BIOMATERIALS
·
2022
·
IF 15.304
Mengqing Xu,Jin Zhang,Yongli Mu,Mohamed Frahat Foda,Heyou Han
Capsaicin is a natural non-toxic small molecular organic substance, which is often used clinically to reduce inflammation and pain. Here, we report an acid-responsive CaCO 3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. The excellent acid responsiveness of calcium carbonate enables it to precisely target the tumor sites. The released capsaicin can specifically activate TRPV1 channel, overloading the intracellular calcium ion concentration and causing cell apoptosis, which provides a new safer and cheaper treatment. We proved that the naturalness and non-toxicity of capsaicin make the CaCO 3 @CAP nanoparticles have excellent biocompatibility, which has good development prospects and clinical application potential.
研究领域:
药理学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Kai Si,Tingting Gong,Suyun Ding,Huiping Liu,Shuyuan Shi,Jianqiu Tu,Linxian Zhu,Li Song,Lushan Song,Xiaowei Zhang
Phosvitin has excellent calcium binding capacity, related to its phosphopeptides. The phosphopeptides may be used as functional ingredients for improving calcium bioavailability, but the calcium-binding mechanism is unclear. In this study, a novel phosvitin phosphorylated pentapeptide (Glu-Asp-Asp-pSer-pSer, EDDpSpS) was selected to prepare an EDDpSpS calcium complex (EDDpSpS-Ca), and the calcium-binding mechanism and bioavailability investigated. The calcium-binding capacity of EDDpSpS was up to 468 ± 152.80 mg/g. Calcium ions prompted the folding of the EDDpSpS structure to form spherical nanoparticles. The calcium binding sites of EDDpSpS involved peptide bonds, carboxyl, amino, and phosphate groups. Molecular forces involved in these interactions were electrostatic in nature. Moreover, EDDpSpS-Ca had excellent bioavailability when compared to CaCO 3 , calcium lactate, and d -calcium gluconate. This study revealed the calcium-binding mechanism of phosvitin phosphopeptide, and suggested that EDDpSpS-Ca has the potential to be a novel, efficient, and promising calcium supplement.
研究领域:
营养学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Shuo Wang,Xuan Meng,Jing Zhang,Xiangyang Zhang,Sitan Wang,Li Shi,Naiwang Liu
Calcium cyanamide was synthesized by the twice calcination of calcium oxide and urea which was different from the traditional calcium carbide method. Including reaction time, reaction temperature, and reaction molar ratio, the more suitable reactions were explored, which improved the utilization of urea and yield of calcium cyanamide. The phenomenon of visco-wall during the reaction process was alleviated by adding sodium chloride, and this effect was explained at the micro level. The chemical bond and weight change of the main byproducts and intermediate products in the reaction process were characterized systematically. A reaction model between urea and calcium oxide was constructed based on density functional theory (DFT), which complemented the reaction conditions and characterization results. Finally, the reaction mechanism between urea and calcium oxide was proposed.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2012
·
IF 2.59
Lei Ling,Yuming Zhou,Jingyi Huang,Qingzhao Yao,Guangqing Liu,Peixin Zhang,Wei Sun,Wendao Wu
In an attempt to control Ca 3 (PO 4 ) 2 , CaCO 3 , and CaSO 4 deposits in industrial recycling water systems, an acrylic acid (AA)-allyloxy poly(ethylene glycol) polyglycerol carboxylate (APEG-PG-COOH) copolymer was synthesized as a nonphosphorus inhibitor. The synthesized polymer was characterized by 1 H NMR. The performance of PAA/APEG-PG-COOH on inhibition of Ca 3 (PO 4 ) 2 , CaCO 3 and CaSO 4 precipitation was studied through static scale inhibition tests. It was shown that PAA/APEG-PG-COOH exhibited excellent ability to control inorganic minerals, with approximately 100% CaSO 4 inhibition and 99.89% Ca 3 (PO 4 ) 2 inhibition at levels of 3 and 6 mg/L PAA/APEG-PG-COOH, respectively. PAA/APEG-PG-COOH also displayed ability to prevent the formation of CaCO 3 scales. The effects on formation of Ca 3 (PO 4 ) 2 , CaCO 3 and CaSO 4 were investigated with combination of Scanning electronic microscopy (SEM), Transmission electron microscopy (TEM), and X-ray powder diffraction (XRD) analysis, respectively.
研究领域:
环境化学
·
材料科学
·
工业水处理
·
高分子化学
·
腐蚀与防护
·
矿物结垢控制
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Guoqing Li,Caiyun Sun,Le Zhu,Yan Zeng,Jinquan Li,Yufei Mei
Cadmium (Cd) is a neurotoxicant that gradually accumulates in the human body with age. High Cd burden is correlated with adult hippocampal neurogenesis (AHN) and memory deficits in mammals. However, little knowledge is known about the mechanism by which Cd exposure impairs neurogenesis and cognition. Here, we investigated the roles of store-operated calcium entry (SOCE)-mediated calcium dyshomeostasis in Cd-induced AHN and memory deficits as well as therapeutic potential for the prevention of Cd-induced neurotoxicity. To achieve this goal, 8 weeks-old C57BL/6 J mice were subjected to different concentrations of cadmium chloride (0, 5, 10, 20 ppm) in drinking water for 8 weeks, we then examined the AHN, calcium homeostasis, SOCE channel and memory in Cd-exposed mice by using immunohistochemistry, calcium imaging, Y-maze and fear conditioning test. Our results indicated that chronic Cd exposure markedly increased Cd levels in serum and cerebrospinal fluid by almost 10-fold, and inhibited the proliferation and differentiation of hippocampal adult neural stem cells in a dose-dependent manner. Additionally, Cd exposure impaired the maturation of hippocampal neural stem cells without inducing gliosis. Transcriptome analysis revealed that Cd exposure inhibited the proliferation of neuroblastoma via alteration of calcium signaling pathway, and attenuated SOCE channels played a pivotal role in mediating Cd-induced cytoplasmic calcium overload and depletion of endoplasmic reticulum calcium stores. Activation of SOCE by hyperforin, a natural derivative from medicinal plant, restored intracellular calcium homeostasis and improved AHN and memory in Cd-exposed mice. Together, this study provided novel insights into the mechanism that Cd exposure impaired AHN and memory by prompting neuronal SOCE-mediated calcium dyshomeostasis, and offered a new therapeutic approach for prevention of Cd-induced neurotoxicity.
研究领域:
神经科学
·
药理学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Yu Wang,Yao Yu,Yi-Ping Hou,Xue-Wei Mao,Zong-Liang Liu,Jian Cui,Bi Wang,Shu Xu,Yi-Yun Qian,Yan-Qin Jiang,Min Wei,Ping-Ping Song
Botrytis cinerea causes gray mold in many fruit and vegetable crops. We previously found that Seselin (SL) displayed antifungal activity against B. cinerea (EC50 = 6.1 μg·mL–1), and this study investigated the effects of Ca2+ and the Ca2+/CN signaling pathway on its antifungal activity against B. cinerea. The results indicated that exogenous Ca2+, Cyclosporine A, and Verapamil reduced the sensitivity of SL against B. cinerea; SL significantly reduced the intracellular Ca2+ concentration in the hyphae; the sensitivity of strains ΔbcCCH1 and ΔbcMID1 to SL were significantly increased; and the expressions of CCH1, MID1, CNA, PMC1, and PMR1 genes of the Ca2+/CN signaling pathway were significantly downregulated by SL treatment. Hence, SL is a potential compound for developing fungicides against B. cinerea. SL dramatically reduces intracellular Ca2+ concentration and disturbs Ca2+ homeostasis, leading to cell death. The Ca2+/CN signaling pathway plays an important role in the antifungal activity of SL against B. cinerea.
研究领域:
植物病理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Na Liu,Ruili Gao,Jingjing Guo,Longwei Fu,Bin Xue,Kun Ma,Chen Lin
The environmental impact of arsenic (As) pollution has been a focal point within environmental science. In arsenic-polluted saline-alkali environment, the addition of exogenous biochar can affect the morphological transformation of As both through direct and indirect mechanisms, with calcium ions (Ca(II)) playing a crucial role. This study investigates the immobilization mechanisms of undissolved biochar (UOB) and dissolved biochar (DOB) on As(V) in the absence and presence of Ca(II) under alkaline conditions and aerobic atmosphere. While UOB and DOB alone are insufficient for As(V) immobilization, their combined action in the presence of Ca(II) achieves remarkable immobilization rates of 91.9% and 98.1%, respectively. Precipitation of calcium arsenate is identified as the primary immobilization pathway in both the UOB-Ca(II)-As(V) and DOB-Ca(II)-As(V) systems. Furthermore, Ca(II) acts as a mediator for As(V) immobilization through the formation of ternary UOB/DOB-Ca-As complexes, which are corroborated by Density Functional Theory (DFT) analysis from a microscopic perspective. Notably, the synergistic immobilization of As by DOB and newly generated CaCO 3 in DOB-Ca(II)-As(V) system is highlighted. Additionally, the increase in Ca(II) concentration (0–100 mM) and solution pH (9.0–12.0) both significantly enhance the immobilization of As(V). An increase in the dosage of UOB (0.4–4 g/L) reduces the immobilization of As(V), while effect of the DOB concentration is insignificant. This study provides new insights into how the release of two biochar fractions into a typical Ca(II)-rich saline-alkali environment may alter the fate and transport of As species.
研究领域:
环境科学
·
化学
·
土壤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2015
·
IF 2.489
Huan Zhou,Shiqin Kong,Sarit B. Bhaduri,Linhong Deng
Calcium phosphates with negative zeta potential belong to a type of materials favoring apatite nucleation, bone regeneration, as well as osseointegration. Unfortunately, there are limited options to produce such materials. The present work demonstrates a simple but versatile method to prepare calcium phosphates with negative zeta potential using sodium calcium polyphosphate as a precursor. The resulting products can be hydroxyapatite , calcium pyrophosphate or monetite, depending on the relevant experimental conditions. Both hydroxyapatite and calcium pyrophosphate were composed of nanoparticles . However, the as-prepared monetite was micro-plates with nanoporous surface structures. Such calcium phosphates may have great potential in bone tissue engineering applications.
研究领域:
生物材料学
·
骨组织工程
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2018
·
IF 1.666
Ying Zhang,Hongquan Yin,Qingshan Zhang,Yunzheng Li,Pengjun Yao,Hongyu Huo
Polyaspartic acid is a green biodegradable antiscalant and widely applied in water treatment field. However, its scale inhibition efficiency is not prominent, especially for calcium orthophosphate. So we introduced acylamino and hydroxyl groups simultaneously to prepare a novel polyaspartic-acid derivative (PASPTU) with multifunctional groups by the reaction of polysuccinimide with threonine and urea. The graft copolymer was analyzed by using nuclear magnetic resonance, gel permeation chromatography, thermogravimetric analyzer and Fourier transform infrared spectroscopy. Its scale inhibition performance for calcium orthophosphate, calcium sulfate and calcium carbonate was evaluated. The findings showed that the scale inhibition rates of the graft copolymer reached up to 100% for calcium orthophosphate, 100% for calcium sulfate and 91% for calcium carbonate at certain dosages. The findings above showed that the copolymer had excellent scale inhibition efficiency for calcium salts in water treatment processes.
研究领域:
材料科学
·
水处理技术
·
环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Hainan Sun,Juan He,Zhiwei Hu,Chien-Te Chen,Wei Zhou,Zongping Shao
The oxygen evolution reaction (OER) plays a crucial role in the application of water splitting, which is a highly competitive option for a sustainable energy future. Thus, it is vital to design highly active and durable electrocatalyst for OER. Herein a hybrid with the nominal composition of Ba 2 Co 1.5 Mo 0.25 Nb 0.25 O 6-δ (denoted as BC1.5 MN) electrocatalyst consisting of both double perovskite and single perovskite structures is synthesized by a solid-state reaction method. When tested as an electrocatalyst for OER, the BC1.5 MN electrocatalyst requires a current density of 10 mA cm −2 at an overpotential of 400 mV, an onset overpotential of 260 mV, and a Tafel slope of 70 mV dec −1 , which are superior to that of precious metal oxide IrO 2 catalyst. Chronoamperometric and cyclic voltammetry studies demonstrate that the BC1.5 MN electrocatalyst has outstanding durability in alkaline solution. The synergistic effect between multi-active sites derived from a single/double perovskite hybrid structure results in one of the most active perovskite-based OER electrocatalysts in alkaline solution.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 35
·20161-20168
·
IF 3.049
Rong Zhang,Bo Xiang,Lei Xu,Liru Xia,Chunhua Lu
GdBaCo2O5+δ (GCBC) has been widely used in various applications because of its unique structural characteristics. However, calcium-doped GCBC materials have not been comprehensively studied in terms of their structure and catalytic properties. Based on the first-principles density functional theory, the structure and electronic density of states were revealed by experiments and simulations. Ca-doping has a great influence on the materials' crystal structure, optical absorption, and catalytic performance. Furthermore, Gd0.8Ca0.2BaCo2O5+δ show the best efficiency in the photocatalytic degradation of congo red (C32H22N6Na2O6S2). The presented Ca-doping method affects the overall band structure, electron cloud distribution, and electronic density of states to strengthen the charge-transfer between O-2p and Co-3d orbitals, and Co may be an active site. Our results provide a deep and systematic study on Gd1−xCaxBaCo2O5+δ based on theoretical calculations and experiments, including analysis of crystal structure, electron distribution, and catalytic performance.
研究领域:
材料科学
·
理论计算化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Liping Fang,Kai Wang,Chen Han,Xinyong Li,Pei Li,Jieshan Qiu,Shaomin Liu
Piezocatalysis utilizes mechanical energy to achieve the required charge separation for redox reactions, a promising method for clean H 2 O 2 production. However, the efficiency of conventional piezocatalysts is limited by the undesirable low piezoelectricity. Herein, novel piezocatalysts composed of La, Sr, Co (Fe) in simple single perovskites (La 0.5 Sr 0.5 FeO 3-δ and La 0.5 Sr 0.5 CoO 3-δ ) and Ruddlesden-Popper (R-P) type perovskites (LaSrFeO 4-δ and LaSrCoO 4-δ ) are developed for piezocatalytic H 2 O 2 production. Results indicate that Fe-containing catalysts outperform Co-containing counterparts and the unique R-P perovskite oxides demonstrate significantly enhanced piezocatalytic performance than the corresponding single perovskites. For example, via piezocatalysis, the LaSrFeO 4-δ exhibits H 2 O 2 yields of 548 (in 10 % ethanol) and 247 µmol g −1 h −1 (without sacrificial agent), improved by a factor of 1.14, 4.94, or 21.73 compared to La 0.5 Sr 0.5 FeO 3-δ , LaSrCoO 4-δ , or La 0.5 Sr 0.5 CoO 3-δ , respectively. The piezoelectricity is an overwhelming factor in determining the H 2 O 2 generation. Furthermore, the piezoelectricity and oxygen vacancy (OV) content is well correlated. The R-P phase with lower OV exhibits a higher piezoelectricity because of the eliminated pining effect to the polarization domain reversion. Mechanism exploration suggests that H 2 O 2 formation stems from the efficient O 2 reduction via a 2-electron transferring pathway, during which the piezoelectric polarization drives the charge separation and transportation, favoring the redox reactions.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）