ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Wenli Guo,Jinjin Zhang,Xiaoqian Zhang,Quanzhong Ren,Guangzhe Zheng,Jianxin Zhang,Guoxing Nie
Cadmium (Cd) pollution is considered a pressing challenge to eco-environment and public health worldwide. Although it has been well-documented that Cd exhibits various adverse effects on aquatic animals, it is still largely unknown whether and how Cd at environmentally relevant concentrations affects iron metabolism . Here, we studied the effects of environmental Cd exposure (5 and 50 μg/L) on iron homeostasis and possible mechanisms in common carp. The data revealed that Cd elevated serum iron, transferrin saturation and iron deposition in livers and spleens, leading to the disruption of systemic iron homeostasis. Mechanistic investigations substantiated that Cd drove hemolysis by compromising the osmotic fragility and inducing defective morphology of erythrocytes. Cd concurrently exacerbated hepatic inflammatory responses, resulting in the activation of IL6-Stat3 signaling and subsequent hepcidin transcription. Notably, Cd elicited ferroptosis through increased iron burden and oxidative stress in livers. Taken together, our findings provide evidence and mechanistic insight that environmental Cd exposure could undermine iron homeostasis via erythrotoxicity and hepatotoxicity. Further investigation and ecological risk assessment of Cd and other pollutants on metabolism-related effects is warranted, especially under the realistic exposure scenarios.
研究领域:
环境科学
·
毒理学
·
水生生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yiqiao Pei,Ye Zhang,Fang Tian,Yanrong Zhao,Xuguang Zhang,Steve W. Cui,Huali Wang,Jianbo Zhang,Hao Wang
Iron supplementation has been an important and complicated health topic. Available iron preparations generally have issues such as instability, inadequate absorption, and low consumer acceptability. This study provided a novel ferric pyrophosphate (FePP) delivery system, the FePP-casein-phosphopeptide-dextran (FCD) complex, with sodium pyrophosphate (NaPP) as a solvent promoter and casein-phosphopeptide (CPP) and β-glucan as wall materials. Compared to FePP, FCD showed better properties, including good water solubility (95% resolubilization), color stability (pH 3.5–6.5), compatibility with sensitive nutrients like vitamin C (VC), and lipid oxidation stability (delayed by approximately 50%). In vitro, FCD demonstrated gradual iron release in the gut with a release rate exceeding 80%. In vivo, FCD effectively alleviated iron deficiency anemia (IDA) symptoms in mice, with superior overall efficacy to FePP. Therefore, this novel FCD iron delivery system had considerable potential to be applied in nutritional food systems or iron supplements.
研究领域:
营养学
·
食品科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
·
2015
·
IF 0
Wei Cai,Chun Lin Fu,Rong Li Gao,Wei Hai Jiang,Xiao Ling Deng,Gang Chen
Bismuth ferrite is an important material in ferroelectric photovoltaic field, because of its narrow band gap and large polarization. Doping is a common method to further improve the photovoltaic properties of bismuth ferrite. Mn-doped bismuth ferrite thin films were prepared by sol-gel method. The effects of manganese on the crystal structure, ferroelectric and photovoltaic properties have been investigated. The result indicates that Mn-doped bismuth ferrite thin films are single phase and the lattice constant increases with the increase of manganese content. As manganese content increases, the remnant polarization and coercive electric field increase, while the short circuit photocurrent density and power conversion efficiency decrease. The open circuit photovoltage increases first and reaches the maximum and then decreases as manganese content increases. The results indicate that enhanced ferroelectricity caused by addition of manganese doesn’t make improvement on the photovoltaic characteristic.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Xiaoli Huang,Di Lu,Yongmin Ma,Limei Zhang,Lina Wang,Jian Deng,Zheng Wang,Yanjun Zhao
We report a self-assembly-based approach for improved iron chelation of small chelators. A model chelator, deferiprone (DFP) is covalently linked to amphiphilic poly(ethylene glycol)-polypeptide block copolymer that can assemble into micelles . The free DFP generally coordinates with iron in a ratiometric manner (3:1). However, the assembly induces DFP packing in the micelle cores, which restricts its conformational freedom. Hence DFP/iron coordination ratio in micelles is reduced (< 3:1), which leads to an enhanced chelation performance of DFP. In addition, the micellar nanocarrier usually exhibits an extended systemic circulation in contrast to the free DFP. The current work opens new avenues for developing novel nanomedicines for iron overload diseases.
研究领域:
生物化学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Tong Li,Wang Jie,Ma Yunjin,Wang Chunying,Fu Yue,Li Qi,Gao Chengjiang,Song Hui,Qin Ying,Zhao Chunyuan,Zhao Wei
Viruses rely on intracellular materials, including iron, to complete their life cycles and iron withholding may limit viral infections. However, the mechanisms through which viruses disrupt host iron homeostasis and the impact of intracellular iron on the host’s antiviral defense aren’t well studied. Here we show that viral infections facilitate the polyubiquitination and degradation of ferroportin (FPN1, the only cellular iron exporter) by upregulating the host E3 ubiquitin ligase DTX3L, leading to an elevation in cellular iron levels. Excessive ferrous iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation in macrophages. FPN1 deficiency suppresses host antiviral defense and facilitates viral replication in vitro and in vivo, while DTX3L deficiency has the opposite effect. These results reveal that viruses hijack host FPN1 to disrupt iron withholding and achieve immune escape, and suggest that iron homeostasis maintained by FPN1 is required for the optimal activation of TBK1- and STING-dependent antiviral responses.
研究领域:
微生物学
·
免疫学
·
生物化学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zishen Lin,Chunli Zheng,Zhenxing Wang,Yuanzhe Peng,Guoqing Geng,Aibin Zhu,Chi He
As one category of promising and efficacious purification material toward environmentally harmful heavy metals, sulfidated amorphous zero-valent Iron (S@AZVI) exhibits unparalleled removal performance. Due to the disruptive crystal growth however, the irreversible loss of Fe 0 component during conventional synthesis route poses a substantial hindrance to its industrial application. To address this, we propose a post-sulfidation strategy to hinder the transformation of Fe 0 by altering the shell composition of AZVI from Fe 2 O 3 to FeS, which maintains a remarkable Fe 0 content up to 75.7 % over finally obtained S@AZVI, far higher than the material obtained through the one-step sulfidation . Attributing to the synergy of FeS shell and substantial Fe 0 , S@AZVI demonstrates impressive performance as the lowest free corrosion potential (−1.050 V) and work function (4.058 eV), and subsequently exhibits a notable enhancement in the removal efficiency of Cr(VI) and Ni(II), surpassing AZVI by 1.8 and 2.0 times, respectively. Results reveal that the adsorption, reduction, and coprecipitation constitute the mechanisms governing the removal of Cr(VI) and Ni(II). In practical electroplating wastewater experiments, S@AZVI effectively removes Cr(VI) and Ni(II) within a 60-min timeframe, meeting established emission standards. These findings provide valuable insights for future AZVI material synthesis for heavy metal elimination.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Longfei Xia,RiSheng Li,Menglin Yao,Xu Deng,Wen Sun,Miaomiao Du
In this study, micron Zero-valent Iron (mZVI), an affordable and well-dispersible reducing agent, was investigated for its potential application in removing Sb(V) from wastewater. Since Sb(V) primarily exists as Sb(OH) 6 - in aqueous solutions, the lower the pH, the more effective mZVI is in removing Sb(V). At a pH level of 3, mZVI (1.0 g/L) was able to remove more than 99 % of Sb(V) (20 mg/L) from the wastewater. The study also compared the influence of cations and anions on mZVI and found that anions had a greater impact on the material's performance. The paper further examined the impact of different heavy metal ions on mZVI and determined that the adsorption capacity of mZVI towards these ions follows the order of their reducing ability. Summarizing the removal mechanism of Sb(V) by mZVI, it was found that both adsorption and redox reactions played crucial roles and Sb(V) is ultimately removed from water through coprecipitation by combining with Fe-O on the mZVI surface. Theoretically, the maximum adsorption capacity of the mZVI material used in this study could reach 21.60 mg/g for Sb(V). This makes mZVI a promising environmental adsorption material and a potential solution for treating water pollution caused by antimony mining.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Applied Ceramic Technology
·
2024
·
IF 1.8
Juan Liu,Yu Sun,Lilin Xiang,TuLai Sun,Zilong Yu,Bing Cui,Chuangui Jin
In the present study, SrTiO 3 was selected to enhance the multiferroic characteristics of Bi 0.88 Sm 0.12 FeO 3 (BSF) ceramics. With increasing SrTiO 3 content, the principal phase of BSF ceramic transitions from rhombohedral R3c to Pna2 1 . Through DSC and dielectric analysis, it was observed that both the Curie temperature and Néel temperature decreased proportionally with the augmentation of SrTiO 3 content. When x = .1, the optimal ferroelectric performance is achieved, and the highest remanent polarization value is 55.47 µC/cm 2 , significantly surpassing that of BSF ceramics. Moreover, the PFM test results showed that as the substitution content increased, the domains in the BSF ceramic gradually transformed from normal ferroelectric domains to polar nanomicro-domains. Magnetic and magnetoelectric results show that when x = .1, the best magnetic properties are obtained, M r = 59.7 emu/mol. The magnetoelectric coefficient α ME initially increased and then decreased with the increasing SrTiO 3 content, reaching its optimum magnetoelectric properties at x = .1, where α ME = .47 mV cm –1 Oe –1 . In summary, when the substitution amount of SrTiO 3 reaches 10%, the ferroelectric, magnetic, and magnetoelectric properties of BSF ceramics are significantly improved.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jieling Ren,Yuanzhe Peng,Aibin Zhu,Chunli Zheng,Chi He,Mudi Ma
Kaolinite-loaded amorphous zero-valent iron composite (K@AZVI) is a promising material for cadmium-contaminated soil remediation. Still, the impact of iron (Fe) oxides on the surface of K@AZVI on the immobilization of cadmium (Cd) in soils caused by varying water management remains unclear. Hence, this study investigated the transformation of Fe oxides in K@AZVI and their effects on Cd morphology under varying soil water management (drying, wetting, and flooding). The results indicated that under K@AZVI treatment, the pe + pH (pe = Eh (oxidation-reduction potential, mV) / 59.2) values decreased from 11.59 to 9.83 and 5.61 with increased soil water management. Meanwhile, the content of crystalline Fe oxides (Fe c ) decreased significantly by 34.02%-72.76%, while the content of amorphous Fe oxides (Fe o ) increased by 29.01%-55.20%. This transformation from crystalline to amorphous Fe oxides significantly enhanced the immobilization of Cd, resulting in a 30.30%-64.59% reduction in the available Cd content compared to the control. In addition, the proportion of low active Cd was enhanced from 32.94% to 56.10%, further indicating that K@AZVI exhibited superior immobilization in flooded soil. Characterization and calculations showed that water management significantly improved the immobilization of Cd by K@AZVI by regulating the crystallinity of Fe oxides and enhancing their electron transfer rate and adsorption capacity. Therefore, investigating the morphological transformation of Fe under varying water management will help us to understand the mechanism of Fe redox-mediated Cd transport and transformation in the soil system.
研究领域:
环境科学
·
土壤学
✓ 已验证
DOI
高影响因子
RESOURCES CONSERVATION AND RECYCLING
·
2025
·
IF 10.9
Fei Han,Yaohui Xie,Lin Qu,Zhenzhou Wang,Wei Zhang,Guang Yang,Huiqin Hu,Meiting Huang,Haoxuan Yu,Liming Yang,Xubiao Luo
Deep removal of trace aluminum from lithium extraction slag (LES) is key to recovering high-purity battery-grade iron phosphate (FePO 4 ). Existing methods exhibit low aluminum removal due to the close solubility product constants of Al (III) and Fe (III). In this work, we propose a novel strategy for trace aluminum removal based on fluoride ion-mediated differential coordination of Al (III) and Fe (III). Through precise control of fluoride ion concentration in phosphoric acid solution, iron preferentially precipitates while aluminum predominantly forms soluble fluoride complexes. This distinct behavior enables precise elemental separation through fluoride content optimization. The developed separation technology achieved aluminum removal rate of 98.89 %. It is noteworthy that the aluminum content of precipitated FePO 4 is below 30 ppm, which meets the standard of battery-grade. This work provides a viable technical pathway for the industrialization of Al/Fe separation in the lithium extraction slag leachate and the regeneration of low-Al, high-purity FePO 4 .
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yang Wang,Guorong Yi,Wanqiang Zhang,Jiawei Hou,Kuok Ho Daniel Tang,Bowen Wang,Hua Li,Quan Wang,Hamada Abdelrahman,Tao Zhang,Sabry M. Shaheen,Ronghua Li
In this study, the effects and mechanisms of water-soluble ferrous salts (WSFS) on the humification and carbon conversion during the co-composting of hoggery slurry (HG) and wheat husks (WH) were investigated. A composting mixture of HG and WH was treated with FeCl 2 addition (T1) and FeSO 4 addition (T2), and compared with an untreated control (CK), as a function of time (28 days). The duration of the high-temperature phase (>50 °C) for CK, T1, and T2 are 17, 15, and 15 days, respectively. Compared to the CK, T1 and T2 treatments reduced CO 2 emissions by 11.4 % and 32.0 %, respectively. The calculated total global warming potential values were 293.67 (CK), 267.69 (T1) and 207.10 (T2) g CO 2 eq kg −1 . The humus concentrations increased in all treatments: CK by 28.10 %, T1 by 53.41 % and T2 by 49.73 % in composting. WSFS addition enhanced biotic humification by elevated the abundance and distribution of Bacillus , which promotes cellulose and hemicellulose decomposition, and Tepidimicrobium , which accelerates the production of humus, through use of sugars and proteins. Besides, WSFS addition decreased the levels of pathogenic bacteria in the final compost product. Notably, WSFS addition also benefited the abiotic humification by production of •OH during oxidation of Fe(II) in composting. This study enhances the understanding of the biotic and abiotic functions of FeSO 4 and FeCl 2 in promoting humification and reducing carbon emissions during composting. The detailed role of hydroxyl radical in composting and the effectiveness of WSFS-addition in composting nitrogen transformation are still need to be addressed in future.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Wenqiang Xu,Chenyun Xia,Feng He,Zhenyu Wang,Liyuan Liang
Sulfidation of nanoscale zerovalent iron (nZVI) can enhance particle performance. However, the underlying mechanisms of nZVI sulfidation are poorly known. We studied the effects of Fe2+ on 24-h dynamics of nZVI sulfidation by HS– using a dosed S to Fe molar ratio of 0.2. This shows that in the absence of Fe2+, HS– rapidly adsorbed onto nZVI particles and reacted with surface iron oxide to form mackinawite and greigite (<0.5 h). As nZVI corrosion progressed, amorphous FeSx in solution deposited on nZVI, forming S-nZVI (0.5–24 h). However, in the initial presence of Fe2+, the rapid reaction between HS– and Fe2+ produced amorphous FeSx, which deposited on the nZVI and corroded the surface iron oxide layer (<0.25 h). This was followed by redeposition of colloidal iron (hydr)oxide on the particle surface (0.25–8 h) and deposition of residual FeSx (8–24 h) on S-nZVI. S loading on S-nZVI was 1 order of magnitude higher when Fe2+ was present. Surface characterization of the sulfidated particles by TEM-SAED, XPS, and XAFS verified the solution dynamics and demonstrated that S2– and S22–/Sn2– were the principal reduced S species on S-nZVI. This study provides a methodology to tune sulfur loading and S speciation on S-nZVI to suit remediation needs.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）