APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Na Li,Zhenyuan Ji,Lizhi Chen,Xiaoping Shen,Yifei Zhang,Shiqing Cheng,Hu Zhou
In this study, highly dispersed Ag nanoparticles anchored on Fe 3 O 4 modified polydopamine sub-micrometer spheres (PSS) nanocomposites were fabricated by a facile two-step approach. The catalytic properties of the as-obtained PSS/Fe 3 O 4 /Ag ternary nanocomposites were evaluated with the reduction of 4-nitrophenol by NaBH 4 as a model reaction. It is shown that the presence of Fe 3 O 4 can significantly decrease the particle size of the in-situ formed Ag nanoparticles on PSS, and optimize the catalytic performance of PSS/Ag nanocomposites. Additionally, the as-synthesized PSS/Fe 3 O 4 /Ag ternary nanocomposites exhibit high catalytic stability for recycle. Magnetic study reveals that the ternary nanocomposites display room-temperature superparamagnetic behavior. It is believed that this simple and effective method can be extended for the preparation of other polydopamine-based multicomponent nanocomposites with intriguing property, which would hold great promise for a variety of applications.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Xiaoshuang Zhao,Jieying Zhang,Yifan Chen,Ziting Chen,Zhe Liu,Yi Xu,Xingjun Zhu,Yang Li,Xianqiang Mi
With the rapid development of precise medicine, microbeads-based fluorescence bio-coding technology for multiplexed detection has attracted increasing attentions. However, traditional multiplexed bio-analysis could not meet the demand for multiplexed detection due to the limitations of labeling dyes and microscope channels. Here, a novel fluorescence encoding strategy was proposed by using multi-color quantum dots (QDs) acted as fluorescence tags and micron sized superparamagnetic particle acted as encoding carrier. By adjusting the color and number of labeled QDs, fluorescence encoded superparamagnetic particles (FESPs) with distinct fluorescence colors and intensities were constructed. The FESPs were prepared by metal coordination-based layer-by-layer assembly with excellent binding effect. By binding DNA capture oligonucleotides, FESP probes were constructed for multiplexed detection of miRNA-21, miRNA-122 and miRNA-130b with excellent specificity. Moreover, the miRNA targets could be easily separated within 5 s originated from the excellent superparamagnetism, enabling great simplified bio-analysis process. The results demonstrated here will provide opportunities to realize the full potentials of fluorescence bio-coding in biomedical detection and diagnosis.
研究领域:
生物医学工程
·
分子诊断学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Sichen Li,Difei Zhang,Yi Li,Jingjing Zhou,Jinghua Chen,Yan Zhang
Cisplatin (CDDP) as a first-line chemotherapy drug has long suffered drawbacks of severe side effects and poor pharmacokinetics. Thus, various nano-carriers of complex architectures and multi-step modifications have been developed to overcome these challenges, but a simple delivery system with integrated multi-functions is still in demand. Herein, we synthesized a new type of glyco-based triple hydrophilic block copolymers for the delivery of CDDP and thereof cancer therapy. The incorporated glucuronic acid part is complexed with CDDP with high entrapment efficiency, while providing pH-responsive release in the acidic tumor microenvironment. The galactose segment is implanted for liver-targeting effect, which can also significantly lower the side effects of CDDP. As a result, the CDDP-loaded nanoparticle PGG2/Pt showed selectively faster endocytosis rates into HepG2 cells in vitro, with the calculated IC 50 value even comparable to that of free CDDP. The in vivo experiments on a HepG2-bearing mouse model, PGG2/Pt showed excellent anti-tumor activity and enhanced drug accumulation on tumor, together with much lowered nephrotoxicity, hepatotoxicity, and splenic toxicity. This work provides a new strategy for CDDP delivery with higher loading efficiency as well as biosafety.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 8
·5750-5762
·
IF 2.779
Ling Chen,Yimin Dai,Qi Lu,Chengqian Fang,Zhiheng Wang,Yaqi Li,Ling Cai,Bo Liu,Yue-fei Zhang,Yan Li,Li Wan
A new environmental-friendly magnetic cellulosic adsorbent MnFe 2 O 4 @Cel-g-p(AA-DMC) was easily synthesized via natural cellulose and easy-recovered magnetic particles MnFe 2 O 4 . Magnetic cellulose composites were characterized by SEM, TEM, XPS, XRD, BET, VSM, TGA and FTIR. The effect of pH, contact time and PMS dosage on adsorption was investigated. Besides, the adsorption kinetic model was well-fitted to the pseudo-second-order model, and the adsorption isotherm were matched with the Frenudlich isotherm model. The MnFe 2 O 4 @Cel-g-p(AA-DMC) posseses the excellent stability, reusability and superior superparamagnetic behavior and its possible adsorption mechanism for the adsorption of CR was proposed.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 219
·期 16
·1800172
·
IF 2.492
Jinggang Wang,Xiaoqing Liu,Jin Zhu
The properties of poly(1,4-cyclohexylenedimethylene terephthalate) (PCT) are manipulated only by tuning the steric configuration of 1,4-cyclohexanedimethanol (CHDM). The chemical structures and compositions of PCTs are confirmed by nuclear magnetic resonance ( 1 H NMR and 13 C NMR) before their thermal and mechanical properties are investigated by differential scanning calorimeter, thermogravimetric analyzer, and dynamic mechanical analysis. Results show that the ratio of cis - to trans -CHDM in PCTs has significant influences on their properties. The melting temperature of PCTs is varied from 251 to 313 °C, and the glass transition temperature is increased from 73 to 92 °C when the content of trans -CHDM in PCTs is increased from 10% to 96%. In addition, the crystallizability of PCT is also increased with the content of trans -CHDM. However, its thermal stability is decreased seriously when the melting temperature of PCT is higher than 280 °C. It is concluded that when the content of trans- CHDM is lower than 50% (PCT-10, PCT-28, and PCT-46), the balance of melting temperature, glass transition temperature, and thermal stability for PCT can be achieved. Just by varying the cis / trans ratio of CHDM, rather than the addition of other components, the properties of PCT can be manipulated.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2015
·
IF 3.85
Shan Zong,Xue Wang,Yongping Yang,Wenbin Wu,Hongjun Li,Yue Ma,Wenhai Lin,Tingting Sun,Yubin Huang,Zhigang Xie,Ying Yue,Shi Liu,Xiabin Jing
Polymer-based local drug delivery system may be suitable for the treatment of cervix cancer. A pilot study was carried out to examine the efficacy of cisplatin-loaded poly(ethylene oxide)/polylactide composite electrospun nanofibers as a local chemotherapy system against cervical cancer in mice via vaginal implantation. The nanofibers were proven to have good mucoadhesive property by in vitro mucoadhesion test and in vivo vaginal retention evaluation. An orthotopic cervical/vaginal cancer model was established by injecting murine cervical cancer U14 cells into the vaginal submucosa nearby the cervix. By inserting the nanofibers mat into the vagina of mice, the cisplatin released from the fiber-mat showed a much more accumulation in the vagina/cervix region than in the peripheral organs such as kidneys, liver, or blood, in contrary to the case of intravenous (i.v) injection. The in vivo trials showed that a better balance between anti-tumor efficacy and systemic safety was achieved in nanofibers group than that in i.v injection group at the equal drug dose. Therefore, electrospun nanofibers present a promising approach to the local drug delivery via vagina against cervical cancer.
研究领域:
肿瘤学
·
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2017
·
IF 4.162
Xing-Yu Long,Jia-Yuan Li,Dong Sheng,Hong-Zhen Lian
The spinel-type magnetic manganese ferrite (MnFe 2 O 4 ) microspheres synthesized by simple solvothermal method were used as a novel adsorbent for selective enrichment and effective isolation of phosphopeptides. The uniform MnFe 2 O 4 magnetic affinity microspheres (MAMSs) had a narrow particle size distribution between 250 and 260 nm, and displayed superparamagnetism with a saturation magnetization value of 67.0 emu/g. Comprehensively, the possible formation mechanism of MnFe 2 O 4 microspheres with ferric and manganous sources as dual precursors was elucidated by comparison with those of Fe 3 O 4 nanoparticles and MnOOH nanosheets respectively with either ferric or manganous source as single precursor. It was suggested that the spherical or sheet nanostructures could be achieved via secondary recrystallization or Ostwald ripening . The MnFe 2 O 4 MAMSs probe exhibited excellent dispersibility in aqueous solution, and rapid magnetic separation within 15 s, as well as good reusability. More importantly, MnFe 2 O 4 was highly selective for phosphopeptides because of the strong coordination interaction between metal ions (Fe 3+ and Mn 2+ ) and phosphate groups of phosphopeptdies. This high specificity was demonstrated by effectively enriching phosphopeptides from digest mixture of β -casein and bovine serum albumin (BSA) with high content of non-phosphopeptides, and embodied further in phosphopeptides enrichment from non-fat milk digests and human serum. Consequently, the prepared MnFe 2 O 4 affinity materials are expected to possess great potential in phosphoproteome research.
研究领域:
生物化学
·
材料科学
·
蛋白质组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2019
·Vol. 9
·期 23
·5157
·
IF 2.217
Yongpeng Chen,Jianguo Zhang,Zhixin Wang,Zunning Zhou
Superparamagnetic iron oxide nanoparticles are of great interest in magnetic targeted drug delivery due to their unique properties. In this paper, size-controlled superparamagnetic iron oxide nanoparticles were synthesized in an ethylene glycol/diethylene glycol (EG/DEG) binary solvent system via a facile solvothermal method. X-ray diffraction (XRD), a scanning electron microscope (SEM), and a vibrating sample magnetometer (VSM) were used to confirm that the prepared samples were superparamagneticFe3O4nanospheres. When theVEG/VDEGwas varied from 100/0 to 80/20, 60/40, and 40/60, the average diameters of the resultingFe3O4nanospheres were approximately 700, 500, 300, and 100 nm, respectively. In addition, the saturation magnetization (Ms) ofFe3O4nanoparticles with a size of 100, 300, 500, and 700 nm was 72.14, 75.94, 80.28, and 85.41 emu/g, and the corresponding remanent magnetization (Mr) was 3.34, 3.97, 3.26, and 4.28 emu/g, respectively. The relevant formation mechanisms ofFe3O4nanoparticles are proposed at the end. These superparamagneticFe3O4nanoparticles with high saturation magnetization may have use as targeted drug carriers.Keywords:targeted drug delivery;superparamagnetic;size-controlled;solvothermal method
研究领域:
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 4
·1982-1989
·
IF 3.049
Chao Zhang,HongLei Zhang,MengNan Han,XueLi Yang,ChaoHong Pei,ZhiDong Xu,Jie Du,Wei Li,Shengxi Chen
Cisplatin is the most widely used anticancer drug, but its side effects limit the maximum systemic dose. To circumvent the side effects, a DNA tetrahedron–affibody nanoparticle was prepared by combination of a DNA chain with cisplatin via interstrand crosslinks or adducts. Each nanocarrier can bind ∼68 molecules of cisplatin. This cisplatin nanoparticle exhibited high selectivity and inhibition for breast cancer HER2 overexpressing cells BT474 and lower toxicity in MCF-7 cells with low HER2 expression. The nano-drug inhibited the growth of BT474 cells by 94.57% at 512 nM (containing 33.3 μM cisplatin), which was higher than that of cisplatin (82.9%, 33.3 μM).
研究领域:
肿瘤学
·
分子生物学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Zhongjuan Wang,Haijuan Zou,Zirui Wang,Jiamin Wu,Zhongsheng Xia,Min Feng
RNA interfere (RNAi)-based technology holds great promise in cancer treatment. The use of small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo when they are diluted in blood biofluids and in the presence of serum and salt. In this study, we developed the polyglutamate derivative polymer brush, poly(ethyleneglycol) monomethyl ether-b-polyglutamate-g-spermine (mPEG-b-PG-g-spermine, PPGS), which could efficiently deliver survivin-siRNA under ultra-high dilution and in the presence of salt (NaCl 150 mM) and serum (10% FBS), most likely due to its PEG-shelled polymer brush structure. On the contrary, aggregation occurred when PEI/siRNA polyplex dispersed in saline and serum-containing media and PEI polyplex dissociated after making a 256-fold dilution. PPGS/si-survivin polyplex exhibited high cellular uptake efficiency and efficiently down-regulated the expression of survivin mRNA in the cisplatin-resistance of non-small cell human lung adenocarcinoma (A549/DDP) cells in the presence of serum. However, either PEI polyplex or Lipofectmine 2000 complex was unstable in serum and salt-containing media and at high dilution rates, which resulted in their dramatical decrease of cellular uptake and gene-silencing efficiency in these conditions. The PPGS/si-survivin polyplex also exhibited synergistic effects of killing the cancer cells by combination treatment with cisplatin . Therefore, the PPGS gene carrier showed great potential in systemic siRNA delivery, and its combination with chemotherapeutic drug is promising in treating drug resistant cancers.
研究领域:
药学
·
肿瘤学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Xiang Kang,Chen Zhao,Lesan Yan,Ruogu Qi,Xiabin Jing,Zehua Wang
A polymer-cisplatin(IV) conjugate was prepared by attaching Pt(IV)-COOH to a biodegradable amphiphilic block copolymer containing pendant OH groups. The conjugate can assemble into micelles (M(Pt)) with a mean diameter of ca. 169 nm. Further, curcumin (CM) was used to sensitize platinum drug based nanoparticles to overcome cisplatin resistance and enhance antitumor efficacy. In vitro studies showed that M(Pt)/CM combinations had great synergistic effect both on cisplatin sensitive and cisplatin resistant cell lines (A2780 and A2780DDP). In vivo studies showed that M(Pt)/CM had a much lower systemic toxicity and an enhanced antitumor efficacy compared to cisplatin alone or the corresponding cisplatin/CM combinations. Therefore, polymer-cisplatin(IV) conjugate with small molecules that serve as a non-cytotoxic or minimally cytotoxic sensitizer or enhancer provide a promising strategy, which may have potential clinical implications in the near future.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 42
·21193-21206
·
IF 9.931
Xueping Liao,Bingyu Wang,Qiang Zhang
The high-affinity interactions between cis-diols and boric/boronic acid have been widely employed as a tool for carbohydrate analysis, protein separation and boron removal. Herein we report the design and synthesis of cyclodextrin-scaffolded glycopolymers as bifunctional nanosponges for boron removal and water treatment for the first time. Different glycopolymer nanosponges (GNs) have been successfully synthesized from monosaccharides and β-cyclodextrin via a combination of a cross-linking reaction, Fischer glycosylation and a click reaction. Such functional GNs are mesoporous polymer frameworks with cis-diol-containing saccharides immobilized on the surface, which have exhibited selective adsorption behaviour towards boric acid depending on the structure of the GNs and the loaded saccharides. The GNs have also shown remarkable adsorption rates and capacities for an organic dye as a model pollutant in this work. Secondary bonding, such as hydrogen bonding and van der Waals forces between the immobilized saccharides and the adsorbates is believed to be responsible for the significantly enhanced adsorption rates and capacities. Such bifunctional materials may exhibit potential applications in seawater desalination and water treatment.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）