IRANIAN POLYMER JOURNAL
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2024
·
IF 2.4
Mao Xiaoyu,Ye Zi,Liang Jiaming,Lin Jiawen,Mei Xinyu,Deng Danfeng,Shi Renjie,Wang Zefeng
The development of durable and effective antibacterial materials has been a research hotspot. Here, we reported a new kind of long-lasting stable antibacterial material [Cu-metal–organic framework (MOF)-embedded polyethylene (PE)/ethylene vinyl acetate copolymer (EVA), namely Cu-MOF-embedded PE/EVA] through extrusion foaming, and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and energy dispersive spectroscopy (EDS). The degree of agglomeration or cluster formation, thermal stability, and melting point temperature of different contents of Cu-MOF/PE/EVA foams were evaluated by scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC), respectively. The results indicated that with the increase of Cu-MOF content, the average size and swelling ratio for foams increased, instead, the density decreased. Besides, the surface gradually showed good hydrophobicity. Remarkably, the water absorption rate was nearly 8 times that of pure PE/EVA when the Cu-MOF content reached 3%. Since Cu-MOF is stably embedded in the foaming structure and well dispersed, it can release Cu 2+ at a rate of about 37 ppb/day in foams containing 3% Cu-MOF, which not only maintains the antimicrobial capacity up to 99.2%, but also have no cytotoxicity. Finally, a promising new candidate for medical material with excellent, durable antibacterial ability was proposed. Graphical Abstract
研究领域:
材料科学
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生物学
·
医学工程
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产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Denghai Sheng,Shuaihang Guo,Aiqing Li,Qiulian Wu,Mengying Zhan,Xiaoli Liu,Hong Chen
Nitric oxide (NO), known for its anticoagulant and antiproliferative effects, holds great promise in anticoagulation therapy. Copper-based metal–organic frameworks, such as CuBTTri, catalyze NO formation, but their impact on vascular cells requires further study. In this work, polydopamine, polyethylenimine, and CuBTTri were codeposited on titanium substrates. To enhance cytocompatibility, heparin-mimicking copolymers were incorporated. By adjusting CuBTTri content, NO release rates and cytotoxicity toward vascular cells were regulated. The heparin-mimicking copolymers improved the cytocompatibility with human umbilical vein endothelial cells, while NO released from CuBTTri inhibited the proliferation of human umbilical vein smooth muscle cells. By integrating NO-releasing CuBTTri with heparin-mimicking copolymers, we successfully developed a composite coating that selectively modulates vascular cell behavior.
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2017
·Vol. 18
·期 7
·1250-1254
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IF 1.113
Chen Yingbo,Liu Huiqiang,Hu Xiaoyu,Cheng Bowen,Liu Dongqing,Zhang Yufeng,Nair Sankar
Membranes with high water permeation capability as well as high rejection to dye molecules are very important for dye separation. In this study, a metal organic framework structure (Cu-BTC) was fabricated in situ on a poly(vinyl difluoride) hollow fiber support for nanofiltration of dye solution. In order to protect the Cu-BTC layer, the surface was coated by crosslinking polyvinyl alcohol. The composite membranes showed no rejection to divalent salts and high rejection to Congo Red dye. It was noticed that several Cu-BTC layers could enhance dye rejection of the composite membranes. This novel composite membrane showed promising applications in the separation of dye molecules from aqueous solutions containing dissolved salts.
研究领域:
材料科学
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环境工程
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Mingshi Deng,Wei Jin,Wenjuan Yang,Lingling Tian,Xinghua Gao,Xuefeng Wang,Lingyan Feng,Metini Janyasupab,Bingpu Zhou,Yuan Zhang
Mycophenolic acid (MPA), which is a potent immunosuppressant, has been widely used to prevent organ rejection after organ transplantation. In clinical practice, it is essential to monitor the free MPA concentration. Herein, convenient and fast electrochemical microsensing technology is developed for directly detecting the MPA concentration. To implement this method, ultrathin copper-based metal–organic framework (Cu–MOF) nanosheets with a thickness of about 6.6 nm are used to detect MPA. An analysis of electrochemical behavior reveals the direct electrochemical catalytic oxidation mechanism of MPA molecules on a Cu(II) tetrakis(4-carboxyphenyl)porphyrin (Cu–TCPP)-modified electrode. Furthermore, electrochemical testing results show that the ultrathin Cu–TCPP nanosheet-based microsensor exhibits high sensitivity and specificity for MPA in the nano- to micromolar range, with a detection limit of 10 nM. X-ray absorption spectroscopy (XAS) characterization reveals that the unsaturated metal ions in ultrathin nanosheets are the active sites responsible for boosting the catalytic oxidation of MPA molecules. High-performance liquid chromatography–tandem mass spectrometry further shows the catalytic oxidation product of MPA and that the phenolic hydroxyl group in the MPA molecule is the active site where the catalytic reaction occurs. The considerable sensing performance of the Cu–TCPP nanosheet-based microsensor proves that it is possible to develop a fast and convenient method for the direct high-frequency monitoring of immunosuppressive drugs.
研究领域:
分析化学
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生物医学工程
·
药物分析
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DOI
高影响因子
Chemical Science
·
2025
·
IF 7.4
Jiye Feng,Danni Shi,Fei Wang,Yiming Zou,Weicheng Li,Wenbiao Zhang,Huai-Jun Lin,Yuying Meng,Qingsheng Gao
The electrochemical reconstruction of metal-organic frameworks (MOFs) offers a promising approach for in situ fabrication of high-performance electrocatalysts. However, this innovation is often hindered by unpredictable structural transformations due to the complex thermodynamic and kinetic interplay of such multiple electrochemical and chemical processes. Herein, the reaction-atmosphere (Ar or CO2) guided reconstruction of Cu-based MOFs to Cu nanoparticles with mix-valence surface/interfaces was for the first time investigated to unravel the kinetic contribution made by intermediate chemisorption. As shown, Cu-1,3,5-benzenetricarboxylate (HKUST-1) with frangible Cu-O4 nodes undergoes thermodynamically favored reduction quickly upon applying cathodic potentials, followed by the varied surface changes kinetically governed by the intermediates of hydrogen evolution or CO2 reduction reactions (HER or CO2RR). Under an Ar atmosphere, the predominant HER increases the [OH-] of the microenvironment near cathodes and thereby boosts the re-oxidation of in-situ formed Cu toward Cu/Cu2O interfaces. Conversely, the CO2RR facilitates the strong adsorption of *CO on Cu surfaces, effectively preserving Cu(0) species. Thanks to the rich Cu/Cu2O interfaces with the lowered energy barrier for *CO-*CO coupling during the subsequent CO2RR test, the restructured electrocatalysts under Ar affords the obviously improved CO2-to-C2H4 conversion as compared with the counterpart restructured under CO2. Such atmosphere-controlled reconstruction strategy is further validated using CuBDC (BDC = 1,4-benzenedicarboxylate) with labile Cu-O4 nodes, while CuPz2 (Pz = pyrazole) with robust Cu-N4 coordination remains stable, highlighting the framework-dependent nature. These findings establish atmosphere-controlled reconstruction of metastable MOFs as a powerful tool for rational electrocatalyst design.
研究领域:
材料科学
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电催化
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能源化学
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产品关联
DOI
PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 2
·e7957
·
IF 0
Yuzhang Yang,Minji Li,Yunqian Gong,Xingliang Li,Jia Zhou,Qinping Wei,Junke Zhang
Enzyme mimics attract wide attentions as detection sensors. However, the widespread application is limited by low efficiency and high cost. Herein, two novel enzyme mimics 1 and 2 were developed with peroxidase-like activities. The chain-like structure of 1 exhibited better stability, energy transformation efficiency, and catalytic property than 2 . Both of them could generate •OH radicals to oxide chromogenic agents, realizing the colorimetric detection of H 2 O 2 . Additionally, under the synergy of glucose oxidase, a cascade strategy for detection of glucose was constructed. This method exhibited excellent selectivity, anti-interference, and storage performance, as well as a wide linear range (1–60 μM) at pH = 7.4, with the low detection limits of 0.095 and 0.061 μM for 1 and 2 , respectively. Furthermore, the strategy was applied for detecting glucose in apple fruit samples. This work overcomes the shortcomings of current enzyme mimics and paves the way for bioanalysis and agricultural applications.
研究领域:
生物化学
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分析化学
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农业科学
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产品关联
DOI
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-13
·
IF 5.3
Wang Xue,Zhao Zixuan,An Long,Wang Tianxiang,Yang Xiaojing,Shan Jiajia
An unlabeled electrochemical sensing strategy based on electroactive copper-centered metal–organic framework (Cu-MOF) film coupled with multiwalled carbon nanotubes (MWCNTs) was proposed for the rapid assessment of nanoplastic concentration. The sensing interface was fabricated via the electro-deposition of Cu-MOF on the pre-modified MWCNTs using the cathodic reduction method. The exposed copper active sites in Cu-MOF showed excellent electrochemical activity, which was further enhanced due to rapid electron transfer induced by highly conductive MWCNTs. Through the adsorption functionality of Cu-MOF film towards polystyrene (PS) nanoplastics, the rapid recognition for nanoplastics in aqueous solution was achieved, thereby causing the inhibition of the current response. The results showed a robust dependence of the inhibition rate on the PS mass concentration. The proposed detection method was used for the quantitative determination of PS nanoplastics with the sizes of 100 nm, 500 nm, and 1 μm. The applicability of this electrochemical sensing platform was successfully validated in real-world water sample analysis. Graphical abstract
研究领域:
环境科学
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材料科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 45
·19753-19758
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IF 3.288
Panpan Huo,Zhijian Li,Congbin Fan,Shouzhi Pu
In this work, we have developed amino-functionalized copper-based metal–organic frameworks (NH2-Cu-MOFs) for the detection of hypochlorite (ClO−). NH2-Cu-MOFs were synthesized using a one-pot hydrothermal method, and they exhibit strong fluorescence at 455 nm under the excitation of 330 nm. In the presence of ClO−, the fluorescence of NH2-Cu-MOFs was quenched due to the electron transfer between NH2-Cu-MOFs and ClO−. The NH2-Cu-MOFs exhibited 87.6% fluorescence quenching efficiency with 12.5 μM ClO− and the limit of detection is 0.036 μM. NH2-Cu-MOFs exhibited the advantages of high sensitivity, high selectivity, and low response reaction time for ClO− detection. This work developed a novel fluorescent probe for the detection of ClO− and the NH2-Cu-MOFs were successfully applied to analyse ClO− in real water samples.
研究领域:
化学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 8
·087502
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IF 3.721
Ya Li,Lina Hou,Zhiling Liu,Wenbo Lu,Man Zhao,He Xiao,Tianjun Hu,Zhanfeng Zheng,Jianfeng Jia,Haishun Wu
Mucin 1 protein (MUC1) is a well-known tumor marker overexpressed in a variety of human malignancies, and thus its highly selective and sensitive detection is significantly desired for clinical diagnostics. Herein, a sensitive electrochemical MUC1 sensing platform has been fabricated based on copper-based metal-organic frameworks (Cu-MOFs) decorated with gold-platinum alloy nanoparticles (AuPt NPs). Besides serving as a redox probe to avoid introducing extra redox media, the electroactive Cu-MOFs function as catalysts in the hydrogen peroxide reduction, resulting in electrochemical signal amplification. Meanwhile, AuPt NPs loaded on the Cu-MOFs mimic horseradish peroxidase to promote the reduction of hydrogen peroxide, giving rise to the secondary-amplified electrochemical signal. Moreover, the target MUC1 triggered catalytic hairpin assembly (CHA) further improves the sensitivity of the developed biosensor via the target recycling amplification. The constructed sensing platform displayed a desirable dynamic range between 10 fM and 10 nM in the MUC1 detection, with a sufficiently low limit-of-detection (3.33 fM). The current strategy of utilizing hybrid nanocomposite consisting of MOFs and alloy NPs and enzyme-free CHA provides a promising platform for the detection of biomarkers in the clinical diagnosis with high selectivity and sensitivity.
研究领域:
生物医学工程
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肿瘤学
·
分析化学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 12
·1-9
·
IF 5.479
Chen Zi-Ang,Lu Wenbo,Bao Cancan,Niu Qiangqiang,Cao Xiaowei,Wang Hui,Yao Ru-Xin
Nanowires of copper(II)-based metal-organic frameworks (Cu-MOFs) of type Cu(II)(1,4-naphthalenedicarboxylic acid) (1,4-NDC) were deposited on the surface of a copper foam by immersion of Cu(OH) 2 nanowires in a solution of 1,4-NDC. An electrochemical immunosensor for the prostate specific antigen (PSA) is obtained by using the nanowire arrays as a redox signal probe. The signal is generated by the conversion of Cu(I) and Cu(II) of Cu-MOFs nanowires. Cu(1,4-NDC) nanowires contain many uncoordinated carboxyl groups which can bind to the amino groups of the PSA antibody. When PSA antibody binds to PSA antigen during an immune response, the current signal will decrease due to the electrical insulation of PSA antigen. The decrease of current is directly proportional to the increase of PSA concentration. The immunosensor, best operated at a voltage of typically −0.08 V (vs. Ag/AgCl), has a low limit of detection (4.4 fg·mL −1 ) and a wide linear range (0.1 pg·mL −1 to 20 ng·mL −1 ). This meets the demands of clinical diagnosis (with values <4 ng·mL −1 ) in serum. The method was applied to the determination of PSA in spiked serum.
Schematic representation of the in-situ growth of ordered Cu-MOFs wrapped with Cu(OH) 2 nanowires, building the core-shell structure as the 3D electrode. A novel electrochemical immunosensor for PSA detection has been exploited, using the Cu-MOFs nanowire arrays on Cu foam as a redox signal probe for the first time.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Gege Wu,Jiping Ma,Shuang Li,Jing Guan,Bo Jiang,Liyan Wang,Jinhua Li,Xiaoyan Wang,Lingxin Chen
Fe 3 O 4 /HKUST-1 magnetic copper based metal-organic frameworks (MOF) were synthesized by a simple and facile method and applied as an effective and recyclable adsorbent for the adsorptive removal of two widely used ciprofloxacin (CIP) and norfloxacin (NOR) fluoroquinolone antibiotics (FQAs) from aqueous solutions. Fe 3 O 4 /HKUST-1 was thoroughly characterized, and the major influence factors including solution pH, adsorbent amount and salt concentration were investigated. Compared to the reported adsorbents, Fe 3 O 4 /HKUST-1 has a very high adsorption rate, and it is found that CIP and NOR could be removed within 30 min. Moreover, the maximum adsorption capacities of the magnetic composites toward CIP and NOR reached as high as 538 mg g −1 and 513 mg g −1 , respectively, much higher than those of most of the reported adsorbents for these two FQAs. The saturation magnetization value of Fe 3 O 4 /HKUST-1 was 44 emu g −1 , which was sufficient for the separation of the Fe 3 O 4 /HKUST-1adsorbent from the aqueous solution by the application of an external magnetic field. Additionally, this magnetic material showed a good reusability with the adsorption capability decreasing only slightly after reuse for ten cycles. These results indicated that the magnetic composites Fe 3 O 4 /HKUST-1 may be a promising adsorbent in the decontamination of FQAs from wastewater due to its high adsorption capability, fast kinetics, easy separation from water, and excellent recyclability. The adsorption mechanism was proposed based on the effects of pH on adsorption and on the zeta potential of the adsorbent. For the adsorption of CIP and NOR by Fe 3 O 4 /HKUST-1, both electrostatic and π-π interactions may be important.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2017
·
IF 4.95
Caihong Wang,Jie Gao,Yili Cao,Hongliang Tan
Nanozymes have been extensively exploited in the construction of colorimetric sensors in the past decade. However, as lack of specific recognition element, these sensors are mostly limited in the detection of hydrogen peroxide and its related agents. In this work, a colorimetric assay for the detection of alkaline phosphatase (ALP) activity was developed by employing copper (II)-based metal-organic frameworks (Cu-MOFs) as peroxidase mimic and pyrophosphate (PPi) as recognition element. Benefiting from its intrinsic porosity, Cu-MOFs built from one-step self-assembly showed a superior catalytic activity over horseradish peroxidase. It was found that, in the presence of PPi, the catalytic activity of Cu-MOFs was greatly inhibited due to the ultrastrong binding ability of Cu 2+ with PPi, and no colorimetric signal was recorded. However, after incubation with ALP, such negative behavior of PPi can be suppressed as the hydrolysis of PPi into orthophosphates (Pi) with low affinity to Cu 2+ , producing a colorimetric signal depending on ALP level. On this basis, a way for quantitative analysis of ALP activity was paved accordingly. Compared with previously reported ALP assays based on nanomaterials , this assay is simple, cost-effective and visualized, which not only allows highly sensitive analysis of ALP activity with a detection limit of 0.19 U/L, but also exhibits a good sensing performance in serum samples. Furthermore, based on the distinct colorimetric signals induced by PPi and ALP, an IMPLICATION logic gate was constructed. We hope that this study could provide a new insight for designing nanozyme-based highly specific colorimetric sensors.
研究领域:
生物化学
·
纳米医学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）