reach 2.2 W·m −1 ·K −1 , and the latent heat retention rate reach 70%. Compared with commercial silicone grease, the developed BMP film can significantly reduce the full-load CPU temperature by 19 °C when with a heat sink, demonstrating excellent thermal management capabilities. Additionally, combining molecular dynamic and quantum chemistry simulations, the influence of functionalized modified nanofillers on the interface regulation was characterized from a microscopic perspective. This work provides a theoretical basis for designing advanced TIM materials with high latent heat and excellent thermal management capabilities, and is expected to promote the iterative update of the thermal management part of electronic devices. Download: Download high-res image (271KB) Download: Download full-size image
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Ziyan Niu,Qian Yin,Chunxia Liu,Mengke Song,Shunyao Li,Jialin Yu,Zhao Ma,Kai Sun
Endocrine disruptors bioaccumulate along food chains, impairing reproductive function in wildlife and elevating chronic disease risk in humans. Natural humification-inspired bioenzymatic catalysis (NH-IBC) can interrupt pollutant transfer from crops to higher trophic levels, but its efficacy in hydroponic root-zone decontamination and carbon sequestration remains poorly characterized. Here, we demonstrated that NH-IBC enhanced the polymerization and humification of dissolved organic carbon in the hydroponic root-zones of ryegrass ( Lolium perenne L.), resulting in a 17.3-fold increase in the dissipation kinetic constant of bisphenol A (BPA, a model endocrine disruptor) relative to the bioenzyme-deficient control. Mechanistically, NH-IBC generated reactive radical intermediates that boosted the copolymerization of root exudates (phenolic acids, amino acids) with BPA, forming water-insoluble, high-molar-mass polymers through stable covalent cross-coupling. This efficient polymerization, coupled with carbon sequestration, reduced BPA phytotoxicity and promoted ryegrass root cell proliferation and elongation. Mass balance and 14 C-ring-labeled BPA analyses confirmed that NH-IBC diminished BPA uptake and subcellular distribution in ryegrass. Hydrophobic BPA oligomers and polymers accumulated primarily in root epidermal and cortical tissues, limiting translocation to the endodermis and edible aerial parts. Our findings present a natural humification-inspired biocatalytic framework to remediate contaminant pollution and sequester carbon, advancing agroecosystem sustainability and improving crop- and animal-derived food safety.
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危险品化学品经营许可证（带存储）