SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Liu Gao,Yuanyuan Su,Liang Yang,Jie Li,Ruiqi Bao,Licheng Peng
Microplastics (MPs; <5 mm) and oil pollution have been receiving global attention. To date, the adsorption mechanism of petroleum by MPs is largely unknown. This study investigated the adsorption of petroleum on micro-sized polyethylene (mPE) undergoing aging (days 0, 15, 30, 90 and 180). The petroleum adsorption capacity of mPE was further assessed at varying pH (2, 5, 7.32, 10 and 12), temperature (4, 15, 25, 45 and 65 °C) and in presence of coexisting pollutants (Cu, bisphenol A (BPA) and petroleum). The results indicated that the adsorption capacity of mPE increased with the prolonged aging time and smaller-sized particles, while the adsorption capacity of the 550 and 165 μm mPE undergoing aging increased by 12.7%—50.9% and 22.1%—63.9%, respectively. The adsorption kinetics and isotherm model of mPE on petroleum were well fitted by pseudo-second order, intraparticle diffusion, Freundlich and Langmuir models, showing the sorption behavior was controlled by the diffusion of pores, liquid film diffusion, and surface adsorption. The petroleum adsorption capacity of mPE was predominant affected by surface roughness , specific surface area, hydrophobicity , oxidation functional groups, adsorption sites, hydrogen bonds , while zeta potential and crystallinity may not be the crucial factors. Likewise, temperature and pH may influence the characteristics of petroleum, and further result in a decreasing adsorption capacity of mPE to petroleum. The highest adsorption capacity of mPE to petroleum was reached at pH 7.32 and 25 °C. The coexisting Cu, BPA and petroleum competed for adsorption sites on the surface of mPE. These findings could fundamentally provide new insights for environmental risk assessment of MPs, particularly for the specific location like harbor which is commonly rich in MPs and petroleum simultaneously.
研究领域:
环境科学
·
海洋学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Ouli Xiao,Minmin Li,Deyong Chen,Jieyin Chen,Jesus Simal-Gandara,Xiaofeng Dai,Zhiqiang Kong
Globally, honeysuckle is consumed as a food and administered as a medicinal agent. However, pesticide residues in honeysuckle limit its application and development of the honeysuckle industry, affecting food safety and endangering human health. Here, the degradation kinetics of 11 typical pesticides, including insecticides, fungicides , and an acaricide , in honeysuckle were investigated. The half-lives of pesticides in Henan and Liaoning fields were 1.90–4.33 and 2.05–4.62 d, respectively. The processing factors (PFs) of these pesticides after oven, sun, and shade drying ranged from 3.52 to 11.2. After decocting, the PFs of the pesticides were <1. Twenty degradation products were identified using ultra high performance liquid chromatography-quadrupole time-of-flight mass spectrometry , and pathways were proposed based on drying and decoction. The ecotoxicities of the degradation products were evaluated using the Toxicity Estimation Software Tool . Finally, the acute hazard indices of these pesticides, as determined via dietary exposure assessment combined with the PFs, were 0.227 and 0.911 for adults and children, respectively. Thus, special populations, such as children, require particularly careful risk control in terms of dietary exposure.
研究领域:
食品安全
·
植物保护
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 47
·28267-28276
·
IF 3.119
Huihui Zhao,Linyan Yang,Yejin Li,Weibo Xue,Kai Li,Yingqi Xie,Shujuan Meng,Guomin Cao
A prevalent group of disinfection by-products (DBPs), i.e., haloacetic acids (HAAs), have raised significant public concern due to their high frequency of occurrence, considerable concentrations and potent toxicity. This study investigated the environmental occurrence of HAAs and the corresponding predicted human exposure to two important water matrices where humans are frequently and long-term exposed, i.e., swimming pool waters (SPWs) and drinking waters (DWs), in Shanghai, China. The sum of five HAAs in SPWs was 241 μg L−1 on average (dominated by dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)), four times as much as its maximum contaminant level (MCL) regulated by the Environmental Protection Agency (EPA) in DWs. The maximum HAA concentration in DWs was 35 μg L−1, with chloroacetic acid (CAA) as the most dominant compound. The higher concentrations (reflected by total organic carbon (TOC), dissolved organic carbon (DOC), and UV254) and more categories (body fluids and personal care products in addition to natural organic matter) of organic contaminants and the higher chlorine in SPWs should be responsible for the differentiated HAA yield and speciation. The qualification rates of samples have been evaluated. The power function models correlating HAAs with multiple water quality parameters were developed with correlation coefficients of 0.614 and 0.798 for SPWs and DWs respectively. These models may provide the preliminary insights on how to minimize HAA formation by grasping the relative importance of each parameter and how to build the framework to predict HAA formation in untreated source water or SPWs subjected to chlorination. The predicted carcinogenic and non-carcinogenic risks of humans exposed to SPWs and DWs with HAAs were within the acceptable levels.
研究领域:
环境科学
·
公共卫生
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Siwei Wang,Xiaonan Wang,Hong Chang,Haibin Sun,Yanping Liu
The presence of pesticides in foodstuffs has received increasing amount of attention worldwide. In this study, an efficient and sensitive QuEChERS/HPLC-MS/MS-based method was established for the simultaneous detection of indaziflam, cyantraniliprole, spirotetramat, and their metabolites on fruits and vegetables. The purification procedure and detection condition parameters were optimized. Good precision and reproducibility were found for the method, and the average recoveries of the target analytes ranged from 71 to 118%, with the relative standard deviation ranging from 2 to 12%. The limits of quantification and the limits of detection were 1–5 and 0.3–1.5 μg kg–1, respectively. The proposed method was used to detect three pesticides and their metabolites in fruit and vegetable samples collected from China’s major producing regions. Furthermore, the dietary risk posed by the pesticide residues on fruits and vegetables was evaluated by risk quotients (RQs) and risk probabilities (RPs). The RQ and RP values were less than 100% for Chinese consumers. This study not only provides a reliable analytical method for monitoring purposes but also serves as a significant guide for food safety and export.
研究领域:
食品安全
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
·
2022
·
IF 2.731
Feng Yizhi,Zhang Aijuan,Pan Jinju,Zuo Bojun,Liang Lin
The aim of this study was to investigate the dissipation and residues of fluopyram in melon under field conditions and to assess its safe use. A liquid chromatography tandem mass spectrometry (LC-MS/MS) with QuEChERS for analysis of fluopyram and its metabolite M25 was established. Under the experimental condition of adding different levels of analytes (0.02 ~ 2 mg kg−1), the average residue recovery of fluopyram and M25 in melon was 96%~105% with a relative standard deviation of 2%~8%. The limit of quantitation of fluopyram and M25 in melon was 0.02 mg kg−1. Field trial results showed that the half-life of fluopyram in melon was 4.5–6.2 days, and the degradation was relatively fast. The residual of M25 in melon was lower than the LOQ. The terminal residues of fluopyram in melon sample were in the range of <0.02 ~ 0.095 mg kg−1, which was lower than the maximum residue limit for melon in EU (0.4 mg kg−1) and South Korea (0.6 mg kg−1). Dietary risk assessment indicated that the long-term intake risk quotient (rqchronic) and short-term intake risk quotient (rqacute) of fluopyram in people from different age groups were 0.000079 ~ 0.000671 and 0.002978 ~ 0.025268, respectively, which were significantly lower than 1. Therefore, the residues of fluopyram in melons would not affect the health of the general population in China.
研究领域:
植物保护学
·
食品安全
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
·
2022
·
IF 3.916
Yong Pan,Chaoqin Ren,Gan Wang,Yanjun Wang,Xin Zhang,Juncheng Jiang,Chi-Min Shu
Aiming at the green and sustainable energy substitution and supply, biomass valorization has become a potential strategy to face the energy crisis and increasing demand all over the world from long-term perspectives. Among the bio-based chemicals, γ-valerolactone (GVL) production from hydrogenation of levulinic acid (LA) and its esters has attracted great interests due to its wide applications, such as fuel, solvent, and additives. However, the safety evaluation for this hydrogenation reaction has received few attentions. To fill this gap, thermal hazard evaluation for GVL production from LA hydrogenation by using formic acid (FA) as hydrogen donor was first performed. The process conditions were optimized by using orthogonal experimental method for further calorimetry study. Thermal stability of chemicals and thermal risk of reaction process under adiabatic conditions were investigated by applying differential scanning calorimetry and accelerating rate calorimeter Phi-Tec II, respectively. The results revealed that the chemicals were stable in temperature range from 30 to 250 °C except FA due to its evaporation and decomposition with endothermic behaviors. The reaction process under isothermal and adiabatic conditions demonstrates that the decomposition of FA was rapid and followed by the hydrogenation of LA to GVL. Based on kinetic model under adiabatic conditions and risk matrix , the thermal runaway risk was found to be medium, indicating that certain safety measures should be properly designed and taken for loss prevention. This work could benefit the safety design and thermal risk prevention for GVL production by using FA as hydrogen donor.
研究领域:
化学工程
·
能源科学
·
安全工程
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 35
·84778-84790
·
IF 5.8
Li Wei,Hou Huizhen,Hu Jiye
Consumers are becoming more concerned about pesticide residues in food. Since citrus represent a significant portion of the diet, it is appropriate to monitor the pesticide residues in citrus. In this paper, we modified a QuEChERS method combined with HPLC-MS/MS to investigate residue levels of 15 pesticides and 3 metabolites in citrus (whole fruit and pulp) and orange juice from the markets in China. And the dietary exposure risks were evaluated by using the hazard quotient (HQ) and hazard index (HI) methods based on deterministic and probabilistic models. The recoveries of the modified method ranged from 70 to 112% at three spike levels of 0.005–0.5 mg/kg with relative standard deviations of 1.0–18.1%. Pesticide residues were detected in 85.84% of the whole citrus and 40.00% of pulp, with concentrations ranging from 0.005 to 0.47 mg/kg, which did not exceed their maximum residue limits (MRLs) in China. The HQ (0.01–11.41%) and HI (0.07–16.2%) were both less than 100%, demonstrating that chronic, acute, and cumulative dietary risks were acceptable. Notably, the risk for children (1–6 years old, 1.96–16.2%) was higher than that for the general population (0.76–6.25%). The results of our study can provide a valuable reference for regular monitoring to protect public health and ensure pesticide management.
研究领域:
食品安全
·
分析化学
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 13
·2555
·
IF 5.2
Song Yu,Lianpeng Zou,Jiawei Zhao,Yiping Zhu
Human health is seriously threatened by mycotoxin contamination, yet health risk assessments are typically based on just one mycotoxin, potentially excluding the additive or competitive interactions between co-occurring mycotoxins. In this investigation, we evaluated the individual or combined toxicological effects of three fumonisin-family B mycotoxins: fumonisin B1 (FB1), fumonisin B2 (FB2), and fumonisin B3 (FB3), by using porcine intestinal epithelial cells (IPEC). IPEC cells were exposed to various concentrations (2.5–40 μM) for 48 h, and a cell counting kit (CCK8) was used to determine cell vitality. Firstly, we discovered that they might inhibit cell viability. Additionally, the cytotoxicity of FB1 was significantly greater than that of FB2 and FB3. The results also indicated that the combinations of FB1-FB2, FB2-FB3, and FB1-FB2-FB3 showed synergistically toxicological effects at the ID10-ID50 levels and antagonistic effects at the ID75-ID90 levels. In addition, the FB1-FB3 exposure was also synergistic at the ID10-ID25 level. We also found that myriocin and resveratrol alleviated the cytotoxicity induced by fumonisin in IPEC cells. In all, this study may contribute to the determination of legal limits, the optimization of risk assessment for fumonisins in food and feed, and the development of new methods to alleviate fumonisin toxicity.Keywords:fumonisins;gastrointestinal toxicity;combined toxicity;risk assessment;control strategy
研究领域:
毒理学
·
食品安全
·
兽医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2016
·
IF 3.698
Xiang Wu,Lizhong Zhu
Under current retrospective risk assessment framework, the total concentrations of organic pollutants in soils have been employed as the standard for over 30 years. The total concentrations reflect the overall accumulation in soils but tend to be overly conservative for assessing the ecological risks, where the bioavailability plays an important role. In this study, the bioavailability of organic pollutants in soils was evaluated using a stepwise and tiered classification method, namely the sequential ultrasonic extraction procedure (SEUP). The water-soluble and acid-soluble fractions extracted by the SEUP were the bioavailable fractions. The reliability and environmental relevance of the speciation method were examined with representative organic pollutants using the root uptake methods and the semipermeable membrane devices (SPMDs). The plant uptake amounts corrected with weight were highly correlated with the bioavailable fractions (R 2 > 0.75). The amounts of the bioavailable fractions were negatively correlated with the log K ow values ( R 2 ranging from 0.71 to 0.77) of the organic pollutants and the contents of soil organic matter ( R 2 ranging from 0.68 to 0.96). As a refinement of the current risk assessment framework, the SUEP that has proved to be a reliable and convenient is thus highly recommended for evaluating the bioavailability of organic pollutants in soils.
研究领域:
环境科学
·
生态学
✓ 已验证
DOI
PubMed
高影响因子
Foods
·
2024
·Vol. 13
·期 9
·1310
·
IF 4.7
Qinghua Yao,Desen Su,Yunyun Zheng,Hui Xu,Minmin Huang,Meizhen Chen,Shaoxiao Zeng
Residual pesticides inAgrocybe aegeritamushroom have emerged as a significant concern and bring much uncertainty due to processing procedures. In this study, a modified QuEChERS sample preparation procedure and UPLC-MS/MS were used to analyze the residual levels of four commonly used pesticides inA. aegeritafrom field to product processing. The field results showed that dissipation of these targeted chemicals was consistent with the first-order kinetics, and the half-life time ranged from 20.4 h to 47.6 h. The terminal residues of the four pesticides at harvest time ranged from 9.81 to 4412.56 μg/kg in raw mushroom. The processing factors (PFs) of clothianidin, diflubenzuron, chlorbenzuron, and pyridaben ranged from 0.119 to 0.808 for the drying process and from 0.191 to 1 for the washing process. By integrating the data from the field trials, the PFs, and the consumption survey, the chronic dietary risks of the target chemicals viaA. aegeritaintake ranged from 2.41 × 10−5to 5.69 × 10−2for children and from 6.34 × 10−6to 1.88 × 10−2for adults, which are considerably below the threshold of 1, indicating no unacceptable risk to consumers in the Fujian province of China. This research offers foundational data for appropriate use and the maximum residue limit (MRL) establishment for these four insecticides inA. aegerita.
研究领域:
食品科学
·
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2015
·
IF 1.202
Junlin Wang,Shuling Kan,Tong Chen,Jianping Liu
The aim of this research was to apply quality by design (QbD) to the development of naproxen loaded core pellets which can be used as the potential core for colon-specific pellets. In the early stages of this study, prior knowledge and preliminary studies were systematically incorporated into the risk assessment using failure mode and effect analysis (FMEA) and fishbone diagram. Then Plackett–Burman design was used to screen eight potential high risk factors (spheronization speed, spheronization time, extrusion speed, drying method, CCMC-Na concentration, lactose concentration, water concentration and Tween 80 concentration) obtained from the above risk assessment. It was discovered that out of the eight potential high risk factors only three factors (spheronization speed, extrusion speed and CCMC-Na concentration) had significant effects on the quality of the pellets. This allowed the use of Box–Behnken design (BBD) to fully elucidate the relationship between the variables and critical quality attribute (CQA). Finally, the final control space was established within which the quality of the pellets can meet the requirement of colon-specific drug delivery system. This study demonstrated that naproxen loaded core pellets were successfully designed using QbD principle.
研究领域:
药剂学
·
制药工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Food Research
·
2025
·
IF 6.2
Ai Liu,Fengyu Li,Jiacheng Ge,Guodong Si,Xianzheng Han,Yun Gao,Wenli Wang,Li Su,Nan Zou,Wei Mu,Xiaomei Li,Xiuyu Pang
This study focuses on the development and validation of a detection method for indoxacarb residues in three major vegetable crops, Chinese cabbage, cabbage, and tomato, which are widely cultivated worldwide. The method was rigorously validated through field trials and dietary risk assessment. A strong linear response was observed for indoxacarb at the concentrations of 0.0005 - 0.25 mg/L, with a limit of quantitation of 0.01 mg/kg. The half-life of indoxacarb ranged from 4.61 to 6.89 days in Chinese cabbage, 3.06 to 6.21 days in cabbage, and 2.28 to 3.46 days in tomato. The terminal residues were <0.01 - 0.2 mg/kg in Chinese cabbage, <0.01 - 0.15 mg/kg in cabbage, and <0.01 - 0.029 mg/kg in tomato. Dietary risk assessment revealed a low probability of long-term risk (12.9 %) associated with the consumption of these crops. Overall, the study suggests that the use of indoxacarb on these three vegetables is safe for the general population, with minimal risk even under long-term exposure.
研究领域:
农学
·
食品安全
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）