Nanoscale
·
2016
·Vol. 8
·期 17
·9318-9327
·
IF 7.76
Jinxia An,Qianqian Guo,Peng Zhang,Andrew Sinclair,Yu Zhao,Xinge Zhang,Kan Wu,Fang Sun,Hsiang-Chieh Hung,Chaoxing Li,Shaoyi Jiang
Effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we designed a hierarchical polymeric nanoparticle structure for anti-cancer chemotherapy delivery by utilizing state-of-the-art polymer chemistry and co-assembly techniques. This novel structural design combines the most desired merits for drug delivery in a single particle, including a long in vivo circulation time, inhibited non-specific cell uptake, enhanced tumor cell internalization, pH-controlled drug release and simultaneous imaging. This co-assembled nanoparticle showed exceptional stability in complex biological media. Benefiting from the synergistic effects of zwitterionic and multivalent galactose polymers, drug-loaded nanoparticles were selectively internalized by cancer cells rather than normal tissue cells. In addition, the pH-responsive core retained their cargo within their polymeric coating through hydrophobic interaction and released it under slightly acidic conditions. In vivo pharmacokinetic studies in mice showed minimal uptake of nanoparticles by the mononuclear phagocyte system and excellent blood circulation half-lives of 14.4 h. As a result, tumor growth was completely inhibited and no damage was observed for normal organ tissues. This newly developed drug nanovehicle has great potential in cancer therapy, and the hierarchical design principle should provide valuable information for the development of the next generation of drug delivery systems.
研究领域:
药剂学
·
肿瘤学
·
生物材料科学
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产品关联
DOI
PubMed
高影响因子
Materials
·
2021
·Vol. 14
·期 21
·6474
·
IF 3.623
Huan Shuai,Jiao Wang,Xianguang Wang,Gaoxiang Du
Herein, using black talc as a carrier, a ternary black talc-TiO2/ZnO composite photocatalyst was prepared by the sol-gel method, and the effect of the black talc on the hetero-structure properties of the TiO2and ZnO was systematically studied. The prepared composite photocatalyst showed an excellent degradation performance of the pollutant, where black talc plays an important role in promoting the interface interaction by enhancing the contact area between the TiO2and ZnO. Moreover, the free carbon element doping in black talc favors the formation of more oxygen vacancies, thereby improving the response as a photocatalyst in visible light. In addition, the carbon in the black talc can also adsorb organic pollutants and enrich the surroundings of the photocatalyst with pollutants, so it further improves the catalytic efficiency of the photocatalyst. Under UV irradiation, the degradation rate of Rhodamine B on black talc-TiO2/ZnO was found 3.3 times higher than that of black talc-TiO2with good stability.Keywords:black talc carrier;heterostructure;photocatalyst;TiO2;ZnO
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2021
·Vol. 9
·期 2
·370-378
·
IF 6.569
Yongyang Zhu,Hao Zhong,Liuzhang Ouyang,Jiangwen Liu,Hui Wang,Huaiyu Shao,Min Zhu
In this work, we reported an energy-saving and cost-efficient process for the (re)generation of NaBH4 by ball milling hydrated borax (Na2B4O7·10H2O) with a Mg–Al alloy under ambient conditions. The introduction of abundant and readily available Al can increase air stability of the reducing agent. A high yield up to 85.2% could be achieved by using Mg17Al12 because of its hardness and brittleness.
研究领域:
材料科学
·
能源化学
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产品关联
DOI
高影响因子
FUEL
·
2023
·
IF 7.4
Haijian Qin,Zelong Yang,Qing Xia,PeifeiYao,Chunzhi Zheng,Guangpin Lin,Zhaolian Ye,Songjian Zhao,Fengli Yang
Because the combination of Co and common support (Al, Ti, et al.) usually shows poor catalytic activity, tantalum has been introduced for CO conversion as a novel carrier due to the excellent performance. In this work, Co 3 O 4 was loaded on four forms of tantalum support (amorphous, mesoporous, crystalline and crystalline mesoporous, abbreviated as Co/Ta-am, Co/Ta-me, Co/Ta-cry and Co/Ta-cm, respectively). And among these four states, Co/Ta-cm presents the highest CO conversion rate. The temperature of 90% CO conversion rate of Co/Ta-cm is approximately 130 ℃ at the high space velocity of 780,000 h −1 , which is 70%, 82% and 88% higher than that of Co/Ta-cry, Co/Ta-me and Co/Ta-am, respectively. Moreover, the characteristics of the catalyst have been studied by XRD, SEM, BET, TGA, and H 2 -TPR, and the results reveal that Co/Ta-cm has the excellent crystallinity and stability, and the morphology is regular. X-ray photon spectroscopy and in-situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTs) have been performed to investigate the reaction mechanism, which indicates that Co 3+ is the active component and lattice oxygen plays a critical role in CO oxidation.
研究领域:
催化化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Lipeng Guo,Jihui Yao,Haibo Zhu
Methylcyclohexane (MCH) dehydrogenation for H 2 production is a promising route in liquid organic hydrogen carriers technology. However, there are few reports on the influence of Pt size on methylcyclohexane dehydrogenation under different reaction atmospheres. In this study, a series of Pt/Al 2 O 3 catalysts with Pt particle sizes ranging from 0.67 to 1.26 nm were prepared via the impregnation method. The influences of Pt particle size on MCH dehydrogenation under H 2 and N 2 atmospheres were investigated. The toluene (TOL) product adsorbed on Pt site has a significant effect on the activity and stability of Pt/Al 2 O 3 for MCH dehydrogenation. Under N 2 atmosphere, the poisoning of Pt/Al 2 O 3 by toluene leads to a low activity in this reaction. By contrast, under H 2 atmosphere, the adsorption of toluene can be effectively inhibited by H 2 , and thus an enhanced catalytic performance can be achieved. The catalyst with Pt size of 0.67 nm exhibits a high turnover frequency (TOF) of 33,530 mol H2 ·mol Pt −1 ·h −1 , corresponding to a H 2 evolution rate of 2,865 mmol·g Pt −1 ·min −1 . These findings provide a deeper understanding of the dependence of catalyst structure and reaction conditions on MCH dehydrogenation, offering fundamental guidance for the design of efficient catalysis system for MCH dehydrogenation.
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Cheng Han,Yinping Zhang,Marc Redmile-Gordon,Huan Deng,Zhenggui Gu,Qiguo Zhao,Fang Wang
This study conducted the sorption and biodegradation of benzo[ a ]pyrene (BaP) by microbial biofilm communities developed on proxies for materials typically found in soils. The half-life of BaP was 4.7 and 2.3 weeks for biofilms on the inorganic carrier (BC INOR , montmorillonite) and on the organic carrier (BC OR , humic acid), respectively. In contrast, the half-life was 7.0 weeks for specialized planktonic cultures (PK). The exposure to BaP caused the development of lipid inclusion bodies inside the bacteria of the PK systems and biofilms of the BC INOR , but not on the biofilms of the BC OR system. Interestingly, the BC OR displayed not only the greatest BaP sorption capacity but also the greatest bacterial density and membrane integrity and the shortest bacteria-to-bacteria distances, which were consistent with the increased production of cell surface extracellular polymeric substances on the BC OR . Both carriers caused a noticeable shift in the bacterial genera during the biodegradation of the BaP. The BC INOR selected for Rhodococcus, Brucella, Chitinophaga , and Labrys , whereas the BC OR favored Rhodococcus and Dokdonella . It indicated that ultra-structure and BaP degradation within the organic carrier-attached biofilms differed from the inorganic ones, and suggested that the microstructural heterogeneity and microbial biodiversity from biofilms on the organic carrier promoted biodegradation.
研究领域:
环境微生物学
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土壤学
·
污染物降解
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Xiongqin Liu,Xuanrui Liu,Jun Zhao,Mingruo Ban,Shutao Wu,Fei Liu
The electrochemical reduction of furfural (FF) offers a sustainable approach for producing value-added furfural alcohol (FA). Nevertheless, the limited adsorbed hydrogen (*H) generation capacity on Cu cathode restricts the reaction performance. Because the competitive adsorption of FF and *H decreases *H coverage and induces severe dimerization, most prior studies employed low FF concentrations (typically 20 mM) under constant potential conditions. In this work, carbon-supported Cu nanoparticles grown on Cu nanowire arrays (defined as Cu@Cu/C) were combined with constant current electrolysis for high-concentration FF reduction. A high Faradaic efficiency (72.9 %) and production rate (0.14 mmol cm −2 h −1 ) of FA were realized at −10 mA cm −2 , with a conversion of 98.1 %. Both the Faradaic efficiency and production rate can be sustained with gradual increases in current density or adjustments of FF concentration within a certain range, showing substantial enhancement relative to Cu-nano. Compared with pure Cu-nano, the favorable interaction between Cu nanoparticles and carbon support was certified to regulate the adsorption configuration and strength of FF, and enhance the *H generation performance, which optimizes the *H coverage at cathodic surface and promotes FF hydrogenation with *H via an electrocatalytic hydrogenation (ECH) mechanism. Overall, this work provides a simple and feasible strategy to promote interfacial *H, thus enhancing higher concentration hydrogenation of FF to FA by constant current electrolysis over Cu-based cathode.
研究领域:
电化学
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催化
·
纳米技术
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绿色化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 9
·3706-3716
·
IF 5.251
Hang Liu,Wei Jiang,Qin Wang,Lifeng Hang,Yucai Wang,Yanmei Wang
Tumor hypoxia, which is indispensable to tumor propagation and therapy resistance, has been one of the most important factors influencing clinical outcomes. To modulate the hypoxia microenvironment, we herein developed reactive oxygen species (ROS)-sensitive arylboronic ester-based biomimetic nanocarriers co-encapsulated with a photosensitizer chlorin e6 (Ce6) and a hypoxia-activated prodrug tirapazamine (TPZp) for tumor-specific release and synergistic photodynamic chemotherapy. In order to bypass macrophage uptake and improve tumor penetration, the nanocarriers were further modified with the red blood cell membrane and iRGD peptide (denoted as NPs@i-RBMCe6+TPZp). After administration, NPs@i-RBMCe6+TPZp exhibited prolonged blood circulation, selective tumor accumulation and excellent penetration into the tumor interior. Upon light irradiation, ROS were generated by Ce6 for photodynamic therapy (PDT), which subsequently caused dissociation of the ROS-responsive nanocarriers. An enhanced therapeutic effect was further achieved through the activation of TPZp in the aggravated local hypoxia microenvironment. The synergistic cancer therapy based on NPs@i-RBMCe6+TPZp significantly suppressed tumor growth with negligible side effects. The biomimetic nanocarriers have great potential to overcome hypoxia-limited PDT, and significantly improve the anticancer efficacy by synergistic tumor-targeted PDT and hypoxia-activated chemotherapy.
研究领域:
癌症治疗
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纳米医学
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生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
Small
·
2021
·Vol. 17
·期 43
·2103584
·
IF 13.281
Jinsong Tao,Zhengjie Wei,Meng Xu,Long Xi,Yaxin Cheng,Simon Ming-Yuen Lee,Wei Ge,Ying Zheng
Polymeric nanocarriers have high biocompatibility for potential drug delivery applications. After entering bloodstream, nanocarriers will circulate, interact with proteins, dissociate, or be cleared by reticuloendothelial system. Zebrafish as a visual animal model, can serve as a tool for screening nanomedicines and monitoring nanocarrier behaviors in vivo. However, a comprehensive correlation between zebrafish and rodent models is currently deficient. Here, different-sized poly(caprolactone) nanocarriers (PCL NCs) are fabricated with or without PEGylation to investigate correlation between zebrafish and mice regarding their biofate via Förster resonance energy transfer technique. Results show that PEGylated PCL NCs have higher integrity in both zebrafish and mice. Small PEG-PCL NCs have longer circulation, while large PEG-PCL NCs have dramatically higher macrophage sequestration in zebrafish and mice spleen, leading to poor circulation. PCL NCs dissociate rapidly with less macrophage sequestration. Moreover, in 7 days postfertilization (dpf) zebrafish, polymers are eliminated via hepatobiliary pathway, which is not fully functional at earlier stages of development. The effects of nanocarrier integrity on macrophage sequestration in zebrafish and good correlation with mice spleen are pioneered to be demonstrated. The findings suggest that 7 dpf zebrafish are suitable as an in vivo screening model of nanocarriers and predict their biofate in rodents.
研究领域:
药剂学
·
纳米医学
·
生物材料
·
药物递送
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产品关联
DOI
PubMed
高影响因子
CHEMBIOCHEM
·
2015
·Vol. 16
·期 11
·1622-1628
·
IF 3.088
Rongqiang Liao,Shouhui Yi,Manshuo Liu,Wenling Jin,Bo Yang
Graphical Get smart: A smart targeting gene carrier for cancer-specific delivery has been successfully prepared by a “multilayer bricks-and-mortar” strategy. Carriers produced by two different self-assembly schemes were investigated for their ability to compact pDNA into nanoparticles. Cell viability studies show that the most suitable (Method A) material has lower cytotoxicity than 25 kDa bPEI and that transfection efficiency is maintained. A targeting gene carrier for cancer-specific delivery was successfully developed through a “multilayer bricks-mortar” strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by two different self-assembly schemes, involving either precomplexation of the PEI-CD with the FA-AD and PEG-AD before pDNA condensation (Method A) or pDNA condensation with the PEI-CD prior to addition of the FA-AD and PEG-AD to engage host–guest complexation (Method B) were investigated for their ability to compact pDNA into nanoparticles. Cell viability studies show that the material produced by the Method A assembly scheme has lower cytotoxicity than branched PEI 25 kDa (PEI-25KD) and that the transfection efficiency is maintained. These findings suggest that the gene carrier, based on multivalent host–guest interactions, could be an effective, targeted, and low-toxicity carrier for delivering nucleic acid to target cells.
研究领域:
生物医学工程
·
分子生物学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
Materials
·
2020
·Vol. 13
·期 7
·1624
·
IF 3.057
Lili Qin,Xinyu Zhao,Yiwei He,Hongqiang Wang,Hanjing Wei,Qiong Zhu,Ting Zhang,Yao Qin,Ai Du
Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug–cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.Keywords:TEMPO-oxidized cellulose;aerogel;resveratrol;drug carrier
研究领域:
生物材料学
·
药剂学
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DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 4
·1643-1651
·
IF 5.251
Zhouxiang Zhao,Chunmei Ding,Yaqin Wang,Hong Tan,Jianshu Li
Traditional antibacterial treatments, such as chlorhexidine (CHX), destroy cariogenic biofilms. However, they exert negative effects in clinical applications, for example, teeth staining, taste disturbance and harm to oral tissue after a long-term exposure. Therefore, biocompatible strategies for efficient antibacterial drug delivery are in high demand. In this study, aimed at dental caries therapy enhancement, we designed a pH-responsive nanocarrier system, capable of releasing CHX in an acidic environment within cariogenic biofilms. Cationic poly(ethylene glycol)-block-poly(2-(((2-aminoethyl)carbamoyl)oxy)ethyl methacrylate) (PEG-b-PAECOEMA) was synthesized first. Modification of PAECOEMA by citraconic anhydride (CA) forms negatively charged PEG-b-PAECOEMA/CA, which could assemble into core–shell polyionic complex micelles (PICMs) when mixed with cationic CHX via electrostatic interactions. PICMs are stable in healthy neutral oral microenvironments with CHX encapsulated in the core and PEG shell exposed. Once in acidic milieu within caries-producing biofilms, they rapidly disassemble and release CHX cargo owing to degradation of citraconic amide groups. Molecular structures of the above copolymers were confirmed using 1H NMR and gel permeation chromatography (GPC) analysis. The pH-dependent degradation rates of citraconic amide in PEG-b-PAECOEMA/CA copolymer were measured by fluorescamine method. Atomic force microscopy (AFM) studies confirmed successful assembly of well-defined spherical PICMs in aqueous solution. The disassembly of PICMs in acidic microenvironment was observed using dynamic light scattering (DLS). PICMs showed an obvious pH-dependent drug release profile when the pH changed from 7.4 to 5.5. More importantly, the micellar system could reduce drug toxicity of CHX and exhibited outstanding antibacterial capability in the biofilm of Streptococcus mutans. Micelles constructed from pH-sensitive PEG-b-PAECOEMA/CA are highly promising for dental caries therapy and provide guidelines for drug-delivery system design in other acidic pathologic systems.
研究领域:
牙科学
·
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）