JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2025
·
IF 3.5
Jianmei Sun,Zhouyang Shen,Yuling Sun,Ye You,Chan Zhu,Shuo Cheng,Guang Yu,Yan Yang,Zongxiang Tang
BACKGROUND Cinnamic acid derivatives, such as p -coumaric acid, caffeic acid, ferulic acid, and chlorogenic acid, exhibit uric acid-lowering effects through the inhibition of xanthine oxidase (XOD). While the clinically used XOD inhibitor allopurinol is associated with significant side effects, these natural polyphenolic compounds exhibit comparable efficacy with improved safety. RESULTS In hyperuricemic mouse models and in vitro assays, these polyphenolic compounds effectively reduced serum uric acid levels through XOD inhibition. Notably, ferulic acid and caffeic acids exhibited superior potency and reduced hepatic and renal toxicity in comparison to p -coumaric acid, with molecular docking studies suggesting competitive binding at the active site of XOD. Additionally, chlorogenic acid demonstrated significant activity. CONCLUSION These findings underscore the potential of naturally derived polyphenolics as promising candidates for the management of hyperuricemia, providing a safer alternative to conventional therapies. © 2025 Society of Chemical Industry.
研究领域:
药理学
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代谢疾病研究
·
天然产物化学
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DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2016
·
IF 2.586
Tao Wu,Zhifen Wang,Qingmei Li,Guoxiang Pan,Jinying Li,Luc R. Van Loon
In order to understand the diffusion properties of anionic radionuclides (RN) in bentonite in the presence of organic compounds with chelating and reducing properties, the effect of humic acid (HA), citrate, oxalate and formate on Re(VII) diffusion was investigated by a through-diffusion method under different pH (pH 7.0 and 10.0) and temperature conditions (10–65 °C). When the molar ratio of oxalate to Re(VII) was higher than 1:1, the accumulated mass and flux were observed to decrease drastically as a function of time. It can be explained by photocatalytic impact of Fe(III) on the reduction of Re(VII) to insoluble Re(IV) by oxalate. Thus, the diffusion of Re(VII) was also observed to decrease in the presence of minor citrate, oxalate and formate. Effective diffusion coefficient (D e ) values decreased from 8.7 × 10 − 11 m 2 /s to (5.1–5.9) × 10 − 11 m 2 /s. In contrast, HA had no significant impact on Re(VII) diffusion. The D e values of 1.54 × 10 − 11 and 6.5 × 10 − 12 m 2 /s were obtained at pH 7.0 and 10.0, respectively. HA thus neither has an effect on the speciation of Re(VII) nor does it change the charge of the surface. The latter is probably due to the fact that HA preferentially interacts with the aluminol sites of the montmorillonite edges without changing the zeta potential of the surface. The dependence of D e of Re(VII) on temperature in the absence and presence of citrate or formate was described by the Arrhenius equation . The activation energy, E a , was in the range of (20.7–25.1) kJ/mol, demonstrating that Re(VII) diffusion followed a pore water diffusion model .
研究领域:
环境科学
·
放射化学
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DOI
高影响因子
Catalysis Science & Technology
·
2016
·Vol. 6
·期 17
·6551-6560
·
IF 5.287
Xincheng Wang,Fengbing Liang,Chongpin Huang,Yingxia Li,Biaohua Chen
Methods to catalytically convert carbohydrates into lactic acid (LA), which is a versatile platform chemical, have been widely investigated. In this study, siliceous tin phosphates were utilized as reusable Brønsted–Lewis acid bifunctional catalysts during the conversion of 1,3-dihydroxyacetone (DHA) to LA under hydrothermal conditions. The product distribution closely depended on the reaction temperature, catalyst loading and substrate concentration. The highest LA yield of 93.8% was achieved with a complete DHA conversion at 140 °C after 5 h. The reaction was facilitated by the vast presence of Brønsted and Lewis acid sites that were confirmed by both pyridine FTIR and NH3-TPD analysis. The incorporation of silica significantly lowered the Sn content and improved the thermal stability of the tin phosphate catalysts. A possible reaction mechanism was proposed in that the Lewis and Brønsted acid sites synergistically catalyzed the conversion of pyruvaldehyde to LA, which was found to be the rate-determining step. The method allows for facile catalyst separation and recycling while expanding the applicability of silica in the field of biomass-to-chemical conversion.
研究领域:
生物化学
·
催化化学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Tongyao Ju,Yuan Meng,Siyu Han,Fanzhi Meng,Li Lin,Jinglin Li,Jianguo Jiang
Coal fly ash (CFA) is a typical industrial solid waste, which has recently been reported to contain rare earth elements (REEs). REEs are important materials in many industrial fields. Therefore, extracting REEs from CFA becomes a win-win strategy to both make full use of CFA and reclaim REEs. However, the stable crystalline structure of CFA is hard to break, which limits the extraction of REEs. The inter-correlation and the leaching patterns of the REEs in CFA also remain unclear. In this work, REEs were enriched by desilication, and the correlation and the influences of multiple acids of the leached REEs were investigated. It was found that desilication could increase the leachable amount of REEs from 137.37 ppm to 346.12 ppm. The light rare earth elements (LREEs) were less inter-correlated than heavy rare earth elements (HREEs) and desilication enhanced the leaching of LREEs more than that of HREEs. The ratio and type of the leaching acids both influenced the extraction of REEs from CFA: HCl and HF played important roles in the extraction from the untreated CFA while HNO 3 and HF were more decisive for the desilicated CFA. In addition, we used statistical analysis to quantificationally confirm that desilication and acids both significantly influenced the extraction of REEs. This work provides evidence for the enrichment of REEs in CFA and acid choosing when leaching REEs from CFA.
研究领域:
环境科学
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材料科学
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化学
·
废物管理
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2025
·
IF 2.4
Yu Lin,Yuanzhuo Ji,Yizhe Zhang,Hualiang An,Qian Zhao,Xinqiang Zhao,Yanji Wang
BACKGROUND Maleic acid (MAc) is a high value-added oxygenic hydrocarbon derivative monomer. The synthesis of MAc from biomass-based furfural is a green process and has important academic research value. Herein, selective catalytic oxidation of renewable furfural to MAc was investigated. RESULTS The effect of using different heteropoly acids as catalyst and different organic acids/H 2 O as solvent was evaluated first, and the ‘phosphomolybdic acid + acetic acid/H 2 O’ composite system with good performance was screened out. Acetate anion acted as free radical acceptor in the reaction to stabilize furfural radical and inhibit the polymerization reaction. Under optimal reaction conditions, the conversion of furfural was 97.8%, and the MAc yield and selectivity were 58.3% and 59.6%, respectively. To further improve the selectivity of MAc, different kinds of Lewis acids were introduced to construct a Brønsted–Lewis dual-acid catalytic system. When Cu(OAc) 2 was as Lewis acid, the MAc selectivity was significantly improved to 72.5% with a furfural conversion of 72.3%. The catalytic mechanism of Brønsted–Lewis dual-acid system was finally clarified. CONCLUSION In this complex system, the synergy of Cu and Mo is responsible for the outstanding catalytic efficiency, where the Mo VI /Mo V redox can be facilitated by the redox of Cu II /Cu I with the assistance of O 2 ; acetate anion can interact with furfural radicals, thereby delaying the chain reaction of free radicals. This process makes the MAc generation reaction more dominant than the polymerization reaction, thus improving MAc selectivity. © 2025 Society of Chemical Industry (SCI).
研究领域:
化学工程
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催化化学
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产品关联
DOI
高影响因子
HYDROMETALLURGY
·
2020
·
IF 3.338
Shaohua Wu,Wenju Tao,Yanchen Zheng,Youjian Yang,Jiangyu Yu,Jingbo Cui,Yu Lu,Zhongning Shi,Zhaowen Wang
A hydrometallurgical process was developed to extract lithium from a spent lithium-containing aluminum electrolyte, reduce the stacking of spent aluminum electrolyte, and recover the valuable elements. In this study, we extracted lithium from an electrolyte using the following three steps: 1) leaching with HNO 3 − Al(NO 3 ) 3 , 2) neutralizing the leachate obtained in the first step, and 3) precipitating the lithium carbonate. A lithium extraction efficiency of 88.0% could be achieved after a leaching time of 6 h, at a leaching temperature of 80 °C and an Al/F molar ratio of 1:6. During the process of neutralization, Al 3+ and F − was precipitated as Al 2 ((OH) 0.46 F 0.54 ) 6 (H 2 O). The obtained Li 2 CO 3 with a high purity of 98.8%.
研究领域:
冶金学
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材料科学
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环境工程
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产品关联
DOI
高影响因子
Fermentation-Basel
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2023
·Vol. 9
·期 5
·451
·
IF 3.7
Xuexin Wu,Qiuping Zhong,Yunzhu Zhang
This study evaluated the effects of caffeic acid and chlorogenic acid on the chemical constituents of lychee wine fermented withSaccharomyces cerevisiaeDV10 when added at 200 mg/L and 300 mg/L before fermentation. Results showed that the caffeic acid and chlorogenic acid addition had no effect on the ability of alcoholic fermentation ofS. cerevisiae.The addition of both acids decreased the utilization of amino nitrogen sources and produced less α-ketoglutaric, succinic, and acetic acid. The addition of 200 mg/L of caffeic acid induced a higher product of typical aroma components of the lychee wine, including trans-rose-oxide, precursors of 1-octane-3-ol, octanoic acid, and isoamyl acetate, and produced more esters, such as ethyl caprylate, ethyl caprate, ethyl hexanoate, isoamyl acetate, citronellyl acetate, ethyl-9-decenoate, geranyl acetate, and phenethyl acetate, compared with the chlorogenic acid addition. These findings indicate that caffeic acid addition could enhance the flavorful character and improve the quality of lychee wine.Keywords:lychee wine;phenolic acid;fermentation;flavor
研究领域:
食品科学
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微生物学
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化学工程
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Qingxia Zhou,Yanrong Cheng,Xia Guo
Developing a simple and effective method for detecting and separating amino acids has practical significance. Aqueous two-phase system (ATPS) has the advantages of mild preparation conditions, good stability, and high biocompatibility. In this study, an ATPS exhibiting distinct responses and selectivity profiles toward Phe, Trp, and Tyr was constructed using (1 S , 2 S )-(-)-1,2-diphenylethylenediamine (DPED), sodium dodecyl sulfate (SDS), and sodium carbonate (Na 2 CO 3 ). It is found that the amino acids can trigger the transformation of the DPED/SDS/Na 2 CO 3 ATPS into a single-phase system, but the critical concentrations required for this phase transition vary significantly among the amino acids: Phe and Trp induce the transition at very low concentrations, whereas Tyr requires a much higher concentration (8–13 times greater than Phe and Trp under optimal conditions). This stark contrast enables the DPED/SDS/Na 2 CO 3 ATPS to serve as a sensitive and visually distinguishable platform for differentiating Tyr from Phe and Trp. Moreover, the DPED/SDS/Na 2 CO 3 ATPS exhibits selective phase partitioning: Phe and Trp preferentially concentrate in the top phase, while Tyr predominantly distributes into the bottom phase. This distinct partitioning behavior allows for the efficient separation of Phe and Trp from Tyr, highlighting the system’s dual functionality for both detection and purification of Tyr from Phe and Trp. These findings indicate the potential of using this system to develop methods for separating and detecting the amino acids.
研究领域:
分析化学
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生物化学
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分离科学
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材料科学
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DOI
高影响因子
CRYSTENGCOMM
·
2022
·Vol. 24
·期 40
·7200-7215
·
IF 3.756
Ningjing Song,Jiangfeng Li,Baosheng Li,Ercai Pan,Juan Gao,Yurong Ma
The shells of P. placenta are composed of foliated calcite laths packed as layered structures and have high mechanical properties and optical transparency. However, the biomineralization mechanism and the influence of the organic matrix on the formation of the foliated calcite laths in the shells of P. placenta are not known. The acid-soluble matrix (ASM) was extracted from the shells of P. placenta and characterized in detail. Sixteen proteins including calcium-binding and chitin-binding proteins were associated to shell formation via proteome analysis of ASM. The ASM was found to be enriched with Gly, Asp and Ser. By tracking the Ca2+ concentration in the solution in the presence of ASM by a potentiometric method, we find that the ASM has a strong effect to stabilize the amorphous calcium carbonate (ACC) precursor in solution with a nucleation time of about 7733 s and a retardation factor of about 2.3, while the concentration of the ASM was 0.3 μg mL−1. In particular, the ASM can inhibit the (secondary) nucleation of calcium carbonate for 10 and 24 hours on the shell surfaces of P. placenta and the glass substrate in the aqueous solution, respectively. An explosive secondary nucleation and quick crystal growth from 50 nm to 10 μm can be finished on the shell surfaces in one hour, in between 10 h and 11 h of reaction time, via a gas diffusion process. This indicates that the ASM has a very strong effect to stabilize ACC and inhibit nucleation. The formation of ACC in the solution and its transformation to calcite crystals on the substrates were tracked by dynamic light scattering, selected-area electron diffraction, infrared spectroscopy, scanning electron microscopy, and confocal laser scanning microscopy. It was found that the ASM was doped in the preliminary nanocrystals with a size of about 50–100 nm, which were formed on the shell surfaces via secondary nucleation, and was occluded into the calcite crystals without preferred adsorption on particular crystal planes. The calcite crystals formed on the shell surfaces became more and more rounded and lost {104} planes with increasing concentration of the ASM in the solution, indicating that the ASM can stabilize other planes instead of the thermodynamic {104} planes. The in vitro crystallization study in this work shows that ASM extracted from the shells of P. placenta has a strong effect on the biomineralization process of foliated calcite laths of P. placenta.
研究领域:
生物矿化
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材料科学
·
海洋生物学
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蛋白质组学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Ou Jiang,Pengxiang Zhang,Haiqi Jia,Jin Liang,Xiuhua Zheng
Acidizing improves geothermal reservoir productivity by dissolving rocks to increase formation permeability, which is achieved by injecting acid fluids into reservoir formations. However, conventional acid fluids either can not achieve effective acidizing or cause geothermal reservoir damages. Foam acid fluids, which have been applied for oil-gas reservoir stimulation, can realize effective acidizing by retarding acid-rock reactions, and can protect reservoirs. Here, a foam acid fluid system is proposed, aiming at achieving efficient acidizing and reservoir protection in low-temperature dolomite geothermal reservoirs. Formic acid (FA) and acetic acid (HAc) are used to replace a portion of hydrochloride (HCl) acid. Alkyl glycine surfactant AGS-12 is added for foaming, while xanthan gum and nano silica particles are used to stabilize foams. Corrosion inhibitor and ferric ion stabilizer are added to inhibit acid corrosion of steel and ferric ion precipitations. The acidizing effect was evaluated through foam stability, dissolution performance, corrosion inhibition performance, and compatibility. Microscopic observation, field emission scanning electron microscope, and numerical simulation were applied to reveal the mechanisms of temporal evolution of foams and acid dissolution behaviors. Results show that the foam acid fluid with 5 wt% FA, 5 wt% HAc and 10 wt% HCl acid has the best foam stability and retardation effect. Compared to non-foam acid fluid, the decrease degree of the cuttings mass change rate in foam acid fluids exceeds 50 %, and foaming primarily retards acid-rock reactions. Simulation results is consistent with the experiment results, demonstrating that the cuttings dissolve less in FA and HAc. Calcium (Ca) content on the cuttings surfaces after acid-rock reactions in foam acid fluids with FA and HAc is less than that after acid-rock reactions in foam acid fluid with sole HCl acid, indicating that FA and HAc inhibit Ca-bearing mineral precipitations, as formate and acetate ions can chelate with Ca 2+ . The replacement of HCl acid by FA and HAc contributes to a low corrosivity and good compatibility of the foam acid fluids due to a reduced hydrogen ions resulted from partial dissociation of weak acids. This study shows the feasibility of foam acid fluids during geothermal reservoir stimulation with eliminated reservoir damages.
研究领域:
石油工程
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地质学
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化学工程
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产品关联
DOI
高影响因子
ChemistrySelect
·
2022
·Vol. 7
·期 27
·e202201140
·
IF 2.307
Xiyang Wang,Siraj Ullah,Shuozhen Hu,Xinsheng Zhang
Graphical The composition of chromogenic impurities in the glyoxylic acid prepared by electroreduction of oxalic acid is studied. The chromogenic impurities are mainly composed of glyceric acid and pyruvic acid. 92.97 % of the chromatic substances can be removed from glyoxylic acid via electrodialysis. Oxalic acid is also separated from glyoxylic acid by electrodialysis method. Electroreduction of oxalic acid (OA) is an effective process to produce glyoxylic acid (GA). However, electrochemically generated GA solution is yellow, which lowers the quality of GA and affects the application in producing the downstream products. It is urgent to investigate the composition of chromogenic substances (CSs) and separate them from the GA solution. In this work, the presence of tartaric acid, glyceric acid, and pyruvic acid in the electrochemically generated GA solution is successfully confirmed by high-performance liquid chromatography-electrospray-mass spectrometry. Tartaric acid is originally generated from GA and glycolic acid, and then further reduced to obtain chromogenic glyceric acid and pyruvic acid. 92.97 % of CSs could be successfully removed from the GA solution by electrodialysis at 240.64 A/m 2 and 25 °C. A separation of OA and GA is also achieved by electrodialysis. This study makes a significant contribution to the industrialization of electroreduction process to prepare GA.
研究领域:
化学工程
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环境科学
·
工业化学
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DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Jinxiang Huang,Xufeng Zang,Wuying Yang,Xiaoli Yin,Jianping Huang,Shumin Wu,Yanping Hong
Eighteen derivatives of pentacyclic triterpene carboxylic acids (Maslinic acid, Corosolic acid and Asiatic acid) have been prepared by coupling the piperazine complex of l -amino acids at the C-28 site of the parent compounds. The α-glucosidase inhibitory activities of the pristine derivatives were evaluated in vitro . The results indicated that the inhibitory activity of some compounds ( 15e IC 50 = 591 μM, 16e IC 50 = 423 μM) was closed to that of the reference acarbose (IC 50 = 347 μM) in ethanol-water system. In addition, compound 16e (IC 50 = 380 μM) showed superior inhibitory activity than acarbose (IC 50 = 493 μM) in the measurement system with DMSO as solvent. The comparison of two different solvent systems showed that the derivatives had better α-glucosidase inhibitory activity in the DMSO system than that of in ethanol-water system. Regrettably, all of the as-synthesized derivatives exhibited inferior α-glucosidase inhibitory activities than those of the parent compounds in both test solvent systems. Furthermore, the result of enzyme kinetics demonstrated that the inhibition mechanism of compound 16e was noncompetitive inhibition with the inhibition constant K i = 552 μM.
研究领域:
药理学
·
有机化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）